Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression by Oudin, Madeleine Julie, Jonas, Oliver H., Kosciuk, Tatsiana, Broye, Liliane C., Candido Guido, Bruna, Wyckoff, Jeffrey, Asokan, Sreeja B., Whittaker, Charles A., Ma, Duanduan, Cima, Michael J., Wisinski, Kari B., Keely, Patricia J., Bear, James E., Gertler, Frank, Riquelme, Daisy Noelia, Lamar, John, Langer, Robert S, Hynes, Richard O, Lauffenburger, Douglas A

“…Haptotaxis on FN gradients requires direct interaction between α5β1 integrin and Mena, an actin regulator, and involves increases in focal complex signaling and tumor-cell-mediated extracellular matrix (ECM) remodeling. …”
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Glycosaminoglycan regulation of cell function by Berry, David (David A.)

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GSK3β interacts with CRMP2 and Notch1 and controls T-cell motility by Mobashar Hussain Urf Turabe Fazil, Prasannan, Praseetha, Wong, Brandon Han Siang, Kottaiswamy, Amuthavalli, Nur Syazwani Mohamed Salim, Sze, Siu Kwan, Verma, Navin Kumar

“…Inhibition of GSK3β by CHIR-99021 or siRNA-mediated knockdown augmented the migratory behavior of human T-lymphocytes stimulated via an engagement of the T-cell integrin LFA-1 with its ligand ICAM-1. Proteomics and protein network analysis revealed ongoing interactions among GSK3β, the surface receptor Notch1 and the cytoskeletal regulator CRMP2. …”
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The interaction of proteins with membranes: combined computational and neutron studies by John, L

“…The proteins of interest were the Kindlin-2 and the T-lymphoma invasion and metastasis 2 (TIAM2) proteins, involved in integrin activation and Rac1 GTPase activation, respectively. …”

Effector functions of mucosal associated invariant T cells in response to viral infections and vaccines by Amini, A

“…The baseline circulating innate-like lymphocytes of IBD patients are distinct from healthy controls, with higher frequencies of Vδ2+ γδ T cells in patients receiving anti-TNF compared to those receiving anti-integrin therapy. Similarly, early IFN-γ generated after ChAdOx1-S prime is lower in IBD patients on anti-TNF, with no difference in type I IFN production. …”

Immunomodulating properties of Sabah Seaweeds Kappaphycus Striatus and Eucheuma Denticulatum by Pan, Shing Yi

“…Wound healing activity involves the signal transduction and interaction of ECM to cell adheSion receptor integrins, cytoplasmic kinases, growth factors and cytokines. …”
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Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma by Guillaume B. Cardin, Monique Bernard, Houda Bahig, Phuc Felix Nguyen-Tan, Olivier Ballivy, Edith Filion, Denis Soulieres, Pierre Philouze, Tareck Ayad, Louis Guertin, Eric Bissada, Francis Rodier, Apostolos Christopoulos

“…Furthermore, high DCBLD1 expression is associated with activation of the integrin signaling pathway and its phosphorylation with EGFR and MET. …”
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Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib by Jung Woo Eun, Jung Hwan Yoon, Hye Ri Ahn, Seokhwi Kim, Young Bae Kim, Su Bin Lim, Won Park, Tae Wook Kang, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Ji Hyang Weon, Soon Sun Kim, Hyo Jung Cho, Jae Youn Cheong

“…CAF‐derived SPP1 activated rapidly accelerated fibrosarcoma (RAF)/mitogen‐activated protein kinase (MAPK) and phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) through the integrin‐protein kinase C‐alpha (PKCα) signaling pathway and promoted epithelial‐to‐mesenchymal transition (EMT). …”
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A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair by Haeun Chung, Jung-Kyun Choi, Changgi Hong, Youngseop Lee, Ki Hyun Hong, Seung Ja Oh, Jeongmin Kim, Soo-Chang Song, Jong-Wan Kim, Sang-Heon Kim

“…Culturing human adipose-derived stem cells (hASCs) with CMG enabled integrin receptors to interact with CMG to form injectable 3-dimensional constructs (CMG-hASCs) with a microporous microarchitecture and enhanced mass transfer. …”
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Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis by Yesheng Fu, Lei Li, Xin Zhang, Zhikang Deng, Ying Wu, Wenzhe Chen, Yuchen Liu, Shan He, Jian Wang, Yuping Xie, Zhiwei Tu, Yadi Lyu, Yange Wei, Shujie Wang, Chun-Ping Cui, Cui Hua Liu, Lingqiang Zhang

“…Moreover, we show that linear ubiquitination of Integrin-linked protein kinase (ILK) decreases focal adhesion formation and promotes the detachment of Shigella flexneri-infected cells. …”
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LC-MS/MS Proteomic Study of MCF-7 Cell Treated with Dox and Dox-Loaded Calcium Carbonate Nanoparticles Revealed Changes in Proteins Related to Glycolysis, Actin Signalling, and Ene... by Hamidu Ahmed, Mokrish Ajat, Rana I. Mahmood, Rozaihan Mansor, Intan Shameha Abdul Razak, Jameel R. Al-Obaidi, Nurhanani Razali, Alhaji Zubair Jaji, Abubakar Danmaigoro, Md Zuki Abu Bakar

“…Bioinformatics analysis revealed the predicted canonical pathways linking the signalling of the actin cytoskeleton, ILK, VEGF, BAG2, integrin and paxillin, as well as glycolysis. This research indicates that proteomic analysis is an effective technique for proteins expression associated with chemotherapy drugs on cancer tumours; this method provides the opportunity to identify treatment targets for MCF-7 cancer cells, and a liquid chromatography-mass spectrometry (LC-MS/MS) system allowed the detection of a larger number of proteins than 2-DE gel analysis, as well as proteins with maximum pIs and high molecular weight.…”
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Tissular Genomic Responses to Oral FB1 Exposure in Pigs by Léonie Dopavogui, Arnaud Polizzi, Anne Fougerat, Pascal Gourbeyre, Chloé Terciolo, Wendy Klement, Philippe Pinton, Joëlle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, Olivier Puel, Yannick Lippi, Claire Naylies, Hervé Guillou, Isabelle P. Oswald, Nicolas Loiseau

“…In response to oral FB1 exposure, we observed common biological processes in the four organs, including predominant and recurrent processes (extracellular matrix organization, integrin activation, granulocyte chemotaxis, neutrophil migration, and lipid and sterol homeostasis), as well as more tissue-specific processes that appeared to be related to lipid outcomes (cell cycle regulation in jejunum, and gluconeogenesis in liver).…”
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CC16 drives VLA-2-dependent SPLUNC1 expression by Natalie Iannuzo, Holly Welfley, Nicholas C. Li, Michael D. L. Johnson, Joselyn Rojas-Quintero, Francesca Polverino, Stefano Guerra, Stefano Guerra, Xingnan Li, Darren A. Cusanovich, Darren A. Cusanovich, Paul R. Langlais, Julie G. Ledford, Julie G. Ledford

“…Likewise, rSPLUNC1 results in decreased Mp burden in mice lacking CC16 mice. The VLA-2 integrin binding site within rCC16 is necessary for induction of SPLUNC1 and the reduction in Mp burden.ConclusionOur findings demonstrate a novel role for CC16 in epithelial-driven host defense by up-regulating antimicrobials and define a novel epithelial receptor for CC16, VLA-2, through which signaling is necessary for enhanced SPLUNC1 production.…”
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Endothelial cell‐derived extracellular vesicles expressing surface VCAM1 promote sepsis‐related acute lung injury by targeting and reprogramming monocytes by Lu Wang, Ying Tang, Jiajian Tang, Xu Liu, Shuangfeng Zi, Songli Li, Hanbing Chen, Airan Liu, Wei Huang, Jianfeng Xie, Ling Liu, Jie Chao, Haibo Qiu

“…Bioinformatics analysis and further mechanistic studies revealed that vascular cell adhesion molecule 1 (VCAM1), overexpressed on EC‐EVs during sepsis, activated the NF‐κB pathway by interacting with integrin subunit alpha 4 (ITGA4) on the monocyte surface, rather than the tissue resident macrophage surface, thereby regulating monocyte differentiation. …”
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Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma by Zhang J, Song H, Dong Y, Li G, Li J, Cai Q, Yuan S, Wang Y, Song H

“…ITGB1−Deg EVs were further loaded with glypican-3 (GPC3)-specific nanobody (HN3) and mouse single-chain IL12 (mscIL12) to generate ITGB1−mscIL12+HN3+Deg EVs, for evaluation of tumor tropism and therapeutic potential in a mice model of hepatocellular carcinoma.Results: Removal of ITGB1 led to the broad suppression of integrins on the EVs surface, resulting in a decrease in cellular uptake. …”
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Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue by Dominik Michalski, Emma Spielvogel, Emma Spielvogel, Joana Puchta, Joana Puchta, Willi Reimann, Willi Reimann, Henryk Barthel, Björn Nitzsche, Björn Nitzsche, Bianca Mages, Carsten Jäger, Henrik Martens, Anja K. E. Horn, Stefan Schob, Wolfgang Härtig

“…While the increased collagen IV signal was restricted to vessels, fibronectin appeared diffusely arranged in the parenchyma with focal accumulations associated to the vasculature. Integrin α5 appeared enriched in the vicinity of fibronectin and vascular elements, while most of the non-vascular NVU elements showed complementary staining patterns referring to fibronectin. …”
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Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration by Ryan Passino, Matthew C. Finneran, Hannah Hafner, Qian Feng, Lucas D. Huffman, Xiao-Feng Zhao, Craig N. Johnson, Riki Kawaguchi, Juan A. Oses-Prieto, Alma L. Burlingame, Daniel H. Geschwind, Larry I. Benowitz, Roman J. Giger

“…Functional ablation of the complement receptor 3 (CD11b/integrin-αM), but not the complement components C1q−/− or C3−/−, reduces ocular inflammation, protects the blood-retina barrier, and enhances RGC regeneration. …”
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Biocompatibility of Subperiosteal Dental Implants: Effects of Differently Treated Titanium Surfaces on the Expression of ECM-Related Genes in Gingival Fibroblasts by Marco Roy, Alessandro Corti, Silvia Dominici, Alfonso Pompella, Mauro Cerea, Elisa Chelucci, Barbara Dorocka-Bobkowska, Simona Daniele

“…At different times of incubation, viability and proliferation of cells, was determined along with the changes in the expression patterns of ECM-related genes involved in fibroblast attachment and differentiation: vinculin, fibronectin, collagen type I-alpha 1 chain, focal adhesion kinase, integrin β-1, and N-cadherin. Three different experiments were carried out for each experimental point. …”
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Central Role of β-1,4-GalT-V in Cancer Signaling, Inflammation, and Other Disease-Centric Pathways by Subroto Chatterjee, Rebecca Yuan, Spriha Thapa, Resham Talwar

“…On the other hand, we also point to the important role of β-1-4 GalT-V-mediated glycosylation in altering the formation of glycosylated precursor forms of proteins and their activation, e.g., β-1 integrin, wingless-related integration site (Wnt)/–β catenin, Frizzled-1, and Notch1. …”
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IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance by Constantin Schmidt, Constantin Schmidt, Aenne Harberts, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voß, Joanna Schmid, Niels Christian Lory, Michael Spohn, Michael Spohn, Michael Spohn, Friedrich Koch-Nolte, Samuel Huber, Friederike Raczkowski, Minka Breloer, Minka Breloer, Hans-Willi Mittrücker

“…Compromised intestinal migration was associated with reduced expression of the intestinal homing receptors α4β7 integrin, CCR9 and GPR15. Identification of IRF4 binding sites in the gene loci of these receptors suggests a direct control of their expression by IRF4. …”
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