LINC00472 inhibits cell migration by enhancing intercellular adhesion and regulates H3K27ac level via interacting with P300 in renal clear cell carcinoma by Songmao Wang, Cheng Luo, Bing Li, Shikuan Zhang, Weijie Liao, Qilei Xin, Naihan Xu, Weidong Xie, Yuanchang Zhu, Yaou Zhang

“…Additionally, we discovered that the integrin family protein ITGB8 is a potential target gene of LINC00472. …”
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HWJMSC-EVs promote cartilage regeneration and repair via the ITGB1/TGF-β/Smad2/3 axis mediated by microfractures by Zhian Chen, Tianhua Zhou, Huan Luo, Zhen Wang, Qiang Wang, Rongmao Shi, Zian Li, Rongqing Pang, Hongbo Tan

“…This was mainly because hWJMSC-EVs carry integrin beta-1 (ITGB1), and cartilage and bone marrow-derived MSCs overexpress ITGB1 after absorbing EVs, thereby activating the transforming growth factor-β/Smad2/3 axis. …”
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Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer by Alexandra Giatromanolaki, Achilleas Mitrakas, Ioannis Anestopoulos, Andreas Kontosis, Ioannis M. Koukourakis, Aglaia Pappa, Mihalis I. Panayiotidis, Michael I. Koukourakis

“…Background: Cancer cells escape macrophage phagocytosis by expressing the CD47 integrin-associated protein that binds to the SIRPα ligand (signal regulatory protein alpha) expressed by macrophages. …”
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INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS by O. I. Stepanova, T. U. Lvova, E. N. Purbeeva, M. I. Mirashvili, M. S. Zainulina, S. A. Selkov, D. I. Sokolov

“…Placental tissue supernatants produced by the first- and third-trimester placental tissue from normal pregnancy, as well as from women with gestosis, induced higher expression of CD31, CD9, CD62E, CD62P, CD34, CD54, CD51/61, CD49d  and  integrin  β7  expression  by  endothelial  cells,  as  compared  with  their  baseline  levels.  …”
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Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells by Jang Mi Han, Hye Jin Jung

“…Moreover, co-treatment with both compounds significantly reduced the expression levels of key GSC markers, including CD133, integrin α6, aldehyde dehydrogenase 1A1 (ALDH1A1), Nanog, Sox2, and Oct4. …”
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Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation by Zeinab Bahrami, Narges Hatamian, Mahmood Talkhabi, Elnaz Zand, David G Mottershead, Rouhollah Fathi

“…Finally, the expression levels of Oct4, Sox2, Cdk-2, Gdf9, Integrin beta1 and Igf2 were analyzed using real-time polymerase chain reaction (PCR) in MII oocytes and two-cell embryos.Results: These analyses showed that GCCM significantly increased the IVM rate, oocyte meiotic resumption and mitochondrial membrane potential (P<0.05). …”
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HSP47 levels determine the degree of body adiposity by Jihoon Shin, Shinichiro Toyoda, Yosuke Okuno, Reiko Hayashi, Shigeki Nishitani, Toshiharu Onodera, Haruyo Sakamoto, Shinya Ito, Sachiko Kobayashi, Hirofumi Nagao, Shunbun Kita, Michio Otsuki, Atsunori Fukuhara, Kazuhiro Nagata, Iichiro Shimomura

“…Mechanistically, HSP47 promotes collagen dynamics in the folding, secretion, and interaction with integrin, which activates FAK signaling and preserves PPARγ protein from proteasomal degradation, partly related to MDM2. …”
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New Approaches Targeting the Invasive Phenotype of Prostate Cancer-Associated Fibroblasts by Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria

“…Mechanistically, our findings posit that AR/FLNa complex recruits β1 integrin and the membrane type-matrix metalloproteinase 1 upon the androgen challenging of CAFs. …”
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Loss of <i>MXRA8</i> Delays Mammary Tumor Development and Impairs Metastasis by Kaitlyn E. Simpson, Christina A. Staikos, Katrina L. Watson, Roger A. Moorehead

“…MXRA8 can also interact with integrin β3 and thus possibly regulate cell–cell interactions and binding to the extracellular matrix. …”
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Alterations in Genes <em>rib</em>, <em>scpB</em> and Pilus Island Decrease the Prevalence of Predominant Serotype V, Not III and VI, of <em>Streptococcus agalactiae</em> from 2008... by I-An Tsai, Yaochi Su, Ying-Hsiang Wang, Chishih Chu

“…Compared to <i>scpB-1</i>, <i>scpB-2</i> had a 128-bp deletion in a PA C5a-like peptidase domain and putative integrin-binding motif RGD. In conclusion, reduction in serotype V may be due to presence of <i>scpB-2</i> or lack of genes <i>scpB</i> and <i>rib</i>.…”
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Rare and heterogeneous manifestations of leucocyte adhesion deficiency type 1: report of two cases with diagnostic dilemmas and novel ITGB2 mutation by Sabiha Anis, Aiysha Abid, Sadaf Aba Umer Kodwavwala, Sabahat Sarfaraz, Samina Junejo, Saba Shahid, Sajid Sultan, Adibul Hasan Rizvi

“…Case Presentation LAD 1 is characterized by homozygous pathogenic variants in the integrin subunit beta 2 (ITGB2) gene. We report two cases of LAD1 with unusual presentations (post-circumcision excessive bleeding and chronic inflammation of the right eye) which were confirmed by flow cytometric analysis and genetic testing. …”
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An Improved αvβ6-Receptor-Expressing Suspension Cell Line for Foot-and-Mouth Disease Vaccine Production by Yongjie Harvey, Ben Jackson, Brigid Veronica Carr, Kay Childs, Katy Moffat, Graham Freimanis, Chandana Tennakoon, Nicholas Juleff, Julian Seago

“…To circumvent the need to cell culture adapt FMDV, we have used a systematic approach to develop recombinant suspension BHK-21 that stably express the key FMDV receptor integrin αvβ6. We show that αvβ6 expression is retained at consistently high levels as a mixed cell population and as a clonal cell line. …”
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Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds by Nausika Betriu, Anna Andreeva, Anna Alonso, Carlos E. Semino

“…The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that participates in integrin-mediated signal transduction and contributes to different biological processes, such as cell migration, survival, proliferation and angiogenesis. …”
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FNDC5/Irisin: Physiology and Pathophysiology by Rashid Waseem, Anas Shamsi, Taj Mohammad, Md. Imtaiyaz Hassan, Syed Naqui Kazim, Anis Ahmad Chaudhary, Hassan Ahmed Rudayni, Mohammed Al-Zharani, Faizan Ahmad, Asimul Islam

“…The receptor of irisin is not completely known; however, in some tissues it probably acts via a specific class of integrin receptors. Here, we review research from the past decade that has identified irisin as a potential therapeutic agent in the prevention or treatment of various metabolic-related and other diseases. …”
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Laminin Triggers Neutrophil Extracellular Traps (NETs) and Modulates NET Release Induced by <i>Leishmania amazonensis</i> by Gustavo Silva-Oliveira, Leandra Linhares-Lacerda, Thayana R. F. Mattos, Camila Sanches, Tatiana Coelho-Sampaio, Ingo Riederer, Elvira M. Saraiva

“…LM-induced NETs were partially inhibited by pretreatment of neutrophils with an anti-α6 integrin antibody. Furthermore, NETs triggered by laminins were dependent on elastase and peptidylarginine deiminase (PAD)-4, enzymes that participate in chromatin decondensation. …”
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Porcine salivary proteome analysis identifies potential early pregnancy-specific protein biomarkers by MONTI DAS, ANKAN DE, PARTHASARATHI BEHERA, MOHAMMAD AYUB ALI, PRASANT KUMAR SUBUDHI, GIRIN KALITA, ASHULI KHOZHIIO KAYINA, JAGAN MOHANARAO GALI

“…Functional classification and pathway analysis of the DEPs revealed involvement of most of the proteins in integrin signalling pathways, blood coagulation, carbohydrate metabolism, oxidative stress response and regulation of protein folding. …”
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Growth Pattern of Hepatic Metastasis as a Prognostic Index Reflecting Liver Metastasis-Associated Survival in Breast Cancer Liver Metastasis by Jieun Lee, Moonhyung Choi, Seungyeon Joe, Kabsoo Shin, Sung-Hak Lee, Ahwon Lee

“…Thirty-one surgical or biopsy specimens for liver metastasis were immunostained for L1 adhesion molecule (L1CAM), Yes-associated protein 1/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ), and β1-integrin. Out of 156 patients, 77 initially had oligometastasis, 58 had nonconfluent mass formation, 14 had confluent mass formation, and 7 had infiltrative liver metastasis. …”
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Ethyl Hydroxyethyl Cellulose—A Biocompatible Polymer Carrier in Blood by Anja Eckelt, Franziska Wichmann, Franziska Bayer, John Eckelt, Jonathan Groß, Till Opatz, Kerstin Jurk, Christoph Reinhardt, Klytaimnistra Kiouptsi

“…Similar to established nanomaterials that are considered biocompatible when added to blood, the EHEC exposure of resting platelets in platelet-rich plasma does not enhance tissue thromboplastin- or ellagic acid-induced blood clotting, or platelet aggregation or activation, as measured by integrin α_IIbβ₃ activation and P-selectin exposure. …”
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HPA-1 polymorphism of αIIbβ3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system by Mihalj Mario, Zotz Rainer B, Hellmig Sabine, Stoldt Volker, Loncar Robert, Scharf Rüdiger E

“…In this study, we evaluated the influence of HPA-1 polymorphism of integrin αIIbβ3 on platelet adhesion onto immobilized fibrinogen using an in vitro system simulating blood flow.…”
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Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging by Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan

“…Results Systems biology analysis implicated molecular functions related to the extracellular matrix, collagen, integrin, heparin, and transmembrane tyrosine kinase signaling in BC susceptibility, with HNF4A and NFKB1 emerging as key molecular regulators. …”
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