Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease. by Orchard, T, Thiyagaraja, S, Welsh, K, Wordsworth, B, Hill Gaston, J, Jewell, D

“…We now report the results of immunogenetic studies in these patients and compare them with other spondyloarthropathies. …”

Celiac Disease in Uzbek Children: Insights into Disease Prevalence and Clinical Characteristics in Symptomatic Pediatric Patients by Altinoy T. Kamilova, Gulnoza K. Azizova, Dimitri Poddighe, Zulkhumar E. Umarnazarova, Dilrabo A. Abdullaeva, Svetlana I. Geller, Noiba D. Azimova

“…Serological, histopathological, and immunogenetic parameters specific to CD, fecal zonulin, and pancreatic elastases were assessed in CD patients. …”
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Scrotum involvement in dermatomyositis by Marta Bagłaj-Oleszczuk, Anita Hryncewicz-Gwóźdź, Joanna Maj, Piotr Nockowski, Jacek Szepietowski, Alina Jankowska-Konsur

“…Its pathogenesis is not fully understood, however, it is believed that immunogenetic and probably other factors have a significant impact on the manifestation of the disease. …”
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Genetics and genomics of infectious disease susceptibility. by Hill, A

“…A large number of genes appear to influence susceptibility to infectious pathogens and defining these can provide insights into pathogenic and protective mechanisms and identify new molecular targets for prophylactic and therapeutic interventions. Immunogenetic associations with infectious diseases have considerable potential to guide immunomodulatory interventions and vaccine design.…”

Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma by Akihiko Kawahara, Jun Akiba, Hirohisa Yano, Ambrogio Fassina, Rocco Cappellesso, Yoshiki Naito, Maria Guido, Paolo Simioni, Giuliana Cortese, Lorenzo Nicolè, Tiziana Sanavia, Valeria Maffeis, Claudia Maria Radu, Davide Serafin, Giacomo Zanus

“…In addition, multivariate survival analysis showed that the expression of RIPK1, RIPK3 and MLKL-p was associated with better overall survival in the two independent cohorts.Conclusions Our results confirmed the immunogenetic properties of necroptosis (NCP) in human HCC, showing that tumor-infiltrating lymphocytes (TILs) and, specifically, CD8+ T cells accumulate in tumors with higher expression of the necroptosis-related genes. …”
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The role of HLA antigens in recurrent primary focal segmental glomerulosclerosis by Ibrahim Batal, Pascale Khairallah, Astrid Weins, Nicole K. Andeen, Michael B. Stokes

“…These findings suggest a role for recipient and donor immunogenetic makeup in recurrent primary FSGS post-transplantation. …”
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Natural Immunity against HIV-1: Progression of Understanding after Association Studies by Ma Luo

“…These studies started from identifying immunogenetic or genetic associations with resistance to HIV acquisition, and followed up with an in-depth investigation to understand the biological relevance of the correlations of protection, and to develop and test novel vaccines and preventions.…”
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A genetic linkage map of the rat derived from recombinant inbred strains. by Pravenec, M, Gauguier, D, Schott, J, Buard, J, Kren, V, Bílá, V, Szpirer, C, Szpirer, J, Wang, J, Huang, H, St Lezin, E, Spence, M, Flodman, P, Printz, M, Lathrop, G, Vergnaud, G, Kurtz, T

“…By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.…”

The importance of H2 haplotype sharing in the induction of specific unresponsiveness by pretransplant blood transfusions. by Niimi, M, Roelen, D, Witzke, O, van Rood, J, Claas, F, Wood, K

“…CONCLUSIONS: These results demonstrate that haplotype-shared blood transfusions can induce a significantly prolonged survival of cardiac allografts in F1 mice. The immunogenetic studies suggest that presentation of alloantigen-derived peptides in the context of self MHC (the indirect pathway of allorecognition) is essential for the beneficial effect of haplotype-shared blood transfusions.…”

High Throughput Genetic Characterisation of Caucasian Patients Affected by Multi-Drug Resistant Rheumatoid or Psoriatic Arthritis by Paola Tesolin, Francesca Eleonora Bertinetto, Arianna Sonaglia, Stefania Cappellani, Maria Pina Concas, Anna Morgan, Norma Maria Ferrero, Alen Zabotti, Paolo Gasparini, Antonio Amoroso, Luca Quartuccio, Giorgia Girotto

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Host response to fungal infections – how immunology and host genetics could help to identify and treat patients at risk by Nina Khanna, Claudia Stuehler, Anna Lünemann, Agnieszka Wójtowicz, Pierre-Yves Bochud, Salomé Leibundgut-Landmann

“…We review the most important genetic and immunological factors that influence human susceptibility to Candida and Aspergillus infections and discuss the potential role of basic research to promote precision medicine for infectious diseases. We discuss how immunogenetic studies can help to provide tools for improved identification of high-risk patients and the development of tailored antifungal therapies. …”
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The Genomics of Hairy Cell Leukaemia and Splenic Diffuse Red Pulp Lymphoma by David Oscier, Kostas Stamatopoulos, Amatta Mirandari, Jonathan Strefford

“…The primary aim of this review is to summarise their cytogenetic, genomic, immunogenetic, and epigenetic features, with a particular focus on the clonal <i>BRAFV600E</i> mutation, present in most cases currently diagnosed with HCLc. …”
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Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques. by Stella J Berendam, Papa K Morgan-Asiedu, Riley J Mangan, Shuk Hang Li, Holly Heimsath, Kan Luo, Alan D Curtis, Joshua A Eudailey, Christopher B Fox, Mark A Tomai, Bonnie Phillips, Hannah L Itell, Erika Kunz, Michael Hudgens, Kenneth Cronin, Kevin Wiehe, S Munir Alam, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar, M Anthony Moody, Genevieve G Fouda

“…Moreover, the epitope specificity and Ig immunogenetic features of vaccine-elicited monoclonal antibodies did not differ between the different vaccine regimens. …”
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PLASMA Th1/Th2/Th17 CYTOKINE PROFILE AND CYTOKINE GENE POLYMORPHISMS (IL12B, IL13, IL31, IL33) IN ASTHMATIC CHILDREN: A MAGNETIC MULTIPLEX ASSAY by M. V. Smolnikova, N. N. Gorbacheva, M. V. Shubina, S. Yu. Tereschenko

“…The aim of this study was to search for immunogenetic markers of severe asthma in Slavs children living in Krasnoyarsk city. …”
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The Value of Gastric Biomarkers in Detecting Precancerous Lesions in Patients with Dyspepsia by Seyed Mohammad Valizadeh Toosi, Vahid Hoseini, Fatemeh KhajeNabi, Fatemeh Toghani hulari, Idraj Maleki

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Juvenile unilesional folliculotropic mycosis fungoides: Two siblings with HLA-DRB1*04 and HLA-DQB1*03 alleles by Hatice Şanlı, İncilay Kalay Yıldızhan, Bengü Nisa Akay, Canan Arı, Aylin Okçu Heper

“…The pathogenesis of mycosis fungoides (MF) is poorly understood, and an immunogenetic mechanism has been suggested to play a role. …”
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Glaucoma Syndromes: Insights into Glaucoma Genetics and Pathogenesis from Monogenic Syndromic Disorders by Daniel A. Balikov, Adam Jacobson, Lev Prasov

“…In this review, we highlight six categories of disorders that feature glaucoma and other ocular or systemic manifestations: anterior segment dysgenesis syndromes, aniridia, metabolic disorders, collagen/vascular disorders, immunogenetic disorders, and nanophthalmos. The genetics, ocular and systemic features, and current and future treatment strategies are discussed. …”
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Natural history of primary progressive multiple sclerosis. by Ebers, G

“…Natural history data from a population-based cohort of patients with PPMS followed for approximately 25 years demonstrate remarkable similarities in the progressive phases of PPMS and SPMS. Immunogenetic and magnetic resonance imaging studies in large numbers of patients also fail to differentiate between the two MS categories. …”

The association of bullous pemphigoid and malignant disease: a case control study. by Venning, V, Wojnarowska, F

“…Three patients with both BP and malignancy were HLA-DR 13 positive, which may point to an immunogenetic predisposition to both diseases.…”

A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss by Caroline Nørgaard-Pedersen, Caroline Nørgaard-Pedersen, Rudi Steffensen, Ulrik Schiøler Kesmodel, Ulrik Schiøler Kesmodel, Ole Bjarne Christiansen, Ole Bjarne Christiansen

“…In an analysis of which autoantibodies were most strongly associated with the low p-MBL/HLA-DRB1*03 combination, antinuclear antibodies were significantly more frequent in these patients (OR 2.0; 95% CI 1.0-3.9, p=0.05) whereas the other autoantibodies were also positively but more weakly associated with this combination.DiscussionIn conclusion, to clarify the pathogenetic background, underlying immunogenetic factors should be examined in autoantibody positive RPL patients (as well as other patients with autoimmune diseases) but the genetic background may be complex.…”
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