Mesenchymal Stem Cell Sheet Centrifuge-Assisted Layering Augments Pro-Regenerative Cytokine Production by Sophia Bou-Ghannam, Kyungsook Kim, Makoto Kondo, David W. Grainger, Teruo Okano

“…Centrifugation enhanced cell physical and biochemical interactions related to intercellular communication and matrix interactions within the single cell sheet, upregulating MSC gene expression of connexin 43, integrin β1, and laminin α5. Single cell sheet centrifugation triggered MSC functional enhancement, secreting higher concentrations of pro-regenerative cytokines vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and interleukin-10 (IL-10). …”
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437 Novel Targeting of Semaphorin 7a-Mediated Survival Signaling in ER+ Breast Cancer to Mitigate Therapy Resistance by Rachel Steinmetz, Traci Lyons

“…SEMA7A is a membrane-bound protein that can inhibit tumor cell death via integrin-mediated PI3K/Akt pro-survival signaling. …”
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Evaluation of ITGB1 expression as a predictor of the therapeutic effects of immune checkpoint inhibitors in gastric cancer by Chao Xu, Xiao-Li Xie, Ning Kang, Hui-Qing Jiang

“…Immunotherapy is an important method for gastric cancer while lack of effective predictor. Integrins play an important role in the development. …”
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Oleanolic Acid’s Semisynthetic Derivatives HIMOXOL and Br-HIMOLID Show Proautophagic Potential and Inhibit Migration of HER2-Positive Breast Cancer Cells In Vitro by Natalia Magdalena Lisiak, Izabela Lewicka, Mariusz Kaczmarek, Jacek Kujawski, Barbara Bednarczyk-Cwynar, Lucjusz Zaprutko, Blazej Rubis

“…They also decreased cell viability, induced autophagy, and (when applied in sub-cytotoxic concentrations) decreased the migration of SK-BR-3 cells.This study is the first to report the cytostatic, proautophagic (mTOR/LC3/SQSTM/BECN1 pathway), and anti-migratory (integrin β1/FAK/paxillin pathway) activities of HIMOXOL and Br-HIMOLID in HER2-positive breast cancer cells.…”
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Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics by Shiv Verma, Eswar Shankar, F. Naz Cemre Kalayci, Amrita Mukunda, Malek Alassfar, Vaibhav Singh, E. Ricky Chan, Gregory T. MacLennan, Sanjay Gupta

“…Amongst the pathways enriched in the enzalutamide-resistant cells were those associated with RUNX2, hedgehog, integrin signaling, and molecules associated with elastic fibers. …”
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RGD-Coated Polymer Nanoworms for Enriching Cancer Stem Cells by Yushu Gu, Valentin Bobrin, Dayong Zhang, Bing Sun, Chun Ki Ng, Sung-Po R. Chen, Wenyi Gu, Michael J. Monteiro

“…RGD was used as a targeting motif and a ligand to bind integrin receptors. We found that the system was able to increase sphere forming efficiency, promote the growth of spheric cells, and maintain stemness-associated properties compared to the current 3D culture. …”
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Identification Analysis of Eukaryotic Expression Plasmid Rap2a and Its Effect on the Migration of Lung Cancer Cells by Jinxia WU, Miaomiao SANG, Wenjia CAO, Junnian ZHENG, Dongsheng PEI

“…Background and objective Rap2a, a member of the small GTPase superfamily, plays a critical role in regulating the function of integrin and cell adhesion, thereby controlling cell motility and cell/matrix interactions. …”
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FITC-Labeled RGD Peptides as Novel Contrast Agents for Functional Fluorescent Angiographic Detection of Retinal and Choroidal Neovascularization by Seung Woo Choi, Hye Kyoung Hong, Jehwi Jeon, Ji Young Choi, Minah Kim, Pilhan Kim, Byung Chul Lee, Se Joon Woo

“…Here, using the arginine−glycine−aspartic acid (RGD) peptide’s affinity for integrin α_vβ₃, which is expressed in the neovascular endothelial cells in ocular tissues, we propose the use of fluorescein isothiocyanate (FITC)-labeled RGD peptide as a novel dye for effective molecular imaging of CNV. …”
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Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy by Chunai Gong, Jing Tian, Zhuo Wang, Yuan Gao, Xin Wu, Xueying Ding, Lei Qiang, Guorui Li, Zhimin Han, Yongfang Yuan, Shen Gao

“…We developed a strategy to isolate Exo exhibiting increased binding to integrin αvβ3. Binding occurred through a modified version of a disintegrin and metalloproteinase 15 (A15) expressed on exosomal membranes (A15-Exo), which facilitated co-delivery of therapeutic quantities of doxorubicin (Dox) and cholesterol-modified miRNA 159 (Cho-miR159) to triple-negative breast cancer (TNBC) cells, both in vitro and in vivo. …”
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<i>Clostridium</i> <i>n</i><i>ovyi’s</i> Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells by Theresa Schweitzer, Harald Genth, Andreas Pich

“…Interestingly, various signaling pathways such as <i>Signaling by Rho Family GTPases</i> or <i>Integrin Signaling</i> were activated on proteome level while being inhibited on phosphorylation level or vice versa as observed for the <i>Role of BRCA1 in DNA Damage Response</i>. …”
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High-Throughput In Vitro Screening Identified Nemadipine as a Novel Suppressor of Embryo Implantation by Xian Chen, Sudini Ranshaya Fernando, Yin-Lau Lee, William Shu-Biu Yeung, Ernest Hung-Yu Ng, Raymond Hang-Wun Li, Kai-Fai Lee

“…The transcript expressions of endometrial receptivity markers, integrin αV (<i>ITGAV</i>) and mucin 1 (<i>MUC1</i>), but not β-catenin (<i>CTNNB1</i>), were significantly decreased at 2.5 dpc in the uterus of treated mice compared with controls. …”
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Transcriptome changes in ERGIC3-knockdown hepatocellular carcinoma cells: ERGIC3 is a novel immune function related gene by Mengyuan Liu, Qiurong Zhao, Xiang Zheng, Lei Yang, Yanyu Zhao, Xueying Li, Mingsong Wu

“…Analysis of the pathways and biological processes that enrich the function of differentially expressed genes showed thatthese differentially expressed genes were mainly involved in vesicular transport, growth factors, PI3K-Akt, NOD-like, Jak-STAT, NF-kappa B and other protein kinase-coupled receptors mediated signal transduction pathways, tumor immune response, collagen-integrin receptor-actin axis, and miRNA pathways. More importantly, most of the significantly altered pathways were related to immunity. …”
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Downregulation of ITGβ3 in colon adenocarcinoma reveals poor prognosis by affecting genome stability, cell cycle, and the tumor immune microenvironment by Lei Zhao, Xiaoting Ma, Guangxin Li, Pengfei Zhao, Haishan Lin, Yingjie Ma, Huihui Li, Jing Yu

“…IntroductionAbnormal expression of integrin subunit beta 3 (ITGβ3), a gene-encoding protein, is related to the occurrence and development of cancers; however, the biological role of ITGβ3 in colon adenocarcinoma (COAD) remains unclear.MethodsWe used the Cancer Genome Atlas database to obtain the clinical data of patients with COAD, analyzed the mRNA gene clusters related to ITGβ3, and analyzed the interaction signal pathway and interaction protein network of the differentially expressed gene clusters. …”
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A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis by William J. Olson, William J. Olson, Bojana Jakic, Verena Labi, Johannes Woelk, Emmanuel Derudder, Gottfried Baier, Natascha Hermann-Kleiter

“…The proliferation of Nr2f6-/- peritoneal B cells was not altered, while the migration marker CXCR5 was reduced on all subsets but Beta7-integrin was reduced only on peritoneal B1b and B2 cells. …”
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Functional and Genetic Characterization of Porcine Beige Adipocytes by Lilan Zhang, Silu Hu, Chunwei Cao, Chuanhe Chen, Jiali Liu, Yu Wang, Jianfeng Liu, Jianguo Zhao, Cong Tao, Yanfang Wang

“…In addition, two genes, integrin alpha-2 (ITGA2) and calponin 1 (CNN1), which were specifically differentially expressed in porcine beige adipocytes, were further functionally characterized using a loss-of-function approach. …”
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Smart nanoplatform for sequential drug release and enhanced chemo-thermal effect of dual drug loaded gold nanorod vesicles for cancer therapy by Falian Zhu, Guozhu Tan, Yingtao Zhong, Yaodong Jiang, Lulu Cai, Zhiqiang Yu, Shuwen Liu, Fei Ren

“…The specific banding of cRGD to αvβ3 integrin receptor on the tumor cell surfaces facilitated the endocytosis of PTX/CUR/Au NRs@cRGD, and the near-infrared ray (NIR) further enhanced the drug release and chemotherapeutical efficiency. …”
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Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomater... by Mischa Selig, Jasmin C. Lauer, Melanie L. Hart, Bernd Rolauffs

“…Ample evidence demonstrates that multiple molecular aspects of CH and mesenchymal stromal cell (MSC) phenotype are susceptible to material stiffness, because proliferation, migration, lineage determination, shape, cytoskeletal properties, expression profiles, cell surface receptor composition, integrin subunit expression, and nuclear shape and composition of CHs and/or MSCs are stiffness-regulated. …”
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Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles by Stella Marie Reamon-Buettner, Susanne Rittinghausen, Annika Klauke, Andreas Hiemisch, Christina Ziemann

“…In all datasets, among highly- scoring predicted canonical pathways were Phagosome Formation, IL8 Signaling, Integrin Signaling, RAC Signaling, and TREM1 Signaling. …”
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Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion by Bianca Cruz Pachane, Ana Carolina Caetano Nunes, Thais Regiani Cataldi, Kelli Cristina Micocci, Bianca Caruso Moreira, Carlos Alberto Labate, Heloisa Sobreiro Selistre-de-Araujo, Wanessa Fernanda Altei

“…In hypoxia, SEVh was responsible for proteolytic and catabolic pathway inducement, interfering with integrin availability and gelatinase expression. Overall, our results demonstrate the importance of hypoxic signaling via SEV in tumors for the early establishment of metastasis.…”
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Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer by Yu-Lian Chen, Wan-Hua Tsai, Ying-Chieh Ko, Ting-Yu Lai, Ann-Joy Cheng, Shine-Gwo Shiah, Jenn-Ren Hsiao, Jang-Yang Chang, Su-Fang Lin

“…The discoidin domain receptor-1 (DDR1) is a non-integrin collagen receptor recently implicated in the collective cell migration of other cancer types. …”
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