DMA, a Small Molecule, Increases Median Survival and Reduces Radiation-Induced Xerostomia via the Activation of the ERK1/2 Pathway in Oral Squamous Cell Carcinoma by Palak Parashar, Monoj Kumar Das, Pragya Tripathi, Tejinder Kataria, Deepak Gupta, Deepak Sarin, Puja Panwar Hazari, Vibha Tandon

“…The reduced expression of αvβ3 integrin and CD44 in DMA alone and DMA with radiation-treated mice suggests a reduced migration of cells and stemness of cancer cells. …”
Get full text

Brain-Derived Neurotrophic Factor (BDNF) Is Associated with Platelet Activity and Bleeding Tendency in Patients with Gaucher Disease by David Azoulay, Mira Naamad, Dafna Frydman, Ellen Broide, Ari Zimran, Galia Stemer, Shoshana Revel-Vilk

“…Flow cytometry was used to test unstimulated and stimulated measurement of platelet surface-activated expression of αIIbβ3 integrin, P-selectin and lysosomal-associated membrane protein (LAMP3/CD63). …”
Get full text

Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance by Fangzhou Liu, Yike Zhao, Yiran Pei, Fengyu Lian, Hui Lin

“…NF-κB expression can modulate osteoblast differentiation by upregulating secreted protein acidic and rich in cysteine (SPARC) and interacting with mTOR signalling, bone morphogenetic protein (BMP) signalling or integrin-mediated signalling under stretch stimulation in the final osteogenic stage. …”
Get full text

Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis by Ludwig T. Weckbach, Andreas Uhl, Felicitas Boehm, Valentina Seitelberger, Bruno C. Huber, Gabriela Kania, Stefan Brunner, Ulrich Grabmaier

“…The lymphocyte function-associated antigen 1 (LFA-1) is a member of the beta2-integrin family and plays a pivotal role for T cell activation and leukocyte trafficking under inflammatory conditions. …”
Get full text

Surface-Modification of Carbonate Apatite Nanoparticles Enhances Delivery and Cytotoxicity of Gemcitabine and Anastrozole in Breast Cancer Cells by Fitya Syarifa Mozar, Ezharul Hoque Chowdhury

“…Besides PEG, a cell specific ligand, in this case fibronectin, was attached to the particles in order to facilitate receptor mediated endocytosis based on fibronectin–integrin interaction. High-performance liquid chromatography (HPLC) was performed to measure uptake of the drugs by breast cancer cells, revealing that surface modification increased the drug uptake, especially for the hydrophobic drug, compared to the uncoated particles and the free drug. …”
Get full text

Five immune-related genes as diagnostic markers for endometriosis and their correlation with immune infiltration by Yi Huang, Qiong Li, Rui Hu, Ruiyun Li, Yuan Yang, Yuan Yang

“…Gene ontology analysis showed that these changes mainly focused on the positive regulation of endometrial cell proliferation, cell metabolism, and extracellular space, and EMS involved the integrin, complement activation, folic acid metabolism, interleukin, and lipid signaling pathways. …”
Get full text

Not all (cells) who wander are lost: Upstream migration as a pervasive mode of amoeboid cell motility by Alexander Buffone, Alexander Buffone, Daniel A. Hammer, Daniel A. Hammer, Sarah Hyun Ji Kim, Nicholas R. Anderson, Ai Mochida, Dong-Hun Lee, Subham Guin

“…Upstream migration occurs when the integrin receptor αLβ2 (also known as lymphocyte function-associated antigen-1, or LFA-1) binds to ICAM-1. …”
Get full text

DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1 by Favour A. Akinjiyan, Ritu M. Dave, Emily Alpert, Gregory D. Longmore, Katherine C. Fuh

“…Furthermore, we demonstrated that DDR2 regulates periostin expression through integrin B1 (ITGB1). Stromal DDR2 is highly correlated with stromal POSTN expression in ovarian cancer patient tumors. …”
Get full text

Retinoic Acid Signaling Is Compromised in DSS-Induced Dysbiosis by Yongchun Li, Lili Sheng, Prasant Kumar Jena, Miranda Claire Gilbert, Yu-Jui Yvonne Wan, Hua Mao

“…The expression of RA-regulated gut homing molecules including α4β7 integrin, and CCR9, along with MADCAM1 were all reduced in colitis mice revealing compromised immunity due to reduced RA signaling. …”
Get full text

Enhanced growth and differentiation of neural stem cells on alginate/collagen/reduced graphene oxide composite hydrogel incorporated with lithium chloride by Azadeh Babaei, Taki Tiraihi, Jajar Ai, Nafiseh Baheiraei

“…Results: Our results showed that the combination of collagen fibers and rGO with alginates increased cell viability and the gene expression of collagen-binding receptor subunits such as integrin α1, and β1. Further, rGO contributed to the controlled release of lithium-ion hydrogel in terms of its plenty of negatively charged functional groups. …”
Get full text

Role of irisin in physiology and pathology by Shiqiang Liu, Fengqi Cui, Kaiting Ning, Zhen Wang, Pengyu Fu, Dongen Wang, Huiyun Xu, Huiyun Xu

“…Irisin can bind to its receptor integrin αV/β5 to induce browning of white fat, maintain glucose stability, keep bone homeostasis, and alleviate cardiac injury. …”
Get full text

The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude by Chunxiang Shang, Tana Wuren, Qing Ga, Zhenzhong Bai, Li Guo, Alicia S. Eustes, Kyra N. McComas, Matthew T. Rondina, Rili Ge

“…Among the significantly, differentially expressed genes (mRNA and protein), were those having canonical roles in platelet activation and thrombosis, including membrane glycoproteins (e.g. GP4, GP6, GP9), integrin subunits (e.g. ITGA2B), and alpha-granule chemokines (e.g. …”
Get full text

Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment by Yalan Dai, Xinyi Zhang, Yingjun Ou, Linglin Zou, Duoli Zhang, Qingfan Yang, Yi Qin, Xiuju Du, Wei Li, Zhanpeng Yuan, Zhangang Xiao, Qinglian Wen

“…Anoikis, a form of apoptosis initiated by cell detachment from the native environment, is an outside-in process commencing with the disruption of cytosolic connectors such as integrin-ECM and cadherin-cell. This disruption subsequently leads to intracellular cytoskeletal and signaling pathway alterations, ultimately activating caspases and initiating programmed cell death. …”
Get full text

3D Bone Morphology Alters Gene Expression, Motility, and Drug Responses in Bone Metastatic Tumor Cells by Ushashi C. Dadwal, Alyssa R. Merkel, Jonathan M. Page, Kristin A. Kwakwa, Michael Kessler, Julie A. Rhoades

“…Drug response differed when tumors were cultured in 3D compared to 2D. Inhibitors for Integrin β3 and TGF-β Receptor II significantly reduced bone-metastatic gene expression in 2D but not 3D, while treatment with the Gli antagonist GANT58 significantly reduced gene expression in both 2D and 3D. …”
Get full text

Endocytosis and physiology: insights from Disabled-2 deficient mice by Wensi Tao, Robert Moore, Elizabeth R. Smith, Xiang-Xi Mike Xu

“…The membrane receptors reported to bind directly to Dab2 include LDL receptor and its family members LRP1 and LRP2 (megalin), growth factor receptors EGFR and FGFR, and the cell adhesion receptor beta1 integrin. Dab2 also serves as an adaptor in signaling pathways. …”
Get full text

BMP-2 Long-Term Stimulation of Human Pre-Osteoblasts Induces Osteogenic Differentiation and Promotes Transdifferentiation and Bone Remodeling Processes by Lena-Christin Ingwersen, Marcus Frank, Hendrik Naujokat, Klaas Loger, Rainer Bader, Anika Jonitz-Heincke

“…The results showed that BMP-2 treatment for 14 or 28 days resulted in increased osteogenesis, through an increase in runt-related transcription factor 2, osterix, alkaline phosphatase, and integrin-binding sialoprotein expression. However, an increase in tumor necrosis factor alpha and receptor activator of nuclear factor kappa-Β ligand protein levels was observed after BMP-2 exposure, indicating also an increased potential for osteoclast activation by osteoblasts. …”
Get full text

Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors by Hilsenbeck Susan G, Daves Marla H, Lau Ching C, Man Tsz-Kwong

“…Pathway analysis of the significant genes showed that the genes were involved in known metastasis-associated pathways, such as integrin signaling, calcium signaling, and VEGF signaling. …”
Get full text

Comprehensive systematic review and pooled analysis of real‐world studies evaluating immunomodulator and biologic therapies for chronic pouchitis treatment by Emi Khoo, Andrew Lee, Teresa Neeman, Yoon‐Kyo An, Jakob Begun

“…We performed a systematic review and pooled analysis of published studies to assess the efficacy of immunomodulators, including thiopurines and methotrexate, and biologics including antitumor necrosis factor, anti‐integrin, and interleukin‐12/23 antagonists. Clinical and endoscopic response and remission rates were combined for pooled analyses. …”
Get full text

Immunological role and prognostic value of somatostatin receptor family members in colon adenocarcinoma by Xiaoqian Yu, Xuejie Yang, Hui Nie, Wenying Jiang, Xiaoyun He, Chunlin Ou, Chunlin Ou

“…We analyzed its correlation with the dendritic cell–integrin subunit alpha X marker gene. The biomarker exploration of the solid tumors portal was used to confirm the correlation between SSTR2 with immunomodulators and immunotherapy responses. …”
Get full text

<i>Brassica oleracea</i> L. var. <i>italica</i> Aquaporin Reconstituted Proteoliposomes as Nanosystems for Resveratrol Encapsulation by Lucia Yepes-Molina, José A. Teruel, Urban Johanson, Micaela Carvajal

“…Moreover, interactions between plant AQP and human integrin were shown, which may increase internalization by the human target cells. …”
Get full text