Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice by Preeti S. Chauhan, Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, Olivia K. Favor, Olivia K. Favor, James G. Wagner, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, Jack R. Harkema, Jack R. Harkema, James J. Pestka, James J. Pestka, James J. Pestka

“…At 1 and 4 wk post-instillation (PI), we compared cSiO2’s effects on innate-/autoimmune-related gene expression and autoantibody (AAb) in lavage fluid/lungs of Con- and DHA-fed mice and related these findings to inflammatory cell profiles, histopathology, cell death, and cytokine/chemokine production.ResultsDHA partially alleviated cSiO2-induced alterations in total immune cell and lymphocyte counts in lung lavage fluid. cSiO2-triggered dead cell accumulation and levels of inflammation-associated cytokines and IFN-stimulated chemokines were more pronounced in Con-fed mice than DHA-fed mice. …”
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The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer by Kazumasa Komura, Kensuke Hirosuna, Satoshi Tokushige, Takuya Tsujino, Kazuki Nishimura, Mitsuaki Ishida, Takuo Hayashi, Ayako Ura, Takaya Ohno, Shogo Yamazaki, Keita Nakamori, Shoko Kinoshita, Ryoichi Maenosono, Masahiko Ajiro, Yuki Yoshikawa, Tomoaki Takai, Takeshi Tsutsumi, Kohei Taniguchi, Tomohito Tanaka, Kiyoshi Takahara, Tsuyoshi Konuma, Teruo Inamoto, Yoshinobu Hirose, Fumihito Ono, Yuichi Shiraishi, Akihide Yoshimi, Haruhito Azuma

“…Transcriptome analysis highlighted TIM3 as the most upregulated immune-related gene in iFGFR3, with differential immune cell compositions observed between iFGFR3 and aFGFR3. …”
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Identification and validation of a dysregulated TME-related gene signature for predicting prognosis, and immunological properties in bladder cancer by Chong Shen, Chong Shen, Wang Chai, Wang Chai, Jingwen Han, Jingwen Han, Zhe Zhang, Zhe Zhang, Xuejing Liu, Shaobo Yang, Shaobo Yang, Yinlei Wang, Yinlei Wang, Donghuai Wang, Donghuai Wang, Fangxin Wan, Zhenqian Fan, Hailong Hu, Hailong Hu

“…Our study also found that TMEscore correlated with drug susceptibility, immune cell infiltration, and the prediction of immunotherapy efficacy. …”
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Bioinformatics identification and experimental validation of m6A-related diagnostic biomarkers in the subtype classification of blood monocytes from postmenopausal osteoporosis pat... by Peng Zhang, Peng Zhang, Honglin Chen, Honglin Chen, Honglin Chen, Bin Xie, Wenhua Zhao, Wenhua Zhao, Qi Shang, Qi Shang, Jiahui He, Jiahui He, Gengyang Shen, Xiang Yu, Zhida Zhang, Guangye Zhu, Guifeng Chen, Guifeng Chen, Fuyong Yu, Fuyong Yu, De Liang, Jingjing Tang, Jianchao Cui, Zhixiang Liu, Hui Ren, Hui Ren, Xiaobing Jiang, Xiaobing Jiang

“…A comprehensive evaluation on the roles of m6A modulators in the diagnostic biomarkers and subtype identification of PMOP on the basis of GSE56815 and GSE2208 datasets was carried out to investigate the molecular mechanisms of m6A modulators in PMOP.MethodsWe carried out a series of bioinformatics analyses including difference analysis to identify significant m6A modulators, m6A model construction of random forest, support vector machine and nomogram, m6A subtype consensus clustering, GO and KEGG enrichment analysis of differentially expressed genes (DEGs) between different m6A patterns, principal component analysis, and single sample gene set enrichment analysis (ssGSEA) for evaluation of immune cell infiltration, experimental validation of significant m6A modulators by real-time quantitative polymerase chain reaction (RT-qPCR), etc.ResultsIn the current study, we authenticated 7 significant m6A modulators via difference analysis between normal and PMOP patients from GSE56815 and GSE2208 datasets. …”
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Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis by Maria-Bernadette Madel, Julia Halper, Lidia Ibáñez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach

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IMMUNOPHENOTYPIC PROFILING REVEALS ALTERED EXPRESSION OF PLATELET ACTIVATION MARKERS IN PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS by VL Bassan, PC Paolini, LMG Ramos, FR Morais, PVB Palma, LC Palma, PMM Garibaldi, LL Figueired-Pontes, FA Castro

“…The oncoinflammation status seems to contribute to immune cell activation, pro-coagulant state, and increased risk for thromboembolic events in MPN patients. …”
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Construction of an HLA Classifier for Early Diagnosis, Prognosis, and Recognition of Immunosuppression in Sepsis by Multiple Transcriptome Datasets by Zhen Chen, Rui Chen, Yangpeng Ou, Jianhai Lu, Qianhua Jiang, Genglong Liu, Liping Wang, Yayun Liu, Zhujiang Zhou, Ben Yang, Liuer Zuo

“…ArrayExpress databases, as external validation, were utilized to evaluate its diagnostic, prognostic, and predictive performance. Immune cell infiltration score was calculated via CIBERSORTx tools and single-sample gene set enrichment analysis (ssGSEA). …”
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T cell mediated combination immunotherapy by Opel, Cary F. (Cary Francis)

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Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT by Butler, CC, Owen-Jones, E, Lau, M, Gillespie, D, Lown, M, Calder, PC, Stanton, H, Wootton, M, Castro Herrera, V, Bayer, A, Davies, J, Edwards, A, Davoudianfar, M, Rutter, H, Hood, K, Moore, M, Little, P, Shepherd, V, Lowe, R, Miles, EA, Townson, J, Hobbs, FDR, Francis, NA

“…There was no evidence that this probiotic combination improved blood immune cell numbers, subtypes or responses to seasonal influenza vaccination.…”

PEOPLE (NTC03447678), a phase II trial to test pembrolizumab as first-line treatment in patients with advanced NSCLC with PD-L1 by Filippo de Braud, Valter Torri, Giuseppe Lo Russo, Claudia Proto, Roberto Ferrara, Monica Ganzinelli, Marina Chiara Garassino, Giuseppe Viscardi, Giorgio Trinchieri, Mario Occhipinti, Rita Leporati, Marta Brambilla, Luca Agnelli, Silvia Brich, Francesco Sgambelluri, Roberta Mortarini, Andrea Anichini, Leonardo Provenzano, Daniele Lorenzini, Arsela Prelaj, James Dolezal, Teresa Beninato, Tiziana Triulzi, Alessandra Fabbri, Laura Mazzeo, Andrea Spagnoletti, Vanja Miskovic, Alessandra Laura Giulia Pedrocchi, Francesco Trovo', Sara Manglaviti, Claudia Giani, Paolo Ambrosini, Andrea Franza, John McCulloch, Tommaso Torelli, Giancarlo Pruneri

“…No microbiome features were selected.Conclusions This multiomics approach was able to identify immune cell subsets and expression levels of genes associated to PFS in patients with PD-L1 <50% NSCLC treated with first-line pembrolizumab. …”
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Leukocyte cell population data in patients with cardiac surgery and cardiopulmonary bypass: A potential readily available tool to monitor immunity by Maxime Nguyen, Maxime Nguyen, Maxime Nguyen, Maxime Nguyen, Laure Stiel, Laure Stiel, Laure Stiel, Adrien Guilloteau, Pierre-Alain Bahr, David Masson, David Masson, David Masson, Charles Thomas, Charles Thomas, Charles Thomas, Mathieu Blot, Mathieu Blot, Mathieu Blot, Mathieu Blot, Julien Guy, Cécile Fontaine, Bastien Durand, Belaid Bouhemad, Belaid Bouhemad, Belaid Bouhemad, Belaid Bouhemad, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot

“…Our objective was to explore leukocyte cell population data in patients undergoing cardiac surgery with cardiopulmonary bypass in order to determine whether CPD could be used to monitor immune cell activation.MethodsThis is an ancillary study of a cohort of patients undergoing cardiac surgery with cardiopulmonary bypass. …”
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Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection by Harry L. Janssen, Young-Suk Lim, Hyung Joon Kim, Leonard Sowah, Cheng-Hao Tseng, Carla S. Coffin, Magdy Elkhashab, Sang Hoon Ahn, Anh-Hoa Nguyen, Diana Chen, Jeffrey J. Wallin, Simon P. Fletcher, Circe McDonald, Jenny C. Yang, Anuj Gaggar, Diana M. Brainard, Scott Fung, Yoon Jun Kim, Jia-Horng Kao, Wan-Long Chuang, Anna E. Brooks, P. Rod Dunbar

“…Selgantolimod increased serum cytokines and chemokines and redistributed several circulating immune cell subsets. No patients achieved the primary efficacy endpoint. …”
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Pegbovigrastim Treatment around Parturition Enhances Postpartum Immune Response Gene Network Expression of whole Blood Leukocytes in Holstein and Simmental Cows by Vincenzo Lopreiato, Ernesto Palma, Andrea Minuti, Juan J. Loor, Mariangela Lopreiato, Francesca Trimboli, Valeria Maria Morittu, Anna Antonella Spina, Domenico Britti, Erminio Trevisi

“…This suggested an improvement of migration, adhesion, and antimicrobial ability and an enhanced inflammatory response, which in turn could trigger immune cell activation and enhance function. Expression of <i>SOD2</i> and <i>ALOX5</i> was also greater in the PEG group. …”
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The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis by Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, Daisuke Kurotaki, Koutarou Nishimura, Akira Nishiyama, Tomohiko Tamura, Takashi Kamatani, Tatsuhiko Tsunoda, Miyako Murakawa, Yasuhiro Asahina, Yoshihiro Hayashi, Hironori Harada, Yuka Harada, Asumi Yokota, Hideyo Hirai, Takao Seki, Makoto Kuwahara, Masakatsu Yamashita, Shigeyuki Shichino, Masato Tanaka, Kenichi Asano

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Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT by Christopher C Butler, Eleri Owen-Jones, Mandy Lau, David Gillespie, Mark Lown, Philip C Calder, Helen Stanton, Mandy Wootton, Vivian Castro Herrera, Antony Bayer, Jane Davies, Alison Edwards, Mina Davoudianfar, Heather Rutter, Kerenza Hood, Michael Moore, Paul Little, Victoria Shepherd, Rachel Lowe, Elizabeth A Miles, Julia Townson, FD Richard Hobbs, Nick A Francis

“…There was no evidence that this probiotic combination improved blood immune cell numbers, subtypes or responses to seasonal influenza vaccination. …”
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Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection by Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain

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Inflammatory response signature score model for predicting immunotherapy response and pan-cancer prognosis by Shuzhao Chen, Mayan Huang, Limei Zhang, Qianqian Huang, Yun Wang, Yang Liang

“…Regardless of the tumor purity, patients in the low score group had a significantly poorer prognosis than those in the high score group. Immune cell infiltration analysis indicated that in the high score cohort, tumor-infiltrating lymphocytes were significantly enriched, particularly effector and natural killer cells. …”
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A novel signature incorporating lipid metabolism- and immune-related genes to predict the prognosis and immune landscape in hepatocellular carcinoma by Ti Yang, Ti Yang, Yurong Luo, Yurong Luo, Junhao Liu, Fang Liu, Zengxin Ma, Zengxin Ma, Gai Liu, Hailiang LI, Jianfan Wen, Chengcong Chen, Xiancheng Zeng

“…With immune analysis, GSVA and GSEA, we identified that there are remarkable differences between the two risk groups in immune pathways, lipid metabolism, tumor development, immune cell infiltration and immune microenvironment, response to immunotherapy, and sensitivity to chemotherapy. …”
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Two Putative Interleukin-1 beta Molecules Involved in the Immune Response of Seriola aureovittata by Lin WANG, Bin WANG, Yongjiang XU, Changtao GUAN

“…Interleukin-1 beta (IL-1β) is the quintessential pro-inflammatory cytokine, playing important roles in immune cell proliferation, differentiation, and apoptosis. …”
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Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer by Jinyan Wang, Jinyan Wang, Dongmei Qin, Zhonghua Tao, Zhonghua Tao, Biyun Wang, Biyun Wang, Yizhao Xie, Yizhao Xie, Ye Wang, Ye Wang, Bin Li, Bin Li, Jianing Cao, Jianing Cao, Xiaosu Qiao, Xiaosu Qiao, Shanliang Zhong, Xichun Hu, Xichun Hu

“…After consensus unsupervised clustering analysis, GC patients were classified into two cuproptosis molecular subtypes, which were significantly associated with clinical features (gender, age, grade and TNM stage), prognosis, metabolic related pathways and immune cell infiltration in TME of GC. GO enrichment analyses of 84 DEGs, obtained from distinct molecular subtypes, revealed that DEGs primarily enriched in the regulation of metabolism and intracellular/extracellular structure in GC. …”
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