Trajectories of interferon-gamma release assay results over two years in independent cohorts from China, South Africa, Tanzania, and the United States by Chen, C, Xue, H, Horsburgh, CR, Amour, M, Hatherill, M, Tameris, M, von Reyn, CF, Rees, C, Shen, Y, McShane, H, García-Basteiro, AL, Liu, D, Wang, Y, Nathavitharana, RR, Graviss, EA, Shao, Y, Liu, Q, Lu, W, Zhu, L, Martinez, L

“…The annual risk of IGRA reversion was assessed after an IGRA conversion and among those with baseline positivity.…”

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Setiabudiawan, TP, Apriani, L, Verrall, AJ, Utami, F, Schneider, M, Indrati, AR, Halim, PP, Kaplonek, P, Malca, H, Lee, JS, Moorlag, SJCFM, de Bree, LCJ, Mourits, VP, Joosten, LAB, Netea, MG, Alisjahbana, B, McNamara, RP, Alter, G, van Laarhoven, A, Ussher, JE, Sharples, K, Koeken, VACM, Hill, PC, van Crevel, R

“…In heavily exposed Indonesian tuberculosis household contacts (n = 1347), a persistently IGRA negative status was associated with presence of a BCG scar, and - especially among those with a BCG scar - with altered innate immune cells dynamics, higher heterologous (Escherichia coli-induced) proinflammatory cytokine production, and higher inflammatory proteins in the IGRA mitogen tube. …”