Primary Prevention of Cardiovascular Disease at Community Clinics in the State of Sao Paulo, Brazil: Results from the Epidemiological Information Study of Communities by Henrique Andrade R. Fonseca, Maria Cristina O. Izar, Luciano F. Drager, Ibraim M. Pinto, José Francisco K. Saraiva, João Fernando Monteiro Ferreira, Álvaro Avezum, Francisco Antonio Fonseca, Otávio Berwanger

“…Subjects were living in Brazilian communities and were of both sexes and ≥18 years old, without a history of a stroke or myocardial infarction but presenting at least one of the following cardiovascular risk factors: hypertension, diabetes mellitus and hypercholesterolemia. The study was carried out in Brazil, including 322 basic health units (BHU) in 32 cities. …”
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Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons by Jeanne Neuffer, Raúl González-Domínguez, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Bénédicte Driollet, Catherine Helmer, Andrea Du Preez, Chiara de Lucia, Silvie R. Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Sandrine Thuret, Claudine Manach, Mercè Pallàs, Mireia Urpi-Sardà, Alex Sánchez-Pla, Cristina Andres-Lacueva, Cécilia Samieri

“…Additional analyses suggested mediation by hypercholesterolemia and diabetes. Propionic acid strongly correlated with blood glucose (r = 0.79) and with intakes of meat and cheese (r > 0.15), but not fiber (r = 0.04), suggesting a minor role of prebiotic foods per se, but a possible link to processed foods, in which propionic acid is a common preservative. …”
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Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis by Elena V. Kozlova, Elena V. Kozlova, Maximillian E. Denys, Jonathan Benedum, Matthew C. Valdez, Dave Enriquez, Anthony E. Bishay, Bhuvaneswari D. Chinthirla, Edward Truong, Julia M. Krum, Nicholas V. DiPatrizio, Poonamjot Deol, Manuela Martins-Green, Margarita C. Curras-Collazo

“…L-DE-71 female offspring were particularly affected, showing hypercholesterolemia, elevated liver lipids and fasting plasma leptin as compared to same-sex VEH/CON, while L- and H-DE-71 male F1 only showed reduced plasma adiponectin. …”
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Chemical Composition, Antioxidant Properties and Hypocholesterolemic Effects of Differently Treated Roselle (Hibiscus Sabdariffa L.) Seeds by Khairul Ikram, Emmy Hainida

“…Effect of dried roselle seeds (DRS), on lipid profiles of rats induced hypercholesterolemia was also conducted. Protein, lipids and dietary fiber were found to be high in all the seeds studied. …”
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Association between systemic immune inflammation index, systemic inflammation response index and adult psoriasis: evidence from NHANES by Rui Ma, Rui Ma, Lian Cui, Lian Cui, Jiangluyi Cai, Jiangluyi Cai, Nan Yang, Nan Yang, Yuanyuan Wang, Yuanyuan Wang, Qianyu Chen, Qianyu Chen, Wenjuan Chen, Wenjuan Chen, Chen Peng, Chen Peng, Hui Qin, Hui Qin, Yangfeng Ding, Yangfeng Ding, Xin Wang, Xin Wang, Qian Yu, Qian Yu, Yuling Shi, Yuling Shi

“…The association between SII levels and psoriasis was stronger in females, obese individuals, people with type 2 diabetes, and those without hypercholesterolemia.ConclusionWe observed positive associations between SII-SIRI pattern, SII, SIRI, and psoriasis among U.S. adults. …”
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Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) by Olga Estévez-Vázquez, Raquel Benedé-Ubieto, Feifei Guo, Beatriz Gómez-Santos, Patricia Aspichueta, Johanna Reissing, Tony Bruns, Carlos Sanz-García, Svenja Sydor, Lars P. Bechmann, Eva Maranillo, José Ramón Sañudo, María Teresa Vázquez, Arantza Lamas-Paz, Laura Morán, Marina S. Mazariegos, Andreea Ciudin, Juan M. Pericàs, María Isabel Peligros, Javier Vaquero, Eduardo Martínez-Naves, Christian Liedtke, José R. Regueiro, Christian Trautwein, Rafael Bañares, Francisco Javier Cubero, Yulia A. Nevzorova

“…Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. …”
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Adropin: An endocrine link between the biological clock and cholesterol homeostasis by Sarbani Ghoshal, Joseph R. Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S. Leon, D.C. Rao, James S. Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V. Nuñez, Kimber L. Stanhope, Deborah A. Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P. Weiss, Alisha R. Coffey, Brian J. Bennett, Praveen Sethupathy, Thomas P. Burris, Peter J. Havel, Andrew A. Butler

“…However, adropin over expression does not prevent hypercholesterolemia resulting from a high cholesterol diet and/or LDL receptor mutations. …”
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An Experimental DUAL Model of Advanced Liver Damage by Raquel Benedé‐Ubieto, Olga Estévez‐Vázquez, Feifei Guo, Chaobo Chen, Youvika Singh, Helder I. Nakaya, Manuel Gómez del Moral, Arantza Lamas‐Paz, Laura Morán, Nuria López‐Alcántara, Johanna Reissing, Tony Bruns, Matías A. Avila, Eva Santamaría, Marina S. Mazariegos, Marius Maximilian Woitok, Ute Haas, Kang Zheng, Ignacio Juárez, José Manuel Martín‐Villa, Iris Asensio, Javier Vaquero, Maria Isabel Peligros, Josepmaria Argemi, Ramón Bataller, Javier Ampuero, Manuel Romero Gómez, Christian Trautwein, Christian Liedtke, Rafael Bañares, Francisco Javier Cubero, Yulia A. Nevzorova

“…Animals fed with DUAL diet elicited a significant increase in body mass index accompanied by a pronounced hypertrophy of adipocytes, hypercholesterolemia, and hyperglycemia. Significant liver damage was characterized by elevated plasma alanine aminotransferase and lactate dehydrogenase levels, extensive hepatomegaly, hepatocyte enlargement, ballooning, steatosis, hepatic cell death, and compensatory proliferation. …”
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Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels by Bożena Sosnowska, Janina Stepinska, Przemyslaw Mitkowski, Agata Bielecka-Dabrowa, Beata Bobrowska, Jan Budzianowski, Pawel Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Mariusz Gasior, Piotr Jankowski, Jacek Kubica, Agnieszka Mickiewicz, Malgorzata Mysliwiec, Tadeusz Osadnik, Aleksander Prejbisz, Renata Rajtar-Salwa, Krystian Wita, Adam Witkowski, Robert Gil, Maciej Banach

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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice by Kenneth R. Hallows, Hui Li, Biagio Saitta, Saman Sepehr, Polly Huang, Jessica Pham, Jonathan Wang, Valeria Mancino, Eun Ji Chung, Eun Ji Chung, Stephen L. Pinkosky, Núria M. Pastor-Soler

“…Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. …”
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FACTORES DE RIESGO DE DIABETES EN UNA POBLACIÓN ADOLESCENTE DE CANGAS DE MORRAZO (GALICIA) (RIVACANGAS) by Rocío Mera-Gallego, José A. Fornos-Pérez, N. Floro Andrés-Rodríguez, Natalia Vérez-Cotelo, Patricia García-Rodríguez, Marta Fernández-Cordeiro, Itxaso Rica-Echevarría

“…Results 630 school, 628 without diabetes: 294 girls (46.8%) and 334 children (53.2%), mean of age 13,8±1,4 years. 7.1% hypercholesterolemia; 1.7% CVD, hypertension 0.8% and 0.3% DM. 5.6% 1st degree of family history of DM. 2nd degree of family history of DM, 18.6%. 23.3% overweight. 7.5% with central obesity (PC>P90). 21.0% WHI>0.5. 63.9% SBP>P90 and 23.7% DBO>P90.  …”
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Niveles séricos de homocisteína total y lipoproteínas en adultos jóvenes de áreas rurales y urbanas de Costa Rica Serum total homocysteine and lipoproteins levels in young adults f... by Ileana Holst -Schumacher, Rafael Monge-Rojas, Mauro Barrantes-Santamaría

“…The prevalences of hyperhomocysteinemia (>15 ìmol/L), hypercholesterolemia (= 5,17 mmol/L) and hypertriglyceridemia (=1,69 mmol/L) in the studied population were 5,8%, 53,6% y 50,1% respectively. 82% of the studied population had LDL-C levels above 2,58 mmol/L and approximately 61% of the adults had HDL-C levels lower than 1,03 mmol/L. …”
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Characteristics, Treatment, and Mortality of Patients Hospitalized for First ST-Segment Elevation Myocardial Infarction without Standard Modifiable Risk Factors in China by Weihong Guo, Yunfeng Wang, Aoxi Tian, Jiayi Yi, Jiamin Liu, Haibo Zhang, Jing Li, Shengshou Hu, Xi Li, Xin Zheng

“…Background: Little is known of the characteristics, treatment, and outcomes of patients with ST-segment elevation myocardial infarction (STEMI) but without standard modifiable cardiovascular risk factors (SMuRFs, including smoking, hypercholesterolemia, diabetes, and hypertension) in developing countries like China. …”
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Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease by Katrīna D. Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S. Hawe, Ulrich Güldener, Annie M. Westerlund, Ling Li, Shichao Pang, Chuhua Yang, Kathrin Saar, Norbert Huebner, Lars Maegdefessel, DigiMed Bayern Consortium, Rüdiger Lange, Markus Krane, Heribert Schunkert, Moritz von Scheidt

“…Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. …”
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Alfosbuvir plus Daclatasvir for Treatment of Chronic Hepatitis C Virus Infection in China by Rui Hua, Fei Kong, Guangming Li, Xiaofeng Wen, Yuexin Zhang, Xingxiang Yang, Chenxin Meng, Wen Xie, Yongfang Jiang, Xiaozhong Wang, Xueji Han, Yan Huang, Qing Mao, Jiefei Wang, Yujuan Guan, Jiayu Chen, Yingjie Ma, Qingfang Xiong, Hong Ma, Xuebing Yan, Huiying Rao, Yingren Zhao, Tong Sun, Liying Zhu, Xiaorong Mao, Jianqi Lian, Guojiong Deng, Yongning Xin, Yifei Wang, Yinong Ye, Bin Xu, Hainv Gao, Youwen Tan, Dongliang Li, Dongliang Yang, Minghua Su, Xiaomeng Zhang, Jie Min, Xinsheng Shi, Lai Wei, Junqi Niu

“…The most common adverse event (AE) (≥ 10%) was hypercholesterolemia. Serious adverse events (SAEs) were reported in 25 (7.7%) patients, none of which was judged to be related to the study drug. …”
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Sobrepeso, obesidad y dislipidemias en población universitaria del noreste de México Sobrepeso, obesidade e dislipidemias em população universitária do nordeste de México Overweigh... by Martha Magallanes Monrreal, Esther Carlota Gallegos Cabriales, Ana Laura Carrillo Cervantes, Daniel Sifuentes Leura, María Antonieta Olvera Blanco

“…Results: a total prevalence of 31,2% overweight was found (45.8% in men and 22.4% in women) and 15.1% of obesity. The hypercholesterolemia global prevalence was of 23.6% (31.4% in men and 18.4% in women) Being higher in manual workers and managers (53.8% and 52.8%, respectively). …”
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FACTORES DE RIESGO DE DIABETES EN UNA POBLACIÓN ADOLESCENTE DE CANGAS DE MORRAZO (GALICIA) (RIVACANGAS) by Rocío Mera-Gallego, José A. Fornos-Pérez, N. Floro Andrés-Rodríguez, Natalia Vérez-Cotelo, Patricia García-Rodríguez, Marta Fernández-Cordeiro, Itxaso Rica-Echevarría

“…Results 630 school, 628 without diabetes: 294 girls (46.8%) and 334 children (53.2%), mean of age 13,8±1,4 years. 7.1% hypercholesterolemia; 1.7% CVD, hypertension 0.8% and 0.3% DM. 5.6% 1st degree of family history of DM. 2nd degree of family history of DM, 18.6%. 23.3% overweight. 7.5% with central obesity (PC>P90). 21.0% WHI>0.5. 63.9% SBP>P90 and 23.7% DBO>P90.  …”
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Association of hypertriglyceridemic-waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN-III study by Roya Kelishadi, Fahimeh Jamshidi, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Ramin Heshmat, Gelayol Ardalan, Silva Hovsepian

“…The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with HW phenotype and MetS than in their peers (p < 0.05). …”
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Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literat... by Iosif Marincu, Felix Bratosin, Iulia Bogdan, Catalin Dumitru, Carmen Nicoleta Stoica, Andrei Nicolae Csep, Narcisa Mederle, Roxana Manuela Fericean, Alexandru Ovidiu Mederle, Reshmanth Prathipati, Gratiana Nicoleta Chicin, Adelina Mavrea, Paula Irina Barata, Adrian Vasile Bota

“…He had several comorbidities, including adrenal insufficiency, duodenal ulcer, and hypercholesterolemia. Lumbar puncture showed elevated leukocyte counts, glucose, and a marked rise of cerebrospinal fluid (CSF) proteins, indicating bacterial meningitis, which was confirmed by CSF culture that isolated <i>S. paucimobilis</i> and <i>Mycobacterium tuberculosis</i>. …”
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Asian Subgroup Analysis of the Randomized Phase 3 CROWN Study of First-Line Lorlatinib Versus Crizotinib in Advanced ALK-Positive NSCLC by Qing Zhou, MD, PhD, Ross A. Soo, MBBS, PhD, Gee-Chen Chang, MD, PhD, Chao-Hua Chiu, MD, Hidetoshi Hayashi, MD, PhD, Sang-We Kim, MD, PhD, Shunsuke Teraoka, MD, Yasushi Goto, MD, PhD, Jianying Zhou, MD, Victor Ho-Fun Lee, MD, Dong-Wan Kim, MD, PhD, Baohui Han, MD, PhD, James Chung Man Ho, MD, FRCP, Chia-Chi Lin, MD, PhD, Shun Lu, MD, Anna Polli, BS, Anna Maria Calella, PhD, Jean-François Martini, PhD, Chew Hooi Wong, PhD, Tony Mok, MD, Hye Ryun Kim, MD, PhD, Yi-Long Wu, MD

“…The definition of nonmeasurable brain metastases is: a brain lesion less than 10 mm in MRI scan is defined as nonmeasurable brain metastasi based on RECIST criteria (Clinical trial evaluation criteria). Hypercholesterolemia, hypertriglyceridemia, and edema were the most frequently reported adverse events with lorlatinib. …”
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