KIR gene content imputation from single-nucleotide polymorphisms in the Finnish population by Jarmo Ritari, Kati Hyvärinen, Jukka Partanen, Satu Koskela

“…Inferring KIR gene content from genetic variant data is therefore desirable for immunogenetic analysis, particularly in the context of growing biobank genome data collections that rely on genotyping by microarray. …”
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Hantavirus Infections in Light of Current Knowledge by Selçuk KAYA

“…However, the main pathogenic mechanism is vascular endothelial dysfunction; viral properties and host immunogenetic factors both play a role in pathogenesis. …”
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Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis by Daniel A. Powell, Daniel A. Powell, Amy P. Hsu, Christine D. Butkiewicz, Hien T. Trinh, Jeffrey A. Frelinger, Steven M. Holland, John N. Galgiani, John N. Galgiani, Lisa F. Shubitz

“…The mitigation of DCM by Δcps1 vaccination in these mice suggests that it could also benefit humans with immunogenetic risks of severe disease.…”
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Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond by Simona Pagliuca, Simona Pagliuca, Carmelo Gurnari, Carmelo Gurnari, Marie Thérèse Rubio, Valeria Visconte, Tobias L. Lenz

“…A highly variable germline HLA genotype can convey immunogenetic protection against infections, be associated with tumor surveillance or influence response to anti-neoplastic treatments. …”
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Genetic insights into disease mechanisms of autoimmunity. by Simmonds, M, Gough, S

“…Clinical and molecular data suggest that shared immunogenetic mechanisms lead to the autoimmune process. …”

Single nucleotide polymorphisms in the interferon gamma gene are associated with distinct types of retinochoroidal scar lesions presumably caused by Toxoplasma gondii infection by Ricardo Guerra Peixe, Marcela Santana Bastos Boechat, Alba Lucinia Peixoto Rangel, Rhonia Franca Gomes Rosa, Maria Luiza Petzl-Erler, Lilian MG Bahia-Oliveira

“…Our findings strongly suggest that immunogenetic studies of individuals with congenital or postnatally acquired infection are needed to better understand the role of IFN-γ and its polymorphisms in the pathogenesis of ocular toxoplasmosis.…”
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Modulation of Radiation Doses and Chimeric Antigen Receptor T Cells: A Promising New Weapon in Solid Tumors—A Narrative Review by Antonio Pontoriero, Paola Critelli, Federico Chillari, Giacomo Ferrantelli, Miriam Sciacca, Anna Brogna, Silvana Parisi, Stefano Pergolizzi

“…LDRT (low-dose radiation therapy, >5–10 Gy/fractions) increases the expansion of CART cells and leads to non-immunogenetic death. An innovative approach, defined as the LATTICE technique, combines a high dose in higher FDG- uptake areas and a low dose to the tumor periphery. …”
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Transition from long-term nonprogression to HIV-1 disease associated with escape from cellular immune control. by Kemal, K, Beattie, T, Dong, T, Weiser, B, Kaul, R, Kuiken, C, Sutton, J, Lang, D, Yang, H, Peng, Y, Collman, R, Philpott, S, Rowland-Jones, S, Burger, H

“…Transition from long-term nonprogressive infection to progressive HIV-1 disease presents an opportunity to investigate pathogenesis in a defined immunogenetic background. We studied a male long-term nonprogressor (LTNP) who remained asymptomatic and viremic and had normal CD4 T-cell counts without antiretroviral therapy for >18 years and then experienced a transition to disease progression. …”

The association of HLA-DQ7 with bullous pemphigoid is restricted to men. by Banfield, C, Wojnarowska, F, Allen, J, George, S, Venning, V, Welsh, K

“…This study examines in detail the HLA associations of 74 patients (40 women and 34 men) with bullous pemphigoid (BP) and compares their immunogenetic profile with that of 604 unrelated control subjects (238 women and 366 men). …”

Contribution from MHC-Mediated Risk in Schizophrenia Can Reflect a More Ethnic-Specific Genetic and Comorbid Background by Lekshmy Srinivas, Neetha N. Vellichirammal, Indu V. Nair, Chandrasekharan M. Nair, Moinak Banerjee

“…Considering tremendous variations in this region and the probability of South Indian populations being quite different from the European gene-pool from an immunogenetic point, the present study was initiated to screen SNPs in the 2.28 MB region, spanning the extended MHC locus, in 492 cases and controls from a South Indian population. …”
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Interleukin-2 gene promoter polymorphism (T330G) and lymphocyte platelet adhesion in influenza A (H3N2) by G. A. Chuprova, A. N. Emel’yanova, A. S. Emel’yanov, Yu. A. Vitkovskii

“…The examine of LPA was carried out by the method of Yuri Vitkovsky et al. (1999).Results. During the immunogenetic study the effect of the polymorphism of the IL-2 gene promoter (T330G) on the function of lymphocyte-platelet adhesion in patients with influenza A(H3N2) was studied. …”
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Association between High Interferon-Gamma Production in Avian Tuberculin-Stimulated Blood from <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i>-Infected Cattle and Candida... by Gerard Badia-Bringué, María Canive, Patricia Vázquez, Joseba M. Garrido, Almudena Fernández, Ramón A. Juste, José Antonio Jiménez, Oscar González-Recio, Marta Alonso-Hearn

“…Taken together, our results define a heritable and distinct immunogenetic profile associated with the production of high IFNɣ levels and with the capacity of the host to lyse MAP-infected macrophages by necroptosis.…”
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Modelling the evolution and spread of HIV immune escape mutants. by Helen R Fryer, John Frater, Anna Duda, Mick G Roberts, SPARTAC Trial Investigators, Rodney E Phillips, Angela R McLean

“…The model is an extension of the well-known SI model of disease transmission and includes three further parameters that describe host immunogenetic heterogeneity and rates of within host viral evolution. …”
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Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy by Mo Cheng, Qingjie Kong, Qing Tian, Weiluo Cai, Chunmeng Wang, Minjia Yuan, Wenxing Wang, Peiyuan Wang, Wangjun Yan

“…Multimodal optical imaging and programmed treatment, including synergistic photothermal-chemodynamic therapy (PTT-CDT) elicits immunogenetic cell death (ICD) is a promising strategy that possesses high bio-imaging sensitivity for accurate osteosarcoma delineating as well as appreciable therapeutic efficacy with ignorable side-effects. …”
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Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis by V A Doronin, E A Nikitin, J. V. Sidorova, A. V. Pivnik

“…We compare clinical, hematological, immunophenotiping and immunogenetic features in Felty’s syndrome pts with and without the LGL leukemia. …”
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Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis by Mikias Negash, Menberework Chanyalew, Tigist Girma, Fekadu Alemu, Diana Alcantara, Ben Towler, Gail Davey, Rosemary J. Boyton, Daniel M. Altmann, Rawleigh Howe, Melanie J. Newport

“…However, functional relationships between the soil trigger, immunogenetic risk factors and the immunological basis of the disease are uncharted. …”
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Diversity in the Toll-Like Receptor Genes of the African Penguin (Spheniscus demersus). by Desiré Lee Dalton, Elaine Vermaak, Marli Roelofse, Antoinette Kotze

“…To date, the only studies on immunogenetic variation in penguins have been conducted on the major histocompatibility complex (MHC) genes. …”
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MHC class I allele diversity in cynomolgus macaques of Vietnamese origin by Shuting Huang, Xia Huang, Shuang Li, Mingjun Zhu, Min Zhuo

“…The results of biomedical experiments strongly depend on the immunogenetic background of animals, especially on the diversity of major histocompatibility complex (MHC) alleles. …”
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The Immunoseasonal Theory of Psychiatric Disorders by Napoleon Waszkiewicz

“…In the spring and summertime, when the compensating anti-Th1 property of the Th2 immune system is activated, it decreases the Th1 response. In individuals immunogenetically susceptible to psychosis and mania, the inhibition of Th1 by the Th2 system may be excessive and lead to Th2-related frontal and subcortical hyperactivation and subsequent psychosis. …”
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Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations by Ruth A. Purcell, Robert M. Theisen, Kelly B. Arnold, Amy W. Chung, Kevin J. Selva

“…We foresee a generation of precision vaccines that consider the mechanistic basis of vaccine response variations associated with both immunogenetic and baseline health differences. Recent efforts have highlighted the importance of balanced and diverse extra-neutralising antibody functions for vaccine-induced protection. …”
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