Use of Chitosan from Southern King Crab to Develop Films Functionalized with RGD Peptides for Potential Tissue Engineering Applications by Juan Carlos Forero, Karina Carvajal, Fanny Guzmán, Cristian Acevedo, Nelson Osses, Paula Santana

“…Therefore, RGD (arginine–glycine–aspartic acid) peptides corresponding to the main integrin recognition site in extracellular matrix proteins have been used to improve the CS surface. …”
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Succinate Injection Rescues Vasculature and Improves Functional Recovery Following Acute Peripheral Ischemia in Rodents: A Multimodal Imaging Study by Anaïs Moyon, Philippe Garrigue, Laure Balasse, Samantha Fernandez, Pauline Brige, Ahlem Bouhlel, Guillaume Hache, Françoise Dignat-George, David Taïeb, Benjamin Guillet

“…A microPET study using a radiolabeled integrin ligand ([⁶⁸Ga]Ga-RGD₂) showed an earlier angiogenic activation in the succinate arm compared to control mice (* <i>p</i> = 0.020) with a prolonged effect. …”
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Platelet Src family kinases: A tale of reversible phosphorylation by Yotis A. Senis, Zoltan Nagy, Jun Mori, Sophia Lane, Patrick Lane

“…For platelet biologists, SFKs have remained an important area of investigation, initiating and amplifying signals from all major adhesion, activation, and inhibitory receptors, including the integrin αIIbβ3, the collagen receptor complex glycoprotein VI–Fc receptor γ‐chain, the G protein–coupled ADP receptor P2Y12 and the inhibitory receptors platelet endothelial cell adhesion molecule‐1 and G6b‐B. …”
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Response to Vaccines in Patients with Immune-Mediated Inflammatory Diseases: A Narrative Review by Beatriz Garcillán, Miguel Salavert, José R. Regueiro, Sabela Díaz-Castroverde

“…B cell-depleting therapies, such as rituximab, strongly impair vaccines immunogenicity, and tumor necrosis factor (TNF) inhibitors and the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) fusion protein abatacept are also associated with attenuated antibody responses, which are further diminished in patients taking concomitant immunosuppressants. On the other hand, integrin, IL-6, IL-12/23, IL-17, and B-cell activating factor (BAFF) inhibitors do not appear to affect the immune response to several vaccines evaluated. …”
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β-Hydroxybutyrate Effects on Bovine Caruncular Epithelial Cells: A Model for Investigating the Peri-Implantation Period Disruption in Ketotic Dairy Cows by Carolin Hildebrand, Julia Hollenbach, Bettina Seeger, Christiane Pfarrer

“…RT-qPCR was used to examine mRNA expressions of <i>TNF</i>, <i>IL6</i>, <i>RELA</i>, prostaglandin E2 synthase (<i>PTGES2</i>) and receptor (<i>PTGER2</i>) as well as integrin subunits <i>ITGAV</i>, <i>ITGA6</i>, <i>ITGB1</i> and <i>ITGB3</i>. …”
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Long-Term Low-Dose Delta-9-Tetrahydrocannbinol (THC) Administration to Simian Immunodeficiency Virus (SIV) Infected Rhesus Macaques Stimulates the Release of Bioactive Blood Extrac... by Yuan Lyu, Steven Kopcho, Mahesh Mohan, Chioma M. Okeoma

“…These include altered tetraspanin and integrin β1 expression; altered levels and distribution of polymerized actin, FAK/pY397 FAK, pERK1/2, cleaved caspase 3, proapoptotic Bid and truncated tBid; and altered adhesion of monocytes to collagen I. …”
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Recent developments on BMPs and their antagonists in inflammatory bowel diseases by Zhuo Xie, Gaoshi Zhou, Mudan Zhang, Jing Han, Ying Wang, Xiaoling Li, Qirui Wu, Manying Li, Shenghong Zhang

“…Biologic agents that target tumour necrosis factor-α, integrin α4β7, and interleukin (IL)12/23p40 have been more successful than conventional therapies in treating IBD. …”
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Mechanisms of tissue degeneration mediated by periostin in spinal degenerative diseases and their implications for pathology and diagnosis: a review by Tomohito Yoshihara, Tadatsugu Morimoto, Hirohito Hirata, Masatoshi Murayama, Toshihiro Nonaka, Masatsugu Tsukamoto, Yu Toda, Takaomi Kobayashi, Kenji Izuhara, Masaaki Mawatari

“…As an ECM protein, POSTN binds to integrin receptors, transduces signals to cells, enabling cell activation. …”
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Assessment of neonatal, cord, and adult platelet granule trafficking and secretion by Anh T. P. Ngo, Jawaad Sheriff, Anne D. Rocheleau, Matthew Bucher, Kendra R. Jones, Anna-Liisa I. Sepp, Lisa E. Malone, Amanda Zigomalas, Alina Maloyan, Wadie F. Bahou, Danny Bluestein, Owen J. T. McCarty, Kristina M. Haley

“…We observed that neonatal and cord blood-derived platelets exhibited diminished PAR1-mediated granule secretion and integrin activation relative to adult platelets, correlating to reduced PAR1 expression by neonatal platelets. …”
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ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration by Sofia K. H. Morsing, Timo Rademakers, Sanne L. N. Brouns, Anne-Marieke D. van Stalborch, Marjo M. P. C. Donners, Jaap D. van Buul

“…Upon actual transmigration, the release from ICAM-1 is required. While Integrin LFA1/Mac1 de-activation is one described mechanism that leads to this, direct cleavage of ICAM-1 from the endothelium represents a second option. …”
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High-intensity interval training attenuates development of autoimmune encephalomyelitis solely by systemic immunomodulation by Yehuda Goldberg, Shir Segal, Liel Hamdi, Hanan Nabat, Nina Fainstein, Efrat Mediouni, Yarden Asis, Paschalis Theotokis, Ilias Salamotas, Nikolaos Grigoriadis, Abram Katz, Tamir Ben-Hur, Ofira Einstein

“…Thus, the beneficial effect of HIIT on EAE development is attributed solely to systemic immunomodulatory effects, likely because of systemic inhibition of autoreactive cell migration and reduced VLA-4 integrin expression.…”
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Aligned Collagen-CNT Nanofibrils and the Modulation Effect on Ovarian Cancer Cells by Wen Li, Naiwei Chi, Elwin D. Clutter, Bofan Zhu, Rong R. Wang

“…AFM analysis revealed that the one-dimensional structure, high stiffness, and low adhesion of COL-CNT greatly facilitated the polarization of SKOV3 cells by regulating the β-1 integrin-mediated cell–matrix interaction, cytoskeleton rearrangement, and cell migration. …”
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Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles by Jingheng Guo, Qian Cheng, Yongjian Li, Lingyu Tian, Delin Ma, Zhao Li, Jie Gao, Jiye Zhu

“…Mechanistically, we demonstrated that FUT5 is essential for the synthesis and glycosylation of several proteins, including versican, β3 integrin, and cystatin 7, which may serve key roles in the precancer effects of FUT5. …”
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Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration by Suh SB, Ahn KJ, Kim EJ, Suh JY, Cho SB

“…The identified DFCM proteins were associated with several pathways for wound repair and hair regeneration, including epidermal growth factor receptor, fibroblast growth factor, integrin, Wnt, cadherin, and transforming growth factor-β signaling pathways.Conclusion: DFCM contains numerous secretory proteins that comprise groups of protein–protein interaction networks that regulate wound repair and hair regeneration.Keywords: human dermal fibroblast, dermal fibroblast-conditioned media, proteomic analysis, secretory protein, wound repair, hair regeneration…”
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Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale by Mingxing Ouyang, Yanling Hu, Weihui Chen, Hui Li, Yingbo Ji, Linshuo Qiu, Linlin Zhu, Baohua Ji, Bing Bu, Linhong Deng

“…We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.…”
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Proteomic Profiling and Artificial Intelligence for Hepatocellular Carcinoma Translational Medicine by Nurbubu T. Moldogazieva, Innokenty M. Mokhosoev, Sergey P. Zavadskiy, Alexander A. Terentiev

“…We discuss conventional and promising proteomic biomarkers of HCC such as AFP, lens culinaris agglutinin (LCA)-reactive L3 glycoform of AFP (AFP-L3), des-gamma-carboxyprothrombin (DCP), osteopontin (OPN), glypican-3 (GPC3), dickkopf-1 (DKK1), midkine (MDK), and squamous cell carcinoma antigen (SCCA) and highlight their functional significance including the involvement in cell signaling such as Wnt/β-catenin, PI3K/Akt, integrin αvβ3/NF-κB/HIF-1α, JAK/STAT3 and MAPK/ERK-mediated pathways dysregulated in HCC. …”
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Contamination of Tap Water with Pseudomonas aeruginosa, Legionella pneumophila, and Escherichia coli in Guilan, Iran by Masoumeh Ahmadi Jalali Moghadam, Hamidreza Honarmand, Sajad Asfaram Meshginshahr

“…Metallo-β-lactamasesgene was found in 11.1% of all samples. We also found Integrin 1 in 28.5% of the samples with <em>P. aeruginosa.…”
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Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation by Mengshi Lei, Weiyou Wang, Hong Zhang, Jihong Gong, Zhili Wang, Hanmian Cai, Xiaofei Yang, Shen Wang, Cong Ma

“…We further demonstrate that the Piezo1-calpain-integrin-β1/E-cadherin signaling cascade regulates the aggregation of DRG neurons. …”
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Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice by Huixin Zhang, Jin Wu, Jiahuan Wu, Qi Fan, Jingchao Zhou, Junwen Wu, Sichen Liu, Jie Zang, Jinhai Ye, Ming Xiao, Tian Tian, Jun Gao

“…Furthermore, RGD-exo:miR-210 are administered once every other day for 14 days, and the expressions of integrin β3, vascular endothelial growth factor (VEGF) and CD34 are significantly upregulated. …”
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Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility by Chiara Zambarda, Carlos Pérez González, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat, Elisabetta Ada Cavalcanti-Adam

“…Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin β1 peripheral adhesions and transmitted to neighboring cells through adherens junctions. …”
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