Tumor inflating lymphocytes. Purification, expanding and cytotoxicity analisys on primary tumor cultures by G. M. Yusubalieva, S. V. Petrichuk, A. L. Krivoshapkin, A. G. Kedrova, Yu. V. Ivanov, A. G. Vinokurov, A. A. Kalinkin, A. E. Sandjarov, S. V. Kim, A. V. Ponomarev, D. G. Kuptsova, Roman Ischenko, Alexander Troitskiy, V. P. Baklaushev

“…An urgent task is the activation of TILs, turning off immunosuppressive mechanisms and increasing their antitumor cytotoxic activity. …”
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Aberrantly Expressed MicroRNAs in Cancer-Associated Fibroblasts and Their Target Oncogenic Signatures in Hepatocellular Carcinoma by Jung Woo Eun, Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Ji Hyang Weon, Jung Hwan Yoon, Hyung Seok Kim, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Bong-wan Kim, Hyo Jung Cho

“…In addition, <i>TGFBR1</i> expression was correlated with the infiltration of immunosuppressive immune cells.…”
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Secondary hemophagocytic syndrome in adult patients. Study of 91 patients by V. G. Potapenko, A. V. Klimovich, M. Yu. Pervakova, S. V. Lapin, O. V. Goloshchapov, A. K. Titov, E. A. Surkova, E. S. Pavluchenko, N. A. Potikhonova, N. V. Vinogradova, E. V. Doguzhieva, G. V. Kachenya, D. D. Avdoshina, I. P. Fedunyak, V. V. Ryabchikova, T. G. Kulibaba, A. V. Rysev, E. V. Karyagina, N. V. Мedvedeva

“…All patients with rheumatic disorders or malignancies had received either immunosuppressive or cytotoxic therapy. Febrile patients received anti-infective treatment according to the local routine protocols.Results. …”
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IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection by Aloysius D. Loglo, Michael Frimpong, Mabel Sarpong Duah, Fred Sarfo, Francisca N. Sarpong, Bernadette Agbavor, Justice K. Boakye-Appiah, Kabiru M. Abass, Mathias Dongyele, Margaret Frempong, Sacha Pidot, Mark Wansbrough-Jones, Timothy P. Stinear, Virginie Roupie, Kris Huygen, Richard O. Phillips

“…Patients elicited lower responses than healthy contacts, possibly due to the immunosuppressive effect of mycolactone, but the responses were enhanced after antibiotic treatment. …”
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Immunotherapy combining tumor and endothelium cell lysis with immune enforcement by recombinant MIP-3α Newcastle disease virus in a vessel-targeting liposome enhances antitumor imm... by Lei Li, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Guang-Hong Tan, Hengyu Chen, Cai-Chun Wang, Wu-Ping Zheng

“…Moreover, iNDV3α-LP treatment could significantly suppress tumor angiogenesis and reverse the tumor immune suppressive microenvironment in both B16-bearing and 4T1-bearing mice.Conclusions In this study, iNDV3α-LP had several functions, such as tumor and vessel lysis, MIP-3α immunotherapy, and binding to αvβ3-expressing tumor and its neovasculature. iNDV3α-LP treatment significantly suppressed tumor angiogenesis and reversed the tumor immunosuppressive microenvironment. These findings offer a strong rationale for further clinical investigation into a combination strategy for oncolytic immunotherapy, such as the formulation iNDV3α-LP in this study.…”
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Features of the subpopulation composition of dendritic cells in patients with rheumatoid arthritis by M. A. Korolev, Yu. D. Kurochkina, N. E. Banshchikova, A. A. Akimova, V. O. Omelchenko, E. A. Letyagina, M. A. Surovtseva, A. P. Lykov, O. V. Poveshchenko

“…It was noted that there was no significant differences in the level of pDCs between RA and OA patients and there was an inverse relationship between the relative peripheral blood level of pDC and disease activity, which confirms the immunosuppressive role of pDCs in the pathogenesis of RA. …”
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Clinical outcomes and safety of immune checkpoint inhibitors in patients with solid tumors and paraneoplastic syndromes by Lucia Kwak, So Yeon Kim, Guru Sonpavde, Elad Sharon, Abdul Rafeh Naqash, Alessio Cortellini, Rana R McKay, Toni K Choueiri, Thomas Marron, Amin H Nassar, Jeffrey A Sparks, Kaushal Parikh, Frank Aboubakar Nana, Jenny Linnoila, Shruti Gupta, Nicole R LeBoeuf, Elio Adib, Ahmad Al-Hader, Edward El-Am, Dory Freeman, Ahmed Bilal Khalid, Marita Salame, Elias Bou Farhat, Arjun Ravishankar, Bachar Ahmad, David Kaldas, Andrea Malgeri, Ole-Petter R Hamnvik, Thomas Dilling, Elie Najem, Talal El Zarif, Serena Rahme, Caiwei Zhong, Tarek H Mouhieddine

“…Grade ≥3 trAEs occurred in 18 (17%) patients. PNS-directed immunosuppressive therapy was required in 55 (50%) patients. …”
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Interaction between chicken TRIM25 and MDA5 and their role in mediated antiviral activity against IBDV infection by Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sánchez-Aparicio, Maria Teresa Sánchez-Aparicio, Lisa Miorin, Lisa Miorin, José F. Rodríguez, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Dolores Rodríguez

“…Infectious Bursal Disease Virus (IBDV) is the causative agent of an immunosuppressive disease that affects domestic chickens (Gallus gallus) severely affecting poultry industry worldwide. …”
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First field study using Strong-LAMP for diagnosis of strongyloidiasis in Cubal, Angola by Beatriz Crego-Vicente, Begoña Febrer-Sendra, Arlette Nindia, Agostinho Pessela, Sandra Aixut, Joan Martínez-Campreciós, Alejandro Mediavilla, Aroa Silgado, Elena Sulleiro, Begoña Treviño, Israel Molina, Antonio Muro, Fernando Salvador, Pedro Fernández-Soto

“…The impact of S. stercoralis infections on human health ranges from mild asymptomatic infections to chronic strongyloidiasis unnoticeable until the host is immunosuppressed. In severe strongyloidiasis, a syndrome of hyperinfection and larval dissemination to various organs can occur with high mortality rates. …”
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Management of infliximab refractory immune checkpoint inhibitor gastrointestinal toxicity: a multicenter case series by Lisa Zimmer, Bastian Schilling, Yinghong Wang, Georgina V Long, Jennifer McQuade, Ana Arance, Douglas B Johnson, Nadia Yousaf, Kazi J Nahar, Matteo S Carlino, Kate Young, Joanna Lee, Liselotte Tas, Serigne N Lo, Christian Blank, Alexander Maxwell Menzies, Catriona Harvey, Janet McKeown, Sheima Farag, Aafke Meerveld-Eggink, Austin Thomas, Roberto Martín Huertas

“…Survival outcomes were examined based on immunosuppressive therapy received.Results 78 patients were identified: median age 60 years; 56% men; majority melanoma (N=70, 90%); 60 (77%) received anti-cytotoxic T-lymphocyte-associated protein 4 alone or in combination with anti-programmed cell death protein-1 and most had colitis (N=74, 95%). 106 post-infliximab treatments were given: 31 calcineurin inhibitors (CNIs); 27 antimetabolites (mycophenolate, azathioprine); 16 non-systemic immunomodulatory agents (eg, mesalazine or budesonide); 15 vedolizumab; 5 other biologics (anti-interleukin-12/23, 16, Janus kinase inhibitors) and 7 interventional procedures (including colectomy); 5 did not receive post-infliximab therapy. …”
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells by Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum

“…Finally, we observe tumor growth suppression and antitumorigenic immunomodulation following ARG2 vaccination in an in vivo setting.Conclusion These findings highlight the ability of ARG2-specific T cells to modulate the immunosuppressive TME and suggest that ARG2-based immunomodulatory vaccines may be an interesting option for cancer immunotherapy.…”
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Comparative efficacy of three regimens (cyclosporine, tacrolimus, and cyclophosphamide) combined with steroids for the treatment of idiopathic membranous nephropathy by Chen Ruo-ji, Xing Fang, Du Zhen-shuang, Zhang Yu-lin, Zheng Zi-li, Lin Wei-yuan

“…Introduction and objectives: To investigate the efficacy of combined immunosuppressive regimens of cyclosporine (CsA), tacrolimus (TAC), or cyclophosphamide (CTX) combined with steroids in the treatment of idiopathic membranous nephropathy (IMN). …”
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CXCR3 chemokine receptor ligands in sarcoidosis by N. M. Lazareva, O. P. Baranova, I. V. Kudryavtsev, N. A. Arsentieva, N. E. Liubimova, T. P. Ses’, M. M. Ilkovich, Areg A. Totolian

“…Our study was aimed for determining the levels of CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC chemokines in peripheral blood of the patients with sarcoidosis, depending on the features of their clinical course before administration of immunosuppressive therapy. We studied peripheral blood plasma samples of the patients with sarcoidosis (n = 52). …”
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Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infect... by Bo Wang, Hassan M. Mahsoub, Wen Li, C. Lynn Heffron, Debin Tian, Anna M. Hassebroek, Tanya LeRoith, Xiang-Jin Meng

“…IMPORTANCE HEV-3 causes chronic hepatitis E that requires antiviral therapy in immunosuppressed individuals. RBV is the main therapeutic option for chronic hepatitis E as an off-label use. …”
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Synergistic Effects of Nanoscale CaO2 Combined with PD-1 Inhibitors in the Treatment of Hepatocellular Carcinoma: A Promising Combination by Wang Y, Ju S, Zhou H, Bai Y, Zhou C, Liu J, Dong X, Zheng C

“…Mice in the combination group showed the longest survival compared with the other groups.Conclusion: CaO2 NPs can improve hypoxia, neutralize acidity, and induce calcium overload within tumors, so as to reduce tumor burden and realize an immunosuppressive tumor transformation to a hot tumor, and play a synergistic role with PD-1 inhibitors in anti-liver cancer.Keywords: calcium peroxide nanoparticles, programmed cell death protein 1 inhibitor, Hepa1-6 model, tumor microenvironment, liver cancer…”
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Liver transplant program at Botkin Hospital. Experience of 100 surgeries by A. V. Shabunin, I. P. Parfenov, M. G. Minina, V. V. Bedin, P. A. Drozdov, O. N. Levina, G. S. Mikhayliants, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, N. A. Ongoev

“…During case follow-up, a prolonged form of calcineurin inhibitor (CNI) was administered as immunosuppressive therapy in mono regimen (85 patients), in combination with mycophenolic acid derivatives (7), and in combination with everolimus (6). …”
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Management of Glucocorticoid-Induced Hyperglycemia by Shah P, Kalra S, Yadav Y, Deka N, Lathia T, Jacob JJ, Kota SK, Bhattacharya S, Gadve SS, Subramanium K, George J, Iyer V, Chandratreya S, Aggrawal PK, Singh SK, Joshi A, Selvan C, Priya G, Dhingra A, Das S

“…Parag Shah,1 Sanjay Kalra,2 Yogesh Yadav,3 Nilakshi Deka,4 Tejal Lathia,5 Jubbin Jagan Jacob,6 Sunil Kumar Kota,7 Saptrishi Bhattacharya,8 Sharvil S Gadve,9 KAV Subramanium,10 Joe George,11 Vageesh Iyer,12 Sujit Chandratreya,13 Pankaj Kumar Aggrawal,14 Shailendra Kumar Singh,15 Ameya Joshi,16 Chitra Selvan,17 Gagan Priya,18 Atul Dhingra,19 Sambit Das20 1Department of Endocrinology, Gujarat Endocrine Centre, Ahmedabad, Gujarat, India; 2Department of Endocrinology, Bharti Hospital & B.R.I.D.E, Karnal, Haryana, India; 3Department of Endocrinology, MAX Super Specialty Hospital, Dehradun, Uttarakhand, India; 4Department of Endocrinology, Apollo Hospital & Dispur Polyclinic and Nursing Home, Guwahati, West Bengal, India; 5Department of Endocrinology, Apollo Hospital, Mumbai, Maharashtra, India; 6Department of Endocrinology, CMC Hospital, Ludhiana, Punjab, India; 7Department of Endocrinology, Diabetes and Endocrine Clinic, Berhampur, Orissa, India; 8Department of Endocrinology, OeHealth Diabates & Endocrinology Centre, Delhi, Delhi, India; 9Department of Endocrinology, Excel Endocrine Centre, Kolhapur, Maharashtra, India; 10Department of Endocrinology, Visakha Diabates & Endocrine Centre, Vishakhapatnam, Andhra Pradesh, India; 11Department of Endocrinology, Endodiab Clinic, Calicut, Kerala, India; 12Department of Endocrinology, St.John’s Medical College & Hospital, Bangalore, Karnataka, India; 13Department of Endocrinology, Endocare Clinic, Nashik, Maharashtra, India; 14Department of Endocrinology, Hormone Care & Research Centre, Ghaziabad, Uttar Pradesh, India; 15Department of Endocrinology, Endocrine Clinic, Varanasi, Uttar Pradesh, India; 16Department of Endocrinology, Endocrine and Diabetes Clinic, Mumbai, Maharashtra, India; 17Department of Endocrinology, Ramaiah Memorial Hospital, Bangalore, Karnataka, India; 18Department of Endocrinology, IVY Hospital, Chandigarh, Punjab, India; 19Department of Endocrinology, Bansal Hospital, Sri Ganganagar, Rajasthan, India; 20Department of Endocrinology, Endeavour Clinic, Bhubaneshwar, Orissa, IndiaCorrespondence: Sanjay Kalra, Kunjpura Road, Model Town, Near State Bank of India, Sector 12, Karnal, Haryana, 132001, India, Tel +9215848555, Email brideknl@gmail.comAbstract: Glucocorticoids are potent immunosuppressive and anti-inflammatory drugs used for various systemic and localized conditions. …”
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Infección experimental de aislados humanos de Blastocystis sp. en ratones inmunosuprimidos con dexametasona by Sánchez A Lissette, Barrios Emilia E, Sardiña A Adriana, Araque Wolfan, Delgado Víctor

“…To evaluate signs, symptoms and laboratory findings produced by Blastocystis sp., dexamethasone immunosuppressed mice were infected with parasite morphologies obtained from symptomatic and asymptomatic patients. …”
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Ocular myasthenia gravis and risk factors for developing a secondary generalisation: description of a Spanish series by I. Díaz-Maroto, J. García-García, P.A. Sánchez-Ayaso, C. Alcahut-Rodríguez, E. González-Villar, J.M. Pardal-Fernández, T. Segura

“…A variable percentage of these patients develop secondary generalisation; the risk factors for conversion and the protective effect of immunosuppressive treatment are currently controversial. …”
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Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor by Alejandra Vargas-Valderrama, Anne-Charlotte Ponsen, Morgane Le Gall, Denis Clay, Sébastien Jacques, Tudor Manoliu, Valérie Rouffiac, Karine Ser-le-Roux, Cyril Quivoron, Fawzia Louache, Georges Uzan, Maria-Teresa Mitjavila-Garcia, Estelle Oberlin, Hind Guenou

“…Interestingly, we identified a hPSC-BC population characterized by the expression of both CD144 and CD45. hPSC-ECs and hPSC-BCs were analyzed by flow cytometry and RT-qPCR; in vivo experiments have been realized by ischemic tissue injury model on a mouse dorsal skinfold chamber and hematopoietic reconstitution in irradiated immunosuppressed mouse from hPSC-ECs and hPSC-EB-CD144+, respectively. …”
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