RGD_PLGA Nanoparticles with Docetaxel: A Route for Improving Drug Efficiency and Reducing Toxicity in Breast Cancer Treatment by Enza Di Gregorio, Chiara Romiti, Antonino Di Lorenzo, Federica Cavallo, Giuseppe Ferrauto, Laura Conti

“…The cyclic RGD tripeptide was linked to the PLGA surface to actively target α_vβ₃ integrins, which are overexpressed in breast cancer. …”
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SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells by Francesca Caccuri, Antonella Bugatti, Alberto Zani, Antonella De Palma, Dario Di Silvestre, Ekta Manocha, Federica Filippini, Serena Messali, Paola Chiodelli, Giovanni Campisi, Simona Fiorentini, Fabio Facchetti, Pierluigi Mauri, Arnaldo Caruso

“…Preliminary data point to the role of integrins in SARS-CoV-2 entry into HL-mECs in the absence of detectable ACE2 expression. …”
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High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes by Sébastien Rinaldetti, Qiong Zhou, Joshua M. Abbott, Florus C. de Jong, Hector Esquer, James C. Costello, Dan Theodorescu, Daniel V. LaBarbera

“…The mesenchymal-like cell lines were exclusively sensitive to the ITGAV inhibitor SB273005. The role of integrins within this mesenchymal-like MIBC subtype was confirmed via its regulon activity and gene essentiality based on CRISPR–Cas9 knock-out data. …”
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“Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel by Jing Sun, Yau Tsz Chan, Ki Wai Kevin Ho, Li Zhang, Liming Bian, Rocky S. Tuan, Yangzi Jiang

“…Transcriptomic analysis reveals 332 mechanoresponsive genes, clustered into cell senescence, mechanical sensitivity, and ECM dynamics, associated with interleukins, integrins, and collagens/matrix metalloproteinase pathways. …”
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Blood–Brain Barrier Biomarkers before and after Kidney Transplantation by Leah Hernandez, Liam J. Ward, Samsul Arefin, Peter Barany, Lars Wennberg, Magnus Söderberg, Stefania Bruno, Vincenzo Cantaluppi, Peter Stenvinkel, Karolina Kublickiene

“…CD31+ microparticles from endothelial cells expressing inflammatory markers such as CD40 and integrins were significantly reduced after KT. KT may, thus, improve the neurological status of CKD patients, as reflected by changes in BBB-specific biomarkers.…”
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Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5 by Xinh-Xinh Nguyen, Ludivine Renaud, Carol Feghali-Bostwick

“…Noticeably, 7% of the DEGs in hIGFBP5-expressing pFBs are receptors and integrins. Furthermore, hub gene analysis revealed 12 hub genes including Fpr1, Bdkrb2, Mchr1, Nmur1, Cnr2, P2ry14, and Ptger3. …”
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Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence by Petra Sántha, Daniela Lenggenhager, Anette Finstadsveen, Linda Dorg, Kristin Tøndel, Manoj Amrutkar, Ivar P. Gladhaug, Caroline Verbeke

“…Twenty-six features involved in key biological processes in PC were analyzed (immuno-)histochemically and morphometrically: cancer cell proliferation (Ki67) and migration (collagen fiber alignment, MMP14), cancer stem cells (CD44, CD133, ALDH1), amount, composition and spatial arrangement of extracellular matrix (epithelial proximity, total collagen, collagen I and III, fibronectin, hyaluronan), cancer-associated fibroblasts (density, αSMA), and cancer-stroma interactions (integrins α2, α5, α1; caveolin-1). All features differed significantly between at least two of the patterns. …”
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Recombinant human secretory leukocyte protease inhibitor (rhSLPI) coated titanium enhanced human osteoblast adhesion and differentiation by Radchanon Leelasukseree, Wannapat Chouyratchakarn, Chayanisa Phutiyothin, Faprathan Pikwong, Onnicha Srisopar, Phornsawat Baipaywad, Suruk Udomsom, Podsawee Mongkolpathumrat, Chayarop Supanchart, Sarawut Kumphune

“…The results indicate that coating titanium with 10–100 µg/ml rhSLPI enhanced the physical properties of the Ti surface and enhanced human osteoblast (hFOB 1.19) cell adhesion, activated actin dynamic, enhanced adhesive forces, upregulated integrins α1, α2, and α5, enhanced cell proliferation, mineralization, alkaline phosphatase activity, and upregulated ALP, OCN, and Runx2. …”
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CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS by E. D. Altman, A. V. Zurochka, S. N. Teplova, E. V. Davydova, D. Sh. Altman

“…Among specific markers determining intensity of MALT-associated aging, a decreased percentage of viable immune cells (below 40%), along with the prevalence of the neutrophilic granulocytes in the salivary secretions (over 98%) (with increased expression of β2-integrins); decreased counts of mononuclear cells, i.e., mononuclear cells with low expression of CD11β adhesion molecules, B-lymhocytes, and Th-lymphocytes have been revealed. …”
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Extracellular Vesicles as Drug Delivery System for the Treatment of Neurodegenerative Disorders: Optimization of the Cell Source by Matthew J. Haney, Yuling Zhao, John K. Fallon, Yue Wang, Samuel M. Li, Emily E. Lentz, Dorothy Erie, Philip C. Smith, Elena V. Batrakova

“…Spherical nanoparticles with average size 110–130 nm and zeta potential around −20 mV are identified for all EVs types. mEVs show the highest levels of tetraspanins and integrins compared with nEVs and aEVs, suggesting superior adhesion and targeting to the inflamed tissues by mEVs. …”
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The mirrored cationic peptide as miRNA vehicle for efficient lung cancer therapy by Wenyan Xu, Lingran Du, Lina Yu, Huiyu Cen, Fangyu Lin, Siran Wang, Zhixiong Ruan, Zhongxiao Lin, Xin Zhang, Na Zhou, Jishuo Chang, Xiyong Yu, Lingmin Zhang, Lu Liang

“…RPRIN exhibited a high transfection efficiency in lung cancer cells via the conjugation between RGD and integrins on the surface of lung cancer cells. Furthermore, RD24 showed matrix metallopeptidase 2 (MMP2) responsiveness, which improved lung cancer cell inhibition induced by the miRNA intracellularly. …”
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Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network by Kim, Min-Cheol, Silberberg, Yaron R., Whisler, Jordan Ari, Kamm, Roger Dale, Asada, Harry

“…This filopodium-ECM interaction is modeled as a stochastic process based on binding kinetics between integrins along the filopodial shaft and the ligands on the surrounding ECM fibers. …”
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In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration by Mi Yeon Ha, Dae Hyeok Yang, Su Jung You, Hyun Joo Kim, Heung Jae Chun

“…In vitro experiments using rat bone marrow-derived mesenchymal stem cells (BMSCs) revealed that the GFOGER-PEG-PCL hydrogel significantly enhanced expression of integrins (β1, α2, and α11), increased expression of FAK, and induced downstream signaling of ERK and p38. …”
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Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing by Joseph Andrew Whitley, Houjian Cai

“…The targeting moieties include viral envelope proteins, recombinant proteins containing a ligand peptide, single‐chain fragment variable (scFv) antibodies, and integrins. However, current strategies still have a number of limitations which prevent their use in clinical trials. …”
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Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach by Oliver Andres, Katja Henning, Gabriele Strauß, Annerose Pflug, Georgi Manukjan, Harald Schulze

“…Due to simultaneous analysis of four fluorophores in a basic panel design, we are able to readily detect the most common and clinically significant platelet disorders: Glanzmann thrombasthenia or Glanzmann-like diseases (fibrinogen receptor GPIIb-IIIa), Bernard–Soulier syndrome (von Willebrand-factor receptor complex GPIb-IX-V) and less well characterized β1-integrins that serve as the collagen, laminin or fibronectin receptor (CD29-CD49b, e and f, respectively). …”
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The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM by Dejun Sun, Miaonan Sun, Wenhe Zhu, Zhiding Wang, Yuefei Li, Jie Ma

“…The RGD (Arg-Gly-Asp) site of disintegrin dominates its interaction with integrins on the surface of the tumor cells. uPA is over-expressed and plays an important role in tumor cell invasiveness and metastatic progression. …”
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Mimicry between respiratory virus proteins and some human immune proteins by I. N. Zhilinskaya

“…Mechanistically, all viruses studied were characterized by sequences homologous to host immune proteins such as complement system proteins, integrins, apoptosis inhibitory proteins, interleukins, and toll-like receptors. …”
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Forging New Therapeutic Targets: Efforts of Tumor Derived Exosomes to Prepare the Pre-Metastatic Niche for Cancer Cell Dissemination and Dormancy by Ranvir Bhatia, Joanna Chang, Jessian L. Munoz, Nykia D. Walker

“…Strategies are discussed to alter exosome cargo content for better loading capacity or direct cell targeting by integrins. Further, pre-clinical models or Phase I clinical trials implementing exosomes or other nanocarriers to attack metastatic cancer cells are highlighted.…”
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New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma by Ioana V. Militaru, Alina Adriana Rus, Cristian V.A. Munteanu, Georgiana Manica, Stefana M. Petrescu

“…We found a set of proteins comprising AHNAK, MYOF, ANXA1, CAPN2, ASPH, EPHA2, THBS1, TGM2, ACTN4 along with proteins involved in cell adhesion/migration (integrins, PLEC, FSCN1, FN1) that are highly expressed in amelanotic melanoma. …”
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High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro. by Emma G Bouck, Marios Arvanitis, William O Osburn, Yaqiu Sang, Paula Reventun, Homa K Ahmadzia, Nicholas L Smith, Charles J Lowenstein, Alisa S Wolberg

“…<h4>Results</h4>Neither EE nor drospirenone, alone or together, changed expression of genes encoding anti- or procoagulant proteins (TFPI, THBD, F3), integrins (ITGAV, ITGB3), or fibrinolytic mediators (SERPINE1, PLAT). …”
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