Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability by Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji

“…Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome these roadblocks have been unsatisfactory. …”
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Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study by Aleksandra Glapa-Nowak, Mariusz Szczepanik, Jarosław Kwiecień, Anna Szaflarska-Popławska, Anna Flak-Wancerz, Barbara Iwańczak, Marcin Osiecki, Jarosław Kierkuś, Tomasz Pytrus, Dariusz Lebensztejn, Tomasz Banasiewicz, Aleksandra Banaszkiewicz, Jarosław Walkowiak

“…Patients diagnosed in winter were significantly younger at diagnosis (11.4 vs. 13.0; <i>p</i>_adj = 0.0180) and first immunosuppressive treatment (11.3 vs. 13.3; <i>p</i>_adj = 0.0109) than those diagnosed in other seasons. …”
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FoxP3+ CD8 T-cells in acute HIV infection and following early antiretroviral therapy initiation by Alexis Yero, Tao Shi, Jean-Pierre Routy, Jean-Pierre Routy, Cécile Tremblay, Cécile Tremblay, Madeleine Durand, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Mohammad-Ali Jenabian, Mohammad-Ali Jenabian

“…FoxP3+ CD8 T-cells in untreated participants expressed higher levels of immunosuppressive LAP(TGF-β1) and CD39 than uninfected controls, whereas early ART did not affect their expression. …”
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Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis by C. Caruso, L. Laterza, C. R. Settanni, S. Colantuono, C. Di Mario, B. Tolusso, F. Castrì, E. Gremese, E. Gremese, F. Scaldaferri, F. Scaldaferri, A. Armuzzi, A. Armuzzi, C. De Simone, K. Peris, A. Chiricozzi, A. Gasbarrini, A. Gasbarrini, A. Gasbarrini

“…In consideration of the poor response to conventional immunosuppressants and the presence of type 2 inflammatory manifestations, treatment with dupilumab at an initial dose of 600 mg, followed by a maintenance dose of 300 mg every other week, according to atopic dermatitis labeled dose, was started and combined to oral budesonide 6 mg/day and 6-mercaptopurine 75 mg/day. …”
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Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients by Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Mihai G. Netea, Athanasios Ziogas

“…Although its broad immunosuppressive effects are well-described, the immunological mechanisms modulated by dexamethasone in patients hospitalized with COVID-19 remain to be elucidated.ObjectiveWe combined functional immunological assays and an omics-based approach to investigate the in vitro and in vivo effects of dexamethasone in the plasma and peripheral blood mononuclear cells (PBMCs) of COVID-19 patients.MethodsHospitalized COVID-19 patients eligible for dexamethasone therapy were recruited from the general care ward between February and July, 2021. …”
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The impact of multifactorial factors on the Quality of Life of Behçet's patients over 10 years by Amal A. Senusi, Amal A. Senusi, John Mather, Dennis Ola, Dennis Ola, Lesley A. Bergmeier, Lesley A. Bergmeier, Bindi Gokani, Farida Fortune, Farida Fortune

“…The 2014 and 2020 surveys reported the QoL is significantly better in patients on immunosuppressant, who did sport, continued in employment and not receiving benefits.ConclusionJoints and neurological symptoms are the main symptoms which had negative impact on BS patients over the 10 years, sociodemographic (gender, age, marital, and education status), lifestyle (medication, cannabis, drinking wine, and regular exercise), employment status (employee and no career change), and accessing benefits (never claim benefit) had significant influence on patients' HRQoL.…”
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Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population by Xin-Hui Khoo, Shin Yee Wong, Nik Razima Wan Ibrahim, Ruey Terng Ng, Kee Seang Chew, Way Seah Lee, Zhi Qin Wong, Raja Affend Raja Ali, Shahreedhan Shahrani, Alex Hwong-Ruey Leow, Ida Normiha Hilmi, Ida Normiha Hilmi

“…Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic populations. …”
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Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin by Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Jesús Martín, Francisco Javier Ortiz-López, Fernando Reyes, Luis A. García, Gloria Blanco, Gloria Blanco, Gloria Blanco

“…Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and neuroprotective among others. The molecular formulae of the 25 remaining compounds were determined by HRMS. …”
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Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy by Gang Zhou, David H Munn, Zhi-Chun Ding, Marco L Davila, Hongyan Xu, Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Gregory Gorman, Roni Bollag, Locke J Bryan, Gary A Piazza

“…Moreover, the beneficial effect of indo in ACT did not rely on its inhibitory effect on the immunosuppressive cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) axis. …”
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Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple‐negative breast cancer to immune checkpoint inhibitors by Xin‐Yu Chen, Bin Li, Ye Wang, Juan Jin, Yu Yang, Lei‐Huan Huang, Meng‐Di Yang, Jian Zhang, Bi‐Yun Wang, Zhi‐Ming Shao, Ting Ni, Sheng‐Lin Huang, Xi‐Chun Hu, Zhong‐Hua Tao

“…Low ARID1A expression in TNBC, causing an immunosuppressive microenvironment, promoted AIR and inhibited CD8+ T cell infiltration and activity through upregulating PD‐L1. …”
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A Novel Risk Score Model of Lactate Metabolism for Predicting over Survival and Immune Signature in Lung Adenocarcinoma by Zhou Jiang, Yongzhong Luo, Lemeng Zhang, Haitao Li, Changqie Pan, Hua Yang, Tianli Cheng, Jianhua Chen

“…Recently, it was found that lactate acid accumulation induced an immunosuppressive microenvironment. However, these results were based on a single gene and it was unclear that lactate acid genes were associated with immunotherapy and able to predict overall survival. …”
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Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration by Honorine Dushime, Stéphanie G. Moreno, Christine Linard, Annie Adrait, Yohann Couté, Juliette Peltzer, Sébastien Messiaen, Claire Torres, Lydia Bensemmane, Daniel Lewandowski, Paul-Henri Romeo, Vanessa Petit, Nathalie Gault

“…Under gas anesthesia, GIS mice were treated or not through an intravenous retro-orbital injection of 50,000 WJ-Muse, freshly isolated or cryopreserved, shortly after an 18 Gy-abdominal IR. No immunosuppressant was delivered to the mice. Mice were euthanized either 24 h post-IR to assess early small intestine tissue response, or 7 days post-IR to assess any regenerative response. …”
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Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Th... by Xinyue Wang, Xinyue Wang, Xinyue Wang, Xinyue Wang, Leidan Zhang, Leidan Zhang, Leidan Zhang, Juan Du, Juan Du, Juan Du, Yuqing Wei, Yuqing Wei, Yuqing Wei, Di Wang, Di Wang, Chuan Song, Chuan Song, Chuan Song, Danying Chen, Danying Chen, Danying Chen, Bei Li, Bei Li, Meiqing Jiang, Meiqing Jiang, Meiqing Jiang, Mengyuan Zhang, Mengyuan Zhang, Mengyuan Zhang, Hongxin Zhao, Hongxin Zhao, Yaxian Kong, Yaxian Kong, Yaxian Kong, Yaxian Kong

“…CD73, both a soluble and a membrane-bound form, display immunosuppressive effects through producing adenosine (ADO). …”
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Negative predictive value of the FebriDx host response point-of-care test in patients presenting to a single Australian emergency department with suspected COVID-19: an observation... by Joseph Miller, Stephen Guy, Alun Pope, Emogene Aldridge, Paul Buntine, Fang Qi (Alex) Wong, Hannah McDonald, Mania Ahmed, Kang Hui Teow, Morgan Roney, Farzaneh Mohammadi, Liam Hackett, Susanna Jenner, Belinda Davis

“…Patients meeting any of the following criteria were excluded: &lt;16 years of age; acute respiratory symptom(s) with onset&gt;14 days prior to testing; current immunosuppressive or interferon therapy; live immunisation within the last 30 days; fever lasting&gt;7 days; antibiotic or antiviral use in the preceding 14 days; experience of major trauma, major surgical intervention or severe burns within the last 30 days.Primary and secondary outcome measures COVID-19 PCR results (detected, not detected) and FebriDx results (bacterial positive, viral negative, viral positive).Results 94 participants were enrolled (female: 46; male: 48), 34% of participants (tested positive for COVID-19 according to PCR results, with a background incidence among all adult ED attenders of 2.5%. …”
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Immunogenicity of Intradermal Versus Intramuscular BNT162b2 COVID-19 Booster Vaccine in Patients with Immune-Mediated Dermatologic Diseases: A Non-Inferiority Randomized Controlled... by Chutima Seree-aphinan, Ploysyne Rattanakaemakorn, Poonkiat Suchonwanit, Kunlawat Thadanipon, Yanisa Ratanapokasatit, Tanat Yongpisarn, Kumthorn Malathum, Pornchai Simaroj, Chavachol Setthaudom, Onchuma Lohjai, Somsak Tanrattanakorn, Kumutnart Chanprapaph

“…Mean differences in log-normalized outcome estimates were calculated with multivariable linear regression adjusting for their baseline values, systemic immunosuppressants used, and prior COVID-19 vaccination history. …”
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Endophthalmitis at a tertiary referral center: Characteristics and treatment outcomes over three decades by Wen-Fei Zhang, Wen-Fei Zhang, Xin-Yu Zhao, Xin-Yu Zhao, Li-Hui Meng, Li-Hui Meng, Huan Chen, Huan Chen, You-Xin Chen, You-Xin Chen

“…Patients with endogenous endophthalmitis were more likely to have binocular involvement; there were also more patients with diabetes mellitus or immunosuppressive diseases, and the prognosis of visual acuity (VA) was poorer. …”
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UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer by Brittney S. Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W. Caminear, Lidia F. Hernandez, Donna Butcher, Elijah F. Edmondson, Nadia Traficante, Joy Hendley, Australian Ovarian Cancer Study, Madeline Gough, Rebecca Rogers, Rohan Lourie, Jyoti Shetty, Bao Tran, Fathi Elloumi, Abdalla Abdelmaksoud, Madhu Lal Nag, Krystyna Mazan-Mamczarz, Carrie D. House, John D. Hooper, Christina M. Annunziata

“…Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs) that are supported by a complex extracellular matrix and immunosuppressive microenvironment. To target TICs to prevent recurrence, we identified genes critical for TIC viability from a whole genome siRNA screen. …”
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Systemic Connective Tissue Disease and Neuromyelitis Optica Spectrum Disorder Coexistence: A Systematic Review and Meta-Analysis by Jessica Elisabetta Esposito, Giovanni Annoni, Milena D’Amato, Alessandra Graziosi, Francesca Troilo, Annalisa Di Risio, Gilda Angelini, Caterina Castiglione, Pierluigi Tocco, Paola Volpe, Giancarlo Di Iorio, Giustino Parruti, Ennio Polilli

“…These considerations should be taken into account in clinical experience of rheumatologists and neurologists, since early diagnosis of both conditions may influence the timing of immunosuppressive therapy and the prevention of systemic disabilities.…”
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BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in<br /> Class 2 Uveal Melanomas by Christopher J. Kaler, James J. Dollar, Anthony M. Cruz, Jeffim N. Kuznetsoff, Margaret I. Sanchez, Christina L. Decatur, Jonathan D. Licht, Keiran S. M. Smalley, Zelia M. Correa, Stefan Kurtenbach, J. William Harbour

“…Using RNA sequencing (RNA-seq), we found that the most highly upregulated gene associated with BAP1 loss across these datasets was <i>PROS1</i>, which encodes a ligand that triggers phosphorylation and activation of the immunosuppressive macrophage receptor MERTK. The inverse association between <i>BAP1</i> and <i>PROS1</i> in class 2 UM was confirmed by single-cell RNA-seq, which also revealed that <i>MERTK</i> was upregulated in CD163+ macrophages in class 2 UM. …”
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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy by Xuan Wang, Jie Dai, Li Zhou, Xuefeng Xia, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xuan Gao, Lirui Tang, Linzi Sun, Zhonghui Qi, Zelong Xu

“…Transcriptome analysis revealed that, compared with NEMM, PMME displayed more significant proliferation and inflammatory features with higher expression of genes related to antigen presentation and differentiation, and a less immunosuppressive signature with lower expression of inhibitory immune checkpoints and dedifferentiation-related genes. …”
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