Allelic variation in HLA‐DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro by Christian Hammer, Jane Ruppel, Lynn Kamen, Julie Hunkapiller, Ira Mellman, Valerie Quarmby

“…In conclusion, our study showed that HLA class II genotype is associated with the risk of developing ADA, and specifically NAb, in patients treated with atezolizumab, but the effect estimates suggest that immunogenetic factors are not sufficient as clinically meaningful predictors.…”
Get full text

Immunophenotypic Characterization of Patients with Chronic Lymphocytic Leukemia by Flow Cytometry; Association with Disease Prognosis by Esmaeil Allahmoradi, Saeid Taghiloo, Ghasem Janbabaei, Ramin Shekarriz, Mohsen Tehrani, Hossein Asgarian-Omran

Get full text

Antibiotic Resistance Pattern of Bacteria Isolated from Automated Teller Machines in Sari, Iran by Alireza Zare, Shima Keshavarzi, Elham Amiri, Maryam Salehian, Leila Ahmadian, Parisa Charkhi, Hamid Reza Goli

Get full text

Growth and meat productivity of bulls depending on the similarity of their blood group B antigens with mothers by Anatolii Ugnivenko, Oleksandr Natalych

“…Therefore, an important place in the qualitative improvement of beef cattle breeds is occupied by the improvement of methods of animal selection using the immunogenetic characteristics of their blood. The purpose of the study is to determine the dependence of weight growth and meat productivity of animals of the Ukrainian beef breed on the number of similar antigenic factors of the B blood group system in them and their mothers. …”
Get full text

In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subty... by Chinoy, H, Salway, F, Fertig, N, Shephard, N, Tait, B, Thomson, W, Isenberg, D, Oddis, C, Silman, A, Ollier, W, Cooper, R

“…In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes.…”

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity by Electra Sofou, Electra Sofou, Laura Zaragoza-Infante, Nikolaos Pechlivanis, Georgios Karakatsoulis, Sofia Notopoulou, Niki Stavroyianni, Fotis Psomopoulos, Elisavet Georgiou, Anne Langlois de Septenville, Frederic Davi, Andreas Agathangelidis, Anastasia Chatzidimitriou, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Kostas Stamatopoulos

“…In conclusion, we provide immunogenetic evidence for intra-VH CDR3 variations, attributed to SHM, in CLL patients carrying ‘truly unmutated’ IGHV genes. …”
Get full text

Spatial organization and early signaling of the B-cell receptor in CLL by Yamit Shorer Arbel, Yotam Bronstein, Tali Dadosh, Talia Kamdjou, Shlomo Tsuriel, Mika Shapiro, Ben-Zion Katz, Ben-Zion Katz, Yair Herishanu, Yair Herishanu

“…Overall, we report fundamental differences in the basal composition, biochemical status, and spatial organization of the BcR in the three examined immunogenetic CLL subtypes that correlate with their clinical behavior. …”
Get full text

HLA-B*0702 class-I allele, anti-FSH, anti-LH, and vitamin D3: Potential links with polycystic ovary syndrome in women of Erbil city, Iraq by Najat Jabbar Ahmed Berwary, Rand Maurice Aziz

“…The results indicated that the HLA-B*0702 allele is associated with PCOS susceptibility and could be used as an immunogenetic marker. It also supported the idea that anti-FSH and anti-LH antibodies are naturally presence antibodies in PCOS patients instead of signs for autoimmunity. …”
Get full text

SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World’s Population by Manuel A. Patarroyo, Manuel E. Patarroyo, Laura Pabón, Martha P. Alba, Adriana Bermudez, María Teresa Rugeles, Diana Díaz-Arevalo, Wildeman Zapata-Builes, María Isabel Zapata, César Reyes, Carlos F. Suarez, William Agudelo, Carolina López, Jorge Aza-Conde, Miguel Melo, Luis Escamilla, Jairo Oviedo, Fanny Guzmán, Yolanda Silva, Martha Forero, Lizdany Flórez-Álvarez, Wbeimar Aguilar-Jimenez, Armando Moreno-Vranich, Jason Garry, Catalina Avendaño

“…Peptide selection was based on tremendous SARS-CoV-2 genetic variability for analysing them concerning vast human immunogenetic polymorphism for developing the first supramutational, Colombian SARS-protection (SM-COLSARSPROT), peptide mixture. …”
Get full text

ROLE OF LECTIN-SUBSTRANCE RECOGNITION IN IMMUNOREGULATORY INTERACTION BETWEEN INTERLEUKIN-2 IGG by S. M. Sobolev, T. N. Nikolaeva, E. A. Grigorjeva, A. V. Pronin

“…Moreover, such a mechanism cannot be also excluded in some physiological immunogenetic interactions, e.g., in feto-maternal system, where it could promote a positive selection for individuals with broader MHC repertoire, which would be necessary for development of individual and population-based resistance to infections…”
Get full text

The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes by Manuel Rojas, Manuel Rojas, Luke S. Heuer, Weici Zhang, Yi-Guang Chen, Yi-Guang Chen, William M. Ridgway

“…Herein, we will review immunogenetic control of tolerance in one of the classic models of autoimmunity, the non-obese diabetic (NOD) mouse model of autoimmune Type 1 diabetes (T1D). …”
Get full text

THE ROLE OF GENETIC POLYMORPHISMS OF GENE IL-1β (-31 Т/С) AND IL-6 (-174 G/C) IN THE COURSE OF CHRONIC HEPATITIS B AND C IN CHILDREN by S. V. Romanova, Т. А. Vidmanova, Е. А. Zhukova, Е. V. Ermolina, N. I. Tolkacheva, I. V. Mayanskaya, I. А. Timchenko

“…Objectives: Chronic viral hepatitis В (CHB) and С (CHC) comprise an important issue of modern pediatrics. Immunogenetic disorders are among key factors of their pathogenesis. …”
Get full text

Associations of IL17A G-197A single nucleotide polymorphism with immunological parameters and structural changes of the brain in schizophrenia by I. K. Malashenkova, V. L. Ushakov, S. A. Krynskiy, D. P. Ogurtsov, N. A. Khailov, A. Yu. Ratushnyy, E. A. Filippova, N. V. Zakharova, G. P. Kostyuk, N. A. Didkovsky

“…The results highlight the importance of immunogenetic factors in the pathogenesis of schizophrenia and indicate that the rs2275913 polymorphism requires further studies as a potential biomarker of immune dysregulation and morphometric brain changes in schizophrenia.…”
Get full text

A Multigene-Panel Study Identifies Single Nucleotide Polymorphisms Associated with Prostate Cancer Risk by Maria Antonietta Manca, Fabio Scarpa, Davide Cossu, Elena Rita Simula, Daria Sanna, Stefano Ruberto, Marta Noli, Hajra Ashraf, Tatiana Solinas, Massimo Madonia, Roberto Cusano, Leonardo A. Sechi

“…Our results provide new insights into the immunogenetic landscape of prostate cancer and the impact that SNPs on immune genes may have on affecting the susceptibility to prostate cancer.…”
Get full text

IRProfiler – a software toolbox for high throughput immune receptor profiling by Christos Maramis, Athanasios Gkoufas, Anna Vardi, Evangelia Stalika, Kostas Stamatopoulos, Anastasia Hatzidimitriou, Nicos Maglaveras, Ioanna Chouvarda

“…In the era of high-throughput sequencing (HTS), the abundance of immunogenetic data has revealed unprecedented opportunities for the thorough profiling of T-cell receptors (TR) and B-cell receptors (BcR). …”
Get full text

Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications by Hedwig D. Vrijmoeth, Jeanine Ursinus, Javier Botey-Bataller, Yunus Kuijpers, Xiaojing Chu, Freek R. van de Schoor, Brendon P. Scicluna, Cheng-Jian Xu, Mihai G. Netea, Bart Jan Kullberg, Cees C. van den Wijngaard, Yang Li, Joppe W. Hovius, Leo A. B. Joosten

“…These findings provide important insights into the immunogenetic susceptibility for LB and may guide future studies on development of preventive or therapeutic measures. …”
Get full text

Brain–Immune Interactions as the Basis of Gulf War Illness: Clinical Assessment and Deployment Profile of 1990–1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) Mult... by Lea Steele, Nancy Klimas, Maxine Krengel, Emily Quinn, Rosemary Toomey, Deborah Little, Maria Abreu, Kristina Aenlle, Ronald Killiany, Bang-Bon Koo, Patricia Janulewicz, Timothy Heeren, Allison N. Clark, Joy Ajama, Joanna Cirillo, Gerardo Buentello, Vanesa Lerma, Janet K. Coller, Kimberly Sullivan

“…The core GWIC case-control clinical study conducted in-depth brain and immune evaluation of 269 Gulf War veterans (223 GWI cases, 46 controls) at three U.S. sites that included clinical assessments, brain imaging, neuropsychological testing, and analyses of a broad range of immune and immunogenetic parameters. GWI cases were similar to controls on most demographic, military, and deployment characteristics although on average were two years younger, with a higher proportion of enlisted personnel vs. officers. …”
Get full text

Prevalence of Eimeria spp. infections and major histocompatibility complex class II DRA diversity in Mongolian Bactrian camels (Camelus bactrianus) by Igori Khatanbaatar, Uranbileg Nyamdolgor, Boldbaatar Chinchuluun, Khandsuren Naranbaatar, Anja Taubert, Carlos R. Hermosilla, Franz Suchentrunk, Felix Knauer, Pamela A. Burger, Gonchigoo Battsetseg

“…To investigate the immunogenetic response of the Mongolian Bactrian camels to Eimeria spp. infection, we screened the genetic diversity in a functional important immune response gene of the major histocompatibility complex (MHC). …”
Get full text

HSV1 microRNAs in glioblastoma development: an in silico study by Mahdi Abdoli Shadbad, Nima Hemmat, Mahla Abdoli Shadbad, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran

“…The TCGA-GTEX, GDSC, CTRP, immunogenetic, and enrichment analyses were performed to study the impact of identified viral HSV1 miRs targets in GBM development. hsv1-miR-H6-3p is upregulated in GBM and can be responsible for EPB41L1 and SH3PXD2A downregulation in GBM tissues. …”
Get full text

Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…To analyze modern approach to pathogenesis of Crohn's diseases (CD), to determine effect of individual immunogenetic factors on development and progression of disease, in particular, in relation to HLA profile.Summary. …”
Get full text