Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus by Ngoc Tuan Tran, Huifen Liang, Ming Zhang, Md. Akibul Hasan Bakky, Yueling Zhang, Shengkang Li

“…In this review, we summarize the current understanding of the functions of cellular receptors, including Toll, C-type lectin, scavenger receptor, β-integrin, polymeric immunoglobulin receptor, laminin receptor, globular C1q receptor, lipopolysaccharide-and β-1,3-glucan-binding protein, chitin-binding protein, Ras-associated binding, and Down syndrome cell adhesion molecule in the innate immune defense of crustaceans, especially shrimp and crabs, in response to WSSV infection. …”
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Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? by Joseph V. Martin, Pradip K. Sarkar

“…A notable cell-membrane binding site for thyroid hormones is integrin αvβ3. Furthermore, thyronines bind specifically to other defined neurotransmitter receptors, including GABAergic, catecholaminergic, glutamatergic, serotonergic and cholinergic systems. …”
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Eribulin and Paclitaxel Differentially Alter Extracellular Vesicles and Their Cargo from Triple-Negative Breast Cancer Cells by Petra J. Pederson, Huiyun Liang, Daria Filonov, Susan L. Mooberry

“…While the concentrations of sEVs released from MTA-treated cells were not significantly altered, levels of CD63 and the CD63-associated cargos, ILK and β-integrin, were reduced in sEVs isolated from eribulin-treated HCC1937 cells as compared to vehicle or paclitaxel-treated cells. …”
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Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes. by Ignacio eMelero, Alvaro eTeijeira, Ana eRouzaut

“…In contrast, inflammatory processes in lymphatic capillaries involve a plethora of cytokines, chemokines, leukocyte integrins and other adhesion molecules. Importantly, under inflammation a role for integrins and their ligands becomes apparent and, as a consequence, the number of leukocytes entering the lymphatic capillaries multiplies several-fold. …”
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Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments by David H. Ramos-Rodriguez, Sheila MacNeil, Frederik Claeyssens, Ilida Ortega Asencio

“…We also reported that human skin cell lines have a dose-dependent response to the bioactive compounds and that their inclusion has the potential to improve cell activity, induce blood vessel formation and alter the expression of relevant epithelial markers (collagen IV and integrin β1). In summary, we have developed fibrous matrixes containing synthetic rete-ridge-like structures that can deliver key bioactive compounds that can enhance skin regeneration and ultimately aid in the development of a complex wound healing device.…”
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Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation by Stefano Navarro, David Stegner, Bernhard Nieswandt, Johan W. M. Heemskerk, Marijke J. E. Kuijpers

“…In addition, platelet activation with the protease-activating receptors 1/4 (PAR1/4) and integrin αIIbβ3 appeared to be prolongedly active and extended to later stages of thrombus and clot formation. …”
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Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells by Tomoya Hada, Yu Sakurai, Hideyoshi Harashima

“…Cyclic RGD (cRGD) is a well-known ligand against αVβ3 integrin that is expressed at high levels in the cell surface of TECs. …”
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The Alleviating Effect of <i>Lagerstroemia indica</i> Flower Extract on Stretch Marks through Regulation of Mast Cells by Miji Yeom, Hyanggi Ji, Jongheon Shin, Eunae Cho, De-Hun Ryu, Deokhoon Park, Eunsun Jung

“…LIFE inhibits the adhesion of rat basophilic leukemia (RBL) cells, RBL-2H3 on fibronectin (FN) and the expression of integrin, a receptor for FN, thereby reducing focal adhesion kinase (FAK) phosphorylation. …”
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Etrolizumab as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis: a protocol of systematic review and meta-analysis of placebo-con... by Wei Zhang, Xuan Qin, Hongxin Shu, Xiaowei Xiong, Menghui Wang, Wenji Liu

“…Introduction Etrolizumab is a gut-targeted, anti-β7 integrin, monoclonal antibody. Recently, data from phase 2 and 3 trials presented different results in patients with moderately to severely active ulcerative colitis. …”
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Reviewing the Regulators of COL1A1 by Hanne Devos, Jerome Zoidakis, Maria G. Roubelakis, Agnieszka Latosinska, Antonia Vlahou

“…COLα1 (I) interacts with a variety of cell receptors including integrinβ, Endo180 and Discoidin Domain Receptors (DDRs). …”
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Differential innate immune response of endometrial cells to porcine reproductive and respiratory syndrome virus type 1 versus type 2. by Muttarin Lothong, Dran Rukarcheep, Suphot Wattanaphansak, Sumpun Thammacharoen, Chatsri Deachapunya, Sutthasinee Poonyachoti

“…PRRSV mediator proteins, CD151, CD163, sialoadhesin (Sn), integrin and vimentin, were upregulated following type 1 and type 2 infection. …”
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Allogenic mouse cell vaccine inhibits lung cancer progression by inhibiting angiogenesis by Jun Zhao, Xiaoling Zhang, Yunyi Du, Lurong Zhou, Ziming Dong, Jimin Zhao, Jing Lu

“…Furthermore, bEnd.3 vaccine and DC vaccine loaded with bEnd.3 both produced the activity of killing bEnd.3 target cells in vitro.The reason may induce the immune mice to produce anti-VEGFR-II, anti-endoglin and anti-integrin αν antibodies to have an anti-angiogenesis function. …”
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Altered N-Linked Glycosylation in Follicular Lymphoma and Chronic Lymphocytic Leukemia: Involvement in Pathogenesis and Potential Therapeutic Targeting by Nurit Hollander, Joseph Haimovich

“…These glycans interact with mannose-specific lectins, especially with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). Lectin binding to FL triggers persistent activating signals, suggesting that lectins within the tumor microenvironment promote cell survival and proliferation. …”
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Biological role of matrix stiffness in tumor growth and treatment by Boer Deng, Ziyi Zhao, Weimin Kong, Chao Han, Xiaochang Shen, Chunxiao Zhou

“…Physical signals induced by matrix stiffness are transmitted to tumor cells primarily by the integrins receptor family and trigger a series of mechanotransduction that result in changes in tumor cell morphology, proliferative capacity, and invasive ability. …”
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Sarcoidosis Mimicking Primary Lung Cancer on ^99mTc-3PRGD2 Scintigraphy in a PTC Patient by Ye Yang, Xi Jia, Yuanbo Wang, Yan Liu, Yu Liu, Rui Gao

“…The asymmetrical focal uptake that was demonstrated in integrin receptor imaging (^99mTc-PEG4-E[PEG4-c(RGDfK)]2 (^99mTc-3PRGD2)) warranted flexible-bronchoscope biopsy. …”
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Integrated proteomic, transcriptomic, and genomic analysis identifies fibrinogen beta and fibrinogen gamma as key modulators of breast cancer progression and metastasis by Hemantkumar Patadia, Ankita Priyadarshini, Ajit Gangawane

“…Our study found fibrinogen gamma (FGG) and fibrinogen beta (FGB) linked to pathways connecting RAS-MAPK, its downstream mutants, integrin signaling, and extracellular matrix remodeling pathways. …”
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Gelatin Coating for the Improvement of Stability and Cell Uptake of Hydrophobic Drug-Containing Liposomes by Gantumur Battogtokh, Yechan Joo, Sharif Md Abuzar, Heejun Park, Sung-Joo Hwang

“…Previous studies revealed that gelatin contains arginyl-glycyl-aspartic acid (RGD) sequences that become ligands for the integrin receptors expressed on cancer cells. Thus, in this study, we aimed to increase the efficiency of drug delivery into cancer cells by coating drug-encapsulating liposomes with gelatin (gelatin-coated liposomes, GCLs). …”
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Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. by Naadiya Carrim, Tony G Walsh, Alessandra Consonni, Mauro Torti, Michael C Berndt, Pat Metharom

“…Subsequent human platelet studies with PF-228 confirmed FAK is essential for GPVI-mediated phosphatidylserine exposure, α-granule secretion (P-selectin (CD62P) surface expression) and integrin αIIbβ3 activation. To determine the precise location of FAK within the GPVI pathway, we analyzed the effect of PF-228 inhibition in CRP-stimulated platelets in conjunction with immunoprecipitation and pulldown analysis to show that FAK is downstream of Lyn, Spleen tyrosine kinase (Syk), PI3-K and Bruton's tyrosine kinase (Btk) and upstream of Rac1, PLCγ2, Ca2+ release, PKC, Hic-5, NOX1 and αIIbβ3 activation.Overall, these data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway.…”
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Human iPSC-Derived Vascular Smooth Muscle Cells in a Fibronectin Functionalized Collagen Hydrogel Augment Endothelial Cell Morphogenesis by Kaiti Duan, Biraja C. Dash, Daniel C. Sasson, Sara Islam, Jackson Parker, Henry C. Hsia

“…A mechanistic study shows that blocking αvβ3 integrin signaling between hiPSC-VSMC and fibronectin impacts the EC network formation via reduced cell viability and proangiogenic growth factor secretion. …”
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Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis by Huang Bo, Wei Min, Hong Li

“…Furthermore, the interaction between miR-137 and HULC or integrin beta-8 (ITGB8) was predicted by miRcode and starBase v2.0 and then verified by dual luciferase reporter and RNA pull-down assays. …”
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