A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation by Henning Sievert, Nora Pällmann, Katharine K. Miller, Irm Hermans-Borgmeyer, Simone Venz, Ataman Sendoel, Michael Preukschas, Michaela Schweizer, Steffen Boettcher, P. Christoph Janiesch, Thomas Streichert, Reinhard Walther, Michael O. Hengartner, Markus G. Manz, Tim H. Brümmendorf, Carsten Bokemeyer, Melanie Braig, Joachim Hauber, Kent E. Duncan, Stefan Balabanov

Subjects: “…Hypusine modification…”
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Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis by Abhishek Kulkarni, Cara M. Anderson, Raghavendra G. Mirmira, Sarah A. Tersey

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Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons by Elham Shojaeinia, Teresa L. Mastracci, Remon Soliman, Orrin Devinsky, Camila V. Esguerra, Alexander D. Crawford

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Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress by Nicolas Melis, Isabelle Rubera, Sebastien Giraud, Marc Cougnon, Christophe Duranton, Mallorie Poet, Gisèle Jarretou, Raphaël Thuillier, Laurent Counillon, Thierry Hauet, Luc Pellerin, Michel Tauc, Didier F. Pisani

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Relevance of the axis spermidine/eIF5A for plant growth and development by Borja eBelda Palazón, Carla eAlmendáriz, Esmeralda eMartí, Juan eCarbonell, Alejandro eFerrando

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Hypusination Orchestrates the Antimicrobial Response of Macrophages by Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson

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Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis by Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci

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DHPS‐Mediated Hypusination Regulates METTL3 Self‐m6A‐Methylation Modification to Promote Melanoma Proliferation and the Development of Novel Inhibitors by Jing‐si Guo, Jian Ma, Xi‐he Zhao, Ji‐fang Zhang, Kai‐li Liu, Long‐tian Li, Yu‐xi Qin, Fan‐hao Meng, Ling‐yan Jian, Yue‐hui Yang, Xin‐yang Li

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Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer by Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson

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Hypusination in intestinal epithelial cells protects mice from infectious colitis by Alain P. Gobert, Caroline V. Hawkins, Kamery J. Williams, Lydia A. Snyder, Daniel P. Barry, Mohammad Asim, Margaret M. Allaman, Kara M. McNamara, Alberto G. Delgado, Yu Wang, Shilin Zhao, Kristie L. Rose, M. Blanca Piazuelo, Keith T. Wilson

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eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production by Rocío Seoane, Yessica Y. Llamas-González, Yessica Y. Llamas-González, Santiago Vidal, Ahmed El Motiam, Yanis Hichem Bouzaher, Danae Fonseca, Rosa Farrás, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, José González-Santamaría, Carmen Rivas, Carmen Rivas

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Half Way to Hypusine—Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase by Elżbieta Wątor, Piotr Wilk, Przemysław Grudnik

Subjects: “…hypusination…”
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Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in <i>P. falciparum</i> by Aiyada Aroonsri, Chayaphat Wongsombat, Philip Shaw, Siegrid Franke, Jude Przyborski, Annette Kaiser

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New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape by Chad R. Schultz, Ryan D. Sheldon, Huirong Xie, Elena Y. Demireva, Katie L. Uhl, Dalen W. Agnew, Dirk Geerts, André S. Bachmann

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Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma by Byung-Sun Park, Heeju Jeon, Yeonseo Kim, Haejin Kwon, Ga-Eun Choi, Sung-Gil Chi, Hyun-Mee Park, Hyunbeom Lee, Tackhoon Kim

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Application of GC7 to reduce hypusination via inhibiting deoxyhypusine synthase in Arabidopsis thaliana seedlings exposed salt stress by Ágnes Szepesi, Edina Kakas, Réka Szőllősi, Árpád Molnár, Péter Pálfi

Subjects: “…Hypusination…”
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Molecular targets of spermidine: implications for cancer suppression by Andreas Zimmermann, Sebastian J. Hofer, Frank Madeo

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Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons by Paola Cavalli, Anna Raffauf, Sergio Passarella, Martin Helmuth, Daniela C. Dieterich, Daniela C. Dieterich, Peter Landgraf

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Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors by Mattia D'Agostino, Stefano Motta, Alice Romagnoli, Alice Romagnoli, Patrick Orlando, Luca Tiano, Anna La Teana, Anna La Teana, Daniele Di Marino, Daniele Di Marino

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Spermidine supplementation in rare translation-associated disorders by Andreas Zimmermann, Didac Carmona-Gutierrez, Frank Madeo

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