Diagnostic and therapeutic dilemma in Stevens–Johnson syndrome-like acute graft-versus-host disease after liver transplantation: A case report by Yi-Teng Hung, Yi-Teng Hung, Yau-Ren Chang, Hsuan-Ning Wang, Hsuan-Ning Wang, Hsuan-Ning Wang, Wei-Chen Lee, Wei-Chen Lee, Chen-Fang Lee, Chen-Fang Lee, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen

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Vitamin D-Dimer: A Possible Biomolecule Modulator in Cytotoxic and Phagocytosis Processes? by Ralf Herwig, Katharina Erlbacher, Amela Ibrahimagic, Mehtap Kacar, Naime Brajshori, Petrit Beqiri, Joachim Greilberger

“…It is not clear how VitD-dgVDBP affects circulating monocytes, macrophages, other immune cell systems, including phagocytosis and apoptosis, and the generation of reactive oxygen species (ROS) compared to dgVDBP. …”
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Identification and validation of a gap junction protein related signature for predicting the prognosis of renal clear cell carcinoma by Yongsheng Huang, Wenyi Guo, Yuan Zeng, Xinrong Wang, Bohao Fan, Ying Zhang, Lei Yan, Gangli Gu, Zhao Liu

“…The GRPS was associated with immune cell infiltration, the TME, the TMB, and sensitivity to chemotherapy drugs. …”
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Glutamine Is Required for M1-like Polarization of Macrophages in Response to Mycobacterium tuberculosis Infection by Qingkui Jiang, Yunping Qiu, Irwin J. Kurland, Karl Drlica, Selvakumar Subbian, Sanjay Tyagi, Lanbo Shi

“…While upregulation of hypoxia-inducible-factor 1 (HIF-1) and a metabolic reprogramming to the Warburg Effect-like state are known to be critical for immune cell activation in response to M. tuberculosis infection, our overall knowledge about the immunometabolism of M1-like macrophages is poor. …”
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Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models by Robbe Salembier, Caro De Haes, Julie Bellemans, Kristel Demeyere, Wim Van Den Broeck, Niek N. Sanders, Steven Van Laere, Traci R. Lyons, Evelyne Meyer, Jonas Steenbrugge

“…Metastatic progression was monitored through bioluminescence imaging. Immune cell changes in primary tumors and lymphoid organs (i.e. axillary lymph nodes and spleen) were investigated through flow cytometry, immunohistochemistry, cytokine profiling and RNA-sequencing. …”
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Sarcoidosis clinical picture governs alterations in type 17 T helper cell subset composition and cytokine profile by N. M. Lazareva, I. V. Kudryavtsev, O. P. Baranova, D. V. Isakov, M. K. Serebriakova, A. A. Bazhanov, N. A. Arsentieva, N. E. Liubimova, T. P. Ses’, M. M. Ilkovich, A. A. Totolian

“…Immune cell hyperactivation along with cytokines they overproduce plays an important role in sarcoidosis and related disease pathogenesis. …”
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Lactate metabolism-related genes to predict the clinical outcome and molecular characteristics of endometrial cancer by Rui Shi, Haojia Li, Sitian Wei, Zhicheng Yu, Jun Zhang, Qi Zhang, Ting Zhou, Yuwei Yao, Qian Zhang, Tangansu Zhang, Hongbo Wang

“…There was a significant correspondence between LMRGs and tumor mutational load, checkpoints and immune cell infiltration. C1, C2, and C4 were the most infiltrated in the high-risk group. …”
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Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study by Giuseppe Ietto, Lorenzo Mortara, Daniela Dalla Gasperina, Domenico Iovino, Lorenzo Azzi, Andreina Baj, Walter Ageno, Angelo Paolo Genoni, Francesco Acquati, Matteo Gallazzi, Giorgia Spina, Grace Coco, Federica Pierin, Douglas Noonan, Andrea Vigezzi, Elisa Monti, Valentina Iori, Federica Masci, Caterina Franchi, Salomone Di Saverio, Giulio Carcano

“…ConclusionsWe will recognize different populations of patients, each one with a specific immunological pattern in terms of cytokines, soluble factor serum levels, and immune cell activity. Anamnestic data, such as preceding vaccinations and comorbidities, biochemical findings like lymphocyte immunophenotyping, and pre-existing persistent cytomegalovirus infection, allow depicting the risk profile of severe COVID-19. …”
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A new CCCH-type zinc finger-related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma patients by Cheng Shen, Cheng Shen, Zhan Chen, Zhan Chen, Jie Jiang, Jie Jiang, Yong Zhang, Yong Zhang, Wei Xu, Wei Xu, Rui Peng, Rui Peng, Wenjing Zuo, Qian Jiang, Yihui Fan, Xingxing Fang, Bing Zheng

“…There were substantial differences in immunological function, immune cell score, and immune checkpoint expression between high- and low-risk groups. …”
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Bioinformatics and immunoinformatics assisted multiepitope vaccine construct against Burkholderia anthina by Maha A. Alshiekheid, Ali M. Dou, Mohammad Algahtani, Wafa Abdullah I. Al-Megrin, Yaseer Ali Alhawday, Arwa Essa Alradhi, Khulud Bukhari, Basmah F. Alharbi, Ahmed N. Algefary, Basmah Awwadh Alhunayhani, Khaled S. Allemailem

“…Moreover, molecular dynamic simulation analysis results revealed that the vaccine construct and immune cell receptor has proper binding stability over various environmental condition, i.e. change in pressure range, temperature, and motion. …”
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Immunologic status and sensitivity of peripheral blood T cells to neurotransmitters in patients with optic neuritis by Nataliya Khramenko, L.M. Velychko, N.V. Konovalova, O.V. Bogdanova, T.M. Serebrina, Iu.O. Zhuravok

“…Studying expression patterns of immune cell subpopulations and genes is of importance for revealing the role and influence of each of them in the early ongoing ON pathological process. …”
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Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach by Jihad Aljabban, Michael Rohr, Vincent J. Borkowski, Mary Nemer, Eli Cohen, Naima Hashi, Hisham Aljabban, Emmanuel Boateng, Saad Syed, Mohammed Mohammed, Ali Mukhtar, Dexter Hadley, Maryam Panahiazar

“…Top downregulated genes largely held roles in cell adhesion and integrity, including claudin 8, PAQR5, and PRKACB.For the active vs inactive CD analysis, we found immune cell adhesion and diapedesis, hepatic fibrosis/hepatic stellate cell activation, LPS/IL-1 inhibition of RXR function, and atherosclerosis as top canonical pathways. …”
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MicroRNAs Regulating Tumor Immune Response in the Prediction of the Outcome in Patients With Breast Cancer by Konstantina Thomopoulou, Konstantina Thomopoulou, Chara Papadaki, Alexia Monastirioti, George Koronakis, Anastasia Mala, Despoina Kalapanida, Dimitrios Mavroudis, Dimitrios Mavroudis, Sofia Agelaki, Sofia Agelaki

“…In summary, deregulated expression of circulating miRNAs involved in tumor and immune cell interactions evaluated before adjuvant and 1st-line chemotherapy can distinguish disease status and emerge as independent predictors for outcomes of breast cancer patients.…”
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Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization by Zachary S Morris, KyungMann Kim, Paul M Sondel, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Ishan Chakravarty, Thomas C Havighurst, Erin J Nystuen

“…To evaluate the effect of MPL on the irradiated tumor microenvironment, primary tumor with tumor draining lymph nodes were harvested for immune cell infiltration analysis and cytokine profiling, and serum was collected for analysis of antitumor antibody populations.Results Combination RT+C4+MPL significantly reduced tumor growth, increased survival and complete response rate compared with RT+C4 in both B78 and Myc-CaP models. …”
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Bioinformatics and Integrative Experimental Method to Identifying and Validating Co-Expressed Ferroptosis-Related Genes in OA Articular Cartilage and Synovium by Ma J, Yu P, Ma S, Li J, Wang Z, Hu K, Su X, Zhang B, Cheng S, Wang S

“…Jinxin Ma,1,* Peng Yu,1,* Shang Ma,1,* Jinjin Li,1 Zhen Wang,1 Kunpeng Hu,1 Xinzhe Su,1 Bei Zhang,1 Shao Cheng,1– 3 Shangzeng Wang1– 3 1School of Osteopathy, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Department of Arthropathy, Henan Province Hospital of Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou, People’s Republic of China; 3School of Osteopathy, Henan Province Engineering Research Center of Basic and Clinical Research of Bone and Joint Repair in Chinese Medicine, Zhengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shao Cheng; Shangzeng Wang, 156 Jinshui East Road, Zhengzhou, Henan, People’s Republic of China, Tel +86 15093141825 ; +86 13838527504, Fax +0371-86667366, Email chengshao4476@163.com; wangsz74@163.comPurpose: Osteoarthritis (OA) is the most common joint disease worldwide and is the primary cause of disability and chronic pain in older adults.Ferroptosis is a type of programmed cell death characterized by aberrant iron metabolism and reactive oxygen species accumulation; however, its role in OA is not known.Methods: To identify ferroptosis markers co-expressed in articular cartilage and synovium samples from patients with OA, in silico analysis was performed.Signature genes were analyzed and the results were evaluated using a ROC curve prediction model.The biological function, correlation between Signature genes, immune cell infiltration, and ceRNA network analyses were performed. …”
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GDF15 Modulates the Zoledronic-Acid-Induced Hyperinflammatory Mechanoresponse of Periodontal Ligament Fibroblasts by Ann Nitzsche, Christoph-Ludwig Hennig, Katrin von Brandenstein, Annika Döding, Ulrike Schulze-Späte, Judit Symmank, Collin Jacobs

“…GDF15 appeared to be particularly relevant to these changes, as siRNA-mediated down-regulation balanced these hyperinflammatory responses by reducing IL-1β and IL-6 expression (IL1B <i>p</i>-value < 0.0001; IL6 <i>p</i>-value < 0.001) and secretion (IL-1β <i>p</i>-value < 0.05; IL-6 <i>p</i>-value < 0.001), as well as immune cell activation (<i>p</i>-value < 0.0001). In addition, ZOL-related reduced RANKL/OPG values and inhibited osteoclast activation were enhanced in <i>GDF15</i>-deficient hPdLFs (both <i>p</i>-values < 0.0001; all statistical tests: one-way ANOVA, Tukey’s post hoc test). …”
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Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation by Zheng-Rong Shi, Yu-Xin Duan, Fang Cui, Zhong-Jun Wu, Mao-Ping Li, Pei-Pei Song, Qi-Ling Peng, Wen-Tao Ye, Kun-Li Yin, Mei-Qing Kang, Yan-Xi Yu, Jian Yang, Wei Tang, Rui Liao

“…Results Multiplex immunostaining revealed no immediate significant change in local immune cell counts in periablational tumor tissues after 30 min of iRFA. …”
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Cuproptosis-related LncRNAs are potential prognostic and immune response markers for patients with HNSCC via the integration of bioinformatics analysis and experimental validation by Liuqing Zhou, Qing Cheng, Yao Hu, Haoyue Tan, Xiaoguang Li, Shuhui Wu, Tao Zhou, Jieyu Zhou

“…In addition, this gene signature was also associated with some immune-related pathways and immune cell infiltration and affected the anti-cancer immune response. …”
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Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors by Haolong Zhang, Yaxin Mo, Ling Wang, Haoling Zhang, Sen Wu, Doblin Sandai, Ahmad Naqib Shuid, Xingbei Chen

“…The diagnostic value of gene expression levels for these key genes was assessed using the Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) The CIBERSORT algorithm determined the infiltration status of 22 immune cell subtypes, exploring differences between EM and IBD patients in both control and disease groups. …”
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Psoriasis Patients with Specific HLA-Cw Alleles and Lower Plasma IL-17 Level Show Improved Response to Topical Lindioil Treatment by Lin YK, Wang CY, Huang YH, Chang YC, Chen CB, Wang CW, Hui RCY, Chung WH

“…Yin-Ku Lin,1,2 Ching-Ya Wang,3,4 Yu-Huei Huang,3,4 Ya-Ching Chang,3,4 Chun-Bing Chen,3– 9 Chuang-Wei Wang,3,5– 7,&ast; Rosaline Chung-Yee Hui,3,4,&ast; Wen-Hung Chung3,5– 12,&ast; 1Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; 4College of Medicine, Chang Gung University, Taoyuan, Taiwan; 5Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; 6Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan; 7Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, People’s Republic of China; 8Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; 9Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan; 10Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 11School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 12Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan&ast;These authors contributed equally to this workCorrespondence: Wen-Hung Chung, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fusing St, Taoyuan, 333, Taiwan, Tel +886 3-3281200 #8495, Fax +886 3-3281200 #2206, Email wenhungchung@yahoo.com; chung1@cgmh.org.twPurpose: Lindioil, a medicine refined from indigo naturalis (a herb used in Chinese medicine), is effective in treating severe psoriasis; however, responses vary across individual patients. …”
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