Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity by Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers

“…Soluble uPAR levels inversely correlated with barrier properties of the HBEC layer in 2D and ALI. Blocking uPAR‐integrin interactions enhanced barrier formation. The gain of function cells showed limited transcriptomic changes. …”
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Early administration of lenalidomide after allogeneic hematopoietic stem cell transplantation suppresses graft‐versus‐host disease by inhibiting T‐cell migration to the gastrointes... by Yukie Tsubokura, Hideaki Yoshimura, Atsushi Satake, Yutaro Nasa, Ryohei Tsuji, Tomoki Ito, Shosaku Nomura

“…The percentage of LPAM‐1 (α4β7‐integrin)‐expressing Foxp3−CD4+ T cells was significantly lower in host mice treated with LEN than in host mice treated with vehicle, whereas that of LPAM‐1‐expressing Tregs was comparable. …”
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The Anti-Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) D16F7 Monoclonal Antibody Inhibits Melanoma Adhesion to Soluble VEGFR-1 and Tissue Invasion in Response to Placenta... by Maria Grazia Atzori, Claudia Ceci, Federica Ruffini, Manuel Scimeca, Rosella Cicconi, Maurizio Mattei, Pedro Miguel Lacal, Grazia Graziani

“…A soluble VEGFR-1 (sVEGFR-1) form is released in the ECM, where it sequesters proangiogenic factors and stimulates endothelial or tumor cell adhesion and chemotaxis through interaction with α5β1 integrin. The anti-VEGFR-1 monoclonal antibody (D16F7 mAb) inhibits VEGF-A or PlGF-mediated signal transduction without affecting ligand interaction, thus preserving sVEGFR-1 decoy function. …”
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Gastric Cancer Pre-Stage Detection and Early Diagnosis of Gastritis Using Serum Protein Signatures by Shahid Aziz, Faisal Rasheed, Rabaab Zahra, Simone König

“…We used samples from pre-malignant stages to extract prospective serum markers for early-stage GC, and present a 29-protein marker panel containing, amongst others, integrin β-6 and glutathione peroxidase. Furthermore, ten serum markers specific for advanced GC, independent of <i>H. pylori</i> infection, are provided. …”
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Korean clinical practice guidelines on biologics for moderate to severe Crohn’s disease by Seong-Joon Koh, Sung Noh Hong, Soo-Kyung Park, Byong Duk Ye, Kyeong Ok Kim, Jeong Eun Shin, Yong Sik Yoon, Hong Sub Lee, Sung Hoon Jung, Miyoung Choi, Soo-Young Na, Chang Hwan Choi, Joo Sung Kim

“…Subsequently, vedolizumab, a monoclonal antibody against integrin α4β7, and ustekinumab, a human monoclonal antibody that inhibits the common p40 subunit of interleukin-12 and interleukin-23, were both approved for clinical use and are efficacious and safe for both induction and maintenance of remission in moderate-to-severe CD patients. …”
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Delineating Zinc Influx Mechanisms during Platelet Activation by Sahithi J. Kuravi, Niaz S. Ahmed, Kirk A. Taylor, Emily M. Capes, Alex Bye, Amanda J. Unsworth, Jonathan M. Gibbins, Nicholas Pugh

“…[Zn²⁺]_o stimulation resulted in the phosphorylation of PKC substates, MLC, and β3 integrin. Platelet activation via GPVI or Zn²⁺ resulted in ZIP7 phosphorylation in a casein kinase 2-dependent manner and initiated elevations of [Zn²⁺]_i that were sensitive to the inhibition of Orai1, ZIP7, or IP₃R-mediated pathways. …”
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Isolation and Characterization of an Anti-Osteoporotic Compound from <i>Melia toosendan</i> Fructus by Seong Cheol Kim, Dong Ryun Gu, Hyun Yang, Sung-Ju Lee, Jin Ah Ryuk, Hyunil Ha

“…TSN treatment downregulated the expression of nuclear factor of activated T cells c1, a pivotal osteoclastogenic transcription factor, along with molecules implicated in osteoclast-mediated bone resorption, including tumor necrosis factor receptor-associated factor 6, carbonic anhydrase II, integrin beta-3, and cathepsin K. Furthermore, treatment of mature osteoclasts with TSN impaired actin ring formation, acidification, and resorptive function. …”
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Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis by Yizhi Wang, Yang Kong, Qifan Yang, Cheng Zhong, Dongkai Zhou

“…GSEA revealed the involvement of FNDC3B in biological processes and signaling pathways related to integrin signaling pathway and cell adhesion. Additionally, ssGSEA analysis indicated a positive correlation between FNDC3B expression and infiltration of Th2 cells and neutrophils, while showing a negative correlation with plasmacytoid dendritic cells and Th17 cells infiltration. …”
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Decreased GRP78 Protein Expression is a Potential Prognostic Marker of Oral Squamous Cell Carcinoma in Taiwan by Tze-Ta Huang, Jeff Yi-Fu Chen, Chih-En Tseng, Yu-Chieh Su, Hsu-Chueh Ho, Moon-Sing Lee, Chiou-Tuz Chang, Yong-Kie Wong, Hau-Ren Chen

“…Results: Of the 11 candidate proteins expressed differentially in both cell lines, six [heat shock protein 90 kDa beta member 1 (94 kDa glucose-regulated protein; GRP94), protein disulfide-isomerase precursor, vimentin, tubulin beta-2C chain, 78 kDa glucose-regulated protein precursor (GRP78), and annexin A2] were increased in OC2 cells (low-grade OSCC), and five (heat shock protein 90-beta, annexin A1, stress-induced phosphoprotein 1, elongation factor-2, and integrin alpha-3 precursor) were increased in OCSL cells (high-grade OSCC). …”
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Impact of Treadmill Interval Running on the Appearance of Zinc Finger Protein FHL2 in Bone Marrow Cells in a Rat Model: A Pilot Study by Alexandre Germain, Celine Bourzac, Chantal Pichon, Hugues Portier, Stéphane Pallu, Philippe Germain

“…We hypothesized that impacts generated by running could activate, in vivo, a specific signaling pathway, through an integrin-mediated mechano-transductive process, leading to the synthesis of FHL2 in bone marrow cells. …”
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Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli‐Responsive Cell‐Adhesive Micromaterials by Tom Kamperman, Niels G. A. Willemen, Cindy Kelder, Michelle Koerselman, Malin Becker, Luanda Lins, Castro Johnbosco, Marcel Karperien, Jeroen Leijten

“…Here, this work report on stimuli‐responsive cell‐adhesive micromaterials (SCMs) that can self‐assemble with cells into 3D living composite microtissues through integrin binding, even under serum‐free conditions. …”
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Evolving Up‐regulation of Biliary Fibrosis–Related Extracellular Matrix Molecules After Successful Portoenterostomy by Antti Kyrönlahti, Nimish Godbole, Oyediran Akinrinade, Tea Soini, Iiris Nyholm, Noora Andersson, Maria Hukkinen, Jouko Lohi, David B. Wilson, Marjut Pihlajoki, Mikko P. Pakarinen, Markku Heikinheimo

“…Highly overexpressed genes promoting biliary fibrosis and bile duct integrity, such as integrin subunit beta 6 and previously unreported laminin subunit alpha 3, emerged as candidates to control liver fibrosis after SPE. …”
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Role of D(−)-Lactic Acid in Prevention of <i>Chlamydia trachomatis</i> Infection in an In Vitro Model of HeLa Cells by Chiara Zalambani, Nicola Rizzardi, Giacomo Marziali, Claudio Foschi, Sara Morselli, Marielle Ezekielle Djusse, Marina Naldi, Romana Fato, Natalia Calonghi, Antonella Marangoni

“…Our findings suggest that D(−) lactic acid significantly affects two non-exclusive mechanisms involved in <i>C. trachomatis</i> infection: regulation of the cell cycle and expression of EGFR and α5β1-integrin.…”
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<i>Ziziphus nummularia</i> Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS by Joelle Mesmar, Manal M. Fardoun, Rola Abdallah, Yusra Al Dhaheri, Hadi M. Yassine, Rabah Iratni, Adnan Badran, Ali H. Eid, Elias Baydoun

“…In addition, ZNE significantly decreased the migratory and invasive capacity of Capan-2 with a concomitant downregulation of integrin α₂ and increased cell–cell aggregation. …”
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Control of craniofacial development by the collagen receptor, discoidin domain receptor 2 by Fatma F Mohamed, Chunxi Ge, Shawn A Hallett, Alec C Bancroft, Randy T Cowling, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Benjamin Levi, Vesa M Kaartinen, Renny T Franceschi

“…Mutations in the discoidin domain receptor 2 gene (DDR2), which encodes a non-integrin collagen receptor, are associated with human craniofacial abnormalities, such as midface hypoplasia and open fontanels. …”
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Aesculetin Inhibits Osteoclastic Bone Resorption through Blocking Ruffled Border Formation and Lysosomal Trafficking by Woojin Na, Eun-Jung Lee, Min-Kyung Kang, Yun-Ho Kim, Dong Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Su Yeon Oh, Young-Hee Kang

“…Micromolar aesculetin deterred the actin ring formation through inhibition of induction of αvβ3 integrin and Cdc42 but not cluster of differentiation 44 (CD44) in RANKL-exposed osteoclasts. …”
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Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy by Bao Li, Haoran Niu, Xiaoyun Zhao, Xiaoyu Huang, Yu Ding, Ke Dang, Tianzhi Yang, Yongfeng Chen, Jizhuang Ma, Xiaohong Liu, Keda Zhang, Huichao Xie, Pingtian Ding

“…Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. …”
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Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy by Elisabeth A Kilroy, Amanda C Ignacz, Kaylee L Brann, Claire E Schaffer, Devon Varney, Sarah S Alrowaished, Kodey J Silknitter, Jordan N Miner, Ahmed Almaghasilah, Tashawna L Spellen, Alexandra D Lewis, Karissa Tilbury, Benjamin L King, Joshua B Kelley, Clarissa A Henry

“…We found that eNMES improves muscle and neuromuscular junction morphology, swimming, and survival. Heme oxygenase and integrin alpha7 are required for eNMES-mediated improvement. …”
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Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array by Sugnet Charles, Awad Tarif, Schweitzer Anthony, Veitch James, Yang Qing, Staples Michelle K, Shimada Brian, Clark Tyson A, Gardina Paul J, Dee Suzanne, Davies Christopher, Williams Alan, Turpaz Yaron

“…Five of the identified splicing events affect mediators of cytoskeletal organization (ACTN1, VCL, CALD1, CTTN, TPM1), two affect extracellular matrix proteins (FN1, COL6A3) and another participates in integrin signaling (SLC3A2). Altogether they form a pattern of colon-cancer specific alterations that may particularly impact cell motility.…”
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Pharmacokinetics, tissue distribution, and antitumor activity of a novel compound, NY-2, in non-small cell lung cancer by Yingshi Zhang, Yingshi Zhang, Chang Xu, Chang Xu, Xiangbo Xu, Xiangbo Xu, Lingxiang Ma, Lingxiang Ma, Ruolan Li, Zihua Xu, Zihua Xu, Qingchun Zhao, Qingchun Zhao

“…NY-2 acts on ADAM17 and simultaneously affects the downstream Notch1 and integrinβ1 signaling pathways resulting in antitumor activity. …”
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