GBS hyaluronidase mediates immune suppression in a TLR2/4- and IL-10-dependent manner during pregnancy-associated infection by Michelle Coleman, Austyn Orvis, Alyssa Brokaw, Anna Furuta, Kavita Sharma, Phoenicia Quach, Avneet Bhullar, Rhea Sanghavi, Shayla Nguyen, Erin Sweeney, Ravin Seepersaud, Blair Armistead, Kristina M. Adams Waldorf, Lakshmi Rajagopal

“…GBS secretes a hyaluronidase enzyme that is thought to digest host hyaluronan into immunosuppressive disaccharides that dampen TLR2/4 signaling, leading to increased bacterial dissemination and adverse outcomes. …”
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Graft Failure Due to Nonadherence among 150 Prospectively-Followed Kidney Transplant Recipients at 18 Years Post-transplant: Our Results and Review of the Literature by Jeffrey J. Gaynor, Giselle Guerra, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Mariella Ortigosa-Goggins, Marina M. Tabbara, Lissett Moni, George W. Burke, Gaetano Ciancio

“…Methods: Determination of the patient becoming NA in taking his/her immunosuppressive medications, and the underlying cause of graft loss, were determined prospectively by the attending physicians. …”
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Comparison of clinical features and outcomes of proliferative, fibrotic, and mixed subtypes of IgG4-related disease: A retrospective cohort study by Linyi Peng, Xinlu Zhang, Jiaxin Zhou, Jieqiong Li, Zheng Liu, Hui Lu, Yu Peng, Yunyun Fei, Yan Zhao, Xiaofeng Zeng, Wen Zhang, Lishao Guo

“…We then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with immunosuppressants. Moreover, risk factors of relapse were revealed by applying the univariate and multivariate Cox regression analysis. …”
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Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry by Antonio Vitale, Francesca Della Casa, Silvana Guerriero, Gaafar Ragab, Angela Mauro, Valeria Caggiano, Marco Cattalini, Emanuela Del Giudice, Rossella Favale, Carla Gaggiano, Irene Bellicini, Maria Pia Paroli, Mohamed Tharwat Hegazy, Jurgen Sota, Abdurrahman Tufan, Alberto Balistreri, Ibrahim Almaghlouth, Francesco La Torre, Ewa Więsik-Szewczyk, Maria Tarsia, Andrea Hinojosa-Azaola, Eduardo Martín-Nares, Bruno Frediani, Gian Marco Tosi, Alex Fonollosa, José Hernández-Rodríguez, Rana Hussein Amin, Giuseppe Lopalco, Donato Rigante, Luca Cantarini, Claudia Fabiani

“…This could be related to a higher use of systemic glucocorticoids (p = 0.002) and conventional immunosuppressants (p = 0.007) at the start of ADA when treating intermediate uveitis/pars planitis. …”
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MZF1 promotes tumour progression and resistance to anti-PD-L1 antibody treatment in hepatocellular carcinoma by Anna Kan, Shuang Liu, Minke He, Dongsheng Wen, Haijing Deng, Lichang Huang, Zhicheng Lai, Yexing Huang, Ming Shi

“…Results: Single-cell RNA-sequencing suggested an immunosuppressive environment and a strong correlation with the immune checkpoint programmed death ligand 1 (PD-L1) in MZF1-overexpressing tumours. …”
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Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Trans... by Daniel N. Marco, María Queralt Salas, Gonzalo Gutiérrez-García, Inés Monge, Gisela Riu, Esther Carcelero, Joan Ramón Roma, Noemí Llobet, Jordi Arcarons, María Suárez-Lledó, Nuria Martínez, Alexandra Pedraza, Ariadna Domenech, Laura Rosiñol, Francesc Fernández-Avilés, Álvaro Urbano-Ispízua, Montserrat Rovira, Mercè Brunet, Carmen Martínez

“…Tacrolimus (Tac) is a pivotal immunosuppressant agent used to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloHSCT). …”
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Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate by Ken Liu, Ken Liu, Ken Liu, Jinbiao Chen, Yang Zhao, Jade Boland, Ka Ka Ting, Glen Lockwood, Catriona McKenzie, James Kench, Mathew A. Vadas, Mathew A. Vadas, Jennifer R. Gamble, Jennifer R. Gamble, Geoffrey W. McCaughan, Geoffrey W. McCaughan, Geoffrey W. McCaughan

“…IntroductionLiver cancers exhibit abnormal (leaky) vasculature, hypoxia and an immunosuppressive microenvironment. Normalization of tumor vasculature is an emerging approach to treat many cancers. …”
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Clinical response trajectories and drug persistence in systemic lupus erythematosus patients on belimumab treatment: A real-life, multicentre observational study by Myrto Nikoloudaki, Myrto Nikoloudaki, Dionysis Nikolopoulos, Sofia Koutsoviti, Irini Flouri, Irini Flouri, Noemin Kapsala, Argyro Repa, Argyro Repa, Pelagia Katsimbri, Evangelos Theotikos, Sofia Pitsigavdaki, Sofia Pitsigavdaki, Katerina Pateromichelaki, Katerina Pateromichelaki, Antonios Bertsias, Antonios Bertsias, Antonia Elezoglou, Prodromos Sidiropoulos, Prodromos Sidiropoulos, Prodromos Sidiropoulos, Antonis Fanouriakis, Antonis Fanouriakis, Dimitrios Boumpas, Dimitrios Boumpas, George Bertsias, George Bertsias, George Bertsias

“…ObjectiveTo obtain real-world data on outcomes of belimumab treatment and respective prognostic factors in patients with systemic lupus erythematosus (SLE).MethodsObservational study of 188 active SLE patients (median disease duration 6.2 years, two previous immunosuppressive/biological agents) treated with belimumab, who were monitored for SLEDAI-2K, Physician Global Assessment (PGA), LLDAS (lupus low disease activity state), remission (DORIS/Padua definitions), SELENA-SLEDAI Flare Index, SLICC/ACR damage index and treatment discontinuations. …”
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Biological activity reduction and mitochondrial and lysosomal dysfunction of mesenchymal stem cells aging in vitro by Ge Zhang, Yuli Wang, Jianhua Lin, Bo Wang, Ali Mohsin, Zhimin Cheng, Weijie Hao, Wei-Qiang Gao, Huiming Xu, Meijin Guo

“…Methods First, we examined cell activities, including proliferation and immigration ability, differentiation potential, and immunosuppressive capacity of UMSCs at an early and late passages as P4 (named UMSC-P4) and P9 (named UMSC-P9), respectively. …”
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Unknown adverse drug reactions from spontaneous reports in a hospital setting: characterization, follow-up, and contribution to the pharmacovigilance system by Francesca Filippi-Arriaga, Cristina Aguilera, Cristina Aguilera, Cristina Aguilera, Elena Guillén, Elena Guillén, Lucía Bellas, Eulàlia Pérez, Lourdes Vendrell, Antònia Agustí, Antònia Agustí, Antònia Agustí, Gloria Cereza, Gloria Cereza

“…Vaccines such as covid-19 and pneumococcus (68, 21.3%), antineoplastics such as paclitaxel, trastuzumab and vincristine (39, 12.2%) and immunosuppressants such as methotrexate and tocilizumab (35, 11%) were the most frequent drug subgroups involved. …”
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CD73 mediated host purinergic metabolism in intestine contributes to the therapeutic efficacy of a novel mesenchymal-like endometrial regenerative cells against experimental coliti... by Bo Shao, Bo Shao, Shao-hua Ren, Shao-hua Ren, Zhao-bo Wang, Hong-da Wang, Hong-da Wang, Jing-yi Zhang, Jing-yi Zhang, Hong Qin, Hong Qin, Yang-lin Zhu, Yang-lin Zhu, Cheng-lu Sun, Cheng-lu Sun, Yi-ni Xu, Yi-ni Xu, Xiang Li, Xiang Li, Hao Wang, Hao Wang

“…As a phenotypic marker of ERCs, CD73 has been largely neglected for its immunosuppressive function in regulating purinergic metabolism. …”
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Novel and Founder Pathogenic Variants in X-Linked Alport Syndrome Families in Greece by Despina Hadjipanagi, Gregory Papagregoriou, Constantina Koutsofti, Christiana Polydorou, Polichronis Alivanis, Aimilios Andrikos, Stalo Christodoulidou, Manthos Dardamanis, Athanasios A. Diamantopoulos, Anastasios Fountoglou, Eleni Frangou, Eleni Georgaki, Ioannis Giannikouris, Velissarios Gkinis, Pavlos C. Goudas, Rigas G. Kalaitzidis, Nikolaos Kaperonis, Georgios Koutroumpas, George Makrydimas, Grigorios Myserlis, Andromachi Mitsioni, Christos Paliouras, Fotios Papachristou, Dorothea Papadopoulou, Nikolaos Papagalanis, Aikaterini Papagianni, Garyfalia Perysinaki, Ekaterini Siomou, Konstantinos Sombolos, Ioannis Tzanakis, Georgios V. Vergoulas, Nicoletta Printza, Constantinos Deltas

“…Importantly, on several occasions, the correct genetic diagnosis reclassified patients as patients with AS, leading to termination of previous immunosuppressive/cyclosporine A therapy and a switch to angiotensin converting enzyme inhibitors (ACEi). …”
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hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC by Sarah Warren, Paola Nisticò, Federico Cappuzzo, Federica Marchesi, Isabella Sperduti, Silvia Carpano, Francesca De Nicola, Frauke Goeman, Lorenzo D'Ambrosio, Vanesa Gregorc, Claudio Tripodo, Vincenzo Russo, Paolo Visca, Francesca Paolini, Paola Trono, Annalisa Tocci, Belinda Palermo, Anna Di Carlo, Daniel D'Andrea, Francesca Di Modugno, Giacomo Corleone, Mariangela Panetta, Silvia Baldari, Paolo Zucali

“…Background Understanding how cancer signaling pathways promote an immunosuppressive program which sustains acquired or primary resistance to immune checkpoint blockade (ICB) is a crucial step in improving immunotherapy efficacy. …”
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BLEEDING, FVIII ACTIVITY, AND SAFETY 3 YEARS AFTER GENE TRANSFER WITH VALOCTOCOGENE ROXAPARVOVEC: RESULTS FROM GENER8-1 by MC Ozelo, J Mahlangu, B Madan, J Mason, F Peyvandi, AV Drygalski, G Yamaguti-Hayakawa, TM Robinson, SW Pipe, TT Gener-Eigh

“…Since the previous data cut, 34/134 participants (25.4%) had alanine aminotransferase (ALT) elevation, mostly Grade 1, but none initiated immunosuppressants. Overall, 106/134 (79.1%) used corticosteroids for ALT elevation for median 33 weeks. …”
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Brevundimonas vesicularis SEPTICAEMIA IN A KID WITH CONGENITAL GOITRE by Mitja Gombač, Igor Gruntar, Pavel Kvapil, Tanja Švara

“…To date, B. vesicularis has been isolated from water, soil, plants and several human clinical specimens, mostly in immunosuppressed patients causing endocarditis, arthritis, keratitis and septicaemia. …”
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A Systematic Review on the Therapeutic Potentiality of PD-L1-Inhibiting MicroRNAs for Triple-Negative Breast Cancer: Toward Single-Cell Sequencing-Guided Biomimetic Delivery by Mahdi Abdoli Shadbad, Sahar Safaei, Oronzo Brunetti, Afshin Derakhshani, Parisa Lotfinejad, Ahad Mokhtarzadeh, Nima Hemmat, Vito Racanelli, Antonio Giovanni Solimando, Antonella Argentiero, Nicola Silvestris, Behzad Baradaran

“…Based on the current evidence, the restoration of miR-424-5p, miR-138-5p, miR-570-3p, miR-200c-3p, miR-383-5p, miR-34a-5p, miR-3609, miR-195-5p, and miR-497-5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. …”
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Linear growth and bone metabolism in pediatric patients with inflammatory bowel disease by Paloma Velez de Andrade Lima Simões Ferreira, André de Souza Cavalcanti, Giselia Alves Pontes da Silva

“…Conclusion: Insufficient growth and low bone mineral density in pediatric patients with inflammatory bowel disease are complex problems that result from multiple factors including chronic inflammation, malnutrition, decreased physical activity, late puberty, genetic susceptibility, and immunosuppressive therapies, such as glucocorticoids. Resumo: Objetivo: Revisar a fisiopatologia e os métodos de avaliação do crescimento linear e densidade mineral óssea em crianças e adolescentes com diagnóstico de doença inflamatória intestinal. …”
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The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation... by Gabriela Gorczyca, Kamil Wartalski, Marek Romek, Marcin Samiec, Małgorzata Duda

“…For those reasons, this study sought to examine whether selected EACs, which encompass the fungicide vinclozolin (Vnz), the androgenic anabolic steroid nandrolone (Ndn) and the immunosuppressant cyclosporin A (CsA), affect the developmental competence and molecular quality (MQ) of porcine cumulus–oocyte complexes (COCs) subjected to in vitro maturation (IVM) under 3D culture conditions. …”
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Incidence and risk factors for cancer in people with type 1 diabetes, stratified by stages of diabetic kidney disease: a nationwide Finnish cohort studyResearch in context by Maija Feodoroff, Valma Harjutsalo, Sari Mäkimattila, Per-Henrik Groop

“…In addition, individuals with a kidney transplant/transplantation (KT) have markedly increased cancer risk due to chronic use of immunosuppressive agents. However, it has not been elucidated whether the observed excess cancer risk is related to KT or whether diabetic kidney disease (DKD) per se is a risk factor for cancer in individuals with T1D. …”
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Differential regulatory T cell signature after recovery from mild COVID-19 by Pedro Henrique de Sousa Palmeira, Rephany Fonseca Peixoto, Bárbara Guimarães Csordas, Isac Almeida de Medeiros, Fátima de Lourdes Assunção Araújo de Azevedo, Robson Cavalcante Veras, Daniele Idalino Janebro, Ian P.G. Amaral, Tatjana Souza Lima Keesen

“…Collectively, our study suggests that changes in the immunosuppressive repertoire of Tregs can influence the development of a distinct COVID-19 clinical profile, revealing that a possible modulation of Tregs exists among volunteers of the Mild Recovered group between those who did and did not develop certain symptoms, leading to mild disease.…”
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