Antibiotic-Induced Immunosuppression—A Focus on Cellular Immunity by Timothy Arthur Chandos Snow, Mervyn Singer, Nishkantha Arulkumaran

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The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers by Christabelle Rajesh, Prakash Radhakrishnan

“…Studying the interaction between Tn/STn antigens and the TIME of gastrointestinal cancers can help develop better and more robust therapies that can counteract immunosuppressive mechanisms to sensitize these tumors to anticancer therapies.…”
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Systemic and local immunosuppression in glioblastoma and its prognostic significance by Aleksei A. Stepanenko, Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia O. Sosnovtseva, Marat P. Valikhov, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Konstantin A. Pavlov, Vladimir P. Chekhonin, Vladimir P. Chekhonin

“…However, various local and systemic mechanisms of immunosuppression operate in cancer patients. Tumor-associated immunosuppression involves deregulation of many components of immunity, including a decrease in the number of T lymphocytes (lymphopenia), an increase in the levels or ratios of circulating and tumor-infiltrating immunosuppressive subsets [e.g., macrophages, microglia, myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs)], as well as defective functions of subsets of antigen-presenting, helper and effector immune cell due to altered expression of various soluble and membrane proteins (receptors, costimulatory molecules, and cytokines). …”
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COVID-19 in Immunosuppressed and Cancer Patients: A review by Shirin Haghighat, Mehdi Dehghani

Subjects: “…covid-19, cancer, immunosuppression…”
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Microbial Metabolite 3-Indolepropionic Acid Mediates Immunosuppression by Carlos Guijas, Lucy E. Horton, Linh Hoang, Xavier Domingo-Almenara, Elizabeth M. Billings, Brian C. Ware, Brian Sullivan, Gary Siuzdak

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Outcome of immunosuppressive therapy in children with acquired aplastic anemia by Alaka Das, Vineeta Gupta, Priyanka Aggarwal, Sandeep Kumar, Akhtar Ali

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CD200 promotes immunosuppression in the pancreatic tumor microenvironment by Reena Shakya, Mary Dillhoff, Brooke Benner, Thomas A Mace, Terence M Williams, Fouad Choueiry, Molly Torok, Kriti Agrawal, Anna Deems, Alice Hinton, Jami Shaffer, Bradley W Blaser, Anne M Noonan, Darwin L Conwell, Phil A Hart, Zobeida Cruz-Monserrate, Xue-Feng Bai, William E Carson III

“…Background A significant challenge to overcome in pancreatic ductal adenocarcinoma (PDAC) is the profound systemic immunosuppression that renders this disease non-responsive to immunotherapy. …”
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Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies by Boyuan Huang, Jin Zhang, Wenjing Zong, Sisi Chen, Zhitao Zong, Xiaojun Zeng, Hongbo Zhang

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SARS-CoV-2 and Cancer: Beyond Immunosuppression by Diogo Mendes Pedro, Marta Maria Mendes Pedro, Emília Valadas, Thomas Hanscheid

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The Immunotherapy and Immunosuppressive Signaling in Therapy-Resistant Prostate Cancer by Pengfei Xu, Logan J. Wasielewski, Joy C. Yang, Demin Cai, Christopher P. Evans, William J. Murphy, Chengfei Liu

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Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression by Mo S, Ru H, Huang M, Cheng L, Mo X, Yan L

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Ovarian endometrioma infiltrating neutrophils orchestrate immunosuppressive microenvironment by Hua Xu, Jing Zhao, Jiaqi Lu, Xiaoxi Sun

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Costs and consequences of immunosuppressive therapy in children with aplastic anemia by Evan B. Shereck, Rebecca J. Deyell, Peter Kurre

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Fournier gangrene in an immunosuppressed patient due to cancer chemotherapy by José Ramón Rodríguez Morales, Ernesto Romagosa Bermúdez, Eduardo Ibáñez Carrillo

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Immunosuppressive therapies in scorpion envenomation: new perspectives for treatment by Mouzarllem Barros Reis, Eliane Candiani Arantes

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IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES by E. A. Starikova, A. V. Sokolov, L. A. Burova, I. S. Freidlin

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Viewpoint about biologic agents for psoriasis: are they immunosuppressants or immunomodulators? by Dea Metko, Tiago Torres, Ronald Vender

“…One of the most challenging components of marketing and prescribing these biologic therapies has been in classifying them as immunomodulators or immunosuppressants. The purpose of this narrative review was to discuss the features that distinguish immunomodulators from immunosuppressants to successfully categorize the biologic therapies used for psoriasis management and subsequently enhance patient and physician understanding of the risks associated with the use of these drugs.…”
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Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma by Yidan Xia, Dongxu Wang, Yuting Piao, Minqi Chen, Duo Wang, Ziping Jiang, Bin Liu

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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression by Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Alexander J. Pfeil, Emily N. Devericks, Muhammad H. Safdar, Marvis Monteiro, Hao Chen, Alyssa N. Ho, Numair Attaar, Hannah M. Malian, Violet A. Kiesel, Alexis Ramos, Matthew Smith, Heena Panchal, Adam Mailloux, Dorothy Teegarden, Stephen D. Hursting, Michael K. Wendt

“…We identify hypoxia-mediated suppression of pyruvate carboxylase (PC), and subsequent induction of lactate production, as a metabolic regulator of immunosuppression. Methods We used qPCR, immunoblot, and reporter assays to characterize repression of PC in hypoxic primary tumors. …”
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Cutaneous Coinfection of Cytomegalovirus and Mycobacterium chelonae Accelerated by Immunosuppression by Yutaka Tsutsumi, Kentaro Odani, Yasuhito Kaneko, Hideo Hashizume, Mitsuhiro Tachibana

“…Pyoderma gangrenosum was clinically diagnosed after the first biopsy, indicating a noninfective ulcer. Immunosuppressive therapy (prednisolone and cyclosporine A) induced complete epithelialization in three months. …”
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