Macrophage-like THP-1 Cells Derived from High-Density Cell Culture Are Resistant to TRAIL-Induced Cell Death via Down-Regulation of Death-Receptors DR4 and DR5 by Yana Vladimirovna Lomovskaya, Margarita Igorevna Kobyakova, Anatoly Sergeevich Senotov, Alexey Igorevich Lomovsky, Vladislav Valentinovich Minaychev, Irina Sergeevna Fadeeva, Daria Yuryevna Shtatnova, Kirill Sergeevich Krasnov, Alena Igorevna Zvyagina, Vladimir Semenovich Akatov, Roman Sergeevich Fadeev

“…The adhesion of THP-1ad cells to the extracellular matrix was mediated by αVβ5 integrin. The cytokine production, as well as the rise of intracellular ROS and NO activities by LPS in THP-1ad cell culture, were characteristic of macrophage-like cells. …”
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Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study by Aimin Jiang, Qingyang Pang, Xinxin Gan, Anbang Wang, Zhenjie Wu, Bing Liu, Peng Luo, Le Qu, Linhui Wang

“…Results We identified five stable metastasis‐related signatures (renin, integrin subunit beta‐like 1, MXRA5, mesenchyme homeobox 2, and anoctamin 3) from multicenter cohorts. …”
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Integrative analyses of biomarkers and pathways for diabetic nephropathy by Bo Li, Xu Zhao, Wanrun Xie, Zhenzhen Hong, Yi Zhang

“…GSEA was mainly enriched in the TYROBP causal network, the inflammatory response pathway, chemokine receptor binding, the interferon signaling pathway, ECM receptor interaction, and the integrin 1 pathway. Meanwhile, mRNA-miRNA and mRNA-TF networks were constructed for common hub genes. …”
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Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model by Eman Soliman, Sophia Bhalla, Ahmed E. M. Elhassanny, Anagha Malur, David Ogburn, Nancy Leffler, Achut G. Malur, Mary Jane Thomassen

“…Furthermore, BAL cells of ABCG1 KO mice instilled with MWCNT exhibit an increase in efferocytosis markers, milk fat globule-EGF factor 8 (MFG-E8) and integrin β3. Therefore, our observations suggest that ABCG1 deficiency promotes pulmonary fibrosis by MWCNT, and this effect may be due to an increase in apoptosis and efferocytosis in BAL cells.…”
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Deletion of <i>Cd44</i> Inhibits Metastasis Formation of Liver Cancer in <i>Nf2</i>-Mutant Mice by Monserrat Gerardo-Ramírez, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Helen Morrison, Helen L. May-Simera, Markus P. Radsak, Jens U. Marquardt, Peter R. Galle, Peter Herrlich, Beate K. Straub, Monika Hartmann

“…CD44 upregulates expression of integrin β2 and promotes transendothelial migration of liver cancer cells, which may facilitate metastatic spreading. …”
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MiR-29b-1-5p regulates the proliferation and differentiation of chicken primary myoblasts and analysis of its effective targets by Yuanfang Li, Bin Zhai, Pengtao Yuan, Shengxin Fan, Wenjiao Jin, Wenting Li, Guirong Sun, Yadong Tian, Xiaojun Liu, Xiangtao Kang, Guoxi Li

“…The correlation analysis showed that these 6 genes, that is, ankyrin repeat domain 9 (ANKRD9), lactate dehydrogenase A (LDHA), transcription factor 12 (TCF12), FAT atypical cadherin 1 (FAT1), lin-9 homolog (LIN9), and integrin beta 3 binding protein (ITGB3BP), can be used as effective candidate target genes of miR-29b-1-5p. …”
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Ultra-Rare Variants Identify Biological Pathways and Candidate Genes in the Pathobiology of Non-Syndromic Cleft Palate Only by Emanuela Iovino, Luca Scapoli, Annalisa Palmieri, Rossella Sgarzani, Nayereh Nouri, Agnese Pellati, Francesco Carinci, Marco Seri, Tommaso Pippucci, Marcella Martinelli

“…GSEA highlighted an enrichment of ultra-rare variants in genes principally belonging to cytoskeletal protein binding pathway (Probability Density Function corrected <i>p</i>-value = 1.57 × 10⁻⁴); protein-containing complex binding pathway (<i>p</i>-value = 1.06 × 10⁻²); cell adhesion molecule binding pathway (<i>p</i>-value = 1.24 × 10⁻²); ECM-receptor interaction pathway (<i>p</i>-value = 1.69 × 10⁻²); and in the Integrin signaling pathway (<i>p</i>-value = 1.28 × 10⁻²). …”
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The RGD region of bone sialoprotein affects metabolic activity in mice by Karin Nagasaki, Karin Nagasaki, Atsuhiro Nagasaki, Atsuhiro Nagasaki, Jocelyn M. Taylor, Bernice D. Kear, Yinyan Ma, Martha J. Somerman, Oksana Gavrilova

“…Previously, we generated BSP-KAE knock-in mice (KAEKI mice) by substituting a non-function KAE (lysine-alanine-glutamic acid) for the integrin-binding RGD (arginine-glycine-aspartic acid) sequence and reported a vital role of the BSP-RGD motif in modulating the periodontal ligament (PDL). …”
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STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis by Yantao Duan, Pengfei Kong, Mingzhu Huang, Yonghao Yan, Yi Dou, Binhao Huang, Jing Guo, Wei Kang, Caixia Zhu, Yuyan Wang, Donglei Zhou, Qiliang Cai, Dazhi Xu

“…Mechanistically, DAB2 served as a scaffold protein for integrin beta 3 (ITGB3) and SRC proto-oncogene non-receptor tyrosine kinase (SRC), facilitated the phosphorylation of SRC, promoted the small GTPase ras homolog family member A (RHOA) activation and phosphorylation of YAP1, and ultimately enhanced the YAP1 transcriptional activity. …”
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Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes by Christien M. Beez, Marion Haag, Oliver Klein, Sophie Van Linthout, Michael Sittinger, Martina Seifert

“…The cytokine stimulation caused CardAP cells to release smaller EVs with a lower integrin ß1 surface expression, while the concentration between both CardAP-EV variants was unaffected. …”
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Convergent Genomic Signatures of Cashmere Traits: Evidence for Natural and Artificial Selection by Wei Wang, Zhuohui Li, Guoxiang Xie, Xinmei Li, Zhipei Wu, Manman Li, Anguo Liu, Yan Xiong, Yu Wang

“…Type IV collagen family genes (<i>COL4A2</i>, <i>COL4A4</i>, <i>COL4A5</i>, <i>COL6A5</i>, <i>COL6A6</i>) and integrin family genes (<i>ITGA2</i>, <i>ITGA4</i>, <i>ITGA9</i>, <i>ITGB8</i>) may be important candidate genes for cashmere formation and development. …”
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Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET by Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn

“…Abstract Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. …”
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Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets by Pierre Cunin, Rim Bouslama, Kellie R Machlus, Marta Martínez-Bonet, Pui Y Lee, Alexandra Wactor, Nathan Nelson-Maney, Allyn Morris, Li Guo, Andrew Weyrich, Martha Sola-Visner, Eric Boilard, Joseph E Italiano, Peter A Nigrovic

“…We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. Tethered neutrophils enter in membrane-bound vesicles before penetrating into the megakaryocyte cytoplasm. …”
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Insight into vitronectin structural evolution on material surface chemistries: The mediation for cell adhesion by Tianjie Li, Lijing Hao, Jiangyu Li, Chang Du, Yingjun Wang

“…Experimental evidences including protein adsorption, cell adhesion and integrin gene expressions were thoroughly investigated. …”
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A pref-1-controlled non-inflammatory mechanism of insulin resistance by Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong, Hong Wu, Grace K. Muller, Yadan Qi, Shuxia Wang, Jinjie Xu, Xiang Gao, Kathleen E. Fifield, Lingyan Wang, Zhengyuan Xia, Jacqueline L. Vanderluit, Suixin Liu, Lin Leng, Guang Sun, John McGuire, Lawrence H. Young, Richard Bucala, Dake Qi

“…Pref-1, released from adipose Pref-1+ cells with characteristics of M2 macrophages, endothelial cells or progenitors, inhibits MIF release from both Pref-1+ cells and adipocytes by binding with integrin β1 and inhibiting the mobilization of p115. …”
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Albumin Fusion at the N-Terminus or C-Terminus of HM-3 Leads to Improved Pharmacokinetics and Bioactivities by Ting Li, Han-Zi Zhang, Guang-Fei Ge, Zhao-Rong Yue, Ru-Yue Wang, Qian Zhang, Yan Gu, Mei-Juan Song, Wen-Bo Li, Min-Zhi Ma, Mei-Zhu Wang, Hui Yang, Yang Li, Hong-Yu Li

“…HM-3, an integrin antagonist, exhibits anti-tumor biological responses and therefore has potential as a therapeutic polypeptide. …”
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Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community by Levi H. Jales Neto, Zofia Wicik, Georgea H. F. Torres, Liliam Takayama, Valéria F. Caparbo, Neuza H. M. Lopes, Alexandre C. Pereira, Rosa M. R. Pereira

“…Validation by qPCR confirmed increased expression in VF group of Syntrophin (SNTG2, fold change = 2.79, p = .009), TRAF3 Interacting Protein2 (TRAF3IP2, fold change = 2.79, p = .020), and Integrin Subunit Alpha 6 (ITGA6, fold change = 2.86, p = .038). …”
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New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies by Agata Ciechanowska, Ewelina Rojewska, Anna Piotrowska, Justyna Barut, Katarzyna Pawlik, Katarzyna Ciapała, Grzegorz Kreiner, Joanna Mika

“…Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently recognized as a second receptor, has not been clarified to date. …”
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miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation by Hong Li, Dan Song, Qihui Liu, Linlin Li, Xiaoshi Sun, Jiamei Guo, Dianlian Li, Ping Li

“…Western blotting was used to detect the expression levels of phosphorylated inosine 3-kinase regulatory subunit 1 (PIK3R1)/serine/threonine kinase 1 (Akt) and apoptosis-related proteins after transfection with integrin subunit β3 (ITGB3) small interfering ribonucleic acid (siRNA). …”
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A Murine Model of X-Linked Moesin-Associated Immunodeficiency (X-MAID) Reveals Defects in T Cell Homeostasis and Migration by Lyndsay Avery, Lyndsay Avery, Tanner F. Robertson, Tanner F. Robertson, Christine F. Wu, Christine F. Wu, Nathan H. Roy, Nathan H. Roy, Samuel D. Chauvin, Samuel D. Chauvin, Eric Perkey, Ashley Vanderbeck, Ivan Maillard, Janis K. Burkhardt, Janis K. Burkhardt

“…Analysis of ex vivo CD4 SP thymocytes reveals defects in chemotactic responses and reduced migration on integrin ligands. While chemokine signaling appears intact, CD4 SP thymocytes from X-MAID mice are unable to polarize and rearrange cytoskeletal elements. …”
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