Evaluation of survival extrapolation in immuno-oncology using multiple pre-planned data cuts: learnings to aid in model selection by Ash Bullement, Anna Willis, Amerah Amin, Michael Schlichting, Anthony James Hatswell, Murtuza Bharmal

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Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer by Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D. Jensen

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Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT) by Catherine R. Hanna, Sean M. O’Cathail, Janet S. Graham, Mark Saunders, Leslie Samuel, Mark Harrison, Lynsey Devlin, Joanne Edwards, Daniel R. Gaya, Caroline A. Kelly, Liz-Anne Lewsley, Noori Maka, Paula Morrison, Louise Dinnett, Susan Dillon, Jacqueline Gourlay, Jonathan J. Platt, Fiona Thomson, Richard A. Adams, Campbell S. D. Roxburgh

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Preoperative Immunotherapy in Hepatocellular Carcinoma: Current State of the Art by Laschtowitz A, Roderburg C, Tacke F, Mohr R

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Systemic therapy for advanced clear cell renal cell carcinoma after discontinuation of immune-oncology and VEGF targeted therapy combinations by Yasser Ged, Ruby Gupta, Cihan Duzgol, Andrea Knezevic, Natalie Shapnik, Ritesh Kotecha, Martin H. Voss, Darren R. Feldman, Oguz Akin, Sujata Patil, Robert J. Motzer, Brian I. Rini, Chung-Han Lee

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Challenges and Opportunities for Immunoprofiling Using a Spatial High-Plex Technology: The NanoString GeoMx® Digital Spatial Profiler by Sharia Hernandez, Rossana Lazcano, Alejandra Serrano, Steven Powell, Larissa Kostousov, Jay Mehta, Khaja Khan, Wei Lu, Luisa M. Solis

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Editorial: The role of epigenetic modification in radiotherapy and immuno-oncology in cancer: from bench to clinical application by Hon-Yi Lin, Hon-Yi Lin, Hon-Yi Lin, Hon-Yi Lin, Michael W. Y. Chan, Vivian W. Y. Lui, Peter J. K. Kuppen, Shih-Kai Hung, Shih-Kai Hung, Shih-Kai Hung

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Rabbit VX2 Liver Tumor Model: A Review of Clinical, Biology, Histology, and Tumor Microenvironment Characteristics by Florentina Pascale, Jean-Pierre Pelage, Jean-Pierre Pelage, Michel Wassef, Saïda H. Ghegediban, Jean-Pierre Saint-Maurice, Thierry De Baere, Thierry De Baere, Alban Denys, Rafael Duran, Frédéric Deschamps, Frédéric Deschamps, Olivier Pellerin, Noboru Maeda, Alexandre Laurent, Julien Namur

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Detection of Immune Checkpoint Receptors – A Current Challenge in Clinical Flow Cytometry by Benjamin Shibru, Katharina Fey, Stephan Fricke, André-René Blaudszun, Friederike Fürst, Max Weise, Sabine Seiffert, Maria Katharina Weyh, Ulrike Köhl, Ulrike Köhl, Ulrike Köhl, Ulrich Sack, Ulrich Sack, Andreas Boldt

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Multiomics characterization of breast angiosarcoma from an Asian cohort reveals enrichment for angiogenesis signaling pathway and tumor-infiltrating macrophages by Tun Kiat Ko, Zexi Guo, Bavani Kannan, Boon Yee Lim, Jing Yi Lee, Zhimei Li, Elizabeth Chun Yong Lee, Bin Tean Teh, Bin Tean Teh, Jason Yongsheng Chan, Jason Yongsheng Chan, Jason Yongsheng Chan

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Comprehensive evaluation of cell death-related genes as novel diagnostic biomarkers for breast cancer by Xiaoyue Shi, Hao Ding, Jing Tao, Yanhui Zhu, Xiaoqiang Zhang, Gao He, Junzhe Yang, Xian Wu, Xiaoan Liu, Xiafei Yu

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Artificial intelligence and digital biomarker in precision pathology guiding immune therapy selection and precision oncology by Ralf Huss, Johannes Raffler, Bruno Märkl

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Trends in medical care utilization in patients with cancer: An analysis of real‐world data in a tertiary hospital in Korea, 2014–2019 by Jung‐Hyun Won, Tae Kyu Chung, Joochul Lee, Sangwon Yoon, Yoomin Jeon, Howard Lee

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Virus-Based Immuno-Oncology Models by Juliana Sitta, Pier Paolo Claudio, Candace M. Howard

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Comprehensive Analysis of the Immune-Oncology Targets and Immune Infiltrates of N6-Methyladenosine-Related Long Noncoding RNA Regulators in Breast Cancer by Xiaoqiang Zhang, Li Shen, Ruyu Cai, Xiafei Yu, Junzhe Yang, Xian Wu, Yanhui Zhu, Xiaoan Liu

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Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies by Shanshan Wan, Ende Zhao, Ende Zhao, Daniel Freeman, Daniel Weissinger, Benjamin A. Krantz, Benjamin A. Krantz, Gregor Werba, Lauren G. Khanna, Despina Siolas, Despina Siolas, Paul E. Oberstein, Paul E. Oberstein, Pratip K. Chattopadhyay, Pratip K. Chattopadhyay, Pratip K. Chattopadhyay, Diane M. Simeone, Diane M. Simeone, Diane M. Simeone, Theodore H. Welling, Theodore H. Welling

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Corrigendum: Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies by Shanshan Wan, Ende Zhao, Ende Zhao, Daniel Freeman, Daniel Weissinger, Benjamin A. Krantz, Benjamin A. Krantz, Gregor Werba, Lauren G. Khanna, Despina Siolas, Despina Siolas, Paul E. Oberstein, Paul E. Oberstein, Pratip K. Chattopadhyay, Pratip K. Chattopadhyay, Pratip K. Chattopadhyay, Diane M. Simeone, Diane M. Simeone, Diane M. Simeone, Theodore H. Welling, Theodore H. Welling

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Dendritic Cell Tumor Vaccination via Fc Gamma Receptor Targeting: Lessons Learned from Pre-Clinical and Translational Studies by Enrique Gómez Alcaide, Sinduya Krishnarajah, Fabian Junker

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Efficacy and Safety of Nivolumab and Ipilimumab for Advanced or Metastatic Renal Cell Carcinoma: A Multicenter Retrospective Cohort Study by Koji Iinuma, Koji Kameyama, Kei Kawada, Shota Fujimoto, Kimiaki Takagi, Shingo Nagai, Hiroki Ito, Takashi Ishida, Makoto Kawase, Kota Kawase, Chie Nakai, Daiki Kato, Manabu Takai, Keita Nakane, Takuya Koie

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Immunotherapy with check-point inhibitors (CPI) in adult malignancies: a protocol for the systematic review of the quality of economic analyses by Ying Wang, Pierre Camateros, Denise Smith, David Dawe, Peter Ellis

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