Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections by Ping Sun, Mintian Cui, Jiongjie Jing, Fanyu Kong, Shixi Wang, Lunxian Tang, Junling Leng, Kun Chen

“…Further, we showed that DRAM1 could maintain survival of a pro-inflammatory monocyte subset, C10_ULK1, which induces systemic inflammation by interacting with other cell subsets via resistin and integrin signaling pathways in blood and kidney tissue, respectively. …”
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Identification of fatty acids synthesis and metabolism-related gene signature and prediction of prognostic model in hepatocellular carcinoma by Ai Zhengdong, Xing Xiaoying, Fu Shuhui, Liang Rui, Tang Zehui, Song Guanbin, Yang Li, Tang Xi, Liu Wanqian

“…A strong interaction between cancer stem cells (CSCs) with high expression of ACACA and macrophages through CD74 molecule (CD74) and integrin subunit beta 1 (ITGB1) signaling was identified. …”
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Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas by Jessica Iorio, Lorenzo Antonuzzo, Emanuela Scarpi, Massimo D’Amico, Claudia Duranti, Luca Messerini, Clotilde Sparano, Damiano Caputo, Daniele Lavacchi, Domenico Borzomati, Alice Antonelli, Lorenzo Nibid, Giuseppe Perrone, Alessandro Coppola, Roberto Coppola, Francesco di Costanzo, Elena Lastraioli, Annarosa Arcangeli

“…In a subset of samples, a different antibody directed against the hERG1/β1 integrin complex was also used. The analysis showed for the first time that hERG1 is expressed in human NETs originating from either the ileum or the pancreas. hERG1 turned out to have a prognostic value in NETs, showing (i) a statistically significant positive impact on OS of patients affected by ileal NETs, regardless the TNM stage; (ii) a statistically significant positive impact on OS of patients affected by aggressive (TNM stage IV) disease, either ileal or pancreatic; (iii) a trend to a negative impact on OS of patients affected by less aggressive (TNM stage I-III) disease, either ileal or pancreatic. …”
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Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model by Esteban Palacios, Lorena Lobos-González, Simón Guerrero, Marcelo J. Kogan, Baohai Shao, Jay W. Heinecke, Andrew F. G. Quest, Lisette Leyton, Manuel Valenzuela-Valderrama

“…In vitro, OMVs induced astrocyte reactivity by increasing the intermediate filament proteins GFAP and vimentin, the plasma membrane αVβ3 integrin, and the hemichannel connexin 43. OMVs also produced neurotoxic factors and promoted the release of IFNγ in a manner dependent on the activation of the transcription factor NF-κB. …”
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Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma by Qiuli Liang, Chao Tan, Feifei Xiao, Fuqiang Yin, Meiliang Liu, Lei Lei, Liuyu Wu, Yu Yang, Hui Juan Jennifer Tan, Shun Liu, Xiaoyun Zeng

“…Survival analysis distinguished 8 hub genes CENPE, SPDL1, Hyaluronan-mediated motility receptor, Rac GTPase activating protein 1, Thyroid hormone receptor interactor 13, cytoskeleton-associated protein (CKAP) 2, CKAP5, and Integrin subunit beta 3 binding protein (ITGB3BP) were considered as prognostic hub genes. …”
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Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation by Afsaneh Golkar-Narenji, Paweł Antosik, Shelly Nolin, Marcin Rucinski, Karol Jopek, Agnieszka Zok, Jarosław Sobolewski, Maurycy Jankowski, Maciej Zdun, Dorota Bukowska, Katarzyna Stefańska, Jędrzej M. Jaśkowski, Hanna Piotrowska-Kempisty, Paul Mozdziak, Bartosz Kempisty

“…The significantly regulated pathways included: EIF2, mTOR, GP6, integrin and HIFα signalling. Differential regulation of gene expression, as well as significant enrichment and modulation of pathway activity, suggest that suspension culture potentially promotes the ex vivo-associated loss of physiological characteristics and gain of plasticity. …”
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The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development: a potential novel therapy by Mei-Feng Chen, Chih-Chien Hu, Yung-Heng Hsu, Yu-Chih Lin, Kai-Lin Chen, Steve W. N. Ueng, Yuhan Chang

“…Administration of β1 and β3 integrin agonists (CD98 protein) increased the expression of SOX9 in OA mice. …”
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FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion by Zhiwen Cao, Qiang Yan, Mei Zhang, Yingchun Zhu, Jingyu Liu, Yue Jiang, Xin Zhen, Manlin Xu, Qiuling Yue, Jidong Zhou, Quan Zhou, Xiaoying Wang, Lijun Ding, Haixiang Sun, Guijun Yan

“…Mechanistically, FHL1 did not regulate HOXA10 mRNA expression but increased HOXA10 protein stability and activated HOXA10, thereby promoting its regulation of downstream gene expression and the β3 integrin/FAK pathway. Meanwhile, FHL1 regulates HOXA10 function by increasing HOXA10 deacetylation through enhanced binding of HOXA10 and SIRT2. …”
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The CBP/β-Catenin Antagonist, ICG-001, Inhibits Tumor Metastasis via Blocking of the miR-134/ITGB1 Axis-Mediated Cell Adhesion in Nasopharyngeal Carcinoma by Luo Chen, Yiu Chun Chiang, Lai Sheung Chan, Wai Yin Chau, Maria Li Lung, Michael Kahn, Kwok Wai Lo, Nai Ki Mak, Hong Lok Lung

“…Subsequently, we found that the ICG-001-induced miR-134 expression resulting in downregulation of integrin β1 (<i>ITGB1</i>). Such downregulation reduced cell adhesion and migration capability, as demonstrated by siRNA-mediated knockdown of <i>ITGB1</i>. …”
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Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity by Jianbo He, Jianbo He, Kai Chen, Tiancheng Deng, Jiewei Xie, Kunjing Zhong, Jinbo Yuan, Ziyi Wang, Zhifeng Xiao, Ronghe Gu, Ronghe Gu, Delong Chen, Xiaojuan Li, Dingkun Lin, Jiake Xu

“…These changes led to the deactivation of osteoclast master transcriptional factor-nuclear factor of activated T cells 1 (NFATc1), as examined by qPCR and Western blot assay, which led to the decreased expression of downstream integrin β3, c-Fos, cathepsin K, and Atp6v0d2. These results suggested that RH could effectively suppress RANKL-regulated osteoclast formation and bone resorption. …”
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Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment by Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen

“…We characterize complement receptor 4 as a strong binder of amyloids and show Aβ aggregates are preferentially phagocytosed and stimulate lysosomal activity through this receptor in stem cell-derived microglia. KIM127 integrin activation in monocytes promotes size selective phagocytosis of Aβ. …”
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System biology approaches to identify hub genes linked with ECM organization and inflammatory signaling pathways in schizophrenia pathogenesis by Piplu Bhuiyan, Zhaochu Sun, Md Arif Khan, Md Arju Hossain, Md Habibur Rahman, Yanning Qian

“…Gene ontology (GO), and pathways analysis showed several biological mechanisms enriched by the commonly shared DEGs, including extracellular matrix organization (ECM) organization, collagen fibril organization, integrin signaling pathway, inflammation mediated by chemokines and cytokines signaling pathway, and GABA-B receptor II and IL4 mediated signaling. …”
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Serological Biomarkers of Extracellular Matrix Turnover and Neutrophil Activity Are Associated with Long-Term Use of Vedolizumab in Patients with Crohn’s Disease by Marta S. Alexdottir, Arno R. Bourgonje, Morten A. Karsdal, Martin Pehrsson, Roberta Loveikyte, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra, Joachim H. Mortensen

“…The introduction of the α4β7-integrin inhibitor vedolizumab (VEDO) has improved disease management, although there is a high rate of primary non-response in patients with CD. …”
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Potential Targets Other Than PSMA for Prostate Cancer Theranostics: A Systematic Review by Mathieu Gauthé, Paul Sargos, Eric Barret, Gaëlle Fromont-Hankard, Jean-Baptiste Beauval, Laurent Brureau, Gilles Créhange, Raphaële Renard-Penna, Charles Dariane, Gaëlle Fiard, Romain Mathieu, Guilhem Roubaud, Alain Ruffion, Morgan Rouprêt, Guillaume Ploussard, on behalf of the CC-AFU

“…Results: We included 38 studies on six different targets: gastrin-releasing peptide receptors (GRPRs) (<i>n</i> = 23), androgen receptor (<i>n</i> = 11), somatostatin receptors (<i>n</i> = 6), urokinase plasminogen activator surface receptor (<i>n</i> = 4), fibroblast activation protein (<i>n</i> = 2 studies) and integrin receptors (<i>n</i> = 1). GRPRs, the most studied target, has a lower expression in high-grade PCa, CRPC and bone metastases. …”
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Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival by Tao Jiang, Jiahui Zhang, Beite Ruan, Xiaobing Xi, Zhuo Yang, Jianmin Liu, Hongyan Zhao, Xing Xu, Min Jiang

“…Further study demonstrated that TCG inhibited Rap1/integrin αvβ3/c-Src/Pyk2 signaling cascade, and consequently led to failed F-actin ring formation. …”
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Identification of a new DC-SIGN binding pentamannoside epitope within the complex structure of Candida albicans mannan by Vadim B. Krylov, Marcos Gómez-Redondo, Arsenii S. Solovev, Dmitry V. Yashunsky, Alistair J.P. Brown, Mark H.T. Stappers, Neil A.R. Gow, Ana Ardá, Jesús Jiménez-Barbero, Nikolay E. Nifantiev

“…The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune C-type lectin receptor that recognizes carbohydrate-based pathogen associated with molecular patterns of various bacteria, fungi, viruses and protozoa. …”
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Clinical, Histological, and Profibrotic Extracellular Matrix Protein Changes in a Model of Tracheal Stenosis Induced by Cervical Tracheal Autotransplantation by Mariana Silva-Martínez, J. Raúl Olmos-Zuñiga, Jazmin Calyeca, Matilde Baltazares-Lipp, Miguel Gaxiola-Gaxiola, Andrea Nachón-Acosta, Lya Edith Pensado-Piedra, Fortunato Juárez-Hernández, Roberto Sotelo-Robledo, Rogelio Jasso-Victoria, Antonia Luna-Flores, Juan Carlos Vázquez-Minero

“…Additionally, to evaluate the clinical and histological changes, as well as the expression of newly formed collagen (NFC), isoforms of transforming growth factor beta (TGFβ), fibronectin (FN), elastin (ELN), integrin β1 (ITGβ1), and matrix metalloproteinase 1 (MMP1) in TS. …”
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Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors by Linlin Guo, Atish Mohanty, Sharad Singhal, Saumya Srivastava, Arin Nam, Charles Warden, Sravani Ramisetty, Yate-Ching Yuan, Hyejin Cho, Xiwei Wu, Aimin Li, Manik Vohra, Srinivas Vinod Saladi, Deric Wheeler, Leonidas Arvanitis, Erminia Massarelli, Prakash Kulkarni, Yiming Zeng, Ravi Salgia

“…Summary: This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance in lung squamous cell carcinoma (LUSC). …”
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Hypoxia-cleavable and specific targeted nanomedicine delivers epigenetic drugs for enhanced treatment of breast cancer and bone metastasis by Zhaofeng Li, Peixin Liu, Wei Chen, Xueying Liu, Fan Tong, Junhui Sun, Yang Zhou, Ting Lei, Wenqin Yang, Dong Ma, Huile Gao, Yi Qin

“…ARNP actively targets breast cancer cells via an RGD-αvβ3 integrin interaction after PEG chain cleavage by responding to hypoxic tumor microenvironment. …”
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Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarkers Involved in Pulmonary Tuberculosis and Pulmonary Tuberculosis-Complicated... by Yunguang Wang, Xinxin He, Danna Zheng, Qiang He, Lifang Sun, Juan Jin

“…Transcriptional data revealed that lipocalin 2 (LCN2), defensin alpha 1 (DEFA1), peptidoglycan recognition protein 1 (PGLYRP1), and integrin subunit alpha 2b (ITGA2B) were significantly upregulated, while chloride intracellular channel 3 (CLIC3) was significantly downregulated in the group with PTB and DM (PTB_DM) in contrast to the healthy control (HC) group. …”
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