Serum Mac-2 binding protein glycosylation isomer and galectin-3 levels in adult-onset Still’s disease and their association with cytokines by Shuhei Yoshida, Tomohiro Koga, Yuya Fujita, Hiroshi Yatsuhashi, Haruki Matsumoto, Yuya Sumichika, Kenji Saito, Shuzo Sato, Tomoyuki Asano, Masao Kobayakawa, Masao Kobayakawa, Hiromasa Ohira, Masashi Mizokami, Masaya Sugiyama, Kiyoshi Migita

“…Furthermore, significant correlations were observed between the serum levels of Gal-3 and various inflammatory cytokines, including interleukin-18, in patients with AOSD. Immunosuppressive treatment in patients with AOSD significantly reduced serum Gal-3 and M2BPGi levels (p = 0.03 and 0.004, respectively).ConclusionsAlthough both Gal-3 and M2BPGi were elevated in patients with AOSD, only Gal-3 was a useful biomarker for predicting disease activity in AOSD. …”
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Immune-Related Pneumonitis Was Decreased by Addition of Chemotherapy with PD-1/L1 Inhibitors: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials (RCTs) by Yi-Xiu Long, Yue Sun, Rui-Zhi Liu, Ming-Yi Zhang, Jing Zhao, Yu-Qing Wang, Yu-Wen Zhou, Ke Cheng, Ye Chen, Cai-Rong Zhu, Ji-Yan Liu

“…Conventional chemotherapy (C) has been considered as an immunosuppressive agent and may thus reduce IRP’s risk when used in combination with PD-1/L1 inhibitors. …”
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Sarcoidosis and lymphoma mortality risk: An observational study from the Spanish National Registry by Víctor Moreno-Torres, María Martínez-Urbistondo, Pedro Durán-del Campo, Pablo Tutor, Begoña Rodríguez, Raquel Castejón, Susana Mellor-Pita

“…In addition to developing strategies that might help to attenuate their occurrence and impact, such as decreasing the immunosuppressive burden, specific early-detection programs for these conditions should be investigated and considered carefully.…”
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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury by Joshua Hefler, Rena Pawlick, Braulio A. Marfil-Garza, Aducio Thiesen, Nerea Cuesta-Gomez, Sanaz Hatami, Darren H. Freed, Constantine Karvellas, David L. Bigam, A.M. James Shapiro

“…Cyclosporine (CsA), which is a well-known immunosuppressive agent that inhibits calcineurin, has the additional effect of inhibiting the mitochondrial permeability transition pore (mPTP), thereby, preventing mitochondrial swelling and injury. …”
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Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors by Clément Anfray, Carmen Fernández Varela, Aldo Ummarino, Akihiro Maeda, Marina Sironi, Sara Gandoy, Sara Gandoy, Jose Brea, María Isabel Loza, Sergio León, Sergio León, Alfonso Calvo, Alfonso Calvo, Juan Correa, Eduardo Fernandez-Megia, María José Alonso, Paola Allavena, José Crecente-Campo, Fernando Torres Andón, Fernando Torres Andón, Fernando Torres Andón

“…BackgroundIn the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. …”
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cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus by Csilla Szebenyi, Yiyou Gu, Teclegiorgis Gebremariam, Sándor Kocsubé, Sándor Kiss-Vetráb, Olivér Jáger, Roland Patai, Krisztina Spisák, Rita Sinka, Ulrike Binder, Mónika Homa, Csaba Vágvölgyi, Ashraf S. Ibrahim, Gábor Nagy, Tamás Papp

“…IMPORTANCE Current treatment options for mucormycosis are inadequate, resulting in high mortality rates, especially among immunosuppressed patients. The development of novel therapies for mucormycosis has been hampered by lack of understanding of the pathogenetic mechanisms. …”
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The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice by Ching-Feng Wu, Ching-Yang Wu, Robin Y.-Y. Chiou, Wei-Cheng Yang, Chuen-Fu Lin, Chao-Min Wang, Po-Hsun Hou, Tzu-Chun Lin, Chan-Yen Kuo, Geng-Ruei Chang

“…Zotarolimus is a semi-synthetic derivative of rapamycin and a novel immunosuppressive agent used to prevent graft rejection. …”
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MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2 by Xin Chen, Hui Li, Yang Yang, Ping Li, Ping Liao, Yifei Wang, Mengmeng Jiang, Liling Niu, Yibo Chen, Jingbin Zheng, Fengyang Chen, Huanhuan He

“…Our results showed that miR-125b-5p had the capacity to inhibit the expression of TNFR2 and immunosuppressive activity of Tregs and consequently enhanced the antitumor efficacy. …”
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Risk factors and the value of microbiological examinations of COVID-19 associated pulmonary aspergillosis in critically ill patients in intensive care unit: the appropriate microbi... by Xiaoyi Zhou, Xiaoyi Zhou, Xiaojing Wu, Ziying Chen, Ziying Chen, Xiaoyang Cui, Ying Cai, Youfang Liu, Youfang Liu, Bingbing Weng, Bingbing Weng, Qingyuan Zhan, Qingyuan Zhan, Qingyuan Zhan, Linna Huang

“…CAPA patients were more immunosuppressed, in more serious condition, required more advanced respiratory support and had more other organ comorbidities. …”
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A novel hypoxia- and lactate metabolism-related signature to predict prognosis and immunotherapy responses for breast cancer by integrating machine learning and bioinformatic analy... by Jia Li, Hao Qiao, Fei Wu, Shiyu Sun, Cong Feng, Chaofan Li, Wanjun Yan, Wei Lv, Huizi Wu, Mengjie Liu, Xi Chen, Xuan Liu, Weiwei Wang, Yifan Cai, Yu Zhang, Zhangjian Zhou, Yinbin Zhang, Shuqun Zhang

“…CIBERSORTx and ImmuCellAI showed that the low-risk group had abundant anti-tumor immune cells, whereas in the high-risk group, immunosuppressive cells were dominant. Independent immunotherapy datasets (IMvigor210 and GSE78220), TIDE, IPS and pRRophetic analyses revealed that the low-risk group responded better to common immunotherapy and chemotherapy drugs.ConclusionsWe constructed a novel prognostic signature combining lactate metabolism and hypoxia to predict OS, immune status, and treatment response of patients with breast cancer, providing a viewpoint for individualized treatment.…”
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Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma by Rong Shen, Di Fu, Lei Dong, Mu-Chen Zhang, Qing Shi, Zi-Yang Shi, Shu Cheng, Li Wang, Peng-Peng Xu, Wei-Li Zhao

“…EZB-like-MYC+ subtype was characterized by an immunosuppressive tumor microenvironment, while EZB-like-MYC- subtype by NOTCH activation. …”
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Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model by David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother

“…Notably, the least therapeutically effective CAR mediated tonic signaling leading to antigen-independent cytokine expression and it had higher levels of the immunosuppressive cytokine interleukin10.Conclusion The findings support the development of affinity-optimized CAR-T cells as a potential treatment for established ovarian cancer, with the most effective CARs mediating a distinct pattern of inflammatory cytokine release in vitro. …”
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Interleukin-6 and indoleamine-2,3-dioxygenase as potential adjuvant targets for Papillomavirus-related tumors immunotherapy by Roberta Liberato Pagni, Patrícia da Cruz Souza, Rafael Pegoraro, Bruna Felício Milazzotto Maldonado Porchia, Bruna Felício Milazzotto Maldonado Porchia, Jamile Ramos da Silva, Luana Raposo de Melo Moraes Aps, Luana Raposo de Melo Moraes Aps, Mariângela de Oliveira Silva, Karine Bitencourt Rodrigues, Natiely Silva Sales, Luís Carlos de Souza Ferreira, Ana Carolina Ramos Moreno, Ana Carolina Ramos Moreno

“…Considering cancer immunosuppressive mechanisms, indoleamine-2,3-dioxygenase (IDO) enzyme and interleukin-6 (IL-6) stand out in HPV-related tumors. …”
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Integrative study reveals the prognostic and immunotherapeutic value of CD274 and PDCD1LG2 in pan-cancer by Xuan Zhou, Yu Wang, Jianwei Zheng, Sinan Wang, Chao Liu, Xiaofeng Yao, Yu Ren, Xudong Wang

“…Furthermore, CD274 and PDCD1LG2 expression were associated with various immunosuppressive biomarkers, such as CTLA4, TIGIT, and LAG3. …”
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Global trends in tumor microenvironment-related research on tumor vaccine: a review and bibliometric analysis by Ying Liu, Ying Liu, Sixin Li, Sixin Li, Lu Chen, Lu Chen, Lin Lin, Caijuan Xu, Caijuan Xu, Huiwen Qiu, Huiwen Qiu, Xinyu Li, Xinyu Li, Hui Cao, Hui Cao, Kun Liu, Kun Liu

“…One factor that can hinder the effectiveness of vaccines is the natural immunosuppressive element present in the tumor microenvironment. …”
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Global Characteristics and Dynamics of Single Immune Cells After Myocardial Infarction by Lingfang Zhuang, Yaqiong Wang, Zhaoyang Chen, Zhigang Li, Ziyang Wang, Kangni Jia, Jiaxin Zhao, Hang Zhang, Hongyang Xie, Lin Lu, Kang Chen, Lei Chen, Keiichi Fukuda, Motoaki Sano, Ruiyan Zhang, Jun Liu, Xiaoxiang Yan

“…In silico tools predicted that the excessively expanded neutrophils at 1 day were attributed to chemokine C‐C motif ligand/chemokine C‐X‐C motif ligand pathways, whereas CD80/inducible T‐cell costimulator (ICOS) signaling was responsible for the immunosuppressive response at day 7 after MI. Finally, the Fos/AP‐1 (activator protein 1) regulon was identified as the critical regulator of proinflammatory responses, which was significantly activated in patients with dilated cardiomyopathy and ischemic cardiomyopathy. …”
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Identification and verification of eight cancer-associated fibroblasts related genes as a prognostic signature for head and neck squamous cell carcinoma by Lei Dong, Qi Sun, Fei Song, Xiaoyu Song, Congxian Lu, Yumei Li, Xicheng Song

“…Cancer-associated fibroblasts (CAFs) can exert their immunosuppressive effects by secreting various effectors that are involved in the regulation of tumor-infiltrating immune cells as well as other immune components in the tumor immune microenvironment (TIME), thereby promoting tumorigenesis, progression, metastasis, and drug resistance. …”
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Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy by Rienk Offringa, Ralf Lesche, Iris Oezen, Michael Platten, Daniel Baumann, Christiane A Opitz, Ahmed Sadik, Catherine Olesch, Frederik Cichon, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Katharina Sahm, Nirmeen Elmadany, Christina Kober, Julian Roewe, Lars Roese, Benjamin Bader, Mátyás Gorjánácz, Helge Gottfried Roider, Gabriele Leder, Horst Irlbacher, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Rafael Carretero, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Ilona Gutcher

“…Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microenvironment are predominantly mediated by the aryl hydrocarbon receptor (AhR), a cytosolic transcription factor that broadly suppresses immune cell function. …”
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Prevalence and risk factors of carbapenem-resistant Enterobacterales positivity by active screening in intensive care units in the Henan Province of China: A multi-center cross-sec... by Bo Guo, Bo Guo, Bo Guo, Bo Guo, Ziqi Guo, Ziqi Guo, Ziqi Guo, Ziqi Guo, Huifeng Zhang, Huifeng Zhang, Huifeng Zhang, Huifeng Zhang, Chuanchuan Shi, Chuanchuan Shi, Chuanchuan Shi, Chuanchuan Shi, Bingyu Qin, Bingyu Qin, Bingyu Qin, Bingyu Qin, Shanmei Wang, Yinjiang Chang, Jian Chen, Peili Chen, Limin Guo, Weidong Guo, Weidong Guo, Huaibin Han, Lihong Han, Yandong Hu, Xiaoye Jin, Yening Li, Hong Liu, Ping Lou, Yibing Lu, Panfeng Ma, Yanhua Shan, Yiyi Sun, Wukui Zhang, Xisheng Zheng, Huanzhang Shao, Huanzhang Shao, Huanzhang Shao, Huanzhang Shao

“…Patients from tertiary hospitals had different clinical features compared with those from secondary hospitals, including longer hospital stays, a higher rate of patients transferred from other hospitals, receiving renal replacement therapy, exposure to immunosuppressive drugs, use of antibiotics, and a higher rate of the previous infection.ConclusionIn ICUs in Henan Province, CRE positive rate was very high, mostly KPC-type CR-KPN. …”
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The Italian data on SARS-CoV-2 infection in transplanted patients support an organ specific immune response in liver recipients by Maria Rendina, Michele Barone, Chiara Lillo, Silvia Trapani, Lucia Masiero, Paolo Trerotoli, Francesca Puoti, Luigi Giovanni Lupo, Francesco Tandoi, Salvatore Agnes, Antonio Grieco, Enzo Andorno, Simona Marenco, Edoardo Giovanni Giannini, Umberto Baccarani, Pierluigi Toniutto, Amedeo Carraro, Antonio Colecchia, Matteo Cescon, Maria Cristina Morelli, Umberto Cillo, Patrizia Burra, Paolo Angeli, Michele Colledan, Stefano Fagiuoli, Stefano Fagiuoli, Luciano De Carlis, Luca Belli, Paolo De Simone, Paola Carrai, Fabrizio Di Benedetto, Nicola De Maria, Giuseppe Maria Ettorre, Valerio Giannelli, Salvatore Gruttadauria, Salvatore Gruttadauria, Riccardo Volpes, Sveva Corsale, Vincenzo Mazzaferro, Vincenzo Mazzaferro, Sherrie Bhoori, Renato Romagnoli, Silvia Martini, Giorgio Rossi, Lucio Caccamo, Maria Francesca Donato, Massimo Rossi, Stefano Ginanni Corradini, Marco Spada, Giuseppe Maggiore, Giuseppe Tisone, Ilaria Lenci, Giovanni Vennarecci, Raffaella Tortora, Marco Vivarelli, Gianluca Svegliati Baroni, Fausto Zamboni, Laura Mameli, Silvio Tafuri, Simona Simone, Loreto Gesualdo, Massimo Cardillo, Alfredo Di Leo

“…The standardized rate of infection, mortality, and lethality rates in LTRs resulted lower compared to NL-SOTRs [1.02 (95%CI 0.81-1.23) vs. 2.01 (95%CI 1.8-2.2); 1.0 (95%CI 0.5-1.5) vs. 4.5 (95%CI 3.6-5.3); 1.6 (95%CI 0.7-2.4) vs. 2.8 (95%CI 2.2-3.3), respectively] and comparable to the Italian GP.DiscussionAccording to the most recent studies on SOTRs and SARS-CoV-2 infection, our data strongly suggest that, in contrast to what was observed in NL-SOTRs receiving a similar immunosuppressive therapy, LTRs have the same risk of SARS-CoV-2 infection, mortality, and lethality observed in the general population. …”
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