Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-S... by Marije E. Kuipers, Marije E. Kuipers, D. Linh Nguyen, Angela van Diepen, Lynn Mes, Erik Bos, Roman I. Koning, Esther N. M. Nolte-’t Hoen, Hermelijn H. Smits, Cornelis H. Hokke

“…We previously reported on specific fucose-containing glycans present on extracellular vesicles (EVs) released by schistosomula, the early juvenile life stage of the schistosome, and the interaction of these EVs with the C-type lectin receptor Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN or CD209). EVs are membrane vesicles with a size range between 30–1,000 nm that play a role in intercellular and interspecies communication. …”
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Constructing interactive networks of functional genes and metabolites to uncover the cellular events related to colorectal cancer cell migration induced by arsenite by Ruijia Zhang, Jin Sun, Lanyin Tu, Wenhua Lu, Yizheng Li, Tiangang Luan, Baowei Chen

“…Following iAsIII treatment, the expression of ZEB1 and SLUG protein was significantly upregulated while the expression of CRB2 was downregulated (p < 0.05), indicating the onset of epithelial to mesenchymal transition (EMT). Meanwhile, integrin- and collagen-mediated biological adhesion were enhanced by SLUG under iAsIII treatment. …”
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Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate S. rosetta by Laura A Wetzel, Tera C Levin, Ryan E Hulett, Daniel Chan, Grant A King, Reef Aldayafleh, David S Booth, Monika Abedin Sigg, Nicole King

“…In animals, glycosyltransferases sculpt the polysaccharide-rich ECM, regulate integrin and cadherin activity, and, when disrupted, contribute to tumorigenesis. …”
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Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis by Asli Kutlu, Merve Arda, Evren Atak, Engin Ulukaya

“…According to the results of upregulated gene sets, integrin cell surface interaction (R-HSA 216083), MET activates PTK2 signaling (R-HSA-8874081), degradation of the extracellular matrix (ECM) (R-HSA-1474228), nonintegrin membrane–ECM interaction (R-HSA-3000171), and assembly of collagen fibrils and other multimeric structures (R-HSA-2022090) are found as common pathways among these data sets, yet there is no reported common pathway within downregulated gene sets. …”
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Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis by Hans I-Chen Harn, Po-Yuan Chiu, Chein-Hong Lin, Hung-Yang Chen, Yung-Chih Lai, Fu-Shiuan Yang, Chia-Ching Wu, Ming-Jer Tang, Cheng-Ming Chuong, Michael W. Hughes

“…Differential gene expression analysis of FAK inhibitor-treated wound RNAseq data showed that cytoskeleton-, integrin-, and matrix-associated genes were downregulated, while hair follicular neogenesis, cell proliferation, and cell signaling genes were upregulated. …”
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iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity by María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia, Marina Simian

“…With the aim of developing a nanoformulation that would simultaneously tackle ER and FN/β1 integrin interactions, we designed polyethylene glycol-polycaprolactone polymersomes polymersomes (PS) that carry Tam and are functionalized with the tumor-penetrating iRGD peptide (iRGD-PS-Tam). …”
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Amelioration of rotenone-induced Parkinson's disease; comparing therapeutic role of erythropoietin versus low-level laser activation of mesenchymal stem cells (an in-vivo and in-vi... by Eman Mumtaz El Mahdy, Maha Gamal, Basma Emad Aboulhoda, Basent Adel Al Dreny, Ashraf Shamaa, Laila Rashed, Ahmed Nour Eldine Abdallah, Asmaa M. Shamseldeen

“…LLLT enhanced MSC expression of integrin β1 which was reflected in the homing of PKH26-labelled MSCs into corpus striatum and SN. …”
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Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1 by Tianzhu Lv, Hongjing Liu, Ling Mao, Yanrong Song, Lili Liao, Kun Zhong, Binbin Shuai, Yingkun Luo, Tingting Guo, Wentao Huang, Shenyingjie Zhang

“…Finally, loss-of-function assays were conducted to corroborate the involvement of polycomb complex protein BMI-1 (BMI1) and integrin beta1 (ITGB1). Results CAF-EVs promoted the malignant behavior of OCSCC cells and accelerated tumor growth and lymph node metastasis in mice. …”
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Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior by Stephan Raiders, Erik Calvin Black, Andrea Bae, Stephen MacFarlane, Mason Klein, Shai Shaham, Aakanksha Singhvi

“…The phosphatidylserine (PS) flippase TAT-1/ATP8A functions with glial PS-receptor PSR-1/PSR and PAT-2/α-integrin to initiate engulfment. This activates glial CED-10/Rac1 GTPase through the ternary GEF complex of CED-2/CrkII, CED-5/DOCK180, CED-12/ELMO. …”
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Maternal high-fat diet alters expression of pathways of growth, blood supply and arachidonic acid in rat placenta by Marloes Dekker Nitert, Kanchan Vaswani, Melissa Hum, Hsiu-Wen Chan, Ryan Wood-Bradley, Sarah Henry, James A. Armitage, Murray D. Mitchell, Gregory E. Rice

“…The up-regulation in messenger RNA expression for five genes Ptgs2 (fatty acid cyclo-oxidase 2; COX2), Limk1 (LIM domain kinase 1), Pla2g2a (phospholipase A2), Itga1 (integrin α-1) and Serpine1 was confirmed by real-time PCR. …”
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Co-Detection of VEGF-A and Its Regulator, microRNA-181a, May Indicate Central Nervous System Involvement in Pediatric Leukemia by Bálint Egyed, Bálint Egyed, Bálint Egyed, Anna Horváth, Ágnes F. Semsei, Csaba Szalai, Judit Müller, Dániel J. Erdélyi, Gábor T. Kovács

“…Serial liquid biopsy samples (n = 65) were analyzed by Elisas to measure the level of essential proteins associated with blast cell CNS trafficking, vascular endothelial growth factor A (VEGF-A) and integrin alpha 6 (ITGA6). In CSF samples from early induction chemotherapy, VEGF-A concentration were uniformly elevated in the CNS-positive group compared to those patients without unambiguous meningeal infiltration (9 vs Nine patients, Δc = 17.2 pg/ml, p = 0.016). …”
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Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology by Daniela Nogueira Rocha, Daniela Nogueira Rocha, Eva Daniela Carvalho, Eva Daniela Carvalho, Eva Daniela Carvalho, João Bettencourt Relvas, João Bettencourt Relvas, João Bettencourt Relvas, Maria José Oliveira, Maria José Oliveira, Maria José Oliveira, Ana Paula Pêgo, Ana Paula Pêgo, Ana Paula Pêgo

“…The mechanisms that mediate mechanotransduction events, like integrin, Rho/ROCK and matrix metalloproteinases signaling pathways are revised. …”
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Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson’s Disease... by Vanessa Penna, Niamh Moriarty, Yi Wang, Kevin C. L. Law, Carlos W. Gantner, Richard J. Williams, David R. Nisbet, Clare L. Parish

“…Hydrogels were fabricated from self-assembling peptides (SAP), presenting an epitope for laminin, the brain’s main extracellular matrix protein, thereby providing cell adhesive support for the grafts and additional laminin–integrin signalling to influence cell fate. We show that SDF1 functionalised SAP hydrogels resulted in larger grafts, containing more DA neurons, increased A9 DA specification (the subpopulation of DA neurons responsible for motor function) and enhanced innervation. …”
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Anti-angiogenic collagen IV-derived peptide target engagement with αvβ3 and α5β1 in ocular neovascularization models by Raquel Lima e Silva, Adam C. Mirando, Stephany Y. Tzeng, Jordan J. Green, Aleksander S. Popel, Niranjan B. Pandey, Peter A. Campochiaro

“…Summary: AXT107, a collagen-derived peptide that binds integrins αvβ3 and α5β1 with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization (NV) and vascular leakage. …”
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Lifitegrast Ophthalmic Solution 5% Is a Safe and Efficient Eyedrop for Dry Eye Disease: A Systematic Review and Meta-Analysis by Jing-Xing Li, Yi-Yu Tsai, Chun-Ting Lai, You-Ling Li, Ying-Hsuen Wu, Chun-Chi Chiang

“…Lifitegrast, a novel T-cell integrin antagonist, was approved in the United States in July 2016 as a 5% (50 mg/mL) ophthalmic solution for DED management. …”
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Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis by Zhao Wei, Meng Lei, Yaohui Wang, Yizhou Xie, Xueyong Xie, Dongwei Lan, Yuanbo Jia, Jingyi Liu, Yufei Ma, Bo Cheng, Sharon Gerecht, Feng Xu

“…We unravel that the high plasticity of the hydrogels promotes stable integrin cluster of ECs and recruitment of focal adhesion kinase with an overenhanced contractility which downregulates the vascular endothelial cadherin expression and destabilizes the adherens junctions between individual ECs. …”
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Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness by Natalie S. Joe, Inês Godet, Nubaira Milki, Noor U. I. Ain, Harsh H. Oza, Gregory J. Riggins, Daniele M. Gilkes

“…We found that MBZ reduces integrin β4 (ITGβ4) expression and cancer stem cell properties. …”
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Differentiation of keratinocytes or exposure to type 2 cytokines diminishes S. aureus internalization by Alexis R. Morgenstern, Liam F. Peterson, Kimberly A. Arnold, Matthew G. Brewer

“…Finally, of the receptors reported for S. aureus binding/internalizing into keratinocytes, expression of the α5 component of the α5β1 integrin was in greatest accordance with the number of internalized bacteria in the context of keratinocyte differentiation.IMPORTANCEIndividuals with chronic cutaneous diseases demonstrate heightened susceptibility for severe and recurrent infections from Staphylococcus aureus. …”
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Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet–Mediated Amyloid Aggregation in Alzheimer’s Disease by Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S. Reichert, Madhumita Chatterjee, Margitta Elvers

“…Enhanced mitochondrial dysfunction triggered platelet-mediated Aβ40 aggregate formation through GPVI-mediated ROS production, leading to enhanced integrin αII_bβ₃ activation during synergistic stimulation from ADP and Aβ40. …”
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Increased circulating platelet-derived extracellular vesicles in severe COVID-19 disease by Tuukka Helin, Mari Palviainen, Marja Lemponen, Katariina Maaninka, Pia Siljander, Lotta Joutsi-Korhonen

“…Small EV detection (sEVs; 50–200 nm) and CD41a (platelet integrin) colocalization with general EV markers CD9, CD63, and CD81 were performed by single particle interferometric reflectance imaging sensor. …”
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