Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites by Margarida L. F. Martins, Paniz Heydari, Paniz Heydari, Wenlong Li, Alejandra Martínez-Chávez, Alejandra Martínez-Chávez, Nikkie Venekamp, Maria C. Lebre, Luc Lucas, Jos H. Beijnen, Jos H. Beijnen, Jos H. Beijnen, Alfred H. Schinkel

Subjects: “…ibogaine/iboga…”
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Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones by Charles Sutton, Erin Q. Williams, Hoomam Homsi, Pieter Beerepoot, Reza Nazari, Dong Han, Amy J. Ramsey, Deborah C. Mash, David E. Olson, David E. Olson, David E. Olson, Bruce Blough, Ali Salahpour

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Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations. by Heidi Koldsø, Henriette Elisabeth Autzen, Julie Grouleff, Birgit Schiøtt

“…The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. …”
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To the Roots: Me, My Brother, Heroin and Iboga by Sagit Mezamer

“…A visual essay following an Ibogaine treatment. By artist and curator, Sagit Mezamer The imagery in this essay is taken from drawings and photographs from Mezamer's new artwork - The Mother of Opium.…”
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A Review on Medicinal Plants Used in Animal Models and Clinical Trials concerning Drug Addiction by S Kianbakht

“…Here, the effects of Hypericum perforatum, Valeriana officinalis, Passiflora incarnata, Rosmarinus officinalis, Papaver rhoea, Tabernanthe iboga, Ginkgo biloba, salvia miltiorrhiza, Pueraria lobata, Opuntia ficus-indica, Cynara scolymus, Panax ginseng, melatonin, ibogaine and its derivative 18-methoxycoronaridine and some other plants active constituents in animal models and clinical trials concerning drug dependence as well as alcohol intake and hangover are reviewed. …”
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Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana by Kam, T.S., Low, Y.Y., Lim, K.H., Choo, Y.M., Pang, H.S., Etoh, T., Hayashi, M., Komiyama, K.

“…A biomimetic partial synthesis of lirofoline A from ibogaine via the Polonovski reaction is carried out. …”
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Psychedelics: A new era of treatment? by S. Torres

“…Results The psychedelics or “classic hallucinogens” can be subdivided into three sub-classes: the plant-derived tryptamines (psilocybin and ibogaine) and phenethylamines (mescaline), and the semisynthetic ergolines (LSD). …”
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Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans by Alan K. Davis, Lynnette A. Averill, Nathan D. Sepeda, Joseph P. Barsuglia, Timothy Amoroso

“…Therefore, this study examined psychedelic treatment with ibogaine and 5-methoxy-N,N-dimethyltryptamine for trauma-related psychological and cognitive impairment among U.S. …”
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Classic and non‐classic psychedelics for substance use disorder: A review of their historic, past and current research by Fúlvio Rieli Mendes, Cristiane dos Santos Costa, Victor Distefano Wiltenburg, Gabriela Morales-Lima, João Ariel Bonar Fernandes, Renato Filev

“…In this non-systematic review we discuss past and current clinical and observational studies with classic (LSD, DMT, psilocybin and mescaline) and non-classic (ibogaine, ketamine, MDMA, salvinorin A and THC) psychedelics for the treatment of SUD published until December 2021. …”
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Trauma-Informed Care in Psychedelic Therapy Research: A Qualitative Literature Review of Evidence-Based Psychotherapy Interventions in PTSD and Psychedelic Therapy Across Condition... by Modlin NL, Creed M, Sarang M, Maggio C, Rucker JJ, Williamson V

“…Psychedelic compounds studied were psilocybin, ibogaine, LSD, MDMA and ketamine, for treatment of substance use disorders, anxiety relating to physical illness, depression, and PTSD. …”
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Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds by Chiara Platella, Francesca Ghirga, Pasquale Zizza, Luca Pompili, Simona Marzano, Bruno Pagano, Deborah Quaglio, Valeria Vergine, Silvia Cammarone, Bruno Botta, Annamaria Biroccio, Mattia Mori, Daniela Montesarchio

“…The combination of molecular docking-based virtual screening and the G4-CPG experimental screening assay proved to be useful to quickly and effectively identify—out of many natural compounds—five hit binders of telomeric and oncogenic G4s, i.e., Bulbocapnine, Chelidonine, Ibogaine, Rotenone and Vomicine. Biophysical studies unambiguously demonstrated the selective interaction of these compounds with G4s compared to duplex DNA. …”
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A mechanism of uncompetitive inhibition of the serotonin transporter by Shreyas Bhat, Ali El-Kasaby, Ameya Kasture, Danila Boytsov, Julian B Reichelt, Thomas Hummel, Sonja Sucic, Christian Pifl, Michael Freissmuth, Walter Sandtner

“…Typical inhibitors (antidepressant drugs and cocaine), partial and full substrates (amphetamines and their derivatives), and atypical inhibitors (ibogaine analogues) bind preferentially to different states in this cycle. …”
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5-HT_2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration by Sofía Villalba, Bruno González, Stephanie Junge, Alejandra Bernardi, Joaquín González, Catherine Fagúndez, Pablo Torterolo, Ignacio Carrera, Francisco J. Urbano, Verónica Bisagno

“…Noribogaine (noribo) is the primary metabolite from ibogaine, an atypical psychedelic alkaloid isolated from the root bark of the African shrub <i>Tabernanthe iboga</i>. …”
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Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review by Simon Zhornitsky, Simon Zhornitsky, Henrique N. P. Oliva, Henrique N. P. Oliva, Laura A. Jayne, Laura A. Jayne, Aza S. A. Allsop, Aza S. A. Allsop, Alfred P. Kaye, Alfred P. Kaye, Alfred P. Kaye, Marc N. Potenza, Marc N. Potenza, Marc N. Potenza, Marc N. Potenza, Marc N. Potenza, Marc N. Potenza, Gustavo A. Angarita, Gustavo A. Angarita

“…Psychedelics included psilocybin/psilocin, lysergic acid diethylamide, N,N-dimethyltryptamine, 2,5-dimethoxy-4-iodoamphetamine, and ibogaine/noribogaine. Mixed findings regarding synaptic changes in the hippocampus and prefrontal cortex (PFC) have been reported when ketamine was administered in a single dose under basal conditions. …”
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