Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro by Laura S. Kupke, Stephanie Arndt, Simon Lenzer, Sophia Metz, Petra Unger, Julia L. Zimmermann, Anja-Katrin Bosserhoff, Michael Gruber, Sigrid Karrer

“…Additionally, flow cytometry showed enhanced integrin and selectin expression, as a marker of activation, on PMN surfaces. …”
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Clinical Applications of Low-Intensity Pulsed Ultrasound and Its Underlying Mechanisms in Dentistry by Yuzi Wei, Yongwen Guo

“…It has been demonstrated that LIPUS can activate multiple signal pathways in the shape of sound wave and one of the most acknowledged downstream response components is integrin/focal adhesion kinase (FAK) complex. In recent years, the functions of LIPUS in bone regeneration, bone healing, bone mass maintenance, and cellular metabolism were found. …”
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Role of Peptides in Diagnostics by Shashank Pandey, Gaurav Malviya, Magdalena Chottova Dvorakova

“…The role of radiolabeled peptides, such as somatostatin receptors, interleukin 2 receptor, prostate specific membrane antigen, αβ3 integrin receptor, gastrin-releasing peptide, chemokine receptor 4, and urokinase-type plasminogen receptor, are well established tools for targeted molecular imaging ortumor receptor imaging. …”
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Impact of vitamin D depletion during development on mouse sperm DNA methylation by Jing Xue, Raad Z. Gharaibeh, Edward W. Pietryk, Cory Brouwer, Lisa M. Tarantino, William Valdar, Folami Y. Ideraabdullah

“…Epimutations localized to regions enriched for developmental and metabolic genes and pathway analyses showed enrichment for Cadherin, Wnt, PDGF and Integrin signaling pathways. These findings show for the first time that vitamin D status during development leads to substantial DNA methylation changes across the sperm genome and that locus susceptibility is linked to genomic and epigenomic context.…”
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CD11a regulates hematopoietic stem and progenitor cells by Lifei Hou, Lifei Hou, Lifei Hou, Lifei Hou, Koichi Yuki, Koichi Yuki, Koichi Yuki, Koichi Yuki

“…Integrin αLβ2 (CD11a/CD18, CD11a) is a critical leukocyte adhesion molecule in leukocyte arrest and immunological synapse formation. …”
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Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma by Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Qingsong Cai, Ruitao Lin, Fangfang Yan, Joseph McIntosh, Yijing Li, Yuxuan Che, Zhihong Chen, Jovanny Vargas, Maria Badillo, John Nelson Bigcal, Heng-Huan Lee, Wei Wang, Yixin Yao, Lei Nie, Christopher R. Flowers, Michael Wang

“…Additionally, BTK knockdown and MALT1 knockout markedly impaired MCL tumor migration and dissemination, and MALT1 pharmacological inhibition decreased MCL cell viability, adhesion, and migration by suppressing NF-κB, PI3K/AKT/mTOR, and integrin signaling. Importantly, cotargeting MALT1 with safimaltib and BTK with pirtobrutinib induced potent anti-MCL activity in ibrutinib-resistant MCL cell lines and patient-derived xenografts. …”
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3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro by Sara Al-Ghadban, India A. Pursell, Zaidmara T. Diaz, Karen L. Herbst, Bruce A. Bunnell

“…The data showed an increase in the expression of the adipogenic genes (ADIPOQ, LPL, PPAR-γ and Glut4), a decrease in matrix metalloproteinases (MMP2, 9 and 11), with no significant changes in the expression of ECM markers (collagen and fibronectin), or integrin A5 in 3D differentiated lipedema spheroids as compared to healthy spheroids. …”
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Bidirectional Tumor-Promoting Activities of Macrophage Ezrin by Krishnendu Khan, Briana Long, Gauravi M. Deshpande, Paul L. Fox

“…Ezrin links the cytoskeleton to cell surface integrins and plasma membrane receptors, contributing to the proliferative and metastatic potential of cancer cells. …”
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ITCH-Mediated Ubiquitylation of ITGB3 Promotes Cell Proliferation and Invasion of Ectopic Endometrial Stromal Cells in Ovarian Endometriosis by Liansuo Zhang, Wei Shao, Mingqing Li, Songping Liu

“…Post-translational modification of proteins is involved in the occurrence of endometriosis (EM); however, the role of ubiquitination modification in EM remains unclear. Integrin β3 (ITGB3) is one of the β-subunits of integrins, which plays a key role in tumor progression. …”
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Cellular communication network factor 1‐stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis by Ki‐Hyun Kim, Naiyuan Cheng, Lester F. Lau

“…The matricellular protein cellular communication network factor 1 (CCN1) acts as a bridging molecule by binding phosphatidylserine in apoptotic cells and integrin αvβ3 in phagocytes, thereby triggering efferocytosis or phagocytic clearance of the apoptotic cells. …”
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Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models by Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Väisänen, Heli Ruotsalainen, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara

“…We discovered a role for ColXVIII as a modulator of epidermal growth factor receptor tyrosine kinase (ErbB) signaling and show that it forms a complex with ErbB1 and -2 (also known as EGFR and human epidermal growth factor receptor 2 [HER2]) and α6-integrin to promote cancer cell proliferation in a pathway involving its N-terminal portion and the MAPK/ERK1/2 and PI3K/AKT cascades. …”
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Preclinical evaluation of oncolytic potential human rotavirus Wt 1-5 in gastric adenocarcinoma. by Henry Sossa-Rojas, Pedro Gabriel Franco-Maz, Carlos Zapata-Acevedo, Luz Dary Gutierrez-Castañeda, Carlos Guerrero

“…This study focused on determining the propagation capacity of the RV Wt1-5 through the tumor and the importance of the expression of cell surface co-receptors, including integrin β3, protein disulfide isomerase (PDI), and heat shock proteins (Hsp-90, -70, -60, -40, and Hsc 70), during infection of tumor cells. …”
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Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy by Baoyun Yan, Huan Qin

“…Moreover, we conjugate this contrast agent with integrin αvβ3 mono-clonal antibody to molecularly target the U87-MG human glioblastoma cells for selective tumor cell killing. …”
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Magnetic Nanoparticles as a Component of Peptide-Based DNA Delivery System for Suicide Gene Therapy of Uterine Leiomyoma by Sofia Shtykalova, Anna Egorova, Marianna Maretina, Vladislav Baranov, Anton Kiselev

“…In this study, we investigate the efficiency of αvβ3 integrin-targeted arginine-rich peptide carrier R6p-cRGD electrostatically bound to magnetic nanoparticles (MNPs) for targeted DNA delivery into the UL cells. …”
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Risk prediction for dermatomyositis-associated hepatocellular carcinoma by Xusheng Zhang, Yongxin Ma, Kejun Liu, Long Chen, Lin Ding, Weihu Ma, Bendong Chen

“…In addition, we also found that the upregulation of SPP1 expression may activate the PI3K/ART signaling pathway through integrin-mediated activation, which in turn regulates the development and progression of hepatocellular carcinoma. …”
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Controlling Gut Inflammation by Restoring Anti-Inflammatory Pathways in Inflammatory Bowel Disease by Paolo Giuffrida, Sara Cococcia, Mariangela Delliponti, Marco Vincenzo Lenti, Antonio Di Sabatino

“…Currently, all therapies approved for IBD manipulate the immune system by inhibiting pro-inflammatory mechanisms, such as tumor necrosis factor-α, gut-homing α₄β₇ integrin, interleukin-12/interleukin-23, and Janus kinases. …”
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Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model by Maria L. Vainieri, Mauro Alini, Avner Yayon, Gerjo J. V. M. van Osch, Sibylle Grad

“…The gene expression at 15 days of culture indicated a marked downregulation of matrix metalloproteinase <i>(MMP)13</i> and <i>MMP3,</i> a decrease of <i>β1</i> integrin and increased mRNA levels of actin in osteochondral samples exposed to complex load. …”
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Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8 by Cletus Cheyuo, Monowar Aziz, Ping Wang, Ping Wang

“…These novel functions of MFG-E8 are primarily mediated through its receptor αvβ3-integrin. Here, we focus on the pivotal role of MFG-E8 in protecting against neuronal diseases by promoting neurogenesis. …”
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Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation by Hiroko Katsuno-Kambe, Jessica L Teo, Robert J Ju, James Hudson, Samantha J Stehbens, Alpha S Yap

“…Applying external stretch as a cell-independent way to reorganize the extracellular matrix, we found that collagen polarization stimulated regional cell proliferation to precipitate symmetry breaking and elongation. This required β1-integrin and ERK signaling. We propose that collagen polarization supports epithelial anlagen elongation by stimulating locoregional cell proliferation. …”
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Cryopreservation and Biological Characteristics of Bangkok Chicken (Thai Game Fowl) Embryonic Fibroblast Cell Culture by Elisa Herawati, Gafia Gayatri

“…The cells exhibited normal detection of protein expression, including integrin, cadherin, actin, and microtubules. It was also noted that after cryopreservation in liquid nitrogen, fibroblast cells took 4-6 days to grow and reach 80% confluency. …”
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