Computational profiling and prognostic modeling based on lysosome-related genes in colorectal cancer by Linjie Zhang, Linjie Zhang, Jingbang Yang, Jingbang Yang, Yizhang Deng, Yizhang Deng, Wuguo Deng, Liren Li, Liren Li

“…Notable differences in immune cell infiltration patterns were observed between clusters, and distinct pathway enrichments were evident. …”
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Pan-cancer analysis of the prognosis and immunological role of AKAP12: A potential biomarker for resistance to anti-VEGF inhibitors by Qiuju Liang, Qiuju Liang, Jinwu Peng, Jinwu Peng, Zhijie Xu, Zhilan Li, Feng Jiang, Lingzi Ouyang, Shangjun Wu, Chencheng Fu, Ying Liu, Yuanhong Liu, Yuanhong Liu, Yuanliang Yan, Yuanliang Yan

“…The present study first systematically analyzed the association of AKAP12 with anti-VEGF inhibitors’ sensitivity, clinical prognosis, DNA methylation, protein phosphorylation, and immune cell infiltration across various cancers via bioinformatic tools. …”
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Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia by Bo Cai, Xiaoyan Zou, Xin Ning, Tieqiang Liu, Bingxia Li, Yaqing Lei, Jianhui Qiao, Kaixun Hu, Yangyang Lei, Zhiqing Liu, Bo Yao, Huisheng Ai, Yi Wang, Changlin Yu, Mei Guo, Rongman Jia, Xiuyuan Hao

“…Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment, and the concomitant symptoms, including cytokine release syndrome (CRS) or immune-related adverse events (irAEs), are frequently reported. …”
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Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations by Tessa S. Groen-van Schooten, Tessa S. Groen-van Schooten, Tessa S. Groen-van Schooten, Micaela Harrasser, Micaela Harrasser, Micaela Harrasser, Jens Seidel, Jens Seidel, Jens Seidel, Emma N. Bos, Emma N. Bos, Emma N. Bos, Tania Fleitas, Monique van Mourik, Monique van Mourik, Roos E. Pouw, Ruben S. A. Goedegebuure, Ruben S. A. Goedegebuure, Benthe H. Doeve, Benthe H. Doeve, Jasper Sanders, Jasper Sanders, Jasper Sanders, Joris Bos, Joris Bos, Joris Bos, Mark I. van Berge Henegouwen, Mark I. van Berge Henegouwen, Victor L. J. L. Thijssen, Victor L. J. L. Thijssen, Victor L. J. L. Thijssen, Nicole C. T. van Grieken, Nicole C. T. van Grieken, Hanneke W. M. van Laarhoven, Hanneke W. M. van Laarhoven, Tanja D. de Gruijl, Tanja D. de Gruijl, Sarah Derks, Sarah Derks, Sarah Derks

“…As the composition of the tumor immune microenvironment drives response to (immuno)therapy we here performed a detailed immune analysis of a large series of GEACs to facilitate the development of a more individualized immunomodulatory strategy.MethodsExtensive immunophenotyping was performed by 14-color flow cytometry in a prospective study to detail the immune composition of untreated gastro-esophageal cancers (n=104) using fresh tumor biopsies of 35 EACs, 38 GEJACs and 31 GACs. The immune cell composition of GEACs was characterized and correlated with clinicopathologic features such as tumor location, MSI and HER2 status. …”
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ELOVLs Predict Distinct Prognosis Value and Immunotherapy Efficacy In Patients With Hepatocellular Carcinoma by Yu Zhang, Shujie Pang, Bo Sun, Minbo Zhang, Xiaoxiao Jiao, Linying Lai, Yiting Qian, Ning Yang, Wenzhuo Yang

“…ELOVL1 could affect immune cell infiltration and immune checkpoint markers such as PD-1 and CTLA4 in HCC. …”
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Association of apoptosis-related variants to malaria infection and parasite density in individuals from the Brazilian Amazon by Camille Sena-dos-Santos, Giovanna C. Cavalcante, Diego Marques, Caio S. Silva, Milene Raiol de Moraes, Pablo Pinto, Mayara Natália Santana-da-Silva, Rafaella S. Ferraz, Sheyla Patrícia T. Costa, Ana Maria R. Ventura, Marinete M. Póvoa, Maristela G. Cunha, Ândrea Ribeiro-dos-Santos

“…Abstract Background In malaria infection, apoptosis acts as an important immunomodulatory mechanism that leads to the elimination of parasitized cells, thus reducing the parasite density and controlling immune cell populations. Here, it was investigated the association of INDEL variants in apoptotic genes—rs10562972 (FAS), rs4197 (FADD), rs3834129 and rs59308963 (CASP8), rs61079693 (CASP9), rs4647655 (CASP3), rs11269260 (BCL-2), and rs17880560 (TP53)—and the influence of genetic ancestry with susceptibility to malaria and parasite density in an admixed population from the Brazilian Amazon. …”
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Effects of smoking on the level of sp-a and sp-d surfactant proteins in the blood of patients without bronchopulmonary diseases by O. S. Kharlamovа, K. Yu. Nikolaev, Yu. I. Ragino, M. I. Voevoda

“…However, the epithelium of the respiratory tract is also a regulator of immunological and inflammatory reactions through secretion of inflammation and immune cell recruitment mediators. An important component of the pulmonary immune system is the surfactant, and, in particular, its proteins SP-A and SP-D, synthesized mainly by type II pneumocytes.Aim. …”
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Deep learning for predicting major pathological response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer: A multicentre studyResearch in context by Yunlang She, Bingxi He, Fang Wang, Yifan Zhong, Tingting Wang, Zhenchuan Liu, Minglei Yang, Bentong Yu, Jiajun Deng, Xiwen Sun, Chunyan Wu, Likun Hou, Yuming Zhu, Yang Yang, Hongjie Hu, Di Dong, Chang Chen, Jie Tian

“…In the biological basis exploration for the deep learning score, a high deep learning score was associated with the downregulation of pathways mediating tumour proliferation and the promotion of antitumour immune cell infiltration in the microenvironment. Interpretation: The proposed deep learning model could effectively predict MPR in NSCLC patients treated with neoadjuvant chemoimmunotherapy. …”
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Pre-treatment inflamed tumor immune microenvironment is associated with FOLFIRINOX response in pancreatic cancer by Zachary Gao, Sung Wook Kang, Sung Wook Kang, Sung Wook Kang, Derek Erstad, Derek Erstad, Derek Erstad, Joseph Azar, George Van Buren, George Van Buren, William Fisher, William Fisher, Zequn Sun, Mark P. Rubinstein, Hyun-Sung Lee, Hyun-Sung Lee, Hyun-Sung Lee, E. Ramsay Camp, E. Ramsay Camp, E. Ramsay Camp

“…The relative proportions of immune cell infiltration were defined using CIBERSORTx and Dirichlet regression.Results145 samples were included in the analysis; 83 received mFFX, 62 received Gem-based therapy. …”
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Nonbronchoscopic Bronchoalveolar Lavage Improves Respiratory Culture Accuracy in Critically Ill Patients by Margaret Jeng, MS, Erica M. Orsini, MD, Jason Yerke, PharmD, Omar Mehkri, MD, Eduardo Mireles-Cabodevila, MD, Hassan Khouli, MD, Samin Mujanovic, RRT, Xiaofeng Wang, PhD, Abhijit Duggal, MD, Vidula Vachharajani, MD, Rachel G. Scheraga, MD

“…There was a trend toward decreased antibiotic use in patients with positive EA cultures if paired with a negative NBBL culture. Alveolar immune cell populations were recovered from NBBL samples, indicating successful alveolar sampling. …”
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Identification of N7-methylguanosine-related miRNAs as potential biomarkers for prognosis and drug response in breast cancer by Danian Dai, Hongkai Zhuang, Mao Shu, Lezi Chen, Chen Long, Hongmei Wu, Bo Chen

“…Single-sample gene set enrichment analysis (ssGSEA) was employed to explore m7G-related miRNA signatures and immune cell relationships in the tumor microenvironment. …”
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Tumor microenvironment-based signatures distinguish intratumoral heterogeneity, prognosis, and immunogenomic features of clear cell renal cell carcinoma by Aihetaimujiang Anwaier, Wenhao Xu, Wangrui Liu, Shiyin Wei, Xi Tian, Yuanyuan Qu, Jianfeng Yang, Hailiang Zhang, Dingwei Ye

“…Next, analyses for prognostic efficacy, correlations with clinicopathological features, functional enrichment, immune cell distributions, DNA variations, immune response, and heterogeneity were performed and validated. …”
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Characterization of the immune system of Ellegaard Göttingen Minipigs - An important large animal model in experimental medicine by Clara P.S. Pernold, Emil Lagumdzic, Maria Stadler, Kerstin H. Mair, Kerstin H. Mair, Sven Jäckel, Michael W. Schmitt, Andrea Ladinig, Christian Knecht, Sophie Dürlinger, Heinrich Kreutzmann, Vera Martin, Spencer Sawyer, Armin Saalmüller

“…We clearly detected a postnatal development of immune cell composition and identified phenotypes indicative of differentiation within the respective leukocyte subsets. …”
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NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis by Dirlei Nico, Fernanda Martins Almeida, Fernanda Martins Almeida, Juliana Maria Motta, Fellipe Soares dos Santos Cardoso, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Paula Melo de Luca, Ana Maria Blanco Martinez, Alexandre Morrot, Alexandre Morrot, Clarisa Beatriz Palatnik-de-Sousa, Clarisa Beatriz Palatnik-de-Sousa

“…Physical contact between dendritic cells (DCs) and T cell lymphocytes is necessary to trigger the immune cell response. CCL19 and CCL21 chemokines bind to the CCR7 receptor of mature DCs, and of T cells and regulate DCs migration to the white pulp (wp) of the spleen, where they encounter lymphocytes. …”
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Insulin-like growth factor 2 receptor is a key immune-related gene that is correlated with a poor prognosis in patients with triple-negative breast cancer: A bioinformatics analysi... by Ying Zhong, Xinyu Ren, Xi Cao, Yali Xu, Yu Song, Yidong Zhou, Feng Mao, Songjie Shen, Zhe Wang, Qiang Sun

“…CIBERSORT was used to predict the differences in immune cell infiltration in patient subsets that were stratified according to risk. …”
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Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function by Si-yu Wang, Yu-xin Wang, Ao Shen, Xian-qi Yang, Cheng-cai Liang, Run-jie Huang, Rui Jian, Nan An, Yu-long Xiao, Li-shuai Wang, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan, Shu-qiang Yuan

“…The correlation between COX7A1 and immune cell infiltration, drug sensitivity scoring, and immunohistochemical staining were performed to initially understand the potential role of COX7A1 in the development and progression of GC. …”
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Immune system disruptions implicated in whole blood epigenome-wide association study of depression among Parkinson's disease patients by Kimberly C. Paul, Cynthia Kusters, Melissa Furlong, Keren Zhang, Yu Yu, Aline Duarte Folle, Irish Del Rosario, Adrienne Keener, Jeff Bronstein, Janet S. Sinsheimer, Steve Horvath, Beate Ritz

“…For PD patients with a history of clinical depression compared to those without, we found no differences in immune cell composition. However, a history of clinical depression among patients was associated with differentially methylated CpGs. …”
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Dissecting shared genetic architecture between obesity and multiple sclerosisResearch in context by Ruijie Zeng, Rui Jiang, Wentao Huang, Jiaxuan Wang, Lijun Zhang, Yuying Ma, Yanjun Wu, Meijun Meng, Hekui Lan, Qizhou Lian, Felix W. Leung, Weihong Sha, Hao Chen

“…We observed tissue-specific level SNP heritability enrichment for BMI mainly in brain tissues for MS in immune-related tissues, and cell-type-specific level SNP heritability enrichment in 12 different immune cell types in brain, spleen, lung, and whole blood. …”
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Spatial profiling of the placental chorioamniotic membranes reveals upregulation of immune checkpoint proteins during Group B Streptococcus infection in a nonhuman primate model by Gygeria Manuel, Gygeria Manuel, Michelle Coleman, Austyn S. Orvis, Jeff Munson, Amanda Li, Amanda Li, Raj P. Kapur, Miranda Li, Miranda Li, Edmunda Li, Blair Armistead, Lakshmi Rajagopal, Lakshmi Rajagopal, Kristina M. Adams Waldorf, Kristina M. Adams Waldorf

“…Investigating the impact of innate immune cell expression of inhibitory immune checkpoints may reveal new insights into placental host-pathogen interactions at the maternal-fetal interface.…”
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Prognostic Value of CAV1 and CAV2 in Head and Neck Squamous Cell Carcinoma by Jingyu He, Simin Ouyang, Yilong Zhao, Yuqi Liu, Yaolong Liu, Bing Zhou, Qiwen Man, Bing Liu, Tianfu Wu

“…More importantly, we found the relationship between different immune cell infiltration degrees in the immune micro-environment in HNSCC and expression levels of CAV1/CAV2 (<i>p</i> < 0.0001). …”
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