The safety profile of vedolizumab in ulcerative colitis and Crohn's disease: 4 years of global post-marketing data by Cohen, R, Bhayat, F, Blake, A, Travis, S

“…<p><strong>Background and Aims</strong> Vedolizumab is a gut-selective antibody to α₄β₇ integrin approved to treat moderate-to-severe ulcerative colitis and Crohn’s disease in adults. …”

Transcriptomics of cortical gray matter thickness decline during normal aging by Kochunov, P, Charlesworth, J, Winkler, A, Hong, L, Nichols, T, Curran, J, Sprooten, E, Jahanshad, N, Thompson, P, Johnson, M, Kent, J, Landman, B, Mitchell, B, Cole, SA, Dyer, T, Moses, E, Goring, H, Almasy, L, Duggirala, R, Olvera, R, Glahn, D, Blangero, J

“…Pathway enrichment analysis identified six functional categories including cellular proliferation, aggregation, differentiation, viral infection, and metabolism. The integrin signaling pathway was significantly (p &lt; 10⁻⁶) enriched with GMT. …”

Structural and functional study of picornaviruses by Zhu, L

“…On the outer surface a polyproline helix structure, not seen previously in picornaviruses is present at the C-terminus of VP1, corresponding to the position where integrin binding motifs are found in some other picornaviruses. …”

Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. by Digby, J, Martinez, F, Jefferson, A, Ruparelia, N, Chai, J, Wamil, M, Greaves, D, Choudhury, R

“…NA potently inhibited monocyte adhesion to activated HUVEC, and VCAM, mediated by the integrin, very late antigen 4. Monocyte chemotaxis was also significantly reduced (by 45.7±1.2%; P&lt;0.001). …”

Integrative structural biology of viruses by Duyvesteyn, HME

“…</p> <p>Finally, preliminary investigations into aphthovirus uncoating include attempts to express full length α_vβ₆ integrin receptor and a preliminary structure of FMDV bound to α_vβ₃ head-group, demonstrating VLP affinity for virus receptors. …”

Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment by Nettleship, J, Ren, J, Scott, D, Rahman, N, Hatherley, D, Zhao, Y, Stuart, D, Barclay, N, Owens, R

“…SIRPγ is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. …”

Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1&prime;<em>S</em>-1&prime;-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells by Liew, S.K., Azmi, M.N., In, L.L.A., Awang, Khalijah, Nagoor, Noor Hasima

“…They also downregulated the expression levels of pFAK/FAK and pAkt/Akt via the integrin β1-mediated signaling pathway. Collectively, ACA and its hemi-synthetic analogs, AEA and AMCA are seen as potential anticancer agents following their abilities to suppress growth, induce apoptosis, and inhibit migration of breast cancer cells.…”

The effect of TGF-β1 and β-estradiol on glycosaminoglycan and type II collagen distribution in articular chondrocyte cultures by Abdul Rahim, S., Selvaratnam, L., Kamarul, Tunku

“…Articular cartilage extracellular matrix (ECM) plays a crucial role in regulating chondrocyte functions via cell—matrix interaction, cytoskeletal organization and integrin‐mediated signaling. Factors such as interleukins, basic fibroblast growth factor (bFGF), bone morphogenic proteins (BMPs) and insulin‐like growth factor (IGF) have been shown to modulate the synthesis of extracellular matrix in vitro. …”

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes by Ahmad Mahfuz, Gazali, Schroderus, Anna-Mari, Salonen, Kirsti Näntö, Rintamäki, Reeta, Pihlajamäki, Jussi, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, Ilonen, Jorma, Kinnunen, Tuure

“…Results Children with newly diagnosed type 1 diabetes displayed a proportional increase of CD8−CD27− MAIT cells compared with healthy control children (median 4.6% vs 3.1% ofMAIT cells, respectively, p = 0.004), which was associated with reduced expression of C-C chemokine receptor (CCR)5 (median 90.0% vs 94.3% of MAIT cells, p = 0.02) and β7 integrin (median 73.5% vs 81.7% of MAIT cells, p = 0.004), as well as decreased production of IFN-γ (median 57.1% vs 69.3% of MAIT cells,…”
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An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility by Keita Negishi, Kenichi Aizawa, Takayuki Shindo, Toru Suzuki, Takayuki Sakurai, Yuichiro Saito, Takuya Miyakawa, Masaru Tanokura, Yosky Kataoka, Mitsuyo Maeda, Shota Tomida, Hiroyuki Morita, Norifumi Takeda, Issei Komuro, Kazuomi Kario, Ryozo Nagai, Yasushi Imai

“…Notably, the Myh11 ∆K/+ mice developed aortic dissections and intramural haematomas when stimulated with angiotensin II. Mechanistically, integrin subunit alpha2 (Itga2) was downregulated in the Myh11 ∆K/∆K aortas, and the smooth muscle cell lineage cells that differentiated from Myh11 ∆K/∆K induced pluripotent stem cells. …”
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Graphene Oxide Loaded on TiO₂-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts by Xu Cao, Keyi Wu, Caiyun Wang, Yatong Guo, Ran Lu, Xin Wang, Su Chen

“…Cell adhesion, cell proliferation, cell immunofluorescence staining, a wound-healing assay, real-time reverse-transcriptase polymerase chain reaction (RT-PCR), and Western blotting showed that the proliferation, adhesion, migration, and adhesion-related relative gene expression of HGFs on TNT-GO were significantly enhanced compared to the control groups, which may be mediated by the activation of integrin β1 and the MAPK-Erk1/2 pathway. Our findings suggest that the biological reactivity of HGFs can be enhanced by the TNT-GO surface, thereby improving the soft tissue sealing ability.…”
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Comparative Evaluation of the Foot-and-Mouth Disease Virus Permissive LF-BK α_Vβ₆ Cell Line for Senecavirus A Research by Jessica Mason, Victoria Primavera, Lauren Martignette, Benjamin Clark, Jose Barrera, Janine Simmons, William Hurtle, John G. Neilan, Michael Puckette

“…The LF-BK α_Vβ₆ cell line is a porcine-derived cell line transformed to stably express an α_Vβ₆ bovine integrin and primarily used for enhanced propagation of Foot-and-mouth disease virus (FMDV). …”
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Selective Inhibition of Histone Deacetylation in Melanoma Increases Targeted Gene Delivery by a Bacteriophage Viral Vector by Samuel Campbell, Keittisak Suwan, Sajee Waramit, Eric Ofori Aboagye, Amin Hajitou

“…AAVP is targeted to these integrins via a double cyclic RGD4C ligand displayed on the phage capsid. …”
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Alternative polyadenylation events in epithelial cells sense endometritis progression in dairy cows by Meagan J. STOTTS, Yangzi ZHANG, Shuwen ZHANG, Jennifer J. MICHAL, Juan VELEZ, Bothe HANS, Martin MAQUIVAR, Zhihua JIANG

“…Host CD59 molecule (CD59), Fc fragment of IgG receptor IIa (FCGR2A), lymphocyte antigen 75 (LY75) and plasminogen (PLG) may serve as initial contacts or combats with pathogens on cell surface, followed by activation of nuclear receptor subfamily 1 group H member 4 (NR1H4) to regulate AXL receptor tyrosine kinase (AXL), FGR proto-oncogene, Src family tyrosine kinase (FGR), HCK proto-oncogene, Src family tyrosine kinase (HCK) and integrin subunit beta 2 (ITGB2) for anti-inflammation. …”
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Transcription Factor ATF3 Participates in DeltaNp63-Mediated Proliferation of Corneal Epithelial Cells by Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Hui-Yi Hsiao, Chao-Min Cheng, Hui-Kang David Ma, Wei-Chi Wu, Hung-Chi Chen

“…The protein levels of keratin 3/14, integrin β1, and involucrin did not differ between <i>ATF3</i>-overexpressing CECs, <i>ATF3</i>-downregulated CECs, and control cells. …”
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Novel Polyethylene Glycol-Conjugated Triazole Derivative with High Thyrointegrin αvβ3 Affinity in Acute Myeloid Leukemia Management by Thangirala Sudha, Kavitha Godugu, Noureldien H. E. Darwish, Tipu Nazeer, Shaker A. Mousa

“…Primary AML cells express membrane αvβ3 integrin, which is associated with adverse prognosis and resistance to chemotherapies. …”
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<i>FERMT1</i> Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m⁶A Modification and Necroptosis by Qian Wu, Jin Li, Pei Wang, Qihang Peng, Zhongcui Kang, Yiting Deng, Jiayi Li, Dehong Yan, Feng Ge, Ying Chen

“…As an important member of the kindlin family, fermitin family member 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. …”
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The Role of Lactic Acid on Wound Healing, Cell Growth, Cell Cycle Kinetics, and Gene Expression of Cultured Junctional Epithelium Cells in the Pathophysiology of Periodontal Diseas... by Taichi Ishikawa, Daisuke Sasaki, Ryo Aizawa, Matsuo Yamamoto, Takashi Yaegashi, Tarou Irié, Minoru Sasaki

“…LA also enhanced mRNA expression of integrin α5, interleukin (IL)-6, IL-8, intercellular adhesion molecule-1, and receptor activator of nuclear factor kappa-B ligand. …”
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Structural analysis and molecular dynamics simulation studies of HIV-1 antisense protein predict its potential role in HIV replication and pathogenesis by Balakumaran Sathiyamani, Balakumaran Sathiyamani, Evangeline Ann Daniel, Evangeline Ann Daniel, Samdani Ansar, Bennett Henzeler Esakialraj, Sameer Hassan, Prasanna D. Revanasiddappa, Amrutha Keshavamurthy, Sujata Roy, Umashankar Vetrivel, Luke Elizabeth Hanna

“…In spite of sequence and structural differences in subtype B and C ASP, both structures appear to share common domains like the Von Willebrand Factor Domain-A (VWFA), Integrin subunit alpha-X (ITGSX), and ETV6-Transcriptional repressor, thereby reiterating the potential role of HIV-1 ASP in transcriptional repression and autophagy, as reported in earlier studies. …”
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New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms by Anna Gorrasi, Anna Maria Petrone, Anna Li Santi, Mariaevelina Alfieri, Nunzia Montuori, Pia Ragno

“…Interestingly, blocking uPAR association with FPRs also impairs β1 integrin partitioning to lipid rafts, whereas blocking its association with β1 integrins has no effect on FPRs partitioning. …”
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