Integrated gene network analysis sheds light on understanding the progression of Osteosarcoma by Hrituraj Dey, Karthick Vasudevan, George Priya Doss C., S. Udhaya Kumar, Achraf El Allali, Alsamman M. Alsamman, Alsamman M. Alsamman, Hatem Zayed

“…The highly enriched signaling pathways include FOXM1 transcription pathway, ATM signal-ling pathway, FAK mediated signaling events, Arf6 signaling events, mTOR signaling pathway, and Integrin family cell surface interactions. Targeting the hub genes and their associated functional partners which we have reported in our studies may be efficacious in developing novel therapeutic targets.…”
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Early Clinical Remission Is a Predictor of Long-Term Remission with the Use of Vedolizumab for Ulcerative Colitis by Keiichi Haga, Tomoyoshi Shibuya, Taro Osada, Shunsuke Sato, Yuka Fukuo, Osamu Kobayashi, Toshio Yamada, Daisuke Asaoka, Kentaro Ito, Kei Nomura, Mayuko Haraikawa, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Mariko Hojo, Akihito Nagahara

“…Vedolizumab (VDZ) is an α4β7 integrin-antibody used to manage refractory ulcerative colitis (UC). …”
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Fibronectin Conformations after Electrodeposition onto 316L Stainless Steel Substrates Enhanced Early-Stage Osteoblasts’ Adhesion but Affected Their Behavior by Séverine Alfonsi, Pithursan Karunathasan, Ayann Mamodaly-Samdjee, Keerthana Balathandayutham, Sarah Lefevre, Anamar Miranda, Olivier Gallet, Damien Seyer, Mathilde Hindié

“…Electrodeposited Fn also diminished α5 integrin secretion and clustering along the plasma membrane. …”
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Proteomic profiling of cell line-derived extracellular vesicles to identify candidate circulatory markers for detection of gallbladder cancer by Ratna Priya, Ratna Priya, Vaishali Jain, Vaishali Jain, Javed Akhtar, Javed Akhtar, Neeraj Saklani, Puja Sakhuja, Anil Kumar Agarwal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Ravi Sirdeshmukh, Sudeshna Kar, Poonam Gautam

“…STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) database was used to perform bioinformatics analysis of 110 proteins which showed ‘cell adhesion molecule binding’, ‘integrin binding’, ‘cadherin binding’ among the top molecular functions and ‘focal adhesion’ to be among the top pathways associated with the EV proteins. …”
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C/D box snoRNA SNORD113-6 guides 2′-O-methylation and protects against site-specific fragmentation of tRNALeu(TAA) in vascular remodeling by Eva van Ingen, Pleun A.M. Engbers, Tamar Woudenberg, M. Leontien van der Bent, Hailiang Mei, Johann Wojta, Paul H.A. Quax, A. Yaël Nossent

“…We previously showed that this snoRNA targets mRNAs of the integrin signaling pathway and affects arterial fibroblast function. …”
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An Activation-Specific Anti-Mac-1 Designed-Ankyrin-Repeat-Protein Attenuates Colitis in Mice by Istvan Bojti, Qianqi Wang, Tibor Bojti, Felicitas Bojti, Patrick Malcolm Siegel, Timo Heidt, Martin Moser, Christoph Bode, Dirk Westermann, Karlheinz Peter, Philipp Diehl

“…The extravasation of activated leukocytes is a critical step in the pathogenesis of these diseases. Leukocyte integrin Mac-1 (α_Mβ₂; CD11b/CD18) is crucial for the extravasation of myeloid cells, and a novel activation-specific anti-Mac-1 Designed Ankyrin Repeat protein (DARPin F7) is a promising therapeutic agent for inflammatory diseases. …”
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Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells by Sukanya Unson, Tung-Cheng Chang, Yung-Ning Yang, Shwu-Huey Wang, Chi-Hung Huang, Dana R. Crawford, Haw-Ming Huang, Zi-Lin Li, Hung-Yun Lin, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Wen-Shan Li

“…A thyroxine-deaminated analogue, tetrac, binds to integrin αvβ3 to induce anti-proliferation in different cancers. …”
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Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers by Nico Hüttmann, Yingxi Li, Suttinee Poolsup, Emil Zaripov, Rochelle D’Mello, Vanessa Susevski, Zoran Minic, Maxim V. Berezovski

“…The presence of transmembrane serine protease matriptase (ST14), claudin-3 (CLDN3), and integrin alpha-7 (ITGA7) in each cell line was validated by Western blot, revealing that ST14 and CLDN3 may be further explored as potential EV biomarkers for BC. …”
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High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels by Johanna Samulin Erdem, Táňa Závodná, Torunn K. Ervik, Øivind Skare, Tomáš Hron, Kristine H. Anmarkrud, Anna Kuśnierczyk, Anna Kuśnierczyk, Julia Catalán, Julia Catalán, Dag G. Ellingsen, Jan Topinka, Shan Zienolddiny-Narui

“…PANTHER pathway analysis of the identified miRNA targets showed that both materials affected growth factor (PDGF, EGF and FGF), Ras/MAPKs, CCKR, GnRH-R, integrin, and endothelin signaling pathways. These pathways are important in inflammation or in the activation, polarization, migration, and regulation of phagocytic capacity of macrophages. …”
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Nox1-based NADPH oxidase regulates the Par protein complex activity to control cell polarization by Alejandra Valdivia, Charity Duran, Mingyoung Lee, Holly C. Williams, Moo-Yeol Lee, Moo-Yeol Lee, Alejandra San Martin, Alejandra San Martin

“…At a molecular level, partitioning-defective (Par) protein complex comprising Par3, Par6, and atypical Protein Kinase (aPKC isoforms ζ and λ/ι) regulates front-rear axis polarization. At the front edge, integrin clustering activates Cdc42, prompting the formation of Par3/Par6/aPKC complexes to modulate MTOC positioning and microtubule stabilization. …”
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YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation by Jiadi Lv, Xiaohan Liu, Yabo Zhou, Feiran Cheng, Haoran Chen, Shunshun Li, Dianheng Wang, Li Zhou, Zhenfeng Wang, Nannan Zhou, Jie Chen, Bo Huang

“…Here, we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like cells. Mechanistically, integrin β8 was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein (YAP). …”
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Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration by Xiaoting Zhang, Xinluan Wang, Yuk-wai Lee, Lu Feng, Bin Wang, Qi Pan, Xiangbo Meng, Huijuan Cao, Linlong Li, Haixing Wang, Shanshan Bai, Lingchi Kong, Dick Ho Kiu Chow, Ling Qin, Liao Cui, Sien Lin, Gang Li

“…Furthermore, mechanism study results indicate that the combination of ICT and HFS additively activates the Integrin–FAK (focal adhesion kinase)–ERK1/2 (extracellular signal-regulated kinase 1/2)–Runx2 (Runt-related transcription factor 2) axis, which could be linked to the beneficial recruitment of MSCs to the implant and subsequent osteogenesis enhancement. …”
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Identification of anoikis-related genes classification patterns and immune infiltration characterization in ischemic stroke based on machine learning by Xiaohong Qin, Xiaohong Qin, Shangfeng Yi, Jingtong Rong, Jingtong Rong, Haoran Lu, Haoran Lu, Baowei Ji, Wenfei Zhang, Rui Ding, Liquan Wu, Zhibiao Chen

“…When cells detach from the correct extracellular matrix, anoikis disrupts integrin junctions, thus preventing abnormal proliferating cells from growing or attaching to an inappropriate matrix. …”
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Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during <i>Xenopus laevis</i> Embryonic Development by Hongchan Lee, Na Young Lee, Youni Kim, Hong-Seok Choi, Tayaba Ismail, Hong-Yeoul Ryu, Dong-Hyung Cho, Zae Young Ryoo, Dong-Seok Lee, Taeg Kyu Kwon, Tae Joo Park, Taejoon Kwon, Hyun-Shik Lee

“…Additionally, transcriptomics analysis of <i>gpx1</i>-knockout embryos demonstrated the involvement of Wnt, cadherin, and integrin signaling pathways in the development of malformed eyes. …”
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Variable clinical expression of a Belgian TGFB3 founder variant suggests the presence of a genetic modifier by Melanie H. A. M. Perik, Emmanuela Govaerts, Steven Laga, Inge Goovaerts, Inge Goovaerts, Johan Saenen, Emeline Van Craenenbroeck, Josephina A. N. Meester, Ilse Luyckx, Ilse Luyckx, Inez Rodrigus, Aline Verstraeten, Lut Van Laer, Bart L. Loeys, Bart L. Loeys

“…The Asp263 residue is essential for integrin binding to the Arg-Gly-Asp (RGD) motif of the TGFβ3-cytokine.Results: The haplotype analysis revealed a shared haplotype of minimum 1.92 Mb and maximum 4.14 Mb, suggesting a common founder originating &gt;400 years ago. …”
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Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis by Li Zhang, Lawrence Fong, Brittany Davidson, David Y Oh, Frances Fan, Alexander Cheung, Hai Yang, Jun Yan He, Yang-Joon Kim, Elvira Mennillo, Iulia Rusu, Jared Bain, Arjun A Rao, Christopher Andersen, Karen Law, Jessica Tsui, Alan Shen, Divyashree Kushnoor, Yimin Shi, Alexis J Combes, Angela O Pisco, Michael G Kattah

“…Endothelial cells in CPI colitis after anti-TNF and anti-cytotoxic T-lymphocyte-associated antigen 4 (anti-CTLA-4) upregulated the integrin α4β7 ligand molecular vascular addressin cell adhesion molecule 1 (MAdCAM-1), which may preferentially respond to vedolizumab (anti-α4β7).Conclusions These findings nominate CD4+ RM and MAdCAM-1+ endothelial cells for targeting in specific subsets of CPI colitis patients.…”
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Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization by Marie‐Daniéla Dubois, Ivan Peyron, Olivier‐Nicolas Pierre‐Louis, Serge Pierre‐Louis, Johalène Rabout, Pierre Boisseau, Annika deJong, Sophie Susen, Jenny Goudemand, Rémi Neviere, Pascal Fuseau, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Caterina Casari

“…(Pro2145Thrfs*5)‐rVWF exhibited reduced binding to type III collagen and αIIbβ3 integrin compared to wild‐type‐rVWF. Conclusions We report two mutations of the D4 domains that induced combined qualitative and quantitative defects.…”
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STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases by Alex S. Ferecskó, Miranda J. Smallwood, Adrian Moore, Corin Liddle, Jia Newcombe, Janet Holley, Jacqueline Whatmore, Nicholas J. Gutowski, Paul Eggleton

“…Human brain endothelial cells were cultured and stimulated with the STING agonist palmitic acid (1–400 μM) and assessed for mitochondrial stress (release of mitochondrial DNA into cytosol, increased oxygen consumption), downstream regulator factors, TBK-1/pIRF3 and inflammatory biomarker interferon-β release and changes in ICAM-1 integrin expression. Results: In neurodegenerative brain diseases, elevated STING protein was observed mainly in brain endothelial cells and neurons, compared to non-neurodegenerative control tissues where STING protein staining was weaker. …”
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Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells by Yao-Jen Chang, Steven Lin, Zhi-Fu Kang, Bin-Jon Shen, Wen-Hai Tsai, Wen-Ching Chen, Hsin-Pin Lu, Yu-Lun Su, Shu-Jen Chou, Shu-Yu Lin, Sheng-Wei Lin, Yin-Jung Huang, Hsin-Hui Wang, Ching-Jin Chang

“…The expression levels of embryonic-related globin gene and a platelet cell marker integrin-beta 3 were increased in <i>TRIM28</i>-K304Q mutant cells, indicating the induction of differentiation. …”
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Dendritic cell-targeting chemokines inhibit colorectal cancer progression by Pengkun Yuan, Yunyi Zhou, Zhixue Wang, Liming Gui, Bin Ma

“…Results: Expression of the four chemokines was positively correlated with the two DC markers [integrin alpha X (ITGAX) and CLEC9A] in human colorectal tumor samples. …”
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