Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining by Yichong Zhang, Yuanbo Zhan, Yuhui Kou, Xiaofeng Yin, Yanhua Wang, Dianying Zhang

“…Finally, using enrichment analysis, we identified several pathways, including integrin signaling, insulin pathway, internalization of ErbB1, urokinase-type plasminogen activator and uPAR-mediated signaling, PDGFR-beta signaling pathway, EGF receptor (ErbB1) signaling pathway, and class I PI3K signaling events, which may be associated with SCI-TBI-HO. …”
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Two-dimensional silicene photodynamic tumor-targeting nanomedicine by Huican Duan, Meiqi Chang, Han Lin, Hui Huang, Wei Feng, Weitao Guo, Lina Wu, Yu Chen, Ruifang Zhang

“…Furthermore, the conjunction of c (RGDyC) onto 2D silicene nanosheets (denoted as SRGD) endows the SRGD nanomedicines with specific targeting properties to αvβ3 integrin-overexpressed cancer cells, accomplishing in vivo and in vitro potent tumor growth inhibition efficiency. …”
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Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase by Magdalena Misiura, Tomasz Guszczyn, Ilona Oscilowska, Weronika Baszanowska, Jerzy Palka, Wojciech Miltyk

“…The activation of epidermal growth factor receptor (EGFR), β₁-integrin, and insulin-like growth factor-1 receptor (IGF-1R) by PRP were investigated by western blot and immunocytochemistry. …”
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Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen. by Zhong-Dong Shi, Hui Wang, John M Tarbell

“…In addition, we show that integrins are crucial for mechanotransduction through HSPGs as they mediate cell spreading and maintain cytoskeletal rigidity.We propose a conceptual mechanotransduction model wherein cell surface glycocalyx HSPGs, in the presence of integrin-mediated cell-matrix adhesions and cytoskeleton organization, sense interstitial flow and activate the FAK-ERK signaling axis, leading to upregulation of MMP expression and cell motility in 3D. …”
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Anti-tumor necrosis factor therapy in Bulgarian pediatric patients with inflammatory bowel disease – an 8-year experience of a referral center by Rayna R. Shentova-Eneva, Denitza R. Kofinova, Mila Zh. Baycheva, Petyo G. Hadzhiyski, Hristo B. Naydenov, Penka G. Yaneva, Elena A. Lazarova

“…A quarter of the patients required therapy escalation and 27.1% switched to another biologic agent due to adverse events, primary non-response, or secondary loss of response (18.8% switched to a second anti-TNF and 8.3% switched to an anti-integrin agent). During the study period, the following serious adverse drug reactions were observed: 3 cases of anaphylactic reactions, 1 case of allergic rash, 1 case of disseminated tuberculosis, 1 case of severe herpes simplex infection, 1 case of herpes zoster infection, and 2 cases of drug-induced psoriasis. …”
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Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients by Lucas Vicuña, Evelyn Pardo, Cristóbal Curkovic, Remziye Doger, Claudia Oyanadel, Claudia Metz, Loreto Massardo, Alfonso González, Andrea Soza

“…We have previously described that Gal-8 induces apoptosis in activated T cells interacting with certain β1 integrins and this effect is counteracted by the anti-Gal-8 autoantibodies. …”
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NFATc1 Regulation of Dexamethasone-Induced <i>TGFB2</i> Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells by Mark S. Filla, Jennifer A. Faralli, Caleigh R. Dunn, Haania Khan, Donna M. Peters

“…In contrast, the expression of other DEX/NFATc1-induced mRNAs (myocilin and β3 integrin) occurred regardless of the proliferative state of the cells. …”
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NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease by Li Chen, Zhiyang Shangguan, Zeya Dong, Qunfan Deng, Yunyun Ding, Shulong Yang

“…ABSTRACTObjective High expression of nuclear factor interleukin-3 (NFIL3) and integrin Alpha M (ITGAM) was found in serum samples from Kawasaki disease (KD) patients through bioinformatics analysis. …”
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Physiologically‐based pharmacokinetic modeling of immunoglobulin and antibody coadministration in patients with primary human immunodeficiency by Sara N. Salerno, Rong Deng, Tarundeep Kakkar

“…Abstract Intravenous immunoglobulin (IVIG) (2000 mg/kg) increased the clearance of the mouse monoclonal antibody 7E3, directed against platelet integrin IIb/IIIa (alpha IIb beta 3, CD41/CD61) in rodents. …”
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LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity by Claire Lacouture, Beatriz Chaves, Delphine Guipouy, Raïssa Houmadi, Valérie Duplan-Eche, Sophie Allart, Nicolas Destainville, Loïc Dupré

“…Abstract T-cell cytotoxic function relies on the cooperation between the highly specific but poorly adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. …”
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Non-monotonic relationships between cell adhesion and protrusions by Dawid Szewczyk, Tetsuya Yamamoto, Daniel Riveline

“…We used a simple model to predict that retrograde flows show non-monotonic behaviors because integrin–fibronectin binding mediates actomyosin and friction forces applied to actin gels. …”
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Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature by Michelangelo La Placa, Riccardo Balestri, Federico Tartari, Andrea Sechi, Francesca Ferrara, Camilla Loi, Annalisa Patrizi, Federico Bardazzi

“…Background: Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. Current literature has shown that a minority of patients present circulating antibodies to laminin-332 and this population seems to be associated with a relatively high risk of malignancy. …”
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Vedolizumab Achieved Clinical and Histologic Remission in a Patient with Lung Cancer Who Had a Steroid-Refractory Upper Gastrointestinal Injury Due to Nivolumab Treatment by Cynthia Nguyen Tran, Hamzah Abu-Sbeih, Wenyi Luo, Yang Lu, Yinghong Wang

“…We herein describe a case of steroid-dependent upper GI toxicity with nivolumab (an anti-programmed death [PD] protein-1) that achieved clinical and histological remission with vedolizumab treatment (a GI tract targeted anti-integrin antibody). A 65-year-old male patient with progressive lung cancer was treated with nivolumab and following 16 cycles, developed severe nausea, vomiting, and epigastric abdominal cramps requiring five hospitalizations. …”
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Extracellular galectin-3 in tumor progression and metastasis by Anneliese eFortuna-Costa, Angélica Maciel Gomes, Eliene Oliveira Kozlowski, Mariana Paranhos Stelling, Mauro Sergio Pavao

“…Galectin-3-dependent clustering of integrins promotes ligand-induced integrin activation, leading to cell motility. …”
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Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells by Jenna Zhang, Igor E. Brodsky, Sunny Shin

“…The anti-phagocytic YopE and YopH, as well as the translocation regulator YopK, were collectively responsible for evading inflammasome activation, in part by inhibiting Yersinia internalization mediated by YadA and β1-integrin signaling. These data provide insight into the mechanisms of Yersinia-mediated inflammasome activation and evasion in human cells and reveal species-specific differences underlying the regulation of inflammasome responses to Yersinia. …”
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Tc-3PRGD SPECT Predicts the Outcome of Endostar and Cisplatin Therapy in Xenograft Animals by Wei Sun, Guifu He, Mingming Zhang, Yi Zhao, Hongmei Yu, Yi Li, Wei Wu, Tiefeng Ji

“…Aims: Our study was designed to investigate the usefulness of 99m Tc-3PRGD 2 single-photon emission computed tomography (SPECT) for noninvasively monitoring the response of integrin α v β 3 expression to antiangiogenic treatment with endostar and cisplatin in xenograft animals. …”
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Mg-incorporated micro/nano-topographical calcium silicate coatings with enhanced osteogenic properties and reduced inflammatory reactions by Kai Li, Dandan Hu, Xinwei Zhang, Jieping Li, Shansong Huang, Heng Ji, Xuebin Zheng

“…With higher Mg2+ release, the Mg1-CS coating exerted greater effect on enhancing fibronectin adsorption, integrin activation, and osteogenic behaviors of BMSCs. …”
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Untangling the Extracellular Matrix of Idiopathic Epiretinal Membrane: A Path Winding among Structure, Interactomics and Translational Medicine by Laura Bianchi, Annalisa Altera, Virginia Barone, Denise Bonente, Tommaso Bacci, Elena De Benedetto, Luca Bini, Gian Marco Tosi, Federico Galvagni, Eugenio Bertelli

“…The performed pathway analysis highlights interactions occurring among ECM molecules, their cell receptors and intra- or extracellular proteins that may play a role in matrix biology in this special context. In particular, integrin β1, cathepsin B, epidermal growth factor receptor, protein-glutamine gamma-glutamyltransferase 2 and prolow-density lipoprotein receptor-related protein 1 are key hubs in the outlined protein–protein cross-talks. …”
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DeepPurpose-based drug discovery in chondrosarcoma by Jianrui Li, Mingyue Shi, Zhiwei Chen, Yuyan Pan

“…DeepPurpose recommended 25 drugs, including integrin beta 3 inhibitors, hypoxia-inducible factor 1 alpha inhibitors, E1A binding protein P300 inhibitors, vascular endothelial growth factor A inhibitors, AKT1 inhibitors, tumor necrosis factor inhibitors, transforming growth factor beta 1 inhibitors, interleukin 6 inhibitors, mitogen-activated protein kinase 1 inhibitors, and protein tyrosine kinase inhibitors. …”
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Comparative transcriptome findings reveal the neuroinflammatory network and potential biomarkers to early detection of ischemic stroke by Jiefeng Luo, Dingzhi Chen, Yujia Mei, Hepeng Li, Biyun Qin, Xiao Lin, Ting Fung Chan, Keng Po Lai, Deyan Kong

“…Furthermore, the result of IPA suggested targeting the inflammasome pathway, integrin-linked kinase signaling pathway, and Th1 signaling pathway for treating ischemic stroke. …”
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