New insights into how trafficking regulates T cell receptor signaling by Jieqiong Lou, Jieqiong Lou, Jeremie Rossy, Jeremie Rossy, Qiji Deng, Qiji Deng, Sophie Victoria Pageon, Sophie Victoria Pageon, Katharina Gaus, Katharina Gaus

“…The trafficking molecules involved in lytic granule (LG) secretion in cytotoxic T lymphocytes (CTL) have been well studied due to the immune disorder known as familial hemophagocytic lymphohisiocytosis (FHLH). …”
Get full text

Invasive Pulmonary Aspergillosis with Marked Eosinophilia as a Unique Presentation of Chronic Granulomatous Disease by Julie Van Woensel, Remy Mostard, Mathie Leers

“…It reminds physicians of the possibility of CGD as an underlying immune disorder in invasive aspergillosis and highlights the challenges of diagnosing invasive pulmonary aspergillosis. …”
Get full text

Chrysophanol Attenuates Manifestations of Immune Bowel Diseases by Regulation of Colorectal Cells and T Cells Activation In Vivo by Hyun-Su Lee, Gil-Saeng Jeong

“…Inflammatory bowel disease (IBD) is an immune disorder that develops due to chronic inflammation in several cells. …”
Get full text

Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective by Tram T. T. Nguyen, Yoon Tae Kim, Geunyeol Jeong, Mirim Jin

“…Abstract Secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (sHLH/MAS) is a life-threatening immune disorder triggered by rheumatic disease, infections, malignancies, or medications. …”
Get full text

Hemophagocytic Lymphohistiocytosis Associated with Coinfection of Scrub Typhus and Dengue Fever in a Child: A Case Report by H. C. Krishna KUMAR, K. Jagadish KUMAR, Manjunath V. G, Sangeetha BALAJI

“…Hemophagocytic lymphohistiocytosis (HLH) is an uncommon life-threatening immune disorder that may be either primary or secondary to infection, malignancy, or rheumatological disease. …”
Get full text

Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory genes in gastric cancer tissues. by Jihan Wang, Zhaohui Ni, Zipeng Duan, Guoqing Wang, Fan Li

“…The data showed that there were 82 differentially expressed genes that could be regulated by these five transcription factors in gastric cancer tissues and these genes formed 95 regulation modes, among which seven genes (MMP1, TIMP1, TLR2, FCGR3A, IRF1, FAS, and TFF3) were hub molecules that are regulated at least by two of these five transcription factors simultaneously and were associated with hypoxia, inflammation, and immune disorder. Real-Time PCR and western blot showed increasing of HIF-1α in mRNA and protein levels as well as TIMP1, TFF3 in mRNA levels in gastric cancer tissues. …”
Get full text

Single-cell RNA sequencing depicts metabolic changes in children with aplastic anemia by Qin Zhou, Lifen Huang, Yong Liu, Junbin Huang, Luping Wen, Jing Yang, Jintang Liang, Yun Chen, Chun Chen

“…The mechanism of this immune disorder is not well understood and therapeutic strategies still need to be improved.MethodsStudies have found that abnormalities in metabolisms promote the survival of AA cells. …”
Get full text

Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway. by Shaoying Zhang, Kang Wu, Yufeng Liu, Yingtong Lin, Xu Zhang, Jie Zhou, Hui Zhang, Ting Pan, Yongshui Fu

“…Further development of FIN-like compounds could be a novel strategy for generating functional MDSCs for immunosuppressive therapies in various immune disorder conditions.…”
Get full text

CLINICAL MANIFESTATION OF BMI, TLC, ALBUMIN AND CD4 AFTER PROVISION OF SNAKEHEAD NUGGET AND COLORED FRUIT JUICE TO PEOPLE WITH HIV by Ngena Ria, Ginta Siahaan, Zuraidah Nasution, Hanna Sriyanti Saragih

“…Snakehead fish has high content of zinc and albumin, it can be given to people with immune disorder. Snakehead fish can be made into various kind of food product that are high in nutrients, have aestetic value, and taste like nugget. …”
Get full text

Evaluación clínicoinmunológica de la otitis media crónica en niños by Miriam Zaldívar Ochoa, Manuel Villar Suárez

“…Significant differences between patients who had been applied treatment for their immune deficit with highly satisfactory response and those with immune disorder that was not solved.…”
Get full text

Effects of Sargassum-derived oligosaccharides, polysaccharides and residues on ameliorating enteritis and dysbiosis in a murine model of food allergy by Rui-En Fang, Yu-Jyun Wei, Shih-Yuan Fang, Chung-Hsiung Huang

“…The prevalence of food allergy, a common immune disorder associated with enteric dysbiosis, has been increasing in recent decades. …”
Get full text

Pannexin1: insight into inflammatory conditions and its potential involvement in multiple organ dysfunction syndrome by Xiangyu Chen, Siyi Yuan, Liangyu Mi, Yun Long, Huaiwu He

“…The development of sepsis involves hyperactive inflammation, immune disorder, and disrupted microcirculation. It is crucial to identify targets within these processes to develop therapeutic interventions. …”
Get full text

<i>Staphylococcus aureus</i> and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis by Enea Gino Di Domenico, Ilaria Cavallo, Bruno Capitanio, Fiorentina Ascenzioni, Fulvia Pimpinelli, Aldo Morrone, Fabrizio Ensoli

“…Atopic dermatitis (AD) is an immune disorder characterized by a marked dysbiosis, with a sharp decline of microbial diversity. …”
Get full text

The significance of Th1,Th2,Th17and treg cells in the prediction and evaluation of ulcerative colitis by Yu Zhang, Wei Shi, Gaigai Cao, Jingru Li, Haijiao Wang, Chonghua Hao

“…Conclusions The dysregulation of Th1, Th2, Th17 and Tregs is a significant phenomena of immune disorder in UC, and these auxiliary indicators correlate with increased disease severity. …”
Get full text

Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency by Jean-Marie Carpier, Carrie L. Lucas

“…Activated PI3Kδ Syndrome (APDS) is an inherited immune disorder caused by heterozygous, gain-of-function mutations in the genes encoding the phosphoinositide 3-kinase delta (PI3Kδ) subunits p110δ or p85δ. …”
Get full text

Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia. by Bibhuti B Mishra, Qun Li, Anthony L Steichen, Brandilyn J Binstock, Dennis W Metzger, Judy M Teale, Jyotika Sharma

“…Sepsis is a complex immune disorder with a mortality rate of 20-50% and currently has no therapeutic interventions. …”
Get full text

Autophagy in Multiple Sclerosis: Two Sides of the Same Coin by Chairi Misrielal, Mario Mauthe, Fulvio Reggiori, Bart J. L. Eggen

“…Multiple sclerosis (MS) is a complex auto-immune disorder of the central nervous system (CNS) that involves a range of CNS and immune cells. …”
Get full text

Desquamative Gingivitis, Oral Hygiene, and Autoimmune Oral Diseases: A Scoping Review by Andrea Scribante, Matteo Pellegrini, Giacomo Li Vigni, Federica Pulicari, Francesco Spadari

“…This scoping review aimed to investigate whether there is a correlation between oral hygiene and gingival lesions induced by autoimmune diseases of the oral cavity and whether periodontal disease can negatively influence a clinical picture of desquamative gingivitis due to an immune disorder of the oral cavity. Case series studies and randomized controlled trials were considered for this scoping review; studies that did not comply with the inclusion criteria were excluded. …”
Get full text

The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors by Jianke Ren, Richard Finney, Kai Ni, Maggie Cam, Kathrin Muegge

“…Lsh/HELLS is critical for normal development and mutations of Lsh in human cause the ICF (Immune deficiency, Centromeric instability, Facial anomalies) syndrome, a severe immune disorder with multiple organ deficiencies. We report here that Lsh, previously known to regulate DNA methylation level, has a genome wide chromatin remodeling function. …”
Get full text

Exploring the Triple Interaction between the Host Genome, the Epigenome, and the Gut Microbiome in Type 1 Diabetes by Duaa Ahmed Elhag, Manoj Kumar, Souhaila Al Khodor

“…Type 1 diabetes (T1D) is an auto-immune disorder characterized by a complex interaction between the host immune system and various environmental factors in genetically susceptible individuals. …”
Get full text