Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol‐associated hepatitis by Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy

“…Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics‐experimental validation of mitochondrial responses were performed in peripheral blood mononuclear cells (PBMC) from patients with AH, healthy controls (HC), and heavy drinkers without evidence of liver disease (HD). …”
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A Novel Prognostic Signature Based on Glioma Essential Ferroptosis-Related Genes Predicts Clinical Outcomes and Indicates Treatment in Glioma by Debo Yun, Debo Yun, Debo Yun, Xuya Wang, Xuya Wang, Wenbo Wang, Wenbo Wang, Xiao Ren, Xiao Ren, Jiabo Li, Jiabo Li, Xisen Wang, Xisen Wang, Jianshen Liang, Jianshen Liang, Jie Liu, Jie Liu, Jikang Fan, Jikang Fan, Xiude Ren, Xiude Ren, Hao Zhang, Hao Zhang, Guanjie Shang, Guanjie Shang, Jingzhang Sun, Jingzhang Sun, Lei Chen, Lei Chen, Tao Li, Tao Li, Chen Zhang, Shengping Yu, Shengping Yu, Xuejun Yang, Xuejun Yang, Xuejun Yang

“…In addition, pathways analysis was used to identify the functional roles of FRGs. Somatic mutation, immune cell infiltration, and immune checkpoint gene expression were analyzed within the risk subgroups. …”
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HIV-1 and opiates modulate miRNA profiles in extracellular vesicles by Allen Caobi, Jesenia Bonilla, Mario Gomez, Mickensone Andre, Adriana Yndart, Francisco A. Fernandez-Lima, Madhavan P. Nair, Madhavan P. Nair, Andrea D. Raymond

“…Opiate abuse increases the risk of HIV transmission and exacerbates HIV neuropathology by increasing inflammation and modulating immune cell function. Exosomal EVs(xEV) contain miRNAs that may be differentially expressed due to HIV infection or opiate abuse. …”
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Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis by Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom

“…Citrullination is induced by immune cell-derived peptidyl-Arg deiminases (PADs), which are overactivated in the inflamed synovium. …”
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RETRACTED ARTICLE: Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects by Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng

“…Furthermore, the mechanism of tumor-specific immune response was further proved by 51Cr cytotoxicity assay in vitro and depletion of CD4, CD8, NK immune cell subsets in vivo. The results suggested that the antitumor mechanism was mainly depended on CD4+, CD8+ T lymphocytes. …”
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Integrating trans-omics, cellular experiments and clinical validation to identify ILF2 as a diagnostic serum biomarker and therapeutic target in gastric cancer by Shao-Song Liu, Qin-Si Wan, Cong Lv, Jin-Ke Wang, Song Jiang, Dan Cai, Mao-Sheng Liu, Ting Wang, Kun-He Zhang

“…In the bioinformatics analysis, only ILF2 (interleukin enhancer-binding factor 2) gene levels were associated with immune cell infiltration, some checkpoint gene expression, chemotherapy sensitivity, and immunotherapy response. …”
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Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression by Boting Ning, Andrew M. Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E. Lenburg, Jennifer E. Beane, Xaralabos Varelas

“…Our observations suggest that YAP/TAZ-TEAD-TP63 associate to cooperatively promote basal epithelial cell proliferation and repress signals associated with interferon responses and immune cell communication. Directly repressed targets we identified include the MHC Class II transactivator CIITA, which is repressed in progressive PMLs and associates with adaptive immune responses in the lung. …”
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Comprehensive analysis to construct a novel immune-related prognostic panel in aging-related gastric cancer based on the lncRNA‒miRNA-mRNA ceRNA network by Cuncan Deng, Juzheng Peng, Cheng Yuan, Huafu Li, Wenchao Li, Hongwu Chu, Hongfa Wei, Yulong He, Yulong He, Leli Zeng, Mingyu Huo, Mingyu Huo, Changhua Zhang, Changhua Zhang

“…According to the TIMER database, this panel was linked to immune infiltrations and immune cell gene markers. TISIDB database indicated that RECK was positively correlated with immune checkpoints (including CD160, CD244, PDCD1, and TGFBR1).Discussion: A novel triple prognostic panel of GC constructed based on the ceRNA network was associated with clinical prognostic, clinicopathological features, immune infiltrations, immune checkpoints and immune gene markers. …”
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CD8+ T and NK cells characterized by upregulation of NPEPPS and ABHD17A are associated with the co-occurrence of type 2 diabetes and coronary artery disease by Chenyu Dai, Damu Wang, Qianqian Tao, Ziyi Li, Peng Zhai, Yingying Wang, Mei Hou, Simin Cheng, Wei Qi, Longyi Zheng, Huaifang Yao

“…Finally, monocytes from peripheral blood samples and their immune cell ratios were analyzed by flow cytometry to validate our findings.ResultsSixteen candidate hub genes were identified as being correlated with immune infiltration. …”
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Integrated analysis of necroptosis-related genes for evaluating immune infiltration and colon cancer prognosis by Wei Yang, Shuaibing Lu, Liangqun Peng, Zhandong Zhang, Yonglei Zhang, Dandan Guo, Fei Ma, Yawei Hua, Xiaobing Chen, Xiaobing Chen

“…Finally, the effect of necroptosis related risk score on different degrees of immune cell infiltration was evaluated.ResultsCALB1, CHST13, and SLC4A4 were identified as NRGs of prognostic significance and were used to establish a risk scoring model. …”
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EXPRESSION of MACROPHAGe-ASSOCIATED GENES IN BREAST TUMORS: RELATION TO TUMOR PROGRESSION by N. V. Litviakov, M. M. Tsyganov, M. K. Ibragimova, I. V. Deryusheva, P. V. Kazantseva, I. V. Mitrofanova, I. G. Frolova, M. A. Buldakov, E. M. Slonimskaya, E. L. Choinzonov, Yu. G. Kzhyshkovska, N. V. Cherdyntseva

“…Tumor-associated macrophages (TAM) are the main innate immunity cells that regulate the relationship between the infiltrating immunocompetent cells, tumor cells and other components of the microenvironment. …”
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Multi-omics analysis unravels the underlying mechanisms of poor prognosis and differential therapeutic responses of solid predominant lung adenocarcinoma by Feng Li, Shuaibo Wang, Yaru Wang, Zhuoheng Lv, Donghui Jin, Hang Yi, Li Fu, Suokai Zhai, Ting Xiao, Yousheng Mao

“…Instead, muti-omics profiling revealed that SPA had stronger immunogenicity and was enriched for positive biomarkers for immunotherapy (higher TMB and T cell receptor diversity; higher PD-L1 expression and more immune cell infiltration; higher frequency of gene mutations predicting efficacious immunotherapy, and elevated expression of immunotherapy-related gene signatures). …”
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Novel hypoxia-related gene signature for predicting prognoses that correlate with the tumor immune microenvironment in NSCLC by Zhaojin Li, Yu Cui, Shupeng Zhang, Jie Xu, Jianping Shao, Hekai Chen, Jingzhao Chen, Shun Wang, Meizhai Zeng, Hao Zhang, Siqian Lu, Zhi Rong Qian, Guoqiang Xing

“…Additionally, we discovered a notable distinction in the enrichment of immune-related pathways, immune cell abundance, and immune checkpoint gene expression between the two subcategories.Conclusion: The proposed 9-HRG signature is a promising indicator for predicting NSCLC patient prognosis and may be potentially applicable in checkpoint therapy efficiency prediction.…”
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MDFI is a novel biomarker for poor prognosis in LUAD by Pengyu Chen, Pengyu Chen, Zhen Quan, Zhen Quan, Xueyu Song, Xueyu Song, Zhaojia Gao, Zhaojia Gao, Kai Yuan, Kai Yuan

“…Assessment of clinical characteristics, tumor mutation burden (TMB), and tumor microenvironment (TME) between high- and low-expression score groups showed lower TMB, richer immune cell infiltration, and better prognosis in the low-risk group.ConclusionThis study showed that MDFI was overexpressed in LUAD and was significantly associated with poor prognosis, indicating that MDFI may be used as a potential novel biomarker for the diagnosis and prognosis of LUAD. …”
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The gut microbiota correlate with the disease characteristics and immune status of patients with untreated diffuse large B-cell lymphoma by Zhouning Lin, Zhouning Lin, Dan Mao, Dan Mao, Changyu Jin, Jiaping Wang, Yanli Lai, Yanli Zhang, Miao Zhou, Qunfang Ge, Ping Zhang, Yongcheng Sun, Kaihong Xu, Yi Wang, Huiling Zhu, Binbin Lai, Hao Wu, Qitian Mu, Guifang Ouyang, Lixia Sheng

“…Absolute ratios of immune cell subset counts in peripheral blood were detected by flow cytometry and peripheral blood cytokine levels were detected by enzyme-linked immunosorbent assay. …”
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Evaluation of pain related behaviors and disease related outcomes in an immunocompetent mouse model of prostate cancer induced bone pain by Juan Miguel Jimenez-Andrade, Martha B. Ramírez-Rosas, Sun Hee Park, Renee Parker, Matthew R. Eber, Rebecca Cain, Mary Newland, Fang-Chi Hsu, Carol A. Kittel, Thomas J. Martin, Enriqueta Muñoz-Islas, Yusuke Shiozawa, Christopher M. Peters

“…This immunocompetent mouse model will be useful when combined with cell type selective transgenic mice to examine tumor, immune cell and sensory neuron interactions in the bone microenvironment and their role in pain and disease progression associated with bone metastatic prostate cancer.…”
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Integrated analysis of single-cell and bulk RNA-sequencing reveals tumor heterogeneity and a signature based on NK cell marker genes for predicting prognosis in hepatocellular carc... by Shuo Li, Shuo Li, Hongbo Du, Hongbo Du, Da’nan Gan, Da’nan Gan, Xiaoke Li, Xiaoke Li, Xiaobin Zao, Xiaobin Zao, Yong’an Ye, Yong’an Ye

“…Background: Natural killer (NK) cells are a type of innate immune cell that recognize and eliminate tumor cells and infected cells, without prior sensitization or activation. …”
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How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers by Kiarash Behrouzfar, Kiarash Behrouzfar, Kimberley Burton, Kimberley Burton, Steve E. Mutsaers, Steve E. Mutsaers, Grant Morahan, Richard A. Lake, Scott A. Fisher, Scott A. Fisher

“…Furthermore, our CC−MexTAg animal model enables in-depth study of the tumor microenvironment, allowing the correlation of immune cell infiltration and gene expression signatures with disease development. …”
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Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL) by Andrea Sitlinger, Michael A. Deal, Erwin Garcia, Dana K. Thompson, Tiffany Stewart, Grace A. MacDonald, Nicolas Devos, David Corcoran, Janet S. Staats, Jennifer Enzor, Kent J. Weinhold, Danielle M. Brander, J. Brice Weinberg, David B. Bartlett

“…Plasma exosomal miRNA profiles, circulating lipids, lipoproteins, inflammation levels, and immune cell phenotypes were also assessed. CLL-FIT was associated with fewer viable OSU-CLL cells at Day 1 (<i>p</i> = 0.003), Day 4 (<i>p</i> = 0.001), and Day 5 (<i>p</i> = 0.009). …”
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Effects of Oral Cannabinoids on Systemic Inflammation and Viral Reservoir Markers in People with HIV on Antiretroviral Therapy: Results of the CTN PT028 Pilot Clinical Trial by Ralph-Sydney Mboumba Bouassa, Eve Comeau, Yulia Alexandrova, Amélie Pagliuzza, Alexis Yero, Suzanne Samarani, Judy Needham, Joel Singer, Terry Lee, Florian Bobeuf, Claude Vertzagias, Giada Sebastiani, Shari Margolese, Enrico Mandarino, Marina B. Klein, Bertrand Lebouché, Jean-Pierre Routy, Nicolas Chomont, Cecilia T. Costiniuk, Mohammad-Ali Jenabian

“…Plasma cytokine levels were determined via Luminex and ELISA. Immune cell subsets were characterized by flow cytometry. …”
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