Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis by Cristina Banfi, Patrizia Amadio, Marta Zarà, Maura Brioschi, Leonardo Sandrini, Silvia S. Barbieri

“…Deletion of <i>Pcyox1</i> reduced the platelet/leukocyte aggregates in whole blood, as well as the platelet aggregation, the alpha granules release, and the α_IIbβ₃ integrin activation in platelet-rich plasma, in response to adenosine diphosphate (ADP) or thrombin receptor agonist peptide (TRAP). …”
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MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines by Yong-Chul Kim, Mary L. Cutler

“…The focus of this study is on the role of miRs in the regulation of RSU1 and proteins in the IPP (integrin linked kinase, PINCH and parvin) complex. …”
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Comparative Proteomics of the <i>Acanthopagrus schlegelii</i> Gonad in Different Sex Reversal by Shuyin Chen, Yunxia Yang, Bo Gao, Chaofeng Jia, Fei Zhu, Qian Meng, Zhiwei Zhang, Zhiyong Zhang, Shixia Xu

“…Furthermore, proteins involved in the integrin signaling pathway, inflammation mediated by the chemokine and cytokine signaling pathways, pyruvate metabolism, CCKR signaling map, de novo purine biosynthesis and the ubiquitin proteasome pathway were upregulated in female gonads, whereas proteins implicated in DNA replication, the heterotrimeric G-protein signaling pathway, Gi alpha- and Gs alpha-mediated pathways, wnt signaling pathway, and hedgehog signaling pathway were upregulated in male gonads. …”
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Cells Dynamically Adapt to Surface Geometry by Remodeling Their Focal Adhesions and Actin Cytoskeleton by Aysegul Dede Eren, Amy W. A. Lucassen, Urandelger Tuvshindorj, Urandelger Tuvshindorj, Roman Truckenmüller, Stefan Giselbrecht, E. Deniz Eren, Mehmet Orhan Tas, Phanikrishna Sudarsanam, Jan de Boer

“…Our results further highlight the importance of integrin-mediated adhesion in the adaptive properties of cells and provide clear links to the development of bioactive materials.…”
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Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells by Jianping He, Abigail M. Abikoye, Brett P. McLaughlin, Ryan S. Middleton, Ryan Sheldon, Russell G. Jones, Zachary T. Schafer

“…Summary: Cancer cells often acquire resistance to cell death programs induced by loss of integrin-mediated attachment to extracellular matrix (ECM). …”
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Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. by Oscar Negrón, Woosuk S Hur, Joni Prasad, David S Paul, Sarah E Rowe, Jay L Degen, Sara R Abrahams, Silvio Antoniak, Brian P Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J Flick

“…Host macrophage depletion or selective elimination of the fibrin(ogen) β2-integrin binding motif both compromised local bacterial killing and enhanced S. aureus systemic dissemination, suggesting fibrin polymer formation in and of itself was not sufficient to retain S. aureus within the peritoneal cavity. …”
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Photosensitizing deep-seated cancer cells with photoprotein-conjugated upconversion nanoparticles by Sung Hyun Park, Soohyun Han, Sangwoo Park, Hyung Shik Kim, Kyung-Min Kim, Suyeon Kim, Dong Yun Lee, Joonseok Lee, Young-Pil Kim

“…Consequently, this photosensitizing process facilitated rapid cell death in cancer cell lines (MCF-7, MDA-MB-231, and U-87MG) overexpressing integrin beta 1 (ITGB1) receptors but not in a cell line (SK-BR-3) with reduced ITGB1 expression and a non-invasive normal breast cell line (MCF-10A). …”
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RANKL-dependent osteoclast differentiation and gene expression in bone marrow-derived cells from adult mice is sexually dimorphic by Suchita Desai, Pernilla Lång, Tuomas Näreoja, Sara H. Windahl, Göran Andersson

“…M-CSF treatment resulted in 1106 differentially expressed genes, while RANKL-treatment gave 473 differentially expressed genes. Integrin, adhesion, and proliferation-associated genes were elevated in the M-CSF-treated female BMDMs. …”
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Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing by Krishnatej Nishtala, Trailokyanath Panigrahi, Rohit Shetty, Dhanananajay Kumar, Pooja Khamar, Rajiv R. Mohan, Vrushali Deshpande, Arkasubhra Ghosh

“…Proteins involved in integrin signaling (Ras-RAP1b, TLN and FN) and SLIT-ROBO pathways (PFN1, CAPR1, PSMA5) as well as extracellular matrix proteins (SERPINH1, SPARC, ITGβ1, CRTAP) showed enhanced expression in corneal fibroblasts and myofibroblasts compared to keratocytes, indicating their possible role in wound healing. …”
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Characterization of Escherichia coli strains isolated from geese by detection of integron-mediated antimicrobial resistance by Wanying Sun, Dongyang Wang, Shuang Yan, Yuan Xue

“…The detection rate of class I integrin gene cassette was 7.42%. Sequence analysis showed that strains carried different integron gene cassettes: dfrA17-aadA5, dfrA1-aadA1, dfrA27-arr-3, and aminoglycoside 3′'-nucleotidyltransferase. …”
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The AhR agonist VAF347 augments retinoic acid‐induced differentiation in leukemia cells by Christopher N. Ibabao, Rodica P. Bunaciu, Deanna M.W. Schaefer, Andrew Yen

“…Our results show that VAF347 enhanced RA‐induced cell cycle arrest, CD11b integrin expression and neutrophil respiratory burst. …”
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Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1 by Yoshihiro Ueda, Koichiro Higasa, Yuji Kamioka, Naoyuki Kondo, Shunsuke Horitani, Yoshiki Ikeda, Wolfgang Bergmeier, Yoshinori Fukui, Tatsuo Kinashi

“…We quantitatively measured cell polarity and revealed critical roles performed by integrin activator Rap1 in this process, independent of substrate adhesion. …”
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D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes. by Yun-Jong Park, David Acosta, Russell Vassell, Juanjie Tang, Surender Khurana, Carol D Weiss, Hana Golding, Marina Zaitseva

“…The production of PGE2 and cytokines in monocytes activated with DD and ICs was sensitive to the inhibitors of β2 integrin and FcγRIIa, and to the inhibitors of calcium signaling, Mitogen-Activated Protein Kinase (MAPK) pathway, and tyrosine-protein kinase. …”
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352 Microglial Behavior and Iba-1 Expression: Evaluating the Cognitive Impact of Vascular Dementia and Long COVID by Grant McGee Talkington, Saifudeen Ismael, Timothy Gressett, Gregory Bix

“…Immunofluorescence and RT-qPCR used to quantify microglia via Iba-1, BBB integrity via claudin-5 as well as occludin, GFAP, and integrin a5. RESULTS/ANTICIPATED RESULTS: We anticipate observing distinct patterns of microglial behavior in subjects with vascular dementia (VaD) and those with long COVID. …”
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L1CAM deployed perivascular tumor niche promotes vessel wall invasion of tumor thrombus and metastasis of renal cell carcinoma by Zonglong Wu, Yaqian Wu, Zhuo Liu, Yimeng Song, Liyuan Ge, Tan Du, Yunchong Liu, Li Liu, Cheng Liu, Lulin Ma

“…L1CAM promotes the adhesion, migration, and invasion ability of RCC and enhances metastasis by interacting with ITGA5, which elicits activation of signaling downstream of integrin α5β1. L1CAM promotes ADAM17 transcription to facilitate transmembrane ectodomain cleavage and release of soluble L1CAM. …”
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Cell-Penetrating Peptides: Applications in Tumor Diagnosis and Therapeutics by Jeffrey Stiltner, Kayla McCandless, Maliha Zahid

“…These methods are currently being used to image integrin-expressing tumors, breast cancer cells, human histiocytic lymphoma and protease-secreting fibrosarcoma cells, to name a few. …”
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Real clinical practice of complicated Crohn’s disease treatment with ustekinumab: clinical case presentation by P. A. Makarchuk, E. Yu. Lomakina, E. A. Belousova, S. E. Dubrova

“…In the cases of steroid refractory CD treatment options include biologics of different classes: tumour necrosis factor alfa - inhibitors (iTNF-α), α4β7 integrin inhibitor (vedolizumab), IL-12/23 inhibitor (ustekinumab). …”
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Molecular and Cellular Characterization of the TH Pathway in the Sea Urchin <i>Strongylocentrotus purpuratus</i> by Maria Cocurullo, Periklis Paganos, Natalie J. Wood, Maria I. Arnone, Paola Oliveri

“…They include genes involved in the synthesis (<i>Sp-Pxdn</i>), metabolism (<i>Sp-Dios</i>), transport (<i>Sp-Ttrl</i>, <i>Sp-Mct7/8/10</i>) and response (<i>Sp-Thr</i>, <i>Sp-Rxr</i> and <i>Sp-Integrin αP</i>) to thyroid hormones. To understand the cell type(s) involved in TH synthesis and/or response, we studied the spatial expression of the TH toolkit during urchin development. …”
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Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. by Karen Wolf, Attila Braun, Elizabeth J Haining, Yu-Lun Tseng, Peter Kraft, Michael K Schuhmann, Sanjeev K Gotru, Wenchun Chen, Heike M Hermanns, Guido Stoll, Klaus-Peter Lesch, Bernhard Nieswandt

“…Although platelets do not synthetize 5-HT, they take 5-HT up from the blood and store it in their dense granules which are secreted upon platelet activation.To identify the molecular composite of the 5-HT uptake system in platelets and elucidate the role of platelet released 5-HT in thrombosis and ischemic stroke.5-HT transporter knockout mice (5Htt-/-) were analyzed in different in vitro and in vivo assays and in a model of ischemic stroke.In 5Htt-/- platelets, 5-HT uptake from the blood was completely abolished and agonist-induced Ca2+ influx through store operated Ca2+ entry (SOCE), integrin activation, degranulation and aggregation responses to glycoprotein VI (GPVI) and C-type lectin-like receptor 2 (CLEC-2) were reduced. …”
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Comprehensive analysis of metastasis-related genes reveals a gene signature predicting the survival of colon cancer patients by Haotang Wei, Jilin Li, Minzhi Xie, Ronger Lei, Bangli Hu

“…Four hub genes (3-oxoacid CoA-transferase 1, actinin alpha 4, interleukin 8, integrin subunit alpha 3) were identified using protein–protein network analysis. …”
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