Perioperative optimization of Crohn's disease by Chun‐Chi Lin, Hung‐Hsin Lin, Hui‐Chuen Chen, Nai‐Chia Chen, I‐Lun Shih, Ji‐Shiang Hung, Te‐Cheng Yueh, Feng‐Fan Chiang, Ping‐Wei Lin, Yuan‐Yao Tsai, Shu‐Chen Wei

“…The increased surgical risk was found to be associated with the use of corticosteroids, but the association of surgical risk with immunomodulators, biologic therapy, such as anti‐TNF mediations, anti‐integrin medications, and anti‐IL 12/23 was low in certainty. …”
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Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum^® Oss_hp) in Critical Calvaria Defect in Rats by Paula Buzo Frigério, Lilian Caldas Quirino, Marisa Aparecida Cabrini Gabrielli, Pedro Henrique de Azambuja Carvalho, Idelmo Rangel Garcia Júnior, Valfrido Antonio Pereira-Filho

“…Euthanasia was performed at 7, 15, 30, and 60 days after surgery. (3) Results: Lower gene expression was observed for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF) and higher expression for Integrin Binding Sialoprotein (IBSP). The results correlated with moderate immunolabeling for osteocalcin (OCN) and slight immunolabeling for osteopontin (OPN) in the PO group. …”
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Engraftment, Fate, and Function of HoxB8-Conditional Neutrophil Progenitors in the Unconditioned Murine Host by Joshua T. Cohen, Michael Danise, Kristina D. Hinman, Kristina D. Hinman, Brittany M. Neumann, Renita Johnson, Zachary S. Wilson, Zachary S. Wilson, Anna Chorzalska, Patrycja M. Dubielecka, Craig T. Lefort

“…Our results indicate that HoxB8-conditional progenitors engraft in a β1 integrin-dependent manner and transiently generate donor-derived mature neutrophils. …”
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Post-warming culture of human vitrified blastocysts with prolactin improves trophoblast outgrowth by Kenji Ezoe, Nanoha Fujiwara, Tetsuya Miki, Keiichi Kato

“…Higher mRNA expression of integrin-based focal adhesion-related genes, ITGA5 and ITGB1, was observed after treatment with PRL for 120 min than in the non- and shorter-treatment groups. …”
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Optical Imaging Biomarkers of Drug-Induced Vascular Injury by Shu-An Lin MS, Donna L. Suresch, Brett Connolly, Gebre Mesfin, Raymond J. Gonzalez, Manishkumar R. Patel, Diane Shevell, Timothy Johnson, Bohumil Bednar

“…Optical agents, AngioSense for the detection of vessel permeability, MMPSense for the detection of activated matrix metalloproteinases (MMPs), and IntegriSense for the detection of α v β 3 integrin, were injected via tail vein 24 hours before fluorescence (FL) ex vivo imaging. …”
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Exosomes derived from placental trophoblast cells regulate endometrial epithelial receptivity in dairy cows during pregnancy by Yue SU, Qianru LI, Qiaochu ZHANG, Zhiming LI, Xinxin YAO, Yong GUO, Longfei XIAO, Xiangguo WANG, Hemin NI

“…Such treatment enhanced the expression of the endometrial receptivity factors, integrin αv, β3, Wnt7a, and MUC1 by changing the extracellular environment, metabolism, and redox balance in EECs via proteome alignment, compared with no treatment according to the DIA quantitation analysis. …”
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Dataset for selection of stable reference genes for accurate quantitative gene expression analysis in silvertip tetra (Hasemania nana): Implications for sex differentiation and det... by Hwa Jin Lee, Ki Tae Kim, Min Sun Kim, Sang Yoon Lee

“…In this study, we evaluated the stability of nine candidate reference genes, labeled elongation factor 1-alpha (EF1A), ERBB receptor feedback inhibitor 1-like isoform x2 (ERRFI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), integrin beta2 like (ITGB2), phosphatidylinositol-binding clathrin assembly protein-like isoform x3 (PICALM), 60 s ribosomal protein L5 (RPL5), 60 s ribosomal protein L7 (RPL7), tubulin beta chain (TUBB), and ubiquitin-conjugating enzyme E2A (UBE2A), in the brain (including pituitary gland) gonads and caudal fins of silvertip tetra (Hasemania nana) males and females. …”
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PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment by Xiaoxiao Huang, Zhaowei Chen, Zilv Luo, Yiqun Hao, Jun Feng, Zijing Zhu, Xueyan Yang, Zongwei Zhang, Jijia Hu, Wei Liang, Guohua Ding

“…Mechanistically, PFKFB3 knockdown likely aggravate Ang II-induced podocyte loss by suppressing talin1 phosphorylation and integrin beta1 subunit (ITGB1) activity. Conversely, PFKFB3 overexpression protected against Ang II-induced podocyte loss. …”
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Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with <it>Streptococcus suis</it> by Quitsch Ulrike, Galla Hans-Joachim, Berger Jürgen, Schmidt M Alexander, Greune Lilo, Wolburg Hartwig, Seibt Annette, Wewer Corinna, Schwerk Christian, Schroten Horst, Tenenbaum Tobias

“…Flow cytometric and transmigration inhibition studies with integrin-specific antibodies showed that PMN traversal is dependent on CD11b/CD18. …”
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Prolactin and Estradiol are Epigenetic Modulators in Bovine Mammary Epithelial Cells during <i>Staphylococcus aureus</i> Infection by María Guadalupe Salgado-Lora, Ivan Medina-Estrada, Joel Edmundo López-Meza, Alejandra Ochoa-Zarzosa

“…By gentamicin protection assays, we determined that combined hormones (bPRL (5 ng/mL) and E2 (50 pg/mL)] decrease <i>S. aureus</i> internalization into bMECs (~50%), which was associated with a reduction in integrin α5β1 membrane abundance (MA) (~80%) determined by flow cytometry. …”
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Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells by Carla Bianca Luena Victorio, Wisna Novera, Arun Ganasarajah, Joanne Ong, Melisyaa Thomas, Jonas Wu, Hilary Si Yin Toh, Alfred Xuyang Sun, Eng Eong Ooi, Ann-Marie Chacko

“…Our findings revealed that Axl and integrin αvβ5 function as cellular receptors mediating ZIKV-LAV infection in GBM cells. …”
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A Low Molecular Weight Protein from the Sea Anemone Anemonia viridis with an Anti-Angiogenic Activity by Erwann P. Loret, José Luis, Christopher Nuccio, Claude Villard, Pascal Mansuelle, Régine Lebrun, Pierre Henri Villard

“…The presence of a two-turn alpha helix observed with circular dichroism and a trypsin activity inhibition suggested that the active principle could be a Kunitz-type inhibitor, which may interact with an integrin due to an Arginine Glycin Aspartate (RGD) motif. …”
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Adhesion Molecule Profile and the Effect of Anti-VLA-4 mAb Treatment in Experimental Autoimmune Encephalomyelitis, a Mouse Model of Multiple Sclerosis by Grażyna Pyka-Fościak, Grzegorz J. Lis, Jan A. Litwin

“…Monoclonal antibodies (mAb) against the α4 subunit of α4-β1 integrin (VLA-4) show beneficial effects in both MS and EAE. (1) Background: The aim of this study was to examine the expression of selected adhesion molecules: VLA-4, VCAM-1, LFA-1, ICAM-1 and PECAM-1 in the successive phases of EAE and the effect of anti-VLA-4 mAb treatment on that expression. (2) Methods: EAE was induced in C57BL/6 mice by immunization with MOG_35–55 peptide. …”
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Culture of glioblastoma U87 stem-like cells and identification of its metabolic phenotype and tumorigenic ability by QIU Jiaxing, LIU Yuhan, GUO Hongjiang, ZHANG Diya, WANG Yucheng, JU Rui, GUO Lei

“…The mRNA transcription of stemness biomarkers such as CD133, nestin, OLIG2, CD44, CD15, and integrin α6(ITGA6) was significantly increased as found in both culture methods, and the protein levels of CD133 and nestin were also increased under both methods(P＜0.05). …”
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Human Adult Astrocyte Extracellular Vesicle Transcriptomics Study Identifies Specific RNAs Which Are Preferentially Secreted as EV Luminal Cargo by Keerthanaa Balasubramanian Shanthi, Daniel Fischer, Abhishek Sharma, Antti Kiviniemi, Mika Kaakinen, Seppo J. Vainio, Geneviève Bart

“…Human adult astrocyte EVs ranged in sizes from 50 to 200 nm, with CD81 as the main tetraspanin marker and larger EVs positive for integrin β1. Comparison of the RNA between the cells and EVs identified RNA preferentially secreted in the EVs. …”
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Swine acute diarrhea syndrome coronavirus induces autophagy to promote its replication via the Akt/mTOR pathway by Siying Zeng, Yan Zhao, Ouyang Peng, Yu Xia, Qiuping Xu, Hongmei Li, Chunyi Xue, Yongchang Cao, Hao Zhang

“…Importantly, we identified integrin α3 (ITGA3) as a potential antiviral target upstream of Akt/mTOR and autophagy pathways. …”
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Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival by Conway, Anne E., Van Nostrand, Eric L., Pratt, Gabriel A., Aigner, Stefan, Wilbert, Melissa L., Sundararaman, Balaji, Lambert, Nicole J., Sathe, Shashank, Liang, Tiffany Y., Essex, Anthony, Landais, Severine, Burge, Christopher B., Jones, D. Leanne, Yeo, Gene W., Freese, Peter Dale, Lambert, Nicole, Burge, Christopher B

“…For cell adhesion, we find IMP1 maintains levels of integrin mRNA specifically regulating RNA stability of ITGB5 in hPSCs. …”
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Interstitial flow promotes macrophage polarization toward an M2 phenotype by Serrano, Jean Carlos, Zaman, Muhammad, Li, Ran, Xing, Hao, Lee, Tara A., Azizgolshani, Hesham, Kamm, Roger Dale

“…Specifically, interstitial flow (IF) polarizes macrophages toward an M2-like phenotype via integrin/Src-mediated mechanotransduction pathways involving STAT3/6. …”
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Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales by Yannas, Ioannis V, Tzeranis, Dimitrios, So, Peter T. C.

“…Keywords: Regeneration, Skin, Peripheral nerves, Phenotype change, Contraction blocking, Integrin-ligand interaction…”
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Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging by Schuerle, Simone, Furubayashi, Maiko, Soleimany, Ava P., Gwisai, Tinotenda, Huang, Wei, Voigt, Christopher A., Bhatia, Sangeeta N

“…To demonstrate the modularity of this versatile platform to incorporate diverse targeting ligands by genetic engineering, we also incorporated the cyclic αv integrin-binding peptide iRGD into separate magnetosomes. …”
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