Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria by Toapanta, FR, Hu, J, Shirey, KA, Bernal, PJ, Levine, MM, Darton, TC, Waddington, CS, Pollard, AJ, Sztein, MB

“…Both CM and IM showed potential to migrate to the gut as integrin α4β7 was upregulated. Unsupervised analysis revealed 7 dynamic cell clusters. …”

Quantitative proteomics analysis revealed compromised chicken dendritic cells function at early stage of very virulent infectious Bursal disease virus infection by Abdul Raham, Nor Yasmin, Omar, Abdul Rahman, Mohd Isa, Noor Farhanah, Hiscox, Julian, Yeap, Swee Keong

“…At the later stage of infection, vvIBDV induced expression of several proteins, namely CD200 receptor 1-A, integrin alpha-5, HSP-90, cathepsin, lysosomal-associated membrane protein, and Ras-related proteins, which play crucial roles in signaling, apoptosis, stress response, and antigen processing as well as in secretion of danger-associated proteins. …”
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Altered Mucosal-Associated Invariant T Cells Phenotype in Children with Newly Diagnosed Type 1 Diabetes but not in Autoantibody-Positive At-Risk Children by Ahmad Mahfuz, Gazali, Näntö-Salonen, Kirsti, Rintamäki, Reeta, Pihlajamäki, Jussi, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, Ilonen, Jorma, Kinnunen, Tuure

“…Further phenotyping revealed that the expression of CD8, CD27, CCR5 and β7 integrin on MAIT cells was lower in children with newly diagnosed T1D compared to AAb+ and healthy children. …”
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Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex by Li Gu, Xin Jin, Huaiyuan Liang, Chong Yang, Yu Zhang

“…In this study, we intended to explore the mechanism associated with regulating the sensitivity of HCC to TKIs. We revealed that integrin subunit β 5 (ITGB5) is abnormally expressed in HCC and contributes to decreased the sensitivity of HCC to sorafenib. …”
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Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis by Rachel Z. Blumhagen, Jonathan S. Kurche, Carlyne D. Cool, Avram D. Walts, David Heinz, Tasha E. Fingerlin, Ivana V. Yang, David A. Schwartz

“…Results We identified 254 differentially expressed genes (DEGs) between IPF and controls in histologically normal-appearing regions of lung parenchyma; pathway analysis identified disease processes such as EIF2 signaling (important for cap-dependent mRNA translation), epithelial adherens junction signaling, HIF1α signaling, and integrin signaling. Within IPF, we identified 173 DEGs between transition and normal-appearing lung parenchyma and 198 DEGs between dense fibrosis and normal lung parenchyma; pathways dysregulated in both transition and dense fibrotic areas include EIF2 signaling pathway activation (upstream of endoplasmic reticulum (ER) stress proteins ATF4 and CHOP) and wound healing signaling pathway deactivation. …”
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Prognostic and immunological role of sulfatide-related lncRNAs in hepatocellular carcinoma by Xing Feng Huang, Li Sheng Fu, Qian Qian Cai, Fei Fan

“…Our previous study reported the specific molecular mechanism for sulfatide regulation of integrin αV expression and cell adhesion in HCC cells through lncRNA AY927503. …”
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Dental Follicle Stem Cells Promote Periodontal Regeneration through Periostin-Mediated Macrophage Infiltration and Reprogramming in an Inflammatory Microenvironment by Xiuqun Wei, Shujuan Guo, Qian Liu, Li Liu, Fangjun Huo, Yafei Wu, Weidong Tian

“…Recombinant human periostin (rhPeriostin) could not only directly promote macrophage reprogramming through the integrin αM/phosphorylated extracellular signal-regulated kinase (p-Erk)/Erk signaling pathway, but it also exhibited the potential to promote periodontal regeneration in rats when loaded in a collagen matrix. …”
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Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression by Li Zhong, Jinqiu Zhao, Lu Huang, Yi Liu, Xiaoxiao Pang, Ke Zhan, Shan Li, Qian Xue, Xiaoli Pan, Liang Deng

“…RNA‐seq and Runx2 ChIP‐seq analysis demonstrated that Runx2 could promote integrin alpha‐V (Itgav) expression by binding to its promoter. …”
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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution by Michael T. H. Ng, Rowie Borst, Hamez Gacaferi, Sarah Davidson, Jessica E. Ackerman, Peter A. Johnson, Caio C. Machado, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Lucy MacDonald, Stefano Alivernini, Micon Garvilles, Kathrin Jansen, Ananya Bhalla, Angela Lee, James Charlesworth, Rajat Chowdhury, Paul Klenerman, Kate Powell, Carl-Philip Hackstein, ICECAP Consortium, Dominic Furniss, Jonathan Rees, Derek Gilroy, Mark Coles, Andrew J. Carr, Stephen N. Sansom, Christopher D. Buckley, Stephanie G. Dakin

“…Micro-cultures of patient-derived cells identify integrin-mediated cell-matrix interactions between MERTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts, suggesting that matrix remodelling plays a role in frozen shoulder resolution. …”
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The expression of SERPINE1 in colon cancer and its regulatory network and prognostic value by Yigang Wang, Jinyan Wang, Jianchao Gao, Mei Ding, Hua Li

“…Pearson correlation analysis revealed that the expression of Integrin Alpha 5 (ITGA5), Matrix Metallopeptidase 19 (MMP19), and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) had the highest correlation with that of SERPINE1. …”
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Impact of Maternal Food Restriction on Heart Proteome in Appropriately Grown and Growth-Restricted Wistar—Rat Offspring by Andreas Zouridis, Antigoni Manousopoulou, Anastasios Potiris, Polyxeni-Maria Sarli, Leon Aravantinos, Panagiota Pervanidou, Efthymios Deligeoroglou, Spiros D. Garbis, Makarios Eleftheriades

“…Bioinformatics analysis of DEPs in FGR vs. control showed decreased integrin and apelin cardiac fibroblast signaling, decreased muscle contraction and glycolysis, and over-representation of a protein network related to embryonic development, and cell death and survival. …”
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Pan-cancer analysis shows that IBSP is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including osteosarcoma by Boyu Pan, Xiaoyun Cheng, Xiaoyun Cheng, Wei Tan, Renfeng Liu, Xin Wu, Jinpeng He, Qizhi Fan, Yan Zhang, Jun Cheng, Jun Cheng, Youwen Deng

“…BackgroundIBSP is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that plays a vital role in bone formation, renewal and repair. …”
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Inhibition of lysyl oxidase‐like 2 overcomes adhesion‐dependent drug resistance in the collagen‐enriched liver cancer microenvironment by Lanqi Gong, Yu Zhang, Yuma Yang, Qian Yan, Jifeng Ren, Jie Luo, Yuen Chak Tiu, Xiaona Fang, Beilei Liu, Raymond Hiu Wai Lam, Ka‐On Lam, Anne Wing‐Mui Lee, Xin‐Yuan Guan

“…LOXL2, an enzyme that facilitates collagen cross‐linking, enhances cell adhesion‐mediated drug resistance by activating the integrin alpha 5 (ITGA5)/focal adhesion kinase (FAK)/phosphoinositide 3‐kinase (PI3K)/rho‐associated kinase 1 (ROCK1) signaling axis. …”
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Synthesis, Characterization and In Vitro Evaluation of Hybrid Monomeric Peptides Suited for Multimodal Imaging by PET/OI: Extending the Concept of Charge—Cell Binding Correlation by Marco Maspero, Xia Cheng, Valeska von Kiedrowski, Clelia Dallanoce, Björn Wängler, Ralph Hübner, Carmen Wängler

“…To address these questions, we synthesized hybrid labels, comprising a chelator, different fluorescent dyes carrying different net charges and a functional group for bioconjugation and introduced them into different peptides, specifically targeting the GRPR, the melanocortin-1 receptor (MC1R) and integrin α_vβ₃. The synthesized conjugates were evaluated with regard to their chemical, radiochemical, photophysical and receptor affinity properties. …”
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A Novel Circular RNA circITGa9 Predominantly Generated in Human Heart Disease Induces Cardiac Remodeling and Fibrosis by Feiya Li, William W. Du, Xiangmin Li, Jindong Xu, Nan Wu, Faryal Mehwish Awan, Yang Yang, Fariborz Asghari Alashti, Sheng Wang, Burton B. Yang

“…Notably, circITGa9, a circRNA derived from integrin-α9, exhibited substantial up-regulation in cardiac hypertrophy patients. …”
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Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expres... by Min Huang, Rong Guan, Jiawei Qiu, Abla Judith Estelle Gnamey, Yusi Wang, Hai Tian, Haoran Sun, Hongbo Shi, Wenjing Sun, Xueyuan Jia, Jie Wu

“…Identified three signatures, CD86, integrin beta 2 (ITGB2) and alpha M (ITGAM), as yielding the strongest associations with TAA/TAV onset, which was verified by areas under the curve (AUC) at levels approximating 0.8 or above under ROC analysis, indicating their predictive value for TAA/TAV onset. …”
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Natural Cyclophilin A Inhibitors Suppress the Growth of Cancer Stem Cells in Non-Small Cell Lung Cancer by Disrupting Crosstalk between CypA/CD147 and EGFR by Jang Mi Han, Sung Min Kim, Hong Lae Kim, Hee Jeong Cho, Hye Jin Jung

“…Notably, C9 and CsA reduced the expression levels of major CSC markers, including integrin α6, CD133, CD44, ALDH1A1, Nanog, Oct4, and Sox2, through dual downregulation of the CypA/CD147 axis and EGFR activity in NSCLC CSCs. …”
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ITGA9 Inhibits Proliferation and Migration of Dermal Microvascular Endothelial Cells in Psoriasis by Hou H, Li J, Wang J, Zhou L, Li J, Liang J, Yin G, Li X, Cheng Y, Zhang K

“…Hui Hou, Jiao Li, Juanjuan Wang, Ling Zhou, Junqin Li, Jiannan Liang, Guohua Yin, Xinhua Li, Yueai Cheng, Kaiming Zhang Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaCorrespondence: Kaiming Zhang, Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital of Shanxi Medical University, No. 5 Dong San Dao Xiang, Jiefang Road, Taiyuan, Shanxi Province, People’s Republic of China, Tel +86-351-5656080, Email zhangkaiming@sina.comBackground: Cell proliferation, migration, and angiogenesis are aberrant in psoriatic human dermal microvascular endothelial cells (HDMECs), resulting in abnormal endothelial function and microvascular dilation in psoriasis.Objective: To explore the role of Integrin subunit alpha 9 (ITGA9) in proliferation and migration of dermal microvascular endothelial cells.Methods: HDMECs were isolated from the skin of 6 psoriatic patients and 6 healthy controls. …”
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Cyanidin-3-O-Glucoside Rescues Zearalenone-Induced Apoptosis via the ITGA7-PI3K-AKT Signaling Pathway in Porcine Ovarian Granulosa Cells by Xiuxiu Li, Jingya Wang, Fali Zhang, Mubin Yu, Ning Zuo, Lan Li, Jinghe Tan, Wei Shen

“…As analyzed, ZEN inhibited mRNA and protein levels of integrin subunit alpha-7 (ITGA7), and promoted the expression of cell cycle inhibition kinase cyclin-D3 (<i>CCND3</i>) and cyclin-dependent kinase inhibitor 1 (<i>CDKN1A</i>). …”
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Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees:... by Axel W. Baltzer, Rita Casadonte, Alexei Korff, Lea Merline Baltzer, Katharina Kriegsmann, Mark Kriegsmann, Mark Kriegsmann, Jörg Kriegsmann, Jörg Kriegsmann, Jörg Kriegsmann

“…We identified discriminating peptides for CD45 and CD29 receptors (receptor-type tyrosine-protein phosphatase C and integrin beta 1), indicating an enhancement of musculoskeletal stem cells, as well as an enhancement of lubricin, collagen alpha-1-(I) chain, and interleukin-receptor-17-E, dampening the inflammatory reaction in the LpPRP-1 group following LpPRP injection.ConclusionsWe could demonstrate for the first time that injection therapy using “autologic-conditioned biologics” may lead to cellular changes in the synovial membrane that might explain the reported prolonged beneficial clinical effects. …”
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