Licensing microgels prolong the immunomodulatory phenotype of mesenchymal stromal cells by Matthew D. Patrick, Ramkumar T. Annamalai

“…We also show that the microgels possess integrin-binding sites to support adipose tissue-derived MSC (AD-MSC) attachment and a net positive charge to sequester the licensing cytokines electrostatically. …”
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Glucose-Dependent Insulin Secretion from β Cell Spheroids Is Enhanced by Embedding into Softer Alginate Hydrogels Functionalised with RGD Peptide by Md Lutful Amin, Kylie Deng, Hien A. Tran, Reena Singh, Jelena Rnjak-Kovacina, Peter Thorn

“…Embedding into alginate–RGD causes activation of integrin responses and repositioning of liprin, a protein that controls insulin secretion. …”
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Gene expression profiling of nasal inflammation induced by diesel particles using an in vivo system by Bongkyun Park, Musun Park, Kyuhyung Jo, Chan-Sik Kim, Su-Jin Baek

“…The terms “regulation of alpha-beta T cell differentiation,” “macrophage differentiation,” and “cell adhesion mediated by integrin” were significantly enriched in each group. …”
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Epigallocatechin-3-Gallate Attenuates Leukocyte Infiltration in 67-kDa Laminin Receptor-Dependent and -Independent Pathways in the Rat Frontoparietal Cortex following Status Epilep... by Ji-Eun Kim, Duk-Shin Lee, Tae-Cheon Kang

“…Epigallocatechin-3-gallate (EGCG) is an antioxidant and a ligand for non-integrin 67-kDa laminin receptor (67LR). However, it is unknown whether EGCG and/or 67LR affect SE-induced leukocyte infiltrations in the FPC. …”
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Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation by Dorota Piekna-Przybylska, Daxiang Na, Jingyuan Zhang, Cameron Baker, John M. Ashton, Patricia M. White

“…ERBB2 induction in vivo generated a new population of cells with de novo expression of a gene network. Called small integrin-binding ligand n-linked glycoproteins (SIBLINGs), these ligands and their regulators can alter NOTCH signaling and promote cell survival, proliferation, and differentiation in other systems. …”
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Using Next-Generation Sequencing and Bioinformatic Methods to Predict New Genes That May Be Regulated by CD47 in Oral Squamous Cell Carcinoma by Chung-Chih Tseng, Chen-Han Tsou, Shi-Ying Huang, Chia-Wei Wu, Tsung-Hua Hsieh

“…CD47 is a ubiquitous cell surface transmembrane protein, also known as integrin-related protein (IAP). Previous studies have pointed out that CD47 can inhibit the growth of OSCC, but the detailed mechanism is not clear. …”
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How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients by Andreja Erman, Urška Kamenšek, Urška Dragin Jerman, Mojca Pavlin, Maja Čemažar, Peter Veranič, Rok Romih

“…We showed that within the first two hours, applied cancer cells adhered to the traumatized epithelium by cell projections containing α3β1 integrin on their tips. Cancer cells then migrated through the epithelium and on day 3, they reached the basal lamina or even penetrated it. …”
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Comparative secretome analysis of human follicular dermal papilla cells and fibroblasts using shotgun proteomics by Chong Hyun Won, Oh Sang Kwon, Yong Jung Kang, Hyeon Gyeong Yoo, Dong Hun Lee, Jin Ho Chung, Kyu Han Kim, Won Seok Park, Nok Hyun Park, Kun Cho, Sang Oh Kwon, Jong-Soon Choi, Hee Chul Eun

“…The biochemically-validated DPC-specific proteins included thrombospondin1 (THBS1), an insulin-like growth factor binding protein3(IGFBP3), and, of particular interest, an integrin beta1subunit (ITGB1) as a key network core protein. …”
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Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp) by Emilse Bermejo, Maria F. Alberto, David S. Paul, Aaron A. Cook, Paquita Nurden, Analia Sanchez Luceros, Alan T. Nurden, Wolfgang Bergmeier

“…Aggregation of patients’ platelets was significantly impaired in response to select agonists including ADP, epinephrine, collagen, and calcium ionophore A23187. Integrin αIIbβ3 activation and granule release were also impaired. …”
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Trogocytosis in innate immunity to cancer is an intimate relationship with unexpected outcomes by Fabrizio Mattei, Sara Andreone, Francesca Spadaro, Francesco Noto, Antonella Tinari, Mario Falchi, Silvia Piconese, Claudia Afferni, Giovanna Schiavoni

“…Here, we report that eosinophils acquire membrane fragments from tumor cells early after contact through the CD11b/CD18 integrin complex. We discuss the impact of trogocytosis in innate immune cells on cancer progression in the context of the evidence that eosinophils can engage in trogocytosis with tumor cells. …”
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Single-Cell RNA Sequencing Reveals Distinct Cardiac-Derived Stromal Cell Subpopulations by Jessica R. Hoffman, Arun R. Jayaraman, Sruti Bheri, Michael E. Davis

“…Further, we identified versican and integrin alpha 2 as potential markers for a fibrotic cell subtype. …”
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Rosuvastatin effects on the HDL proteome in hyperlipidemic patients by Vavlukis Ana, Mladenovska Kristina, Davalieva Katarina, Vavlukis Marija, Dimovski Aleksandar

“…Platelet factor 4 variant (PF4V1), Pregnancy-specific beta-1-glycoprotein 2 (PSG2), Profilin-1 (PFN1) and Keratin type II cytoskeletal 2 epidermal (KRT2) showed decreased expressions, while Integrin alpha-IIb (ITGA2B) showed an increased expression after treatment with rosuvastatin. …”
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Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response by Duaa Ahmed Elhag, Manoj Kumar, Marwa Saadaoui, Anthony K. Akobeng, Fatma Al-Mudahka, Mamoun Elawad, Souhaila Al Khodor

“…Moreover, considering the high unmet need for novel therapeutic approaches for IBD patients, various new modulators of cytokine signaling events (for example, JAK/TYK inhibitors), inhibitors of cytokines (for example IL-12/IL-23, IL-22, IL-36, and IL-6 inhibitors), anti-adhesion and migration strategies (for example, β7 integrin, sphingosine 1-phosphate receptors, and stem cells), as well as microbial-based therapeutics to decolonize the bed buds (for example, fecal microbiota transplantation and bacterial inhibitors) are currently being evaluated in different phases of controlled clinical trials. …”
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Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies by Verónica Hortigüela, Enara Larrañaga, Anna Lagunas, Gerardo A. Acosta, Fernando Albericio, Jordi Andilla, Pablo Loza-Alvarez, Elena Martínez

“…Nanopatterns of cell adhesive peptides of different size and spacing were produced, and their impact in integrin receptor clustering and the formation of cell focal adhesions was studied. …”
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Positive selection on ADAM10 builds species recognition in the synchronous spawning coral Acropora by Masaya Morita, Seiya Kitanobo, Seiya Kitanobo, Shun Ohki, Kogiku Shiba, Kazuo Inaba

“…We identified gamete proteins of Acropora digitifera using mass spectrometry and screened the genes that support branch site models that set the “foreground” branches showing strict fertilization specificity. ADAM10, ADAM17, Integrin α9, and Tetraspanin4 supported branch-site model and had positively selected site(s) that produced polymorphic regions. …”
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Delivery of platelet-derived growth factor as a chemotactic factor for mesenchymal stem cells by bone-mimetic electrospun scaffolds. by Matthew C Phipps, Yuanyuan Xu, Susan L Bellis

“…Previously we determined that bone-mimetic electrospun scaffolds composed of polycaprolactone, collagen I and nanohydroxyapatite (PCL/col/HA) supported greater MSC adhesion, proliferation and activation of integrin-related signaling cascades than scaffolds composed of PCL or collagen I alone. …”
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RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells by Priyanka Swami, Swetha Thiyagarajan, Arianna Vidger, Venkata S. K. Indurthi, Stefan W. Vetter, Estelle Leclerc

“…At the molecular level, we show that RAGE up-regulation was associated with decreased activity of FAK, Akt, Erk1/2, and NF-κB signaling pathways and greatly reduced levels of α2 and β1 integrin expression, which is in agreement with the observed decreases in cell migration. …”
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Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation by Wen Gao, Kemin Wang, Lin Zhang, Jian Li, Junling Liu, Xue Chen, Xinping Luo

“…PF-4708671 also accelerated integrin αIIbβ3-mediated clot retraction and spreading. …”
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Ultraviolet Light Treatment of Titanium Enhances Attachment, Adhesion, and Retention of Human Oral Epithelial Cells via Decarbonization by Kourosh Nakhaei, Manabu Ishijima, Takayuki Ikeda, Amirreza Ghassemi, Juri Saruta, Takahiro Ogawa

“…Hemi-desmosome-related molecules, integrin β4 and laminin-5, were upregulated at the gene and protein levels in the cells on UV-treated surfaces. …”
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Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells by Mukul Rastogi, Subendu Sarkar, Ankita Makol, Rana Sandip Singh, Uma Nahar Saikia, Dibyajyoti Banerjee, Seema Chopra, Anuradha Chakraborti

“…The promoter hypomethylation of various key inflammatory cytokines (TNFα, IL-6, and IL-8), integrin (ICAM1) associated with leukocyte transendothelial migration, and extracellular matrix genes (vimentin, and laminin) were also observed. …”
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