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Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
Published 2013-11-01Get full text
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Analysis of related gene of the HLA system class I in women with cervical intraepithelial neoplasia grades II and III
Published 2023-02-01“…The study group was treated in the Department of Pathology of the Cervical Erasto Gaertner Hospital, Curitiba and the control group was recruited in cervical cancer prevention campaigns promoted by public entities in association with the Department of Obstetrics and Gynecology, Hospital de Clínicas, Federal University of Parana and Histocompatibility and Immunogenetics Laboratory, Department of Genetics, UFPR. …”
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Congenitally impaired pattern-recognition receptors in pathogenesis of pediatric invasive and recurrent pneumococcal infection
Published 2019-07-01“…Thus, based on available data, we concluded that impaired B-cell function, the complement components deficiency as well as receptor-recognition receptors (TLR-2, -9, -4, MYD88 adapter protein, TLR cascade enzymes: IRAK4, NEMO, NOD-like receptors: NOD2, NLRP3; C-type lectins: MBL, Dextin-2, and, possibly, ficoline) play the most important role among congenital immunodeficiencies predisposing to invasive and recurrent pneumococcal infections play the most important role among congenital immunodeficiencies predisposing to invasive and recurrent pneumococcal infections, and should be used as a rationale for immunological surveillance and organizing immunogenetics screening in these patients.…”
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Influences of MHC Class II Haplotypes on Avian Influenza Traits in Thai Indigenous Chicken
Published 2006-06-01“…These traits were related to immunogenetics, especially, the major histocompatibility complex (MHC) class I and class II molecules. …”
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Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer
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Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics
Published 2021-01-01“…Subsequent pairing of the heavy chain with a germline human kappa light chain serves to facilitate bispecific antibody production by increasing the efficiency of correct pairing.Abbreviations: AID: activation-induced cytidine deaminase; bsAb: bispecific antibody; CDR: complementarity-determining region; CL: light chain constant region; CmLC: common light chain; D: diversity region; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; Fc: fragment crystallizable; FcRn: neonatal Fc receptor; FR: framework region; GEM: gel-encapsulated microenvironment; Ig: immunoglobulin; IMGT: the international ImMunoGeneTics information system®; J: joining region; KO: knockout; mAb: monoclonal antibody; NGS: next-generation sequencing; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PGC: primordial germ cell; PGRN: progranulin; TCR: T cell receptor; V: variable region; VK: kappa light chain variable region; VL: light chain variable region; VH: heavy chain variable region…”
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Molecular Signatures of Natural Killer Cells in CMV-Associated Anterior Uveitis, A New Type of CMV-Induced Disease in Immunocompetent Individuals
Published 2021-03-01“…As patient demographics indicated contributions from genetic background and immunosenescence as possible underlying pathological mechanisms, we analyzed the immunogenetics of the cohort in conjunction with cell phenotypes to identify molecular signatures of CMV-AU. …”
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Examining the feasibility of data-driven decision support for the virtual crossmatch for solid organ transplantation: A single center study
Published 2023-09-01“…We sought to examine the feasibility of an algorithmic approach to interpreting virtual crossmatch data.We examined Histocompatibility and Immunogenetics laboratory data from 1,152 transplant patients and 1,180 donors from an academic medical transplant center over a ten-year time interval. …”
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