Neutrophil activation status in stable coronary artery disease. by Eva Särndahl, Ida Bergström, Veronika Patcha Brodin, Johnny Nijm, Helen Lundqvist Setterud, Lena Jonasson

“…Chemoattractants (Interleukin-8 and Leukotriene B(4)) did not increase either the expression or the amount of high-affinity CD11b/CD18-integrins in CAD patients compared to controls, and had no effect on the production of ROS. …”
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The endothelium: gatekeeper to lung ischemia-reperfusion injury by Huy Q. Ta, Maniselvan Kuppusamy, Swapnil K. Sonkusare, Mark E. Roeser, Victor E. Laubach

“…In this review, we highlight the more significant mediators of IRI-induced endothelial dysfunction discovered over the past decade including the extracellular glycocalyx, endothelial ion channels, purinergic receptors, kinases, and integrins. While there are no definitive clinical therapies currently available to prevent lung IRI, we will discuss potential clinical strategies for targeting the endothelium for the treatment or prevention of IRI. …”
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Model of a six immunoglobulin-like domain fragment of filamin A (16-21) built using residual dipolar couplings. by Tossavainen, H, Koskela, O, Jiang, P, Ylänne, J, Campbell, I, Kilpeläinen, I, Permi, P

“…Many of the filamin interactions including those for glycoprotein Ibα and integrins have been mapped to the region comprising FLN domains 16-21. …”

Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex. by Wild, M, Cambiaggi, A, Brown, M, Davies, E, Ohno, H, Saito, T, Van Der Merwe, P

“…The T cell antigen receptor (TCR) and its ligand peptide-major histocompatibility complex (MHC) are small (approximately 7 nm) compared with other abundant cell surface molecules such as integrins, CD43, and CD45 (23-50 nm). We have proposed that molecules at the T cell/antigen-presenting cell (APC) interface segregate according to size, with small "accessory" molecules (e.g., CD2, CD4, CD8, CD28, and CD154) contributing to the formation of a close-contact zone, within which the TCR engages peptide-MHC, and from which large molecules are excluded (Davis, S.J., and P.A. van der Merwe. 1996. …”

Spectrum-Wide Exploration of Human Adenoviruses for Breast Cancer Therapy by Nicolas Mach, Jian Gao, Lukas Schaffarczyk, Sebastian Janz, Eric Ehrke-Schulz, Thomas Dittmar, Anja Ehrhardt, Wenli Zhang

“…We found that all analyzed BC cell lines show low expression levels of CAR, while alternative receptors such as CD46, DSG-2, and integrins were also detected. We identified Ad3, Ad35, Ad37, and Ad52 as potential candidates for BC virotherapy.…”
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Melanocyte Transformation Associated with Substrate Adhesion Impediment by Sueli M. Oba-Shinjo, Mariangela Correa, Tatiana I. Ricca, Femanda Molognoni, Maria A. Pinhal, Izabel A. Neves, Sueli K. Marie, Lúcia O. Sampaio, Helena B. Nader, Roger Chammas, Miriam G. Jasiulionis

“…No significant differences in cell surface expression of integrins were detected, but a clear electrophoretic migration shift, compatible with an altered glycosylation pattern, was observed for β1 chain in transformed cell lines. …”
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Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development by Muhammad Idrees, Seon-Hwa Oh, Tahir Muhammad, Marwa El-Sheikh, Seok-Hwan Song, Kyeong-Lim Lee, Il-Keun Kong

“…Src-homology-2-containing phosphotyrosine phosphatase (SHP2) is a ubiquitously expressed, multifunctional protein that plays a central role in the signaling pathways involved in growth factor receptors, cytokine receptors, integrins, and G protein-coupled receptors. Over recent decades, researchers have recapitulated the protein signaling networks that influence gamete progenitor specification as well as gamete differentiation and maturation. …”
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Membranes Prepared from Recombinant RGD-Silk Fibroin as Substrates for Human Corneal Cells by Elham Nili, Damien G. Harkin, Rebecca A. Dawson, Neil A. Richardson, Shuko Suzuki, Traian V. Chirila

“…Further studies are required to confirm if the benefits of this formulation are due to changes in the expression of integrins, components of the extracellular matrix, or other events at the transcriptional level.…”
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The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection by Yingxin Zhao, Dianhua Qiao, Melissa Skibba, Allan R. Brasier

“…We observe that RSV induces N-glycosylation and the secretion of proteins related to ECM organization, secretion, or proteins integral to plasma membranes, such as integrins, laminins, collagens, and ECM-modifying enzymes, in an IRE1α–XBP1 dependent manner. …”
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Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors by Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Melanie Heroult, Dmitry Zubov, Kersten Matthias Gericke, Harvey Wong, Melanie M. Frigault, Amy J. Johnson, Raquel Izumi, Ahmed Hamdy

“…Here, for the first time, we disclose the structure and the synthesis of VIP236, an SMDC designed for the treatment of metastatic solid tumors by targeting αvβ3 integrins and extracellular cleavage of the 7-ethyl camptothecin payload by neutrophil elastase in the tumor microenvironment. …”
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Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer by Jiangang Zhao, Hans A. Schlößer, Zhefang Wang, Jie Qin, Jiahui Li, Felix Popp, Marie Christine Popp, Hakan Alakus, Seung-Hun Chon, Hinrich P. Hansen, Wolfram F. Neiss, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…The serum EVs’ TGF-β1 levels were quantified by ELISA. We found that integrins were enriched in PDAC-derived EVs. The expression of NKG2D, CD107a, TNF-α, and INF-γ in NK cells was significantly downregulated after co-culture with EVs. …”
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Playing with Biophysics: How a Symphony of Different Electromagnetic Fields Acts to Reduce the Inflammation in Diabetic Derived Cells by Federica Zanotti, Martina Trentini, Ilaria Zanolla, Elena Tiengo, Chiara Mantarro, Luca Dalla Paola, Elena Tremoli, Maria Sambataro, Luisa Sambado, Massimo Picari, Sara Leo, Letizia Ferroni, Barbara Zavan

“…Moreover, the results confirm that the CMF treatment induced a reduction in the ROS production, an increase in the macrophage M2 anti-inflammatory phenotype through the activation of miRNA 5591, a reduction in inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6, an increase in anti-inflammatory ones, such as IL-10 and IL-12 and an increase in the markers related to improved wound healing such as collagen type I and integrins. In conclusion, our findings encourage the use of CMFs for the treatment of diabetic foot.…”
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Plant‐Derived Zein as an Alternative to Animal‐Derived Gelatin for Use as a Tissue Engineering Scaffold by Apurva Limaye, Venkatesan Perumal, Courtney M. Karner, Treena Livingston Arinzeh

“…Human mesenchymal stem cells (MSCs) on zein scaffolds express focal adhesion kinase and integrins such as α v β 3, α 4, and β 1 similar to gelatin scaffolds. …”
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Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics by Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian

“…A plethora of molecules, including ion channels, integrins, focal adhesion kinases, and myokines, are mechanosensitive and transduce mechanical stimuli into intercellular signaling, regulating growth, mineralized extracellular matrix biosynthesis, and resorption. …”
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Sterculic Acid Alters Adhesion Molecules Expression and Extracellular Matrix Compounds to Regulate Migration of Lung Cancer Cells by Rafael Peláez, Rodrigo Ochoa, Ana Pariente, Ángela Villanueva-Martínez, Álvaro Pérez-Sala, Ignacio M. Larráyoz

“…The results reveal that SA induces tumoral cell death at high doses, but we also observed that lower SA-treatments induce cell adhesion-migration capacity reduction as a result of modifications in the expression of genes related to integrins and extracellular matrix compounds. Overall, the functional and transcriptomic findings suggest that SA could represent a new inhibitor activity of epithelial to mesenchymal transition.…”
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Rotavirus Interactions With Host Intestinal Epithelial Cells by Joshua Oluoch Amimo, Joshua Oluoch Amimo, Sergei Alekseevich Raev, Juliet Chepngeno, Alfred Omwando Mainga, Alfred Omwando Mainga, Yusheng Guo, Linda Saif, Anastasia N. Vlasova

“…For successful cell attachment and entry, RVs use sialic acid, histo-blood group antigens, heat shock cognate protein 70 and cell-surface integrins as attachment factors and/or (co)-receptors. …”
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Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair by Bi-Qin Lai, Yu-Rong Bai, Wei-Tao Han, Bao Zhang, Shu Liu, Jia-Hui Sun, Jia-Lin Liu, Ge Li, Xiang Zeng, Ying Ding, Yuan-Huan Ma, Ling Zhang, Zheng-Hong Chen, Jun Wang, Yuan Xiong, Jin-Hua Wu, Qi Quan, Ling-Yan Xing, Hong-Bo Zhang, Yuan-Shan Zeng

“…Interestingly, laminin could also guide linear axon regeneration via interactions with specific integrins on the axon surface. The WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin, NT-3 and OL cells to achieve significant structural repair of SCI. …”
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Double-edged role of mechanical stimuli and underlying mechanisms in cartilage tissue engineering by Yao Jia, Yao Jia, Hanxiang Le, Hanxiang Le, Xianggang Wang, Jiaxin Zhang, Yan Liu, Jiacheng Ding, Changjun Zheng, Fei Chang

“…These mechanical signals are sensed by receptors in the cell membrane, such as primary cilia, integrins, and ion channels, which next activate downstream pathways. …”
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The Proteomes of Oral Cells Change during Co-Cultivation with <i>Aggregatibacter actinomycetemcomitans</i> and <i>Eikenella corrodens</i> by Boris Schminke, Philipp Kauffmann, Phillipp Brockmeyer, Nicolai Miosge, Christof Lenz, Andrea Schubert

“…Mesodermal lineage cells generally exhibited similar proteomes after co-cultivation with bacteria; in particular, collagens and integrins were expressed at higher levels. Conclusions: The results of the present study will help us elucidate the cellular mechanisms of periodontitis. …”
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New Gene Markers of Exosomal Regulation Are Involved in Porcine Granulosa Cell Adhesion, Migration, and Proliferation by Jakub Kulus, Wiesława Kranc, Magdalena Kulus, Dorota Bukowska, Hanna Piotrowska-Kempisty, Paul Mozdziak, Bartosz Kempisty, Paweł Antosik

“…The complexity of intercellular interactions in the ovarian follicle is also based on multilevel intercellular signaling, including the mechanisms involving cadherins, integrins, and the extracellular matrix. The processes in the ovary leading to the formation of a fertilization-ready oocyte are extremely complex at the molecular level and depend on the oocyte’s ongoing relationship with granulosa cells. …”
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