Hypomethylation of <i>CLDN4</i> Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer by Fumisato Maesaka, Masaomi Kuwada, Shohei Horii, Shingo Kishi, Rina Fujiwara-Tani, Shiori Mori, Kiyomu Fujii, Takuya Mori, Hitoshi Ohmori, Takuya Owari, Makito Miyake, Yasushi Nakai, Nobumichi Tanaka, Ujjal Kumar Bhawal, Yi Luo, Masuo Kondoh, Kiyohide Fujimoto, Hiroki Kuniyasu

“…The TJ-unintegrated CLDN4 was found to bind integrin β1 and increase stemness, drug resistance, and metastatic ability of the cells as well as show an anti-apoptosis effect likely via FAK phosphorylation, which reduces upon knockdown of CLDN4. …”
Get full text

ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity by Matthieu Halfon, Li Zhang, Driss Ehirchiou, Vishnuprabu Durairaj Pandian, Suzan Dahdal, Uyen Huynh-Do, Andreas Pasch, Camillo Ribi, Nathalie Busso

“…Objectives: CD11B/ITGAM (Integrin Subunit α M) mediates the adhesion of monocytes, macrophages, and granulocytes and promotes the phagocytosis of complement-coated particles. …”
Get full text

Novel Prognostic Model Construction of Tongue Squamous Cell Carcinoma Based on Apigenin-Associated Genes by Jianfei Lai, Chen Fang, Guohua Zhang, Chao Shi, Feng Yu, Weiguo Gu, Jianxiong Deng, Jingbiao Xu, Chaoxing Liu, Feng Qiu

“…Among API-related genes, TSCC cells treated with API, compared to the control group, have higher levels of transmembrane protein 213 (TMEM213) and G protein-coupled receptor 158 (GPR158), and lower levels of caspase 14 (CASP14) and integrin subunit alpha 5 (ITGA5). An 7 API-associated gene model was built through Lasso regression and multivariate Cox regression that could direct TSCC prognostic status and tumor immune cell infiltration. …”
Get full text

LRP-1-dependent control of calpain expression and activity: A new mechanism regulating thyroid carcinoma cell adhesion by Benoit Langlois, Benoit Langlois, Julie Martin, Julie Martin, Christophe Schneider, Christophe Schneider, Cathy Hachet, Cathy Hachet, Christine Terryn, Damien Rioult, Laurent Martiny, Laurent Martiny, Louis Théret, Louis Théret, Stéphanie Salesse, Stéphanie Salesse, Stéphane Dedieu, Stéphane Dedieu

“…We showed that LRP1-mediated calpain inhibition participates in talin-positive focal adhesions dissolution and limits β1-integrin expression at carcinoma cell surface. In conclusion, we identified an additional and innovative intracellular mechanism which demonstrates LRP-1 pro-motile action in thyroid cancer cells. …”
Get full text

Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wo... by Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang

“…We previously identified a cyclic peptide LXW7 that specifically binds to integrin αvβ3 on endothelial progenitor cells (EPCs) and endothelial cells (ECs), activates vascular endothelial growth factor (VEGF) receptors, and promotes EC growth and maturation. …”
Get full text

IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing by Sara Andreone, Francesca Spadaro, Carla Buccione, Jacopo Mancini, Antonella Tinari, Paola Sestili, Adriana Rosa Gambardella, Valeria Lucarini, Giovanna Ziccheddu, Isabella Parolini, Cristiana Zanetti, Maria Teresa D’Urso, Adele De Ninno, Luca Businaro, Claudia Afferni, Fabrizio Mattei, Giovanna Schiavoni

“…Blocking of CD11b/CD18 signaling significantly reduced IL-33-activated eosinophils&#8217; binding and subsequent killing of tumor cells, indicating a crucial role for this integrin in triggering degranulation. Our findings provide novel mechanistic insights for eosinophil-mediated anti-tumoral function driven by IL-33. …”
Get full text

Comparison of a New ⁶⁸Ga-Radiolabelled PET Imaging Agent sCD146 and RGD Peptide for In Vivo Evaluation of Angiogenesis in Mouse Model of Myocardial Infarction by Anaïs Moyon, Philippe Garrigue, Samantha Fernandez, Fabien Hubert, Laure Balasse, Pauline Brige, Guillaume Hache, Vincent Nail, Marcel Blot-Chabaud, Françoise Dignat-George, Francesca Rochais, Benjamin Guillet

“…On that basis, we developed an AMOT-targeting radiotracer, ⁶⁸Ga-sCD146 and performed the first in vivo evaluation on a myocardial infarction mice model and then, compared AMOT expression and α_vβ₃-integrin expression with ⁶⁸Ga-sCD146 and ⁶⁸Ga-RGD₂ imaging. …”
Get full text

Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial–Mesenchymal Transition by Kentaro Tokumo, Takeshi Masuda, Taku Nakashima, Masashi Namba, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Yoshihiro Miyata, Morihito Okada, Hironobu Hamada, Noboru Hattori

“…Additionally, an RNA microarray analysis revealed upregulation of the integrin-induced EMT pathway in osimertinib-tolerant cells. …”
Get full text

Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases by Lorenzo Bertani, Gian Paolo Caviglia, Luca Antonioli, Rinaldo Pellicano, Sharmila Fagoonee, Marco Astegiano, Giorgio Maria Saracco, Elisabetta Bugianesi, Corrado Blandizzi, Francesco Costa, Davide Giuseppe Ribaldone

“…Vedolizumab, a monoclonal antibody directed against integrin α4β7, is an effective treatment for inflammatory bowel diseases. …”
Get full text

Association of Circulating Neutrophils with Relative Volume of Lipid-Rich Necrotic Core of Coronary Plaques in Stable Patients: A Substudy of SMARTool European Project by Silverio Sbrana, Antonella Cecchettini, Luca Bastiani, Annamaria Mazzone, Federico Vozzi, Chiara Caselli, Danilo Neglia, Alberto Clemente, Arthur J. H. A. Scholte, Oberdan Parodi, Gualtiero Pelosi, Silvia Rocchiccioli

“…Conclusions: These preliminary findings suggest that a sustained increase in circulating neutrophils, together with the up-regulation of the integrin/activation membrane neutrophil marker CD11b may contribute, through the progressive intra-plaque accumulation of necrotic/apoptotic cells exceeding the efferocytosis/anti-inflammatory capacity of infiltrating macrophages and lymphocytes, to the relative enlargement of the lipid-rich necrotic core volume of coronary plaques in stable CAD patients, thus increasing their individual risk of acute complication.…”
Get full text

¹⁸F Site-Specific Labelling of a Single-Chain Antibody against Activated Platelets for the Detection of Acute Thrombosis in Positron Emission Tomography by Katie S. Ardipradja, Christian W. Wichmann, Kevin Hickson, Angela Rigopoulos, Karen M. Alt, Hannah A. Pearce, Xiaowei Wang, Graeme O’Keefe, Andrew M. Scott, Karlheinz Peter, Christoph E. Hagemeyer, Uwe Ackermann

“…We, previously, generated a fluorine-18 labelled single-chain antibody (scFv) against ligand-induced binding sites (LIBS) on activated platelets, binding it to the highly abundant platelet glycoprotein integrin receptor IIb/IIIa. We used a non-site-specific bio conjugation approach with <i>N</i>-succinimidyl-4-[¹⁸F]fluorobenzoate (S[¹⁸F]FB), leading to a mixture of products with reduced antigen binding. …”
Get full text

Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors by Bandeira, Francisco, Goh, Tze-Wei, Setiawan, Melina, Yam, Gary Hin-Fai, Mehta, Jodhbir Singh

“…Results: CD73high/CD90high/CD105high/CD166high/CD14negative/CD31negativehuman ADSC underwent MET, giving viable epithelial-like progenitors expressingδNp63, CDH1 (E-cadherin), epidermal growth factor receptor, integrin-β4, and cytokeratin (CK)-5, 9. Under defined epithelial differentiation culture, these progenitors generated MET-Epicells expressing cell junction proteins ZO1 and occludin. …”
Get full text

The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling by Mobashar Hussain Urf Turabe Fazil, Chirumamilla, Chandra Sekhar, Perez-Novo, Claudina, Wong, Brandon Han Siang, Kumar, Sunil, Sze, Siu Kwan, Berghe, Wim Vanden, Verma, Navin Kumar

“…We found that WFA dose-dependently (within the concentration range of 0.3-1.25 μM) inhibited the ability of human T-cells to migrate via cross-linking of the lymphocyte function-associated antigen-1 (LFA-1) integrin with its ligand, intercellular adhesion molecule 1 (ICAM-1). …”
Get full text

Identification of novel genetic variants and in-silico pathway analysis in patients with dilated cardiomyopathy / Rafezah Razali by Razali, Rafezah

“…In the present study, novel candidate genes for DCM have been identified, including Myosin light chain 2 (MYL2), Myosin light chain 7 (MYL7), Kruppel-associated box domain (KRAB) Zinc-fingers gene family, zinc finger MYM-type containing 4 (ZMYM4), Interleukin 23 receptor (IL23R), F-box protein 22 (FBX022), phospolipase C gamma 1 (PLCG1), Ryanodine receptor 1 (RYR1), Integrin beta 7 (ITGB7) and GNAS complex locus (GNAS) genes that involve in the sarcomere assembly in providing structural integrity of cardiomyocytes, autoimmune and inflammatory response, calcium signalling and regulation of actin cytoskeletal pathways. …”
Get full text

Characterization of candidate proteins involved in calreticulin-dependent invasion using breast cancer tissue biopsies by Noudehi, Zahra Yekta Moghaddam

“…CRT is a high-capacity calcium-binding protein found in the endoplasmic reticulum (ER) lumen and has been implicated in a variety of functions outside of the ER, including cell adhesion and integrin-dependent calcium signaling. CRT has been found to be over-expressed in cancers including breast cancer. …”
Get full text

In vitro and in vivo anti-lung cancer properties of leaf ethanolic extract of morinda citrifolia l. by Lim, Swee Ling

“…The MLE suppressed lung and liver cancer invasive migration or metastasis via down-regulating angiogenesis biochemical pathways (EGFR, MMP9 and integrin). The 300 mg/kg body-weight MLE significantly (and dose-dependently) suppressed lung tumour growth, more effectively than the 50 mg/kg body-weight Erlotinib treatment for most of the parameters measured. …”
Get full text

Association of gene polymorphisms and XPD expression on risk of nasopharyngeal carcinoma and survival among Malaysians by Ban, Eng Zhuan

“…ITGA2 is the alpha subunit of the transmembrane receptor integrin and is mainly responsible for cell-cell and cellextracellular matrix interaction. …”
Get full text

HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer by Zhenyu Li, Ran Wei, Shunyu Yao, Fang Meng, Lingsuo Kong

“…Reinforced by qRT-PCR, we identified Integrin beta-1 (ITGB1), C–C motif chemokine ligand 2 (CCL2), striatin 3 (STRN3), and endothelin-1 (EDN1) as pivotal downstream genes influenced by HIF-1A. …”
Get full text

Engineering the viscoelasticity of gelatin methacryloyl (GelMA) hydrogels via small “dynamic bridges” to regulate BMSC behaviors for osteochondral regeneration by Changjiang Liu, Qifan Yu, Zhangqin Yuan, Qianping Guo, Xiting Liao, Feng Han, Tao Feng, Guoping Liu, Runze Zhao, Zhuang Zhu, Haijiao Mao, Caihong Zhu, Bin Li

“…RNA-sequencing and immunofluorescence suggested that the viscous dissipation of hydrogels activated Yes-associated protein (YAP) by stabilizing integrin β1, and further promoted nuclear translocation of smad2/3 and β-catenin to enhance chondrogenesis and osteogenesis. …”
Get full text

Phosphorylated pullulan promotes calcification during bone regeneration in the bone defects of rat tibiae by Yasuhito Morimoto, Yasuhito Morimoto, Tomoka Hasegawa, Hiromi Hongo, Tomomaya Yamamoto, Tomomaya Yamamoto, Haruhi Maruoka, Mai Haraguchi-Kitakamae, Mai Haraguchi-Kitakamae, Ko Nakanishi, Tsuneyuki Yamamoto, Hotaka Ishizu, Hotaka Ishizu, Tomohiro Shimizu, Kumiko Yoshihara, Kumiko Yoshihara, Yasuhiro Yoshida, Tsutomu Sugaya, Norio Amizuka

“…No significant differences were observed in the expression of Alp, Integrin αv, Osteopontin, Osteocalcin, and Dmp-1 in PPL-treated MC3T3-E1 osteoblastic cells, suggesting that PPL did not facilitate osteoblastic differentiation. …”
Get full text