Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells. by Masato Nagaoka, Motohiro Kobayashi, Chie Kawai, Sunil K Mallanna, Stephen A Duncan

“…In an attempt to generate a substratum that supports undifferentiated properties and differentiation into hepatic lineage cells, we designed novel substrates consisting of vitronectin fragments fused to the IgG Fc domain. hPSCs adhered to these substrates via interactions between integrins and the RGD (Arg-Gly-Asp) motif, and the cells maintained their undifferentiated phenotypes. …”
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Insights into the Role of Sialylation in Cancer Metastasis, Immunity, and Therapeutic Opportunity by Jianmei Huang, Jianming Huang, Guonan Zhang

“…Tumor cells activate endothelial cells and metastasize to distant organs in part by the interactions of abnormally sialylated integrins with selectins. Furthermore, cancer sialylation masks tumor antigenic epitopes and induces an immunosuppressive environment, allowing cancer cells to escape immune monitoring. …”
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The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions by Fernando Salgado-Polo, Anastassis Perrakis

“…Then, we present the known ATX catalysis-independent functions, including binding to cell surface integrins and proteoglycans. Next, we analyse all crystal structures of ATX bound to inhibitors and present them based on the four inhibitor types that are established based on the binding to the orthosteric and/or the allosteric site. …”
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Increase of CXCR4 Expression on Expanded Non-enriched Cord Blood CD34+ Cells Using MSCs by Masoud Soleimani, Hossein Mozdarani, Ali Akbar Pourfathollah, Yousef Mortazavi, Kamran Alimoghaddam, Abbas Hajifathali, Zahra Zonobi

“…Introduction: A number of potential cell adhesion molecules, which mediate essential cell-to-cell or cell-to-matrix interactions, are expressed on the surface of CD34+ hematopoietic progenitor cells (HPCs), including integrins, CD44, and CXCR4. These molecules are essential for homing process. …”
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The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders by Eleonora Terrabuio, Elena Zenaro, Gabriela Constantin

“…We also discuss the relevance of trafficking molecules such as selectins, mucins and integrins controlling the extravasation of CD8+ T cells into the CNS and promoting disease development. …”
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Transient outward potassium current and Ca2+ homeostasis in the heart: beyond the action potential by R.A. Bassani

“…Reelin and tenascin are extracellular matrix components that attract or repel neuronal precursors and axons during development through interaction with membrane receptors, and netrin associates with laminin and heparan sulfate proteoglycans, and binds to the extracellular matrix receptor integrins present on the neuronal surface. Altogether, the dynamic changes in the composition and distribution of extracellular matrix components provide external cues that direct neurons leaving their birthplaces to reach their correct final location. …”
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Effect of TiO₂ Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts by Juan Shong Khaw, Christopher R. Bowen, Sarah H. Cartmell

“…Recent studies demonstrated that the activation of integrins is affected not by only the surface chemistry between the cell-material interfaces, but also by the features of surface nanotopography, including nanotube diameter. …”
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Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion by Irina Jahin, Thomas Phillips, Stefania Marcotti, Mark-Alexander Gorey, Susan Cox, Maddy Parsons

“…Changes in extracellular stiffness and other physical characteristics are sensed by integrins which integrate these extracellular cues to intracellular signaling, resulting in modulation of proliferation and invasion. …”
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Human platelets express CAR with localization at the sites of intercellular interaction by Othman Maha, Buriachkovskaia Liudmila, Gupalo Elena

“…Virus entry inside cells is facilitated by integrins αVβ3 and αVβ5. Mice platelets are shown to be the predominant Ad binding blood cell type and the virus is documented inside platelets. …”
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Molecular Ultrasound Imaging by Gurbet Köse, Milita Darguzyte, Fabian Kiessling

“…It has proven promising to diagnose angiogenesis, inflammation, and thrombosis, and many intravascular targets, such as VEGFR2, integrins, and selectins, have been successfully visualized in vivo. …”
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New Therapies of Neovascular AMD—Beyond Anti-VEGFs by Praveen Yerramothu

“…Furthermore, novel therapies such as NACHT, LRR and PYD domains containing protein 3 (NLRP3) inflammasome inhibition, inhibitors of integrins and tissue factor are currently being tested at the level of clinical trials to treat nAMD. …”
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Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis. by Ashish V Chintakuntlawar, Xiaohong Zhou, Jaya Rajaiya, James Chodosh

“…These results demonstrate that adenovirus infection of the cornea induces chemokine expression and subsequent infiltration by leukocytes principally through RGD contact between viral capsid and the host cell, possibly through direct interaction between the viral capsid penton base and host cell integrins.…”
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PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. by Sakthianandeswaren, A, Christie, M, D'Andreti, C, Tsui, C, Jorissen, R, Li, S, Fleming, N, Gibbs, P, Lipton, L, Malaterre, J, Ramsay, R, Phesse, T, Ernst, M, Jeffery, R, Poulsom, R, Leedham, S, Segditsas, S, Tomlinson, I, Bernhard, O, Simpson, R, Walker, F, Faux, M, Church, N, Catimel, B, Flanagan, D

“…In large adenomas, carcinomas, and metastases PHLDA1 expression became widespread, with increased expression and nuclear localization at invasive margins. siRNA-mediated suppression of PHLDA1 in colon cancer cells inhibited migration and anchorage-independent growth in vitro and tumor growth in vivo. The integrins ITGA2 and ITGA6 were downregulated in response to PHLDA1 suppression, and accordingly cell adhesion to laminin and collagen was significantly reduced. …”

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis by Sakthianandeswaren, A, Christie, M, D'Andreti, C, Tsui, C, Jorissen, R, Li, S, Fleming, N, Gibbs, P, Lipton, L, Malaterre, J, Ramsay, R, Phesse, T, Ernst, M, Jeffery, R, Poulsom, R, Leedham, S, Segditsas, S, Tomlinson, I, Bernhard, O, Simpson, R, Walker, F, Faux, M, Church, N, Catimel, B, Flanagan, D

“…In large adenomas, carcinomas, and metastases PHLDA1 expression became widespread, with increased expression and nuclear localization at invasive margins. siRNA-mediated suppression of PHLDA1 in colon cancer cells inhibited migration and anchorage-independent growth in vitro and tumor growth in vivo. The integrins ITGA2 and ITGA6 were downregulated in response to PHLDA1 suppression, and accordingly cell adhesion to laminin and collagen was significantly reduced. …”

The guidance receptor plexin D1 is a mechanosensor in endothelial cells by Mehta, V, Pang, KL, Rozbesky, D, Nather, K, Keen, A, Lachowski, D, Kong, Y, Karia, D, Ameismeier, M, Huang, J, Fang, Y, Hernandez, ADR, Reader, JS, Jones, EY, Tzima, E

“…In endothelial cells, PLXND1 is a direct force sensor and forms a mechanocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanosensitivity upstream of the junctional complex and integrins. PLXND1 achieves its binary functions as either a ligand or a force receptor by adopting two distinct molecular conformations. …”

Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer. by Hu, J, Bianchi, F, Ferguson, M, Cesario, A, Margaritora, S, Granone, P, Goldstraw, P, Tetlow, M, Ratcliffe, C, Nicholson, A, Harris, A, Gatter, K, Pezzella, F

“…Angiogenic tumours have higher levels of genes coding for membrane vesicles, integrins, remodelling, angiogenesis and apoptosis. …”

Fibrin and fibrinogen degradation products with an intact D-domain C-terminal gamma chain inhibit an early step in accessory cell-dependent lymphocyte mitogenesis. by Robson, S, Saunders, R, Purves, L, De Jager, C, Corrigall, A, Kirsch, R

“…This specific binding may be competitively inhibited by monoclonal antibodies to CD11b/CD18 or by peptide analogues of the C-terminal gamma chain of fibrinogen that mimic the adhesion recognition site of integrins. We postulate that DD and D1 bind to CD11b/CD18 on adherent monocytes and modulate lymphocyte activation. …”

TB domain proteins: evolutionary insights into the multifaceted roles of fibrillins and LTBPs. by Robertson, I, Jensen, S, Handford, P

“…These include covalent binding of the TGFβ propeptide, and RGD-directed interactions with a repertoire of integrins. TB domains are found interspersed with long arrays of EGF (epidermal growth factor)-like domains, which occur more widely in extracellular proteins, and also mediate binding to a large number of proteins and proteoglycans. …”

Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. by Robertson, S, Twigg, SR, Sutherland-Smith, A, Biancalana, V, Gorlin, R, Horn, D, Kenwrick, S, Kim, C, Morava, E, Newbury-Ecob, R, Orstavik, K, Quarrell, O, Schwartz, C, Shears, D, Suri, M, Kendrick-Jones, J, Wilkie, A

“…Filamin A, encoded by the gene FLNA, is a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes and second messengers. …”

The molecular pathogenesis of corticotroph tumours. by Dworakowska, D, Grossman, AB

“…CONCLUSIONS: We would expect that over the next 5 years, more detailed analysis of inter-cellular communication pathways between pituitary cells, including the cadherins and integrins, and their interactions with other signalling pathways such as the β-catenin cascade will help elucidate what exactly goes awry in the formation of a benign corticotroph adenoma. …”