Optogenetic Approaches for the Spatiotemporal Control of Signal Transduction Pathways by Markus M. Kramer, Levin Lataster, Wilfried Weber, Gerald Radziwill

“…The main part deals with the engineering and application of optogenetic tools for the control of transmembrane receptors including receptor tyrosine kinases, the T cell receptor and integrins, and their effector proteins. We also address the hallmarks of optogenetics, the spatial and temporal control of signaling events.…”
Get full text

Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs by Soo-Young Na, You Sun Kim

“…These drugs include sphingosine-1-phosphate receptor modulators and anti-integrins to block immune cell migration, and cytokine and Janus kinase inhibitors to block immune cell communications. …”
Get full text

Osteopontin in Pulmonary Hypertension by Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov

“…Osteopontin modulates a plethora of cellular processes within the pulmonary vasculature, including cell proliferation, migration, apoptosis, extracellular matrix synthesis, and inflammation via binding to various receptors such as integrins and CD44. In this article, we provide a comprehensive overview of the current understanding of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as consider research issues required for the development of therapeutics targeting osteopontin as a potential strategy for the management of PH.…”
Get full text

Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes by Lagarrigue, Frederic, Ginsberg, Mark H., Cantor, Joseph M., Gertler, Frank

“…Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates the recruitment of talin to integrins, thereby supporting their activation. In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development. …”
Get full text
Get full text

Peritoneal inflammation – A microenvironment for Epithelial Ovarian Cancer (EOC) by Liu Jinsong, Deavers Michael, Freedman Ralph S, Wang Ena

“…These alterations may involve a number of proteins, including cytokines, chemokines, growth factors, either membrane or non-membrane bound, and integrins. Interactions between these molecules and molecular structures within the extracellular matrix, such as collagens and the proteoglycans, may contribute to a peritoneal mesothelial surface and stromal environment that is conducive to tumor cell proliferation and invasion. …”
Get full text

Factors of angiogenesis in the development of physiological and pathological processes of the female gonads by V. G. Zenkina

“…Angiogenic activity in the ovary is also under the control of other growth factors: fibroblast growth factor, epidermal growth factor, platelet growth factor, insulin-like growth factor-1 and cytokines such as tumor necrotic factor, interleukins, components of the extracellular matrix (laminin, fibronectin) and their receptors (integrins), matrix metalloproteinases and their tissue inhibitors and regulators, proteases (plasminogen, activators urokinase and urokinase tissue type), as well as hypoxia, hypoglycemia and stress. …”
Get full text

The reception and the party after: how vascular endothelial growth factor receptor 2 explores cytoplasmic space by P Berger, K Ballmer-Hofer

“…In addition, VEGFs interact with co-receptors such as neuropilins, integrins, semaphorins or heparansulfate glycosaminoglycans. …”
Get full text

Deciphering Mechanisms of Action of Sortilin/Neurotensin Receptor-3 in the Proliferation Regulation of Colorectal and Other Cancers by Jean Mazella

“…This review focuses particularly on the implication of membrane-bound and soluble Sortilin/NTSR3 in colorectal cancer tissues and cells depending on its ability to be associated either to neurotrophins (NTs) or to NTS receptors, as well as to other cellular components such as integrins. At the end of the review, some hypotheses are suggested to counteract the deleterious effects of these proteins in order to develop effective anti-cancer treatments.…”
Get full text

Biomechanics of Neutrophil Tethers by Andrea Cugno, Alex Marki, Klaus Ley

“…Leukocytes, including neutrophils, propelled by blood flow, can roll on inflamed endothelium using transient bonds between selectins and their ligands, and integrins and their ligands. When such receptor–ligand bonds last long enough, the leukocyte microvilli become extended and eventually form thin, 20 µm long tethers. …”
Get full text

The role of PTEN in innate and adaptive immunity by Taylor, H, Laurence, A, Uhlig, H

“…PTEN acts downstream from T- and B-cell receptors, costimulatory molecules, cytokine receptors, integrins, and also growth factor receptors. Loss of PTEN activity in human and mice is associated with cellular and humoral immune dysfunction, lymphoid hyperplasia, and autoimmunity. …”

Upregulation of adhesion complex proteins and fibronectin by human keratinocytes treated with an aqueous extract from the leaves of Chromolaena odorata (Eupolin) by Phan, T, Allen, J, Hughes, M, Cherry, G, Wojnarowska, F

“…The expression of the β1 and β4 integrins was upregulated by the extract at low concentrations (0.1 and 1 μg/ml), but the expression was decreased at higher doses of Eupolin (10 μg-150 μg/ml). …”

A humanized CD18 antibody can block function without cell destruction. by Sims, M, Hassal, D, Brett, S, Rowan, W, Lockyer, M, Angel, A, Lewis, A, Hale, G, Waldmann, H, Crowe, J

“…Leukocyte integrins are intimately involved in transient adherence of leukocytes to endothelium and to each other in the processes of extravasation and cell activation. …”

Lymphatic trafficking of immune cells and insights for cancer metastasis by Jackson, DG

“…Typically these include directional guidance via chemotaxis, haptotaxis and durotaxis, adhesion to the vessel surface via receptors including integrins, and junctional re-modelling by MMPs (Matrix MetalloProteinases) and ADAMs (A Disintegrin And Metalloproteinases) [5–7]. …”

Upregulation of adhesion complex proteins and fibronectin by human keratinocytes treated with an aqueous extract from the leaves of Chromolaena odorata (Eupolin). by Phan, T, Allen, J, Hughes, M, Cherry, G, Wojnarowska, F

“…The expression of the b1 and b4 integrins was upregulated by the extract at low concentrations (0.1 and 1 microg/ml), but the expression was decreased at higher doses of Eupolin (10 microg-150 microg/ml). …”

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor. by Fry, E, Tuthill, T, Harlos, K, Walter, T, Rowlands, D, Stuart, D

“…In contrast to FMDV, which uses integrins as cellular receptors, the receptor for ERAV has been reported to involve the sugar moiety sialic acid. …”

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule by Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith

“…It mediates cellular adhesive interactions by binding to the β2 integrins macrophage antigen 1 and leukocyte function-associated antigen 1, as well as other ligands. …”
Get full text

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 by Yagmur Kan, YiTing Paung, Markus A. Seeliger, W. Todd Miller

“…In addition to being a downstream effector of receptor tyrosine kinases (RTKs) and integrins, Ack1 can act as an epigenetic regulator, modulate the degradation of the epidermal growth factor receptor (EGFR), confer drug resistance, and mediate the progression of hormone-sensitive tumors. …”
Get full text

The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer by Han Yeoung Lee, Seung Wan Son, Sokviseth Moeng, Soo Young Choi, Jong Kook Park

“…Multiple cellular factors and events, such as apoptosis, survival factors, cell cycle, EMT, stemness, autophagy, and integrins influence the anoikis resistance and anchorage-independent cell growth in cancer. …”
Get full text

Mn-Containing Bioactive Glass-Ceramics: BMP-2-Mimetic Peptide Covalent Grafting Boosts Human-Osteoblast Proliferation and Mineral Deposition by Leonardo Cassari, Paola Brun, Michele Di Foggia, Paola Taddei, Annj Zamuner, Antonella Pasquato, Adriana De Stefanis, Veronica Valentini, Vicentiu Mircea Saceleanu, Julietta V. Rau, Monica Dettin

“…Mn activates human osteoblast (h-osteoblast) integrins, enhancing cell proliferation with a dose-dependent effect, whereas Mn-enriched glasses induce inhibition of Gram-negative or Gram-positive bacteria and fungi. …”
Get full text

<a name="home"></a>Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling by C.C. Lopes, C.P. Dietrich, H.B. Nader

“…More recently, the core proteins of the syndecan family transmembrane proteoglycans have also been shown to be involved in cell signaling through interaction with integrins and tyrosine kinase receptors.…”
Get full text