Engineering polymer biomaterial interfaces for promoting cellular morphogenesis by Sofman, Marianna.

Get full text

Force-induced calcium concentration change and focal adhesion translocation : effects of force amplitude and frequency by Mack, Peter J. (Peter Joseph), 1980-

Get full text

A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures by Wu, Jonathan (Jonathan G.)

Get full text

Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia by Bosutti, Alessandra, Qi, Jie, Pennucci, Roberta, Bolton, David, Matou, Sabine, Ali, Kamela, Tsai, Li-Huei, Krupinski, Jerzy, Petcu, Eugene B., Montaner, Joan, Al Baradie, Raid, Caccuri, Francesca, Caruso, Arnaldo, Alessandri, Giulio, Kumar, Shant, Rodriguez, Cristina, Martinez-Gonzalez, Jose, Slevin, Mark

“…Here, we have identified a critical role of Cdk5 in cytoskeleton/focal dynamics, wherein its activator, p35, redistributes along actin microfilaments of spreading cells co-localising with p[subscript (Tyr15)]Cdk5, talin/integrin beta-1 at the lamellipodia in polarising cells. …”
Get full text
Get full text

Mechanism of acquired temozolomide resistance in glioblastoma by McFaline-Figueroa, José L

Get full text

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function by Barzik, Melanie, McClain, Leslie Marie, Gupton, Stephanie L., Gertler, Frank

“…Moreover, in the absence of Ena/VASP, filopodia generated by mDia2 did not support initiation of integrin-dependent signaling cascades required for adhesion and subsequent lamellipodial extension, thereby causing a defect in early cell spreading. …”
Get full text
Get full text
Get full text

Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness by Kotecki, Maciej, Zeiger, Adam S., Van Vliet, Krystyn J., Herman, Ira M.

“…We now report that the neutral cysteine protease, calpain, modulates pericyte contractility and cellular stiffness via talin, an integrin-binding and F-actin associating protein. Digital imaging and quantitative analyses of living cells reveal significant perturbations in contractile force transduction detected via deformation of silicone substrata, as well as perturbations of mechanical stiffness in cellular contractile subdomains quantified via atomic force microscope (AFM)-enabled nanoindentation. …”
Get full text
Get full text

Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma by Datta, Arnab, Chen, Christopher P., Sze, Siu Kwan

“…Bioinformatics analysis and data mining revealed up-regulation of brain-specific proteins including myelin basic protein, proteins of coagulation cascade (e.g., fibrinogen alpha chain, fibrinogen beta chain) and focal adhesion (e.g., integrin alpha-IIb, talin-1, and filamin-A) while albumin was down-regulated in both groups of patients with adverse outcome. …”
Get full text
Get full text

Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration by Ong, Seow Theng, Freeley, Michael, Skubis-Zegadło, Joanna, Fazil, Mobashar Hussain Urf Turabe, Kelleher, Dermot, Fresser, Friedrich, Baier, Gottfried, Verma, Navin Kumar, Long, Aideen

“…Following stimulation of T- cells through the integrin LFA-1 or the chemokine receptor CXCR4, Rab5a is phosphorylated on a N-terminal T7 site by PKC ε . …”
Get full text
Get full text

The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation by Tan, Hui-Foon, Tan, Suet-Mien

“…Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. …”
Get full text

Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapy by Zhang, Yonghe, Zhao, Ruibo, Liu, Jia, Kong, Hao, Zhang, Kebiao, Zhang, Yuan-Ning, Kong, Xiangdong, Zhang, Quan, Zhao, Yanli

“…Once they reach the tumor site, the first-stage size reduction occurs due to the hydrolysis of the Schiff base bond between polyethylene glycol and the cyclic Arg-Gly-Asp peptide in the acidic tumor microenvironment (pH~6.5), facilitating tumor penetration and specific recognition by cancer cells overexpressing integrin ανβ3 receptors. Upon the endocytosis by cancer cells, the second-stage size reduction is triggered by more acidic pH in lysosomes (pH~4.5). …”
Get full text

Nγ-hydroxyasparagine: a multifunctional unnatural amino acid that is a good P1 substrate of asparaginyl peptide ligases by Xia, Yiyin, To, Janet, Chan, Ning-Yu, Hu, Side, Liew, Heng Tai, Balamkundu, Seetharamsing, Zhang, Xiaohong, Lescar, Julien, Bhattacharjya, Surajit, Tam, James P., Liu, Chuan-Fa

“…By this approach, we synthesized several bioactive Asp-containing cyclic peptides (MCoTI-II, kB2, SFTI, and integrin-targeting RGD peptides) that are otherwise difficult targets for PAL-catalyzed cyclization owing to unfavorable kinetics of the P1-Asp substrates. …”
Get full text

Physical forces guide curvature sensing and cell migration mode bifurcating by Feng, Luyi, Zhao, Tiankai, Xu, Hongmei, Shi, Xuechen, Li, Changhao, Hsia, K. Jimmy, Zhang, Sulin

“…Here, we reveal a curvature sensing mechanism in which surface tension can selectively activate either actin or integrin flows, leading to bifurcating cell migration modes: focal adhesion formation that enables cell crawling at convex front edges and actin cable assembly that pulls cells forward at concave front edges. …”
Get full text

LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway by Ong, Seow Theng, Low, Jian Hui, Kottaiswamy, Amuthavalli, Kizhakeyil, Atish, Kumar, Sunil, Panda, Aditya K., Freeley, Michael, Smith, Sinead M., Boehm, Bernhard O., Kelleher, Dermot, Verma, Navin Kumar, Mobashar Hussain Urf Turabe Fazil, Chalasani, Madhavi Latha Somaraju, Praseetha P

“…In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. …”
Get full text
Get full text

Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer. by Khong, T, Thairu, N, Larsen, H, Dawson, P, Kiriakidis, S, Paleolog, E

“…These additional genes included chemokines (CCL-11/eotaxin-1 and interleukin-8), collagen type IV α3 chain, integrin β3 chain, TGFα and VEGF receptor KDR. CONCLUSION: These findings suggest that although EGFR phosphorylation activates the MAP kinase signalling and promotes HIF stabilisation in CRC, this alone is not sufficient to induce angiogenic gene expression. …”

Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms by Digby, J, Martinez, F, Jefferson, A, Ruparelia, N, Chai, J, Wamil, M, Greaves, DR, Choudhury, R

“…NA potently inhibited monocyte adhesion to activated HUVEC, and VCAM, mediated by the integrin, very late antigen 4. Monocyte chemotaxis was also significantly reduced (by 45.7±1.2%; P<0.001). …”

A study of the Human Platelet Antigen 1a (HPA-1a) antibody response in neonatal alloimmune thrombocytopenia (NAIT) by Allen, D, David L Allen

“…In Caucasians, antibodies against the Leu33 (HPA-1a) polymorphism of integrin β3 (part of the platelet αIIbβ3 complex) account for >70% of cases. …”

1 α ,25-dihydroxyvitamin D3 acts via transforming growth factor- β to up-regulate expression of immunosuppressive CD73 on human CD4 + Foxp3 - T cells by Mann, E, Chambers, E, Chen, Y, Richards, D, Hawrylowicz, C

“…Although 1,25(OH)2D3 did not affect the mRNA expression of latent TGF‐β1, 1,25(OH)2D3 did up‐regulate expression of TGF‐β‐associated molecules [latency‐associated peptide (LAP), glycophorin A repetitions predominant (GARP), GP96, neuropilin‐1, thrombospondin‐1 and αv integrin] which is likely to have contributed to the observed enhancement in TGF‐β bioactivity. …”

Impaired P2X1 receptor-mediated adhesion in eosinophils from asthmatic patients by Wright, A, Mahaut-Smith, M, Symon, F, Sylvius, N, Ran, S, Bafadhel, M, Muessel, M, Bradding, P, Wardlaw, A, Vial, C

“…Healthy human eosinophils express functional P2X1 receptors whose activation leads to eosinophil αMβ2 integrin-dependent adhesion. P2X1 responses are constitutively reduced in asthmatic compared with healthy eosinophils, probably as the result of an increase in extracellular nucleotide concentration.…”

The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. by Hollis-Moffatt, J, Rowley, K, Phipps-Green, A, Merriman, M, Dalbeth, N, Gow, P, Harrison, A, Highton, J, Jones, P, Stamp, L, Harrison, P, Wordsworth, B, Merriman, T

“…The ITGAV +gene encodes a cell cycle-associated antigen, integrin alphanubeta 3, which plays a role in RA angiogenesis. …”