Isolation and characterization of bovine bone collagen peptides with stimulatory effects on mineralization in osteoblasts by Jianing Wang, Hanfeng Li, Tong Zhang, Di Sun, Weipeng Lu, Weijie Zhang, Yihu Wang, Ming Ma, Xiaofeng Cao, Bing Zhang, Yanchuan Guo

“…Moreover, it was found that the interaction between peptides and integrinα5β1 may be responsible for osteoblast mineralization stimulation activity.…”
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Cocaine Induces Cytoskeletal Changes in Cardiac Myocytes: Implications for Cardiac Morphology by Avnish Verma, Ayse Orme Merve, Vytautas Remeškevičius, Pola Sobiecka, Luke Taylor, Scott Lawton, Ben P Jones, Elena Polycarpou, Jason Bennett, Brian Rooney

“…Cocaine downregulated phosphorylation of cofilin, decreased expression of adhesion modulators (integrin-β3) and increased expression of ezirin within three hours of 1 μg/mL treatments. …”
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Severe gastrointestinal involvements in patients with adult dermatomyositis with anti-NXP2 antibody by Zhiwei Chen, Xiaodong Wang, Shuang Ye, Qi Feng, Qiong Fu, Jie Chen, Liyang Gu, Jie Fan, Yuting Dai, Yakai Fu, Mingshi Gao

“…Finally, vedolizumab, an anti-α4β7-integrin monoclonal antibody, exhibited promising therapeutic signals which should be further investigated.Conclusions GI involvement is a unique complication in patients with adult NXP2+DM. …”
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Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model by Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel Zigler, Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghosh

“…Ligand receptor (LR)-loop analysis and cell culture studies revealed that M1 microglia also induce the expression of neutrophil adhesion mediators (integrin β1/α4) through their interaction with CD14 on microglia. …”
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Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway by Wei Hu, Yaorui Hu, Yao Pei, Rongrong Li, Fuyi Xu, Xiaodong Chi, Jia Mi, Jonas Bergquist, Lu Lu, Luping Zhang, Chunhua Yang

“…Ingenuity pathway analysis revealed that the majority of the proteins were involved in the regulation of eIF4 and p70S6K signaling and mTOR signaling. Among 46 DEPs, Integrinβ6 (ITGB6), PPP1CB, TMPO, PTGES3 (P23) and DTX3L were significantly upregulated, while Desmin (DES) was significantly downregulated in CC tissues compared with the adjacent normal tissues. …”
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Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions by Ravindra K. Zirmire, Dyuti Saha, Rakesh Dey, Habibu Tanimu, Rania Zaarour, Deborah Bird, Prakash Cherian, Isha Rana, Nita Roy, Aryasekhar Sanyal, Namita Misra, Colin Jamora

“…Bacopa monnieri-mediated changes in focal adhesions are dependent on α5β1 integrin activation and subsequent phosphorylation of focal adhesion kinase (FAK). …”
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The imminent role of microRNAs in salivary adenoid cystic carcinoma by Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain

“…Furthermore, we have found that miRNAs also target many vital genes and pathways like mitogen-activated protein kinases-snail family transcriptional repressor 2 (MAPK-Snai2), p38/JNK/ERK, forkhead box C1 protein (FOXC1), mammalian target of rapamycin (mTOR), integrin subunit beta 3 (ITGB3), epidermal growth factor receptor (EGFR)/NF-κB, programmed cell death protein 4 (PDCD4), signal transducer and activator of transcription 3 (STAT3), neuroblastoma RAS (N-RAS), phosphatidylinositol-3-kinase (PI3K)/Akt, MEK/ERK, ubiquitin-like modifier activating enzyme 2 (UBA2), tumor protein D52 (TPD52) which play a crucial role in the regulation of salivary adenoid cystic carcinoma. …”
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hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model by Huiming Xu, Wei Jiang, Xuejia Li, Jiaohua Jiang, Shabbir Khan Afridi, Longhui Deng, Rui Li, Ermei Luo, Zhaoqing Zhang, Yu-Wen Alvin Huang, Yaxiong Cui, Kwok-Fai So, Haijia Chen, Wei Qiu, Changyong Tang

“…We also elucidate that the MFGE8/Integrin αvβ3/NF-κB signaling pathway is partially responsible for structural and functional recovery, in addition to motor functional enhancements induced by hUC-MSC exposure. …”
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Exposure to Electronic Waterpipes Increases the Risk of Occlusive Cardiovascular Disease in C57BL/6J Mice by Precious O. Badejo MS, Shelby S. Umphres MS, Hamdy E.A. Ali PhD, Ahmed B. Alarabi PhD, Shahnaz Qadri PhD, Fatima Z. Alshbool PharmD, PhD, Fadi T. Khasawneh PhD

“…Also, flow cytometry analysis of surface markers of platelet activation showed that both P-selectin and integrin GPIIb-IIIa activation were enhanced in the e-waterpipe exposed platelets, relative to the controls. …”
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Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT16... by Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki

“…The aim of this study was to investigate the humoral and cellular response in immunosuppressed patients with inflammatory bowel disease (IBD) on treatment with anti-TNF (infliximab, adalimumab) and anti-α4ß7-Integrin (vedolizumab) 6 months after mRNA vaccination against SARS-CoV-2 compared to healthy subjects. …”
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Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair by Wu, Shan, Ph. D. Massachusetts Institute of Technology

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Generation of Effector Memory T Cell-Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination by Li, Adrienne Victoria, Moon, James J., Abraham, Wuhbet, Suh, Heikyung, Elkhader, Jamal, Seidman, Michael A., Yen, Minmin, Im, Eung-Jun, Foley, Maria Hottelet, Barouch, Dan H., Irvine, Darrell J., Yen, Minmin

“…Nanocapsules primed 13-fold more T cells than did equivalent soluble vaccines, elicited increased expression of mucosal homing integrin α4β7+, and generated long-lived T cells in both the lungs and distal (for example, vaginal) mucosa strongly biased toward an effector memory (TEM) phenotype. …”
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Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation by Kalailingam, Pazhanichamy, Mohd-Kahliab, Khalilatul-Hanisah, Ngan, SoFong Cam, Iyappan, Ranjith, Melekh, Evelin, Lu, Tian, Zien, Gan Wei, Sharma, Bhargy, Guo, Tiannan, MacNeil, Adam J., MacPherson, Rebecca Ek, Tsiani, Evangelia Litsa, O'Leary, Deborah D., Lim, Kah-Leong, Su, I Hsin, Gao, Yong-Gui, Richards, A. Mark, Kalaria, Raj N., Chen, Christopher P., McCarthy, Neil E., Sze, Siu Kwan

“…We previously reported that age-linked damage to amino acid sequence NGR (Asn-Gly-Arg) results in "gain-of-function" conformational switching to isoDGR (isoAsp-Gly-Arg). This integrin-binding motif activates leukocytes and promotes chronic inflammation, which are characteristic features of age-linked cardiovascular disorders. …”
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Modulating stem cell differentiation via cell-material interaction by Tijore, Ajay

“…Nanoscale distribution study of integrins revealed that ITG-β1 clusters were uniformly spread within FAs of patterned hMSCs, whereas ITG-β1 clusters were expressed at the periphery of FAs of unpatterned hMSCs. …”
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Molecular dynamics simulations of the dimerization of transmembrane alpha-helices. by Psachoulia, E, Marshall, D, Sansom, MS

“…The multiscale approach has been applied to a more complex system, the heterodimeric alphaIIb/beta3 integrin TM helix dimer. In CG-MD, both right-handed and left-handed structures were formed. …”

Comparative transcriptome analysis of papilla and skin in the sea cucumber, Apostichopus japonicus by Xiaoxu Zhou, Jun Cui, Shikai Liu, Derong Kong, He Sun, Chenlei Gu, Hongdi Wang, Xuemei Qiu, Yaqing Chang, Zhanjiang Liu, Xiuli Wang

“…Development-related genes were also enriched, such as fibroblast growth factor, transforming growth factor-β, collagen-α2 and Integrin-α2, which may be related to the formation of the papilla and skin in sea cucumber. …”
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Repurposing of α1-Adrenoceptor Antagonists: Impact in Renal Cancer by Meredith Mihalopoulos, Zachary Dovey, Maddison Archer, Talia G. Korn, Kennedy E. Okhawere, William Nkemdirim, Hassan Funchess, Ami Rambhia, Nihal Mohamed, Steven A. Kaplan, Reza Mehrazin, Dara Lundon, Che-Kai Tsao, Ketan K. Badani, Natasha Kyprianou

“…Mechanistically these drugs overcome anoikis resistance in tumor cells by targeting cell survival regulators AKT and FAK, disrupting integrin adhesion (α5β1 and α2β1) and engaging extracellular matrix (ECM)-associated tumor suppressors. …”
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Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques by Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber

“…While both delivery routes induced highly functional Ag-specific CD4 T cells with a Th1* phenotype (CXCR3+CCR6+), gavage vaccination induced the co-expression of the gut-homing integrin α4β7 on Ag-specific Th1* cells, which was associated with reduced migration into the airways. …”
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Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells by N. Nojszewska, O. Idilli, D. Sarkar, Z. Ahouiyek, Y. Arroyo-Berdugo, C. Sandoval, MS Amin-Anjum, S. Bowers, D. Greaves, L. Saeed, M. Khan, S. Salti, S. Al-Shami, H. Topoglu, JK Punzalan, JG Farias, Y. Calle

“…We also found that vs epithelial tumours, AML cells display a distinct patterns of co-expression of VIM and the actin binding and adhesion regulatory proteins that regulate F-actin dynamics and integrin-mediated adhesions involved in the invasive migration in cells undergoing EMT. …”
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Alternative C3 Complement System: Lipids and Atherosclerosis by Maisa Garcia-Arguinzonis, Elisa Diaz-Riera, Esther Peña, Rafael Escate, Oriol Juan-Babot, Pedro Mata, Lina Badimon, Teresa Padro

“…In cell culture studies of human VSMCs, we evidenced the expression of C3, C3aR (anaphylatoxin receptor) and the integrin α_Mβ₂ receptor for C3b/iC3b (RT-PCR and Western blot). …”
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