Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14 by Lucía Sanjurjo, Esmeralda Castelblanco, Josep Julve, Nuria Villalmanzo, Érica Téllez, Anna Ramirez-Morros, Núria Alonso, Dídac Mauricio, Maria-Rosa Sarrias

“…Interestingly, HG-oxLDL upregulated CD14 gene expression, although its total cellular protein abundance remained unaltered. sCD14 shedding via PRAS40/Akt-dependent mechanisms, with pro-inflammatory activity, was significantly increased in cultured macrophages and plasma from subjects with diabetes and subclinical atherosclerosis or hypercholesterolemia. Our data support an enhanced synergistic pro-inflammatory effect induced by HG and oxLDL in cultured human macrophages, possibly explained by increased sCD14 shedding.…”
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Anlotinib plus platinum‐etoposide as a first‐line treatment for extensive‐stage small cell lung cancer: A single‐arm trial by Pengbo Deng, Chengping Hu, Cen Chen, Liming Cao, Qihua Gu, Jian An, Ling Qin, Min Li, Baimei He, Juan Jiang, Huaping Yang

“…The most common AEs with grade 3–4 were hand–foot syndrome (17%), granulocytosis (17%), stomatitis (14%), hypertriglyceridemia (11%), hypercholesterolemia (11%), as well as nausea and vomiting (11%), and no grade 5 AEs were recorded. …”
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Risk factors and longitudinal changes of dyslipidemia among Chinese people living with HIV receiving antiretroviral therapy by Xiuxia Li, Xiaojing Song, Yang Han, Zhifeng Qiu, Wei Cao, Taisheng Li

“…At baseline, the concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were 4.1 ± 0.91 mmol/L, 1.2 (interquartile ranges [IQR] 0.85–1.75) mmol/L, 1.1 ± 0.37 and 2.4 ± 0.76 mmol/L, respectively. The rate of hypercholesterolemia, hyperglyceridemia, high LDL-C, and low HDL-C were 10.18%, 26.39%, 9.08%, and 44.94%, respectively. …”
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Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study by Rosário Serrão, Kamal Mansinho, Fernando Maltez, Nuno Marques, Alexandre Carvalho, Rosário Pazos, Alexandra Zagalo, Josefina Mendez, Isabel Neves, Joaquim Oliveira, Patrícia Pacheco, Ricardo Correia de Abreu, Ana Cláudia Miranda, Paula Camacho, Laura Paixão, Joana Almeida

“…Approximately half of the patients had at least one non-AIDS-related comorbidity at baseline (53.3%), such as hypercholesterolemia, arterial hypertension, diabetes mellitus, and depression. …”
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Experience with Optical Coherence Tomography Enhanced by a Novel Software (Ultreon™ 1.0 Software)—The First One Hundred Cases by Stanisław Bartuś, Wojciech Siłka, Karol Kasprzycki, Karol Sabatowski, Krzysztof Piotr Malinowski, Łukasz Rzeszutko, Michał Chyrchel, Leszek Bryniarski, Andrzej Surdacki, Krzysztof Bartuś, Rafał Januszek

“…Significant predictors of stent underexpansion assessed by simple linear univariable analysis included: hypercholesterolemia, obstructive bronchial diseases and treatment with inhalators, family history of cardiovascular disease, PCI of other than the left main coronary artery, stent and drug-eluting stent implantation, PCI without drug-eluting balloon, paclitaxel antimitotic agent, greater maximal stent diameter and lower mean Euroscore II value. …”
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Plant-Based Fermented Beverages: Nutritional Composition, Sensory Properties, and Health Benefits by Belén Hidalgo-Fuentes, Edgar de Jesús-José, Anselmo de J. Cabrera-Hidalgo, Ofelia Sandoval-Castilla, Teodoro Espinosa-Solares, Ricardo. M. González-Reza, María L. Zambrano-Zaragoza, Andrea M. Liceaga, José E. Aguilar-Toalá

“…Plant-based beverages have gained consumers’ attention for being the main substitutes for dairy milk, especially for people with lactose intolerance, milk allergies, and a prevalence of hypercholesterolemia. Moreover, there is a growing demand for a more sustainable diet and plant-based lifestyle due to concerns related to animal wellbeing, environmental impacts linked to dairy production, and the rising cost of animal-derived foods. …”
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Body Composition Analysis during Allogeneic Hematopoietic Stem Cell Transplantation in Overweight/Obese Patients with Hematologic Diseases by Hui ZHOU, Chenjie LING, Shengli XUE, Jing YANG

“…Moreover, the incidence of abnormal fasting glucose and hypercholesterolemia in overweight/obesity group was significantly higher (χ2=7.250, 4.665, P<0.05) . …”
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PCSK9: A emerging participant in heart failure by Qian Xu, Yi-meng Zhao, Nai-qi He, Rong Gao, Wen-xin Xu, Xiu-juan Zhuo, Zhong Ren, Chun-yan Wu, Lu-shan Liu

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9), a gene mainly related to familial hypercholesterolemia, was discovered in 2003. Aside from regulating lipid metabolism, PCSK9 may be involved in other biological processes such as apoptosis, autophagy, pyroptosis, inflammation, and tumor immunity and related to diabetes and neurodegenerative diseases. …”
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Lower incidence of diabetes mellitus in patients with aneurysmal subarachnoid hemorrhage: a large case–control study with propensity score matching by Weiying Zhong, Weiying Zhong, Weiying Zhong, Kai Chen, Ziyin Song, Yizhou Xiao, Donglin Zhou, Mingxiang Zhang, Yunyan Wang, Donghai Wang, Wandong Su

“…Female sex, current drinking, and hypercholesterolemia were associated with a higher risk of aSAH, whereas old age, former smoking, and DM were associated with a lower risk of aSAH in multivariate analysis (p < 0.05). …”
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Abstract 152: Exploring Age‐related Changes in Brain Metabolism among Individuals with Cardiovascular Risk Factors: An FDG‐PET Analysis by Eric M. Teichner, Robert C. Subtirelu, Tom Werner, Abass Alavi

“…Introduction Patients with cognitive impairment often have a history of cardiovascular disease (CVD) or multiple cardiovascular risk factors (CRFs) such as hypertension, obesity, and hypercholesterolemia. The literature reports that CVD with CRFs may increase the risk of developing vascular dementia and Alzheimer’s Disease. 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) allows for the in vivo study of cerebral glucose metabolism, and can detect metabolic alterations in several neurological diseases. …”
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CHLAMYDIAL INFECTION IN CHILDREN: THE CURRENT STATE OF THE PROBLEM by Zhuk L. A.

“…Atherosclerosis in hypercholesterolemia develops faster in the presence of not only viable but inactivated chlamidophyll in the body. …”
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Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population by Amira Aker, Pierre Ayotte, Élyse Caron-Beaudoin, Sylvie Ricard, Éric Gaudreau, Mélanie Lemire

“…The high concentrations of perfluoroalkyl acids (PFAAs) may be contributing to this since PFAAs have been linked with hypercholesterolemia, diabetes, and high blood pressure. …”
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Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie’s disease and are there any implications for a... by Felice Crocetto, Ciro Imbimbo, Biagio Barone, Davide Turchino, Umberto Marcello Bracale, Antonio Peluso, Marco Panagrosso, Alfonso Falcone, Benito Fabio Mirto, Luigi De Luca, Enrico Sicignano, Francesco Del Giudice, Gian Maria Busetto, Giuseppe Lucarelli, Gaetano Giampaglia, Celeste Manfredi, Matteo Ferro, Giovanni Tarantino

“…As a likely risk factor for the presence of Peyronie’s disease, a higher prevalence of hypercholesterolemia, hyperglycemia and hypertension was discovered in the patients compared to controls. …”
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Comprehensive association analysis of speech recognition thresholds after cisplatin‐based chemotherapy in survivors of adult‐onset cancer by Mohammad Shahbazi, Xindi Zhang, Paul C. Dinh, Victoria A. Sanchez, Matthew R. Trendowski, Megan M. Shuey, Tessa Nguyen, Regeneron Genetics Center, Darren R. Feldman, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Neil E. Martin, Lawrence H. Einhorn, Nancy J. Cox, Robert D. Frisina, Lois B. Travis, Mary Eileen Dolan

“…In contrast, cumulative cisplatin dose, peripheral sensory neuropathy, hypertension, and hypercholesterolemia were not associated with SHD. Although no genetic variants had an association p value < 5 × 10−8, 22 genetic variants were suggestively associated (p < 10−5) with SRT deterioration. …”
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A Multicenter Randomized Phase II Study of Single Agent Efficacy and Optimal Combination Sequence of Everolimus and Pasireotide LAR in Advanced Thyroid Cancer by Julie E. Bauman, Zhengjia Chen, Chao Zhang, James P. Ohr, Robert L. Ferris, Gerald M. McGorisk, Stephen Brandt, Sumathi Srivatsa, Amy Y. Chen, Conor E. Steuer, Dong M. Shin, Nabil F. Saba, Fadlo R. Khuri, Taofeek K. Owonikoko

“…The most frequent adverse events were anemia, stomatitis, fatigue, hyperglycemia, and hypercholesterolemia. Conclusions: The combination of everolimus and pasireotide-LAR showed promising efficacy over single agent. …”
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Cardiovascular risk factors in patients with calcium pyrophosphate crystal deposition disease by M. S. Eliseev, O. V. Zhelyabina, M. N. Chikina, A. M. Novikova

“…In addition to the high detection  rate of traditional  cardiovascular risk factors (hypertension, smoking, hypercholesterolemia, and DM),  the presence of chronic microcrystalline  inflammation, concomitant metabolic disorders and diseases (hyperuricemia, HPT,  decreased renal function)  should be taken into account when determining the cardiovascular risk in patients with CPCDD.…”
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Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1α/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and... by Yen-Kuang Lin, Chi-Tai Yeh, Kuang-Tai Kuo, Vijesh Kumar Yadav, Iat-Hang Fong, Nicholas G. Kounis, Patrick Hu, Ming-Yow Hung

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) can promote the degradation of low-density lipoprotein (LDL) receptor (LDLR), leading to hypercholesterolemia and myocardial dysfunction. The intracellular regulatory mechanism by which the natural polyphenol pterostilbene modulates the PCSK9/LDLR signaling pathway in cardiomyocytes has not been evaluated. …”
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Clinical efficacy of Diabecon in treatment of type 2 diabetes mellitus, in newly diagnosed diabetic patients and in those on drug treatment (Glibenclamide and Metformin) in Erbil G... by Mohammed F. S, Ansam N. Al-Hassani

“…Its main effect is on the reduction of TC which could be beneficial since hypercholesterolemia is strongly associated with cardiovascular disease. …”
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Prevalence of hypertension and correlation with mental health in women with burning mouth syndrome: A case-control study by Federica Canfora, Elena Calabria, Giuseppe Pecoraro, Stefania Leuci, Noemi Coppola, Cristina Mazzaccara, Cristina Mazzaccara, Francesca Spirito, Massimo Aria, Luca D'Aniello, Michele Davide Mignogna, Daniela Adamo

“…A strongly linear correlation between HTN and employment status, systemic diseases, and education level (p &lt; 0.001**) was found in WBMS, while a strong correlation between HTN and employment status, hypercholesterolemia, systemic diseases, and drug consumption was found in HW (p &lt; 0.001**). …”
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Exome Sequencing Revealed a Novel Splice Site Variant in the <i>CRB2</i> Gene Underlying Nephrotic Syndrome by Anam Simaab, Jai Krishin, Sultan Rashid Alaradi, Nighat Haider, Muqadar Shah, Asmat Ullah, Abdullah Abdullah, Wasim Ahmad, Torben Hansen, Sulman Basit

“…<i>Background and Objectives</i>: Nephrotic syndrome (NS) is a kidney disease where the patient has a classic triad of signs and symptoms including hypercholesterolemia, hypoalbuminemia, proteinuria (>3.5 g/24 h), and peripheral edema. …”
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