Targeting Tissue Factor to Tumor Vasculature to Induce Tumor Infarction by Andrew F. Berdel, Christian Schwöppe, Caroline Brand, Saliha Harrach, Kathrin Brömmel, Heike Hintelmann, Georg Lenz, Ruediger Liersch, Hauke Heinzow, Christoph Schliemann, Rolf M. Mesters, Wolfgang E. Berdel, Torsten Kessler

“…Among these targets were vascular adhesion molecules, oncofetal variants of fibronectin, prostate-specific membrane antigens, vascular endothelial growth factor receptors and co-receptors, integrins, fibroblast activation proteins, NG2 proteoglycan, microthrombus-associated fibrin-fibronectin, and aminopeptidase N. …”
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Modulation of Adhesion Molecules Expression by Different Metalloproteases Isolated from <i>Bothrops</i> Snakes by Bianca C. Zychar, Patrícia B. Clissa, Eneas Carvalho, Adilson S. Alves, Cristiani Baldo, Eliana L. Faquim-Mauro, Luís Roberto C. Gonçalves

“…Toxins (0.5 µg) or PBS (100 µL) were injected into the scrotum of mice, and 2, 4, or 24 h later, the protein and gene expression of CD54 and CD31 in the endothelium, and integrins (CD11a and CD11b), expressed in leukocytes were evaluated. …”
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Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles by Masato Yoshihara, Shigehiko Mizutani, Yukio Kato, Kunio Matsumoto, Eita Mizutani, Hidesuke Mizutani, Hiroki Fujimoto, Satoko Osuka, Hiroaki Kajiyama

“…In EECs, RGD-recognizing integrins are important bridging receptors for fibronectin, whereas the non-RGD binding of fibronectin includes interactions with dipeptidyl peptidase IV (DPPIV)/cluster of differentiation (CD) 26. …”
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Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14 by Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S Lukesch, Calin C Guet, Michael Sixt

“…Binding of the pathogenic strain CFT073 to CD14 reduced DC migration by overactivation of integrins and blunted expression of co-stimulatory molecules by overactivating the NFAT (nuclear factor of activated T-cells) pathway, both rate-limiting factors of T cell activation. …”
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets by Xingpeng Di, Xiaoshuai Gao, Liao Peng, Jianzhong Ai, Xi Jin, Shiqian Qi, Hong Li, Kunjie Wang, Deyi Luo

“…The key effectors responding to mechanical stimulations are listed, such as Piezo channels, integrins, Yes-associated protein (YAP) /transcriptional coactivator with PDZ-binding motif (TAZ), and transient receptor potential vanilloid 4 (TRPV4). …”
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In Situ Quantification of Surface Chemistry in Porous Collagen Biomaterials by Tzeranis, Dimitrios, Soller, Eric Charles, Buydash, Melissa Christine, So, Peter T. C., Yannas, Ioannis V

“…The optimized methodology is utilized to quantify the ligands of integrins α[subscript 1]β[subscript 1], α[subscript 2]β[subscript 1] on two kinds of matched porous collagen scaffolds, which are shown to possess significantly different ligand density, and significantly different ability to induce peripheral nerve regeneration in vivo. …”
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Electrospun nanofibers as a bioadhesive platform for capturing adherent leukemia cells by Chan, Jerry Kok Yen, Cao, Xue, Kwek, Kenneth, Chan, Casey K. H., Lim, Mayasari

“…The expression of α-integrins was equally high in both captured and uncaptured leukemia cell populations demonstrating no relation to its adhesive nature. …”
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Transcriptomic Analysis Reveals Differential Expression of Genes between Lung Capillary and Post Capillary Venules in Abdominal Sepsis by Milladur Rahman, Zhiyi Ding, Carl-Fredrik Rönnow, Henrik Thorlacius

“…In contrast, PCV are more enriched with genes related to chemotaxis, cell–cell adhesion by integrins, chemokine biosynthesis, regulation of actin filament process and neutrophil homeostasis after sepsis. …”
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The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling by Naoki Ichikawa-Tomikawa, Kotaro Sugimoto, Korehito Kashiwagi, Hideki Chiba

“…Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear. …”
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New insight into Epstein-Barr virus infection using models of stratified epithelium. by Ian R Hayman, Rachel M Temple, Cole K Burgess, Mary Ferguson, Jason Liao, Craig Meyers, Clare E Sample

“…Undifferentiated epithelial cells expressed proposed EBV receptors in monolayer and were susceptible to viral binding and entry. Integrins, and occasionally ephrin A2, were expressed in the basal layer of gingiva and tonsil derived organotypic cultures, but the known B-cell receptors HLAII and CD21 were not detected. …”
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Role of Truncated <i>O</i>-GalNAc Glycans in Cancer Progression and Metastasis in Endocrine Cancers by Diluka Pinto, Rajeev Parameswaran

“…Recent studies in glycobiology have shown truncated <i>O</i>-glycans to be a hallmark of cancer cells, and when expressed, increase the oncogenicity by promoting dedifferentiation, risk of metastasis by impaired adhesion (mediated by selectins and integrins), and resistance to immunological killing by NK cells. …”
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Immunotherapy in inflammatory bowel disease: Novel and emerging treatments by Ignacio Catalan-Serra, Øystein Brenna

“…We also highlight new emerging therapies targeting the adhesion and migration of leukocytes into the inflamed intestinal mucosa by blocking selectively different subunits of α4β7 integrins or binding alternative adhesion molecules like MAdCAM-1. …”
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Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and Function by Brahim Chaqour, Charles Karrasch

“…Interestingly, vascular cells sense physical forces, including the stiffness of their ECM, through mechanosensitive integrins, their associated proteins and the actomyosin cytoskeleton, which generates biochemical signals that culminate in a rapid expression of matricellular proteins such as cellular communication network 1 (CCN1) and CCN2 (aka connective tissue growth factor or CTGF). …”
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Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases by Paulina Korta, Ewa Pocheć, Agnieszka Mazur-Biały

“…In some tissues irisin probably acts via integrins, which are widely expressed transmembrane receptors. …”
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Mycobacterium bovis BCG increase the selected determinants of monocyte/macrophage activity, which were diminished in response to gastric pathogen Helicobacter pylori by Weronika Gonciarz, Maciej Chyb, Magdalena Chmiela

“…We determined the influence of onco-BCG on the phagocytic capacity of human THP-1 monocyte/macrophage cells, using the model of Escherichia coli bioparticles and Hp fluorescently labeled. Deposition of cell integrins CD11b, CD11d, CD18, membrane/soluble lipopolysaccharide (LPS) receptors, CD14 and sCD14, respectively, and the production of macrophage chemotactic protein (MCP)-1 were determined. …”
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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes by A. Razzaque Ahmed, Sarah Anwar, Pedro A. Reche

“…These included BPAG1, BPAG2 and subunits of α6 and β4 human integrins. Our objective was to find a molecular basis for the global incidence of Pg diseases and a mechanism that will explain the vast differences in clinical phenotypes and outcomes. …”
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Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure by Claudio Humeres, Arti V. Shinde, Anis Hanna, Linda Alex, Silvia C. Hernández, Ruoshui Li, Bijun Chen, Simon J. Conway, Nikolaos G. Frangogiannis

“…Smad7 interacted with ErbB2 in a TGF-β–independent manner and restrained ErbB1/ErbB2 activation, suppressing fibroblast expression of fibrogenic proteases, integrins, and CD44. Smad7 induction in myofibroblasts serves as an endogenous TGF-β–induced negative feedback mechanism that inhibits postinfarction fibrosis by restraining Smad-dependent and Smad-independent TGF-β responses, and by suppressing TGF-β–independent fibrogenic actions of ErbB2.…”
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Hitting the Target! Challenges and Opportunities for TGF-β Inhibition for the Treatment of Cardiac fibrosis by Maria Vistnes

“…Targeting activators of latent TGF-β, including ADAMTS enzymes, thrombospondin, and integrins, emerges as a potentially safer strategy to reduce TGF-β-induced fibrosis but it requires the identification of appropriate targets. …”
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The BRD9/7 Inhibitor TP-472 Blocks Melanoma Tumor Growth by Suppressing ECM-Mediated Oncogenic Signaling and Inducing Apoptosis by Lawrence David Mason, Suresh Chava, Kiran Kumar Reddi, Romi Gupta

“…Mechanistically, using a transcriptome-wide mRNA sequencing profile we identified TP-472 treatment downregulates genes encoding various extracellular matrix (ECM) proteins, including integrins, collagens, and fibronectins. Reactome-based functional pathway analyses revealed that many of the ECM proteins are involved in extracellular matrix interactions required for cancer cell growth and proliferation. …”
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The role of prostate cancer microvesicles in epithelial mesenchymal transition by Alokozai, Sarah

“…Importantly this study identified key proteins in PC3 MVs that may have contributed to the process of EMT, such as integrins which play a vital role in the biology of invasive carcinoma and setting up a pre-metastatic niche.…”
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