Multiscale simulations suggest a mechanism for integrin inside-out activation. by Kalli, A, Campbell, I, Sansom, MS

“…Integrins are large cell-surface adhesion receptors that can be activated to a high affinity state by the formation of an intracellular complex between the integrin β-subunit tail, the membrane, and talin. …”

Integrin binding immunoglobulin type filamin domains have variable stability. by Jiang, P, Campbell, I

“…It is, however, appreciably stabilized upon binding to integrins. FLNa21 is noticeably less stable than neighboring homologous modules, such as FLNa19 and FLNa17. …”

Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. by Liu, D, Bryceson, Y, Meckel, T, Vasiliver-Shamis, G, Dustin, M, Long, E

“…Thus, cytotoxic immune synapses include a central region of bidirectional vesicular traffic, which is controlled by integrin signaling.…”

Crystal structure of a heparin- and integrin-binding segment of human fibronectin. by Sharma, A, Askari, J, Humphries, M, Jones, E, Stuart, D

“…The IDAPS motif implicated in integrin alpha4beta1 binding is at the FN13-14 junction, rendering the critical Asp184 inaccessible to integrin. …”

Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. by Lad, Y, Jiang, P, Ruskamo, S, Harburger, D, Ylänne, J, Campbell, I, Calderwood, D

“…In this specific case, displacement of integrin tails from filamin by migfilin may provide a mechanism for switching between different integrin-cytoskeleton linkages.…”

Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. by Conant, K, St Hillaire, C, Nagase, H, Visse, R, Gary, D, Haughey, N, Anderson, C, Turchan, J, Nath, A

“…Among such receptors is the alpha(2)beta(1) integrin, a complex that has previously been linked to leukocyte death. …”

Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit by Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya

Subjects: “…α6β4 integrin…”
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Correction: Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3 by Nareerat Petpiroon, Boonchoo Sritularak, Pithi Chanvorachote

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Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism by Eva Juengel, Jasmina Makarević, Michael Reiter, Jens Mani, Igor Tsaur, Georg Bartsch, Axel Haferkamp, Roman A. Blaheta

“…The physiological relevance of the integrins was then determined by blocking studies and small interfering RNA knockdown. …”
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Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients by Evgeniya Grigoryeva, Liubov Tashireva, Vladimir Alifanov, Olga Savelieva, Marina Zavyalova, Maxim Menyailo, Anna Khozyainova, Evgeny V. Denisov, Olga Bragina, Nataliya Popova, Nadezhda V. Cherdyntseva, Vladimir Perelmuter

“…Background Integrins enable cell communication with the basal membrane and extracellular matrix, activating signaling pathways and facilitating intracellular changes. …”
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Integrins regulation of wound healing processes: insights for chronic skin wound therapeutics by Dong Yu, Dong Yu, Zhaoyu Lu, Zhaoyu Lu, Fengsong Nie, Fengsong Nie, Yang Chong, Yang Chong

Subjects: “…integrin…”
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Ligand-independent integrin β1 signaling supports lung adenocarcinoma development by Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent

“…To date, most integrin-targeted cancer therapeutics have disrupted integrin-ECM interactions, which are viewed as critical for integrin functions. …”
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Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation by Aakanksha Jha, Erika Moore

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Effects of β2 Integrins on Osteoclasts, Macrophages, Chondrocytes, and Synovial Fibroblasts in Osteoarthritis by Tiantian Hu, Zhan Zhang, Chunbo Deng, Xun Ma, Xueyong Liu

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Assessment of endometrial integrin beta 5 in women with unexplained recurrent pregnancy loss by Ahmed Mohamed Fathy, Ahmed Youssef Rizk, Nahla Abd El Azeez Nosair, Ahmed Mohamed Abdelkarim, Mostafa Farag Ellakany

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Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif. by Shigeki Suzuki, Seiji Kobuke, Naoto Haruyama, Hiroaki Hoshino, Ashok B Kulkarni, Fusanori Nishimura

“…PP and DMP-1 are phosphorylated extracellular matrix proteins that belong to the family of small integrin-binding ligand N-linked glycoproteins (SIBLINGs). …”
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Heart Failure Promotes Cancer Progression in an Integrin β1-Dependent Manner by Irina Langier Goncalves, Lama Awwad, Sharon Aviram, Talel Izraeli, Laris Achlaug, Ami Aronheim

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Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3 by Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan

“…Thus, we have identified 24HC as another oxysterol that binds to integrin αvβ3 and promotes a proinflammatory response via the integrin-FAK-NFκB pathway.…”
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Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment by Stephan Niland, Johannes A. Eble

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In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells by Maximilian Huber, Javier Casares-Arias, Reinhard Fässler, Daniel J. Müller, Nico Strohmeyer

“…Here we report that, similar to interphase, mitotic cells can employ integrins to initiate adhesion to the ECM in a kindlin- and talin-dependent manner. …”
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