Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function by Isaacson, Keith B., Cook, Christi Dionne, Hill, Abby, Guo, Margaret G., Stockdale, Linda, Papps, Julia P, Lauffenburger, Douglas A, Griffith, Linda G

“…Then, using a co-culture system of epithelial cells cultured on top of gel-encapsulated stromal cells, we show that inclusion of ECM-binding peptides in the hydrogel, along with the integrin-binding peptide, leads to enhanced accumulation of basement membrane beneath the epithelial layer and more fibrillar collagen matrix assembly by stromal cells over two weeks in culture. …”
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Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease by Okpala, Iheanyi, Ren, Hongmei, Ghebremeskel, Kebreab, Ugochukwu, Cynthia C., Ibegbulam, Obike, Crawford, Michael A.

“…Previously, we found high expression of the adhesion molecules αMβ2 integrin and L-selectin in HbSS individuals with severe disease. …”

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN by Saliba, R, Regis Saliba

“…Among them, DC-Specific ICAM-3 Grabbing Non-integrin CD209 (DC-SIGN) is very specifically expressed only on one subset of DCs called interstitial DCs. …”

Isolation, characterization and quantitative proteomics analysis of chicken dendritic cells following infection with infectious bursal disease virus by Abd Rahaman, Nor Yasmin

“…Most of the protein functions that were impaired at 3 hpi were related to signaling, stress response and immune response, for instance integrin α and β, heat shock proteins (HSPs) especially HSP90α and HSP60. …”
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The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis by Jia Song, Yuning Zhang, Yunyang Bai, Xiaowen Sun, Yanhui Lu, Yusi Guo, Ying He, Min Gao, Xiaopei Chi, Boon Chin Heng, Xin Zhang, Wenjing Li, Mingming Xu, Yan Wei, Fuping You, Xuehui Zhang, Dan Lu, Xuliang Deng

“…By removing the K63‐linked polyubiquitin chains on SEC23B Lysine 81, the deubiquitinase OTUD1 negatively regulates the COPII secretory machinery and limits protein ER‐to‐Golgi trafficking, thus restricting the surface expression of integrin‐regulated proteins, CD9 and CD47. Accordingly, blockade of protein transport by Brefeldin A (BFA) curbs recruitment of Otud1‐deficient TINs and attenuates inflammation‐induced alveolar bone destruction. …”
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Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adh... by Zhaojie Wang, Huiyi Yang, Xu Xu, Hongxing Hu, Yuxin Bai, Jian Hai, Liming Cheng, Rongrong Zhu

“…Transcriptome sequencing revealed significant regulatory roles of the extracellular matrix (ECM) and integrin receptors of focal adhesion signaling pathway in enhancing chondrogenic differentiation and thus prompting tissue regeneration. …”
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STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC ProgressionSummary by Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Hidetoshi Eguchi, Nobuyuki Takemura, Norihiro Kokudo, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara

“…Meanwhile, hepatoma cells produced CTGF to stimulate integrin/nuclear factor kappa B signaling and up-regulate IL-6 family cytokines from stromal cells, which could in turn activate gp130/STAT3 signaling in hepatoma cells. …”
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Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination by Hyunbin D. Huh, Yujin Sub, Jongwook Oh, Ye Eun Kim, Ju Young Lee, Hwa-Ryeon Kim, Soyeon Lee, Hannah Lee, Sehyung Pak, Sebastian E. Amos, Danielle Vahala, Jae Hyung Park, Ji Eun Shin, So Yeon Park, Han Sang Kim, Young Hoon Roh, Han-Woong Lee, Kun-Liang Guan, Yu Suk Choi, Joon Jeong, Junjeong Choi, Jae-Seok Roe, Heon Yung Gee, Hyun Woo Park

“…Induction of AST in adherent cells 1) suppress global integrin/ECM gene expression via Hippo-YAP/TEAD inhibition to evoke spontaneous cell–matrix dissociation and 2) upregulate globin genes that prevent oxidative stress to acquire anoikis resistance, in the absence of lineage differentiation. …”
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Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale by Xiaoman Wang, Tingting Liao, Cong Wan, Xiaoyu Yang, Jiexiang Zhao, Rui Fu, Zhaokai Yao, Yaping Huang, Yujia Shi, Gang Chang, Yi Zheng, Fang Luo, Zhaoting Liu, Yu Wang, Xinliang Mao, Xiao-Yang Zhao

“…Then, we examined the gene expression of germ cell marker genes and the key epigenetic modifications of the EpCAM-/INTEGRINα6-high cells from the 3D MC induction system and the U96 system via quantitative PCR and immunofluorescence. …”
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Characterization of CD41+ cells in the lymph node by Li Dai, Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni, Takaharu Ichimura, Melissa M. Lee-Sundlov, Melissa M. Lee-Sundlov, Vivek Kasinath, Jade A. Sullivan, Heyu Ni, Heyu Ni, Francesca Barone, Silvia Giannini, Baharak Bahmani, Peter T. Sage, Nikolaos A. Patsopoulos, Nikolaos A. Patsopoulos, George C. Tsokos, Jonathan S. Bromberg, Karin Hoffmeister, Karin Hoffmeister, Liwei Jiang, Reza Abdi

“…Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells. CD41 (integrin αIIb) is known to be expressed by platelets and hematolymphoid cells. …”
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Thyroid hormone action controls multiple components of cell junctions at the ventricular zone in the newborn rat brain by Katherine L. O’Shaughnessy, Benjamin D. McMichael, Benjamin D. McMichael, Aubrey L. Sasser, Aubrey L. Sasser, Kiersten S. Bell, Kiersten S. Bell, Cal Riutta, Cal Riutta, Jermaine L. Ford, Tammy E. Stoker, Rachel D. Grindstaff, Arun R. Pandiri, Mary E. Gilbert

“…Immunohistochemistry of integrin αvβ3 and isoforms of both thyroid receptors (TRα/TRβ) showed highly overlapping expression patterns, including enrichment in the VZ. …”
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Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface by Tetta Takahashi, Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, Toshiki Ochi, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Tomoko Honjo, Yoshihiko Sakaguchi, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Yusuke Inoue, Junichiro Futami, Shinichi Toyooka, Yoshito Zamami, Masakiyo Sakaguchi

“…BackgroundOur earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst to lock annexin A2 on the cell membrane surface, which accelerates invasive outgrowth of the cancer through the binding of integrin-β1 on the cell surface. However, whether this machinery is subject to the LOXL4-mediated intrusive regulation remains uncertain.MethodsCell invasion was assessed using a transwell-based assay, protein–protein interactions by an immunoprecipitation–Western blotting technique and immunocytochemistry, and plasmin activity in the cell membrane by gelatin zymography.ResultsWe revealed that cell surface annexin A2 acts as a receptor of plasminogen via interaction with S100A10, a key cell surface annexin A2-binding factor, and S100A11. …”
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ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1 by Yu-kun Li, An-bo Gao, Tian Zeng, Dan Liu, Qun-feng Zhang, Xiao-min Ran, Zhen-zi Tang, Yan Li, Jue Liu, Ting Zhang, Gang-qing Shi, Wen-chao Zhou, Wen-da Zou, Juan Peng, Juan Zhang, Hui Li, Juan Zou

“…In the OC microenvironment, ESM1 may interfere with the binding of ANGPTL4 to integrin and vascular-endothelial cadherin (VE-Cad), which leads to stabilization of vascular integrity and ultimately promotes angiogenesis. …”
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USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer by Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang

“…Herein, we sought to better understand how ubiquitin‐specific peptidase 51 (USP51)/PD‐L1/integrin beta‐1 (ITGB1) signaling performs a cell‐intrinsic role in mediating chemotherapeutic resistance in non‐small cell lung cancer (NSCLC). …”
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The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated CancerSummary by Maxime K. Collard, Julien Tourneur-Marsille, Mathieu Uzzan, Miguel Albuquerque, Maryline Roy, Anne Dumay, Jean-Noël Freund, Jean-Pierre Hugot, Nathalie Guedj, Xavier Treton, Yves Panis, Eric Ogier-Denis

“…Blocking lymphocyte trafficking to the colon with the anti-α4β7 integrin antibody or a sphingosine-1-phosphate receptor agonist suppressed the inducing effect of the appendectomy on tumors’ number and on CD3+/CD8+ intratumoral density. …”
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Comparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis by Sini Li, Yan Qu, Lihui Liu, Xue Zhang, Yan He, Chao Wang, Yufeng Guo, Li Yuan, Zixiao Ma, Hua Bai, Jie Wang

“…Regarding heterogeneity, LM-DEEPs primarily consisted of proteoglycans, lipoprotein, integrin, and heat shock protein, whereas the BM-DEEPs consisted of calcium-dependent/S100 proteins. …”
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Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers by Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana Gupta, Pierre-François Lenne, Bianca H Habermann, Olivier Theodoly, Olivier Pourquié, Frank Schnorrer

“…Furthermore, we found that myofiber ends stably attach to other myofibers using integrin-based attachments and thus myofiber bundling coincides with stable myofiber bundle attachment in vitro. …”
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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids by Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Laura Santana Gonzalez, Moiad Alazzam, Jason Jiang, Beena Abdul, Hooman Soleymani majd, Levi L. Blazer, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed

“…Using functional approaches, as well as bulk and single-cell transcriptomics analyses, we show that an endogenous hormonally regulated WNT7A-FZD5 signaling axis is critical for stem cell renewal and that WNT/β-catenin pathway-activated cells form a distinct transcriptomic cluster of FT cells enriched in extracellular matrix (ECM) remodeling and integrin signaling pathways. Overall, we provide a deep characterization of FT stem cells and their molecular requirements for self-renewal, paving the way for mechanistic work investigating the role of stem cells in FT health and disease.…”
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Pharmacological targeting of MTHFD2 suppresses NSCLC via the regulation of ILK signaling pathway by Feng Zhou, Ziyi Yuan, Yuyan Gong, Luyao Li, Yanmao Wang, Xian Wang, Chunbo Ma, Lehe Yang, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao, Xiaoying Huang

“…However, little is known about how MTHFD2 functions in NSCLC. Integrin-linked kinase (ILK) signaling plays key a role in tumor progression including metastasis, proliferation and migration. …”
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Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry by Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer

“…Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels represents a major pathway for Ca2+ influx from the extracellular space in multiple cell types. …”
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