Fcγ receptors on aging neutrophils by Thaís Helena GASPAROTO, Thalita Marcato DALBONI, Nádia Ghinelli AMÔR, Aneli Eiko ABE, Graziela PERRI, Vanessa Soares LARA, Narciso Almeida VIEIRA, Carlos Teodoro GASPAROTO, Ana Paula CAMPANELLI

“…Conclusions Our results suggest that, in humans, the overall pattern of FcγR expression and integrin CD11b are altered during aging and immunosenescence might contribute to age-related infection.…”
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Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells by Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv

“…Single-cell RNA sequencing analysis of WT and Lrg1 −/− mouse brain tissues after cerebral ischemia‒reperfusion injury revealed that Lrg1 knockout enhances blood‒brain barrier (BBB) by upregulating claudin 11, integrin β5, protocadherin 9, and annexin A2. Lrg1 knockout also promoted an anti-inflammatory and tissue-repairing phenotype in microglia and macrophages while reducing neuron and oligodendrocyte cell death. …”
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Modeling of Biological Activity of PEO-Coated Titanium Implants with Conjugates of Cyclic RGD Peptide with Amino Acid Bisphosphonates by Lyudmila V. Parfenova, Zulfiya R. Galimshina, Guzel U. Gil’fanova, Eliza I. Alibaeva, Ksenia V. Danilko, Veta R. Aubakirova, Ruzil G. Farrakhov, Evgeny V. Parfenov, Ruslan Z. Valiev

“…Therefore, the aim of this work was to develop approaches to control the biological activity of the titanium surface by creating coatings that combine both an inorganic phase with a given morphology and organic molecules containing an integrin-selective peptide that regulate cell adhesion and proliferation. …”
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T Cell Repertoire Homogeneity and Blood-Gut Overlap in Patients With Inflammatory Bowel DiseaseSummary by Kyle G. Williams, Ramya Kongala, Donna M. Shows, Andrew J. Konecny, Duncan C. Hindmarch, Astrid S. Clarke, James D. Lord

“…CD8 TCR repertoires overlapped between the colon and each peripheral blood subpopulation studied, with the highest overlap seen for integrin α4β7+ T cells. Inflamed tissue consistently overlapped more than uninflamed tissue with each blood subpopulation. …”
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Quantitative proteomics reveals potential anti-inflammatory protein targets of radial extracorporeal shock wave therapy in TNF-α-induced model of acute inflammation in primary huma... by Ruidong Ge, Qianzheng Zhu, Die Liu, Qi Zhang, Shan Jiang, Xueying Yu, Jun Shu, Fuqiang Gao, Jingwei Guo, Shengxuan Chen, Beiyao Gao

“…Further, we identified integrin α2, selenoprotein S, and NLR family CARD domain-containing protein 4 as pivotal molecular targets of the anti-inflammatory effects of rESWT. …”
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Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations by Adriana Di-Battista, Bianca Pereira Favilla, Malú Zamariolli, Natália Nunes, Alexandre Defelicibus, Lucia Armelin-Correa, Israel Tojal da Silva, Alexandre Reymond, Mariana Moyses-Oliveira, Maria Isabel Melaragno

“…Results We observed differential expression in 85 coding genes, associated with protein regulation, multicellular regulation, integrin signaling, and immune response pathways, and 120 differential peaks for the three interrogated histone marks, most of which were mapped in high-activity chromatin state regions. …”
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Ameliorative Effects of Camel Milk and Its Exosomes on Diabetic Nephropathy in Rats by Amira M. Shaban, Mai Raslan, Safa H. Qahl, Khaled Elsayed, Mohamed Sayed Abdelhameed, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Ola Hammouda, Mohammed A. El-Magd

“…Treatment with camel milk and/or its EXOs ameliorated DN as evidenced by (1) reduced levels of kidney function parameters (urea, creatinine, retinol-binding protein (RBP), and urinary proteins), (2) restored redox balance (decreased lipid peroxide malondialdehyde (MDA) and increased the activity of antioxidants enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), (3) downregulated expression of DN-related genes (transforming growth factor-beta 1 (<i>TGFβ1</i>), intercellular adhesion molecules 1 (<i>ICAM1</i>), and transformation specific 1 (<i>ETS1</i>), integrin subunit beta 2 (<i>ITGβ2</i>), tissue inhibitors of matrix metalloproteinase 2 (<i>TIMP2</i>), and kidney injury molecule-1 (<i>KIM1</i>)), and (4) decreased renal damage histological score. …”
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Biologics in Focus: A Comprehensive Review of the Current Biological Therapies for Ulcerative Colitis in the United Arab Emirates (UAE) by Ahmed El-Sayed, Ceyhun Oztumer, Camellia Richards, Omar-Adam Salim, Mathuri Sivakumar, Laith Alrubaiy

“…There is only one licensed medication in the remaining classes: vedolizumab (anti-integrin) and ustekinumab (anti-interleukin). The length of studies varied from 6–8 weeks for induction studies and 52 weeks for maintenance studies. …”
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New Insights into the Role of HMGB2 in ST-Segment Elevation Myocardial Infarction by Qin H, Wang W, Hu L, Yu Z, Chen Y, Zhao Y, Liao Y, Yang R

“…Further investigation showed that the platelet aggregation induced by ADP, the activation of integrin αIIbβ 3 and CD62P expression on platelet surface were all enhanced by the recombinant HMGB2 (rHMGB2).Conclusion: In conclusion, HMGB2 may be the key molecule to regulate platelet activation in patients with STEMI, which may serve as a potential therapeutic target for STEMI.Keywords: ST-segment elevation myocardial infarction, STEMI, proteomics analysis, platelet, HMGB2…”
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Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation by Yvonne L. Latour, Kara M. McNamara, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Mohammad Asim, Kamery J. Williams, Caroline V. Hawkins, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson

“…Abstract The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major contributor to disease pathogenesis. Integrins are ubiquitously expressed cellular receptors that are highly involved in immune cell adhesion to endothelial cells while in the circulation and help facilitate extravasation into tissues. …”
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Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology by Yury O. Nunez Lopez, Anton Iliuk, Alejandra M. Petrilli, Carley Glass, Anna Casu, Richard E. Pratley

“…Among characteristic changes in the PDM and T2DM EVs, “integrin switching” appeared to be a central feature. …”
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MicroRNA-539-5p-Loaded PLGA Nanoparticles Grafted with iRGD as a Targeting Treatment for Choroidal Neovascularization by Jouri S. Alanazi, Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Awwad A. Radwan, Ahmed Bari, Qamraa Hamad Alqahtani, Hosam Gharib Abdelhady, Ibrahim Alsarra

“…The NPs were decorated with internalizing arginylglycylaspartic (RGD) peptide (iRGD), which specifically targets the alpha-v-beta-3 (αvβ3) integrin receptor that is overexpressed in blood vessels of ocular tissue in CNV patients. …”
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Initiation of fibronectin fibrillogenesis is an enzyme-dependent process by Shay Melamed, Shelly Zaffryar-Eilot, Elisabeth Nadjar-Boger, Rohtem Aviram, Huaning Zhao, Wesal Yaseen-Badarne, Rotem Kalev-Altman, Dalit Sela-Donenfeld, Oded Lewinson, Sophie Astrof, Peleg Hasson, Haguy Wolfenson

“…Summary: Fibronectin fibrillogenesis and mechanosensing both depend on integrin-mediated force transmission to the extracellular matrix. …”
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Interstitial flow influences direction of tumor cell migration through competing mechanisms by Charest, Joseph L., Polacheck, William Joseph, Kamm, Roger Dale

“…Data from experiments investigating the effects of cell concentration, interstitial flow rate, receptor activity, and focal adhesion kinase phosphorylation support our hypothesis that the competing stimulus is integrin mediated. This mechanism may play an important role in development of metastatic disease.…”
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Rictor Phosphorylation on the THR-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2 by Boulbes, Delphine, Chen, Chien-Hung, Shaikenov, Tattym, Agarwal, Nitin K., Addona, Terri A., Keshishian, Hasmik, Carr, Steven A., Magnuson, Mark A., Sarbassov, Dos D., Sabatini, David, Peterson, Timothy Richard

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X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis by Jain, Neeraj, Tan, Jun Hou, Feng, Shijin, George, Bhawana, Thanabalu, Thirumaran

“…The majority of missense mutations causing WAS and XLT are found in the WH1 (WASP Homology) domain of WASP, known to mediate interaction with WIP (WASP Interacting Protein) and CIB1 (Calcium and Integrin Binding). Results: We analyzed two WASP missense mutants (L46P and A47D) causing XLT for their effects on T cell chemotaxis. …”
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Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice by Chong, Han Chung, Chan, Jeremy Soon Kiat, Goh, Chi Qin, Gounko, Natalia V., Luo, Baiwen, Wang, Xiaoling, Foo, Selin, Wong, Marcus Thien Chong, Choong, Cleo Swee Neo, Kersten, Sander, Tan, Nguan Soon

“…We showed ANGPTL4-induced nitric oxide production through an integrin/JAK/STAT3-mediated upregulation of inducible nitric oxide synthase (iNOS) expression in wound epithelia, thus revealing a hitherto unknown mechanism by which ANGPTL4 regulated angiogenesis via keratinocyte-to-endothelial-cell communication. …”
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Dendritic cell-intrinsic Ezh2 expression maintains thymic homeostasis and prevents premature thymic involution by Sint Thida Bo

“…Ezh2, a well-known histone methyltransferase, was previously shown to regulate the integrin-dependent migration of dendritic cells (DCs) via the non-canonical cytosolic methylation of the cytoskeleton protein Talin. …”
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ANGPTL4 T266M variant is associated with reduced cancer invasiveness by Tan, Zhen Wei, Teo, Ziqiang, Tan, Carol, Choo, Chee Chong, Loo, Wei Sheng, Song, Yiyang, Tam, Zhi Yang, Ng, Sean Pin, Koh, Hong Zheng, Ng, Yi Siang, Shochat, Susana Geifman, Yau, Yin Hoe, Zhu, Pengcheng, Tan, Nguan Soon

“…We found that T266M cANGPTL4 bound to integrin α5β1 with a reduced affinity compared to wt, leading to weaker activation of downstream signaling molecules. …”
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HIV-specific interleukin-10 responses and immune modulation by Clutton, G

“…A proportion of the population (median 48% and 9% respectively) expressed the β7 chain of the gut-homing integrin α4β7 and the chemokine receptor CXCR3, which mediates lymphocyte migration to sites of inflammation.…”