High prevalence of cardiovascular disease and risk factors among type 2 diabetes patients followed in a hospital setting in Portugal: The PICT2RE observational study by Helena Cardoso, Carlos Tavares Bello, Luís Andrade, Francisco Sobral do Rosário, Joana Louro, Cláudia Nogueira, Elisabete Rodrigues, Nuno Bernardino Vieira, Teresa Carqueja

“…CVD was significantly associated with hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol, hypertriglyceridemia and smoking. …”
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Various Expressions of <i>PIK3C2A</i> and <i>TXNIP</i> Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome by Shimaa E. Soliman, Mai A. H. Abouelenin, Neven I. Samy, Marwa M. Omar, Abeer A. Alrefai

“…<i>TXNIP</i> was significantly upregulated in STEMI-ACS patients compared to CSA (<i>p</i> = 0.045) and NSTEMI ACS (<i>p</i> = 0.046), among non-diabetic (<i>p</i> = 0.023) smokers (<i>p</i> = 0.036) with hypertension (<i>p</i> = 0.005) and hypercholesterolemia (<i>p</i> = 0.001). ROC (receiver operating characteristic) curve analysis revealed that <i>PIK3C2A</i> (0.981; <i>p</i> < 0.001; 98.18) was the most sensitive mRNA for discriminating ACS from control, followed by <i>TXNIP</i> (0.775; <i>p</i> < 0.001; 70.91). …”
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Modificaciones de los lípidos séricos de ratas suplementadas con cobre por vía oral by Oscar M. Alarcón-Corredor, Elizabeth Carnevalí de Tatá, José Reinosa-Füller, Yaritza Contreras, María Ramírez de Fernández, Claudia Yánez-Domínguez

“…Previous studies have reported that hypercholesterolemia and hypertriglyceridemia are associated with elevated hepatic iron concentrations in copper deficient rats. …”
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Changing from lipoprotein apheresis to evolocumab treatment lowers circulating levels of arachidonic acid and oxylipins by Chaoxuan Wang, Anne Kaufmann, Nadja Kampschulte, Ulf Elbelt, Ursula Kassner, Elisabeth Steinhagen-Thiessen, Anne Pietzner, Christoph Schmöcker, Dev Datta, Tiziana Sanpietro, Nils Helge Schebb, Karsten-H. Weylandt, Nadine Rohwer

“…This has not been examined for treatment with protein convertase subtilisin/kexin type 9 inhibitors such as evolocumab, which are increasingly used instead of lipoprotein apheresis in treatment-resistant familial hypercholesterolemia. The aim of this study was to compare the effects of evolocumab treatment and lipoprotein apheresis on the fatty acid profile and on formation of lipid mediators in blood samples. …”
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Effects of Oryzanol and Tocotrienol on Platelet Aggregation and Blood Lipid Profile in Rats by Maliki, Nur Zillah

“…The second treatment batch on the other hand received intervention diets after hypercholesterolemia induction. They were also randomly distributed into 7 groups (n=10/group); Control, HCD (Control + 1% cholesterol + 0.15% cholic acid), ASA (0.5% aspirin), ORY (0.5% oryzanol in triolein), TRF (0.5% tocotrienol-rich fraction in triolein), OT (0.5% oryzanol + tocotrienol in triolein) and EMUL (0.5% oryzanol + tocotrienol emulsion). …”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. by Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty

“…<h4>Background</h4>While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. …”
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T cells with increased responsiveness cause obesity in mice without diet intervention by Ida Gregersen, Xiang Y. Kong, Sander Kooijman, Håvard Foyn, Helene Grannes, Maria B. Olsen, Anna M. Lone, Kuan Yang, Ana Quiles-Jiménez, Marianne Tran, Jonas Øgaard, Filip M. Segers, Azita Rashidi, Ellen Lund Sagen, Knut H. Lauritzen, Amanda C.M. Pronk, Jan Freark de Boer, Kirsten B. Holven, Espen Melum, Pål Aukrust, Kjetil Taskén, Sverre Holm, Patrick C.N. Rensen, Tuva B. Dahl, Bente Halvorsen

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Mortality of patients with ST-segment-elevation myocardial infarction without standard modifiable risk factors among patients without known coronary artery disease: Age-stratified... by Sun-Joo Jang, Luke K. Kim, Navjot Kaur Sobti, Ilhwan Yeo, Jim W. Cheung, Dmitriy N. Feldman, Nivee P. Amin, David L. Narotsky, Parag Goyal, S. Andrew McCullough, Udhay Krishnan, Stuart Zarich, S. Chiu Wong, Samuel M. Kim

“…Objective: The proportion of ST-segment elevation myocardial infarction (STEMI) patients without standard modifiable risk factors (SMuRFs: hypertension, diabetes, hypercholesterolemia and smoking) has increased over time. …”
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Lessons Learned from the Pilot Phase of a Population-Wide Genomic Screening Program: Building the Base to Reach a Diverse Cohort of 100,000 Participants by Caitlin G. Allen, Leslie Lenert, Kelly Hunt, Amy Jackson, Elissa Levin, Catherine Clinton, John T. Clark, Kelli Garrison, Sam Gallegos, Karen Wager, Wenjun He, Katherine Sterba, Paula S. Ramos, Cathy Melvin, Marvella Ford, Kenneth Catchpole, Lori McMahon, Daniel P. Judge

“…Screening healthy adults for Tier 1 conditions of hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia using a population-based approach can help identify the 1–2% of the US population at increased risk of developing diseases associated with these conditions and tailor prevention strategies. …”
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Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Canc... by Ruan Pimenta, Carolina Mie Mioshi, Guilherme L. Gonçalves, Patrícia Candido, Juliana A. Camargo, Vanessa R. Guimarães, Caroline Chiovatto, Vitória Ghazarian, Poliana Romão, Karina Serafim da Silva, Gabriel A. dos Santos, Iran A. Silva, Miguel Srougi, William C. Nahas, Kátia R. Leite, Nayara I. Viana, Sabrina T. Reis

“…Our study aimed to evaluate the potential suppressive effect of miR-137 in a model of advanced PCa with and without diet-induced hypercholesterolemia. In vitro, PC-3 cells were treated with 50 pmol of mimic miR-137 for 24 h, and gene and protein expression levels of SRC-1, SRC-2, SRC-3, and AR were evaluated by qPCR and immunofluorescence. …”
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Lipid profile of patients treated with evolocumab in Spanish hospital nephrology units (RETOSS NEFRO) by Marian Goicoechea, Vicente Álvarez, Alfonso Segarra, Manuel Polaina, Guillermo Martín-Reyes, Nicolás Roberto Robles, Verónica Escudero, Cristhian Orellana, Sergio Bea Granell, Joaquín de Juan-Ribera, Milagros Fernández Lucas, Jose Maria Graña, Javier Reque, Rosa Sánchez Hernández, Santiago Villamayor, Jose Luis Górriz

“…Results: 60 patients were enrolled: 53.3% women; mean (SD) age, 56.9 (12.8) years, 45.0% with familial hypercholesterolemia (FH) (5.0% homozygous and 40.0% heterozygous) and 65.0% with atherosclerotic cardiovascular disease. …”
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The Assessment of Oxidative Stress Parameters in the Urban Drivers Blood Serum in Comparison with Suburban Drivers with the Impact of Traffic Pollutants: A Prospective Cohort Study by Leila Tabarestani, FereshtehRahmati Rahmati, Shirin Jalili, Amirhossein Esmaeili

“…A questionnaire was also completed for each person including demographic information and history of cardiac risk factors in the past (hypercholesterolemia, diabetes). The methods used in this study were taken from the book of biochemical experiments of Dr. …”
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Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis by Víctor Micó, Rodrigo San-Cristobal, Roberto Martín, Miguel Ángel Martínez-González, Miguel Ángel Martínez-González, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Jordi Salas-Salvadó, Dolores Corella, Dolores Corella, Montserrat Fitó, Montserrat Fitó, Ángel M. Alonso-Gómez, Ángel M. Alonso-Gómez, Julia Wärnberg, Julia Wärnberg, Jesús Vioque, Jesús Vioque, Dora Romaguera, Dora Romaguera, José López-Miranda, José López-Miranda, Ramon Estruch, Ramon Estruch, Francisco J. Tinahones, Francisco J. Tinahones, José Lapetra, José Lapetra, J. Luís Serra-Majem, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Aurora Bueno-Cavanillas, Josep A. Tur, Josep A. Tur, Josep A. Tur, Vicente Martín Sánchez, Vicente Martín Sánchez, Xavier Pintó, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Josep Vidal, Clotilde Vázquez, Clotilde Vázquez, Ana García-Arellano, Salvador Pertusa-Martinez, Alice Chaplin, Alice Chaplin, Antonio Garcia-Rios, Antonio Garcia-Rios, Carlos Muñoz Bravo, Carlos Muñoz Bravo, Helmut Schröder, Nancy Babio, Nancy Babio, Jose V. Sorli, Jose V. Sorli, Jose I. Gonzalez, Jose I. Gonzalez, Diego Martinez-Urbistondo, Estefania Toledo, Estefania Toledo, Vanessa Bullón, Miguel Ruiz-Canela, María Puy- Portillo, María Puy- Portillo, María Puy- Portillo, Manuel Macías-González, Manuel Macías-González, Nuria Perez-Diaz-del-Campo, Jesús García-Gavilán, Jesús García-Gavilán, Lidia Daimiel, J. Alfredo Martínez, J. Alfredo Martínez, J. Alfredo Martínez

“…The first was determined by hypercholesterolemia and associated treatments, the second factor exhibited glycemic disorders and accompanying treatments and the third factor was characterized by hepatic enzymes. …”
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PENINGKATAN AKTIVITAS ENZIM LIPOPROTEIN LIPASE (LPL) DAN PERUBAHAN HISTOPATOLOGIS HATI TIKUS (Rattus norvegicus) HIPERKOLESTEROLEMIA YANG DIBERI EKSTRAK SARANG SEMUT (Myrmecodia sp... by Roslizawaty R, Rusli R, Nazaruddin N, Syafruddin S, Indahlia Syahfitri Bangun, Jumaidar J

“…Key words: Myrmecodia sp., LPL activity, histopathological liver, hypercholesterolemia…”
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LDL‐aférese no tratamento de hipercolesterolemia familiar: experiência do Hospital Santo António by Isabel Palma, Ana Rita Caldas, Isabel Mangas Palma, José Alexandre Queirós, Anselmo Madureira, José Carlos Oliveira, Paulo Palma, Carlos Correia, Maria Helena Ramos

“…Palavras‐chave: Adsorção direta de lipoproteínas‐aférese, Lipoproteínas de baixa densidade‐aférese, Doença cardiovascular, Lipoproteína (a), Hipercolesterolemia familiar, Keywords: Direct adsorption of lipoprotein apheresis, Low‐density lipoprotein apheresis, Cardiovascular disease, Serum lipoprotein(a), Familial hypercholesterolemia…”
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